List of works - Nigel J. Waters

Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 1: volume of distribution at steady state.

scientific article

Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 2: clearance.

scientific article

Editorial [Hot topic: Drug Design from the ADME/PK Perspective: Does Chemical Intuition Suffice in Multifaceted Drug Discovery? (Guest Editors: Franco Lombardo & Nigel J. Waters)]

scientific article published on 01 January 2011

High-resolution magic angle spinning (1)H NMR spectroscopy of intact liver and kidney: optimization of sample preparation procedures and biochemical stability of tissue during spectral acquisition

scientific article published on 01 June 2000

Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor

scientific article

In silico human and rat Vss quantitative structure-activity relationship models

scientific article published in March 2006

In silico prediction of total human plasma clearance

scientific article

In silico prediction of volume of distribution in human using linear and nonlinear models on a 669 compound data set.

scientific article published in July 2009

Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions

scientific article

Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis

article

Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity

scientific article published in April 2005

NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate

scientific article

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia ⬇️

scientific article published on June 25, 2013

Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas

scientific article published on 15 February 2011

Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases

scientific article

The role of metabonomics at the interface between drug metabolism and safety assessment.

scientific article published on October 2010

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds

scientific article

Use of the Øie-Tozer model in understanding mechanisms and determinants of drug distribution

scientific article

Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding

scientific article published in October 2008

List of works by Nigel J. Waters

Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 1: volume of distribution at steady state.

Comprehensive assessment of human pharmacokinetic prediction based on in vivo animal pharmacokinetic data, part 2: clearance.

Editorial [Hot topic: Drug Design from the ADME/PK Perspective: Does Chemical Intuition Suffice in Multifaceted Drug Discovery? (Guest Editors: Franco Lombardo & Nigel J. Waters)]

High-resolution magic angle spinning (1)H NMR spectroscopy of intact liver and kidney: optimization of sample preparation procedures and biochemical stability of tissue during spectral acquisition

Identification of NVP-TNKS656: the use of structure-efficiency relationships to generate a highly potent, selective, and orally active tankyrase inhibitor

In silico human and rat Vss quantitative structure-activity relationship models

In silico prediction of total human plasma clearance

In silico prediction of volume of distribution in human using linear and nonlinear models on a 669 compound data set.

Integrated in vitro analysis for the in vivo prediction of cytochrome P450-mediated drug-drug interactions

Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis

Metabonomic deconvolution of embedded toxicity: application to thioacetamide hepato- and nephrotoxicity

NMR and pattern recognition studies on liver extracts and intact livers from rats treated with alpha-naphthylisothiocyanate

Potent inhibition of DOT1L as treatment of MLL-fusion leukemia ⬇️

Protein kinase C inhibitor sotrastaurin selectively inhibits the growth of CD79 mutant diffuse large B-cell lymphomas

Structure-efficiency relationship of [1,2,4]triazol-3-ylamines as novel nicotinamide isosteres that inhibit tankyrases

The role of metabonomics at the interface between drug metabolism and safety assessment.

Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds

Use of the Øie-Tozer model in understanding mechanisms and determinants of drug distribution

Validation of a rapid equilibrium dialysis approach for the measurement of plasma protein binding