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List of works by James K. Chen

A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies.

scientific article published on 19 February 2018

A crucial requirement for Hedgehog signaling in small cell lung cancer

scientific article

A novel missense variant in the GLI3 zinc finger domain in a family with digital anomalies.

scientific article

A small molecule that binds Hedgehog and blocks its signaling in human cells

scientific article

A small-molecule smoothened agonist prevents glucocorticoid-induced neonatal cerebellar injury

scientific article

Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2

scientific article

Affinity electrophoresis in multisectional polyacrylamide slab gels is a useful and convenient technique for measuring binding constants of aryl sulfonamides to bovine carbonic anhydrase B

scientific article published on 01 May 1993

An inducible long noncoding RNA amplifies DNA damage signaling.

scientific article published on 26 September 2016

Arhgap36-dependent activation of Gli transcription factors

scientific article

Basal constriction during midbrain-hindbrain boundary morphogenesis is mediated by Wnt5b and Focal Adhesion Kinase

Centrosome repositioning in T cells is biphasic and driven by microtubule end-on capture-shrinkage.

scientific article

Chemical 'Jekyll and Hyde's: small-molecule inhibitors of developmental signaling pathways

scientific article

Chemical structure-guided design of dynapyrazoles, cell-permeable dynein inhibitors with a unique mode of action

scientific article published on 19 May 2017

Chemical technologies for probing embryonic development

scientific article published on 7 May 2008

Control of inflammation by stromal Hedgehog pathway activation restrains colitis.

scientific article

Controlling destiny through chemistry: small-molecule regulators of cell fate

scientific article

Converse conformational control of smoothened activity by structurally related small molecules

scientific article

Correcting glucose-6-phosphate dehydrogenase deficiency with a small-molecule activator

scientific article published in Nature Communications

Crystal structure of P13K SH3 domain at 20 angstroms resolution

scientific article

Cyclic caged morpholinos: conformationally gated probes of embryonic gene function

scientific article published on 11 June 2012

Cytoplasmic Dynein Antagonists with Improved Potency and Isoform Selectivity

scientific article

Diacylglycerol promotes centrosome polarization in T cells via reciprocal localization of dynein and myosin II

scientific article

Direct kinetochore-spindle pole connections are not required for chromosome segregation

scientific article

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

scientific article (publication date: 31 August 2000)

Emerging technologies in molecular imaging: new windows into biology

scientific article published on 22 July 2013

Fish 'n clicks

scientific article published on 01 July 2008

Functional inhibition of UQCRB suppresses angiogenesis in zebrafish.

scientific article

Gene regulation technologies in zebrafish.

scientific article published on 20 February 2008

General method for regulating protein stability with light

scientific article published on 8 November 2013

Germ cell migration in zebrafish is cyclopamine-sensitive but Smoothened-independent

scientific article published on 04 February 2009

Hedgehog and retinoic acid signaling cooperate to promote motoneurogenesis in zebrafish

scientific article

Hyaluronic acid synthesis is required for zebrafish tail fin regeneration

scientific article

I only have eye for ewe: the discovery of cyclopamine and development of Hedgehog pathway-targeting drugs

scientific article published on 20 January 2016

Illuminating developmental biology through photochemistry

scientific article published in May 2017

In vivo imaging of Hedgehog pathway activation with a nuclear fluorescent reporter

scientific article (publication date: 2014)

Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened

scientific article

Light-controlled gene silencing in zebrafish embryos

scientific article

Lineage labeling of zebrafish cells with laser uncagable fluorescein dextran

scientific article

Medulloblastoma growth inhibition by hedgehog pathway blockade

scientific article published in August 2002

Neuropilins are positive regulators of Hedgehog signal transduction.

scientific article published on 3 November 2011

Nitroreductase-activatable morpholino oligonucleotides for in vivo gene silencing

scientific article published on 28 July 2014

Oligonucleotide-based tools for studying zebrafish development

scientific article published on March 2010

Optochemical dissection of T-box gene-dependent medial floor plate development

scientific article

Post-transcriptional mechanisms contribute to Etv2 repression during vascular development

scientific article

Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

scientific article

Roles of Hedgehog pathway components and retinoic acid signalling in specifying zebrafish ventral spinal cord neurons

scientific article

Sequential gene silencing using wavelength-selective caged morpholino oligonucleotides

scientific article

Small molecule modulation of Smoothened activity

scientific article

Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein

scientific article published on 18 March 2012

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

scientific article published on 05 August 2009

Small-molecule regulation of zebrafish gene expression

scientific article published on 21 January 2007

Smoothened signal transduction is promoted by G protein-coupled receptor kinase 2

scientific article

Spatiotemporal control of embryonic gene expression using caged morpholinos.

scientific article

Spatiotemporal resolution of the Ntla transcriptome in axial mesoderm development

scientific article published on 29 January 2012

Stromal response to Hedgehog signaling restrains pancreatic cancer progression

scientific article

Structure-activity mapping of ARHGAP36 reveals regulatory roles for its GAP homology and C-terminal domains

scientific article published on 17 May 2021

Synthetic strategies for studying embryonic development

scientific article

Targeted and Conditional Gene Expression Workshop, 8th International Conference on Zebrafish Development and Genetics

scientific article

Targeted cell ablation in zebrafish using optogenetic transcriptional control

scientific article published on 15 May 2020

Tbx16 regulates hox gene activation in mesodermal progenitor cells

scientific article

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier–Gorlin syndrome

scientific article

The Stanford Institute for Chemical Biology

scientific article published in September 2013

The decoupling of Smoothened from Galphai proteins has little effect on Gli3 protein processing and Hedgehog-regulated chick neural tube patterning

scientific article published on 18 June 2008

The identification of myriocin-binding proteins

scientific article published on April 1999

The imidazopyridine derivative JK184 reveals dual roles for microtubules in Hedgehog signaling

scientific article

Thinking big with small molecules

scientific article

Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions

scientific article

Ultrasensitive optical imaging with lanthanide lumiphores

scientific article

Versatile synthesis and rational design of caged morpholinos

scientific article

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