List of works - Holger Grohganz

A theoretical and spectroscopic study of co-amorphous naproxen and indomethacin

scientific article

Adsorption of the decapeptide Cetrorelix depends both on the composition of dissolution medium and the type of solid surface

scientific article published in February 2004

Amino Acids as Co-amorphous Excipients for Simvastatin and Glibenclamide: Physical Properties and Stability

scientific article published on 04 June 2014

Amino acids as co-amorphous stabilizers for poorly water soluble drugs--Part 1: preparation, stability and dissolution enhancement

scientific article published on 26 March 2013

Amino acids as co-amorphous stabilizers for poorly water-soluble drugs--Part 2: molecular interactions.

scientific article published on 6 April 2013

Amorphization within the tablet: Using microwave irradiation to form a glass solution in situ

scientific article published on 20 January 2017

Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and l-Arginine.

scientific article published on 9 April 2018

Aspartame as a co-former in co-amorphous systems

Characterising glass transition temperatures and glass dynamics in mesoporous silica-based amorphous drugs

scientific article published on 01 September 2019

Characterization of Amorphous and Co-Amorphous Simvastatin Formulations Prepared by Spray Drying.

scientific article

Classification of lyophilised mixtures using multivariate analysis of NIR spectra.

scientific article

Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions

article

Co-former selection for co-amorphous drug-amino acid formulations

scientific article published on 19 December 2018

Coamorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen.

scientific article published on 15 August 2011

Correlation between calculated molecular descriptors of excipient amino acids and experimentally observed thermal stability of lysozyme.

scientific article published on 20 March 2017

Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy

scientific article published on 15 May 2012

Design space approach in the optimization of the spray-drying process

scientific article published on 29 September 2011

Detecting phase separation of freeze-dried binary amorphous systems using pair-wise distribution function and multivariate data analysis.

scientific article

Determination of the Optimal Molar Ratio in Amino Acid-Based Coamorphous Systems

scientific article published on 09 March 2020

Development and in vitro evaluation of a liposome based implant formulation for the decapeptide cetrorelix

scientific article

Development and validation of a HPLC method for routine quantification of the decapeptide Cetrorelix in liposome dispersions

scientific article published in March 2004

Development of a screening method for co-amorphous formulations of drugs and amino acids.

scientific article published on 13 August 2016

Dipeptides as co-formers in co-amorphous systems

scientific article published on 20 November 2018

Efflux Inhibitor Bicalutamide Increases Oral Bioavailability of the Poorly Soluble Efflux Substrate Docetaxel in Co-Amorphous Anti-Cancer Combination Therapy

scientific article published on 11 January 2019

Emerging trends in the stabilization of amorphous drugs.

scientific article published on 28 April 2012

Exploring the chemical space for freeze-drying excipients

scientific article published on 27 May 2019

Formation Mechanism of Coamorphous Drug-Amino Acid Mixtures.

scientific article published on 23 June 2015

Formation of mannitol hemihydrate in freeze-dried protein formulations--a design of experiment approach

scientific article

Fuzzy Logic-based expert system for evaluating cake quality of freeze-dried formulations

scientific article

Glass Forming Ability of Amorphous Drugs Investigated by Continuous Cooling and Isothermal Transformation

scientific article published on 26 August 2016

Glass-Transition Temperature of the β-Relaxation as the Major Predictive Parameter for Recrystallization of Neat Amorphous Drugs

scientific article published on 02 March 2018

Improvement of the physicochemical properties of Co-amorphous naproxen-indomethacin by naproxen-sodium

scientific article

Improving co-amorphous drug formulations by the addition of the highly water soluble amino Acid, proline

scientific article published on 14 July 2014

In situ amorphisation of indomethacin with Eudragit® E during dissolution

scientific article published on 18 September 2013

In situ co-amorphisation in coated tablets - The combination of carvedilol with aspartic acid during immersion in an acidic medium

scientific article published on 12 January 2019

In situ co-amorphisation of arginine with indomethacin or furosemide during immersion in an acidic medium - a proof of concept study

scientific article published on 16 October 2018

In vitro and in vivo comparison between crystalline and co-amorphous salts of naproxen-arginine

scientific article published on 25 September 2018

Influence of Glass Forming Ability on the Physical Stability of Supersaturated Amorphous Solid Dispersions

scientific article published on 13 March 2019

Influence of PVP molecular weight on the microwave assisted in situ amorphization of indomethacin

scientific article published on 3 October 2017

Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations

scientific article

Influence of preparation pathway on the glass forming ability

scientific article published on 20 February 2017

Influence of preparation technique on co-amorphization of carvedilol with acidic amino acids

scientific article

Influence of the cooling rate and the blend ratio on the physical stability of co-amorphous naproxen/indomethacin

scientific article published on 13 October 2016

Influence of variation in molar ratio on co-amorphous drug-amino acid systems

scientific article published on 28 June 2016

Inhibition of surface crystallisation of amorphous indomethacin particles in physical drug–polymer mixtures

scientific article published on 03 September 2013

Investigation of physical properties and stability of indomethacin-cimetidine and naproxen-cimetidine co-amorphous systems prepared by quench cooling, coprecipitation and ball milling

scientific article published on 14 December 2015

Is there a correlation between the glass forming ability of a drug and its supersaturation propensity?

scientific article

Large-Scale Biophysical Evaluation of Protein PEGylation Effects: In Vitro Properties of 61 Protein Entities

scientific article published on 4 April 2016

Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin.

scientific article published on 27 October 2015

Multivariate analysis of phenol in freeze-dried and spray-dried insulin formulations by NIR and FTIR

scientific article published on 11 May 2011

Near-infrared imaging for high-throughput screening of moisture induced changes in freeze-dried formulations

scientific article published on 24 March 2014

On the role of salt formation and structural similarity of co-formers in co-amorphous drug delivery systems

scientific article published in November 2017

Organic acids as co-formers for co-amorphous systems - Influence of variation in molar ratio on the physicochemical properties of the co-amorphous systems

scientific article published on 21 July 2018

Performance comparison between crystalline and co-amorphous salts of indomethacin-lysine

scientific article published on 22 September 2017

Preparation and characterization of spray-dried co-amorphous drug-amino acid salts

scientific article published on 05 August 2015

Preparation and recrystallization behavior of spray-dried co-amorphous naproxen-indomethacin

scientific article

Preparation of Co-Amorphous Systems by Freeze-Drying

scientific article published on 30 September 2020

Probing Pharmaceutical Mixtures during Milling: The Potency of Low-Frequency Raman Spectroscopy in Identifying Disorder.

scientific article published in November 2017

Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations

scientific article published on 09 January 2019

Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storage.

scientific article published on 19 April 2016

Quality by design approach in the optimization of the spray-drying process.

scientific article

Rapid solid-state analysis of freeze-dried protein formulations using NIR and Raman spectroscopies

scientific article published on 21 January 2011

Recent advances in co-amorphous drug formulations

scientific article

Recent trends in stabilising peptides and proteins in pharmaceutical formulation - considerations in the choice of excipients.

scientific article

Refining stability and dissolution rate of amorphous drug formulations

scientific article published on 23 April 2014

Role of excipients in the quantification of water in lyophilised mixtures using NIR spectroscopy

scientific article published on 24 January 2009

Solid state properties and drug release behavior of co-amorphous indomethacin-arginine tablets coated with Kollicoat® Protect

scientific article published on 8 June 2017

Solid-state properties and dissolution behaviour of tablets containing co-amorphous indomethacin–arginine

scientific article published on 18 July 2015

Supersaturating drug delivery systems: The potential of co-amorphous drug formulations.

scientific article

Surface area, volume and shape descriptors as a novel tool for polymer lead design and discovery

scientific article published on 12 March 2017

The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

scientific article published on 21 September 2018

The Role of Glass Transition Temperatures in Coamorphous Drug–Amino Acid Formulations

scientific article published on 30 July 2018

The impact of surface- and nano-crystallisation on the detected amorphous content and the dissolution behaviour of amorphous indomethacin

scientific article published on 06 June 2012

The influence of lysozyme on mannitol polymorphism in freeze-dried and spray-dried formulations depends on the selection of the drying process

scientific article published on 13 March 2013

The significance of the amorphous potential energy landscape for dictating glassy dynamics and driving solid-state crystallisation

scientific article published on 2 November 2017

The use of molecular descriptors in the development of co-amorphous formulations.

scientific article published on 9 April 2018

Towards a robust water content determination of freeze-dried samples by near-infrared spectroscopy

scientific article published on 30 July 2010

Transformations between Co-Amorphous and Co-Crystal Systems and Their Influence on the Formation and Physical Stability of Co-Amorphous Systems

scientific article published on 25 January 2019

Undesired co-amorphisation of indomethacin and arginine during combined storage at high humidity conditions

scientific article published on 15 April 2018

Unintended and in situ amorphisation of pharmaceuticals.

scientific article published on 23 December 2015

Using dextran of different molecular weights to achieve faster freeze-drying and improved storage stability of lactate dehydrogenase

scientific article published on 20 June 2018

Well-plate freeze-drying: a high throughput platform for screening of physical properties of freeze-dried formulations

scientific article published on 13 January 2014

Whey proteins as stabilizers in amorphous solid dispersions

scientific article published on 04 December 2018

List of works by Holger Grohganz

A theoretical and spectroscopic study of co-amorphous naproxen and indomethacin

Adsorption of the decapeptide Cetrorelix depends both on the composition of dissolution medium and the type of solid surface

Amino Acids as Co-amorphous Excipients for Simvastatin and Glibenclamide: Physical Properties and Stability

Amino acids as co-amorphous stabilizers for poorly water soluble drugs--Part 1: preparation, stability and dissolution enhancement

Amino acids as co-amorphous stabilizers for poorly water-soluble drugs--Part 2: molecular interactions.

Amorphization within the tablet: Using microwave irradiation to form a glass solution in situ

Application of a Salt Coformer in a Co-Amorphous Drug System Dramatically Enhances the Glass Transition Temperature: A Case Study of the Ternary System Carbamazepine, Citric Acid, and l-Arginine.

Aspartame as a co-former in co-amorphous systems

Characterising glass transition temperatures and glass dynamics in mesoporous silica-based amorphous drugs

Characterization of Amorphous and Co-Amorphous Simvastatin Formulations Prepared by Spray Drying.

Classification of lyophilised mixtures using multivariate analysis of NIR spectra.

Co-amorphous simvastatin and glipizide combinations show improved physical stability without evidence of intermolecular interactions

Co-former selection for co-amorphous drug-amino acid formulations

Coamorphous drug systems: enhanced physical stability and dissolution rate of indomethacin and naproxen.

Correlation between calculated molecular descriptors of excipient amino acids and experimentally observed thermal stability of lysozyme.

Design of experiments-based monitoring of critical quality attributes for the spray-drying process of insulin by NIR spectroscopy

Design space approach in the optimization of the spray-drying process

Detecting phase separation of freeze-dried binary amorphous systems using pair-wise distribution function and multivariate data analysis.

Determination of the Optimal Molar Ratio in Amino Acid-Based Coamorphous Systems

Development and in vitro evaluation of a liposome based implant formulation for the decapeptide cetrorelix

Development and validation of a HPLC method for routine quantification of the decapeptide Cetrorelix in liposome dispersions

Development of a screening method for co-amorphous formulations of drugs and amino acids.

Dipeptides as co-formers in co-amorphous systems

Efflux Inhibitor Bicalutamide Increases Oral Bioavailability of the Poorly Soluble Efflux Substrate Docetaxel in Co-Amorphous Anti-Cancer Combination Therapy

Emerging trends in the stabilization of amorphous drugs.

Exploring the chemical space for freeze-drying excipients

Formation Mechanism of Coamorphous Drug-Amino Acid Mixtures.

Formation of mannitol hemihydrate in freeze-dried protein formulations--a design of experiment approach

Fuzzy Logic-based expert system for evaluating cake quality of freeze-dried formulations

Glass Forming Ability of Amorphous Drugs Investigated by Continuous Cooling and Isothermal Transformation

Glass-Transition Temperature of the β-Relaxation as the Major Predictive Parameter for Recrystallization of Neat Amorphous Drugs

Improvement of the physicochemical properties of Co-amorphous naproxen-indomethacin by naproxen-sodium

Improving co-amorphous drug formulations by the addition of the highly water soluble amino Acid, proline

In situ amorphisation of indomethacin with Eudragit® E during dissolution

In situ co-amorphisation in coated tablets - The combination of carvedilol with aspartic acid during immersion in an acidic medium

In situ co-amorphisation of arginine with indomethacin or furosemide during immersion in an acidic medium - a proof of concept study

In vitro and in vivo comparison between crystalline and co-amorphous salts of naproxen-arginine

Influence of Glass Forming Ability on the Physical Stability of Supersaturated Amorphous Solid Dispersions

Influence of PVP molecular weight on the microwave assisted in situ amorphization of indomethacin

Influence of Solvent Composition on the Performance of Spray-Dried Co-Amorphous Formulations

Influence of preparation pathway on the glass forming ability

Influence of preparation technique on co-amorphization of carvedilol with acidic amino acids

Influence of the cooling rate and the blend ratio on the physical stability of co-amorphous naproxen/indomethacin

Influence of variation in molar ratio on co-amorphous drug-amino acid systems

Inhibition of surface crystallisation of amorphous indomethacin particles in physical drug–polymer mixtures

Investigation of physical properties and stability of indomethacin-cimetidine and naproxen-cimetidine co-amorphous systems prepared by quench cooling, coprecipitation and ball milling

Is there a correlation between the glass forming ability of a drug and its supersaturation propensity?

Large-Scale Biophysical Evaluation of Protein PEGylation Effects: In Vitro Properties of 61 Protein Entities

Multivariate Quantification of the Solid State Phase Composition of Co-Amorphous Naproxen-Indomethacin.

Multivariate analysis of phenol in freeze-dried and spray-dried insulin formulations by NIR and FTIR

Near-infrared imaging for high-throughput screening of moisture induced changes in freeze-dried formulations

On the role of salt formation and structural similarity of co-formers in co-amorphous drug delivery systems

Organic acids as co-formers for co-amorphous systems - Influence of variation in molar ratio on the physicochemical properties of the co-amorphous systems

Performance comparison between crystalline and co-amorphous salts of indomethacin-lysine

Preparation and characterization of spray-dried co-amorphous drug-amino acid salts

Preparation and recrystallization behavior of spray-dried co-amorphous naproxen-indomethacin

Preparation of Co-Amorphous Systems by Freeze-Drying

Probing Pharmaceutical Mixtures during Milling: The Potency of Low-Frequency Raman Spectroscopy in Identifying Disorder.

Process Optimization and Upscaling of Spray-Dried Drug-Amino acid Co-Amorphous Formulations

Properties of the Sodium Naproxen-Lactose-Tetrahydrate Co-Crystal upon Processing and Storage.

Quality by design approach in the optimization of the spray-drying process.

Rapid solid-state analysis of freeze-dried protein formulations using NIR and Raman spectroscopies

Recent advances in co-amorphous drug formulations

Recent trends in stabilising peptides and proteins in pharmaceutical formulation - considerations in the choice of excipients.

Refining stability and dissolution rate of amorphous drug formulations

Role of excipients in the quantification of water in lyophilised mixtures using NIR spectroscopy

Solid state properties and drug release behavior of co-amorphous indomethacin-arginine tablets coated with Kollicoat® Protect

Solid-state properties and dissolution behaviour of tablets containing co-amorphous indomethacin–arginine

Supersaturating drug delivery systems: The potential of co-amorphous drug formulations.

Surface area, volume and shape descriptors as a novel tool for polymer lead design and discovery

The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

The Role of Glass Transition Temperatures in Coamorphous Drug–Amino Acid Formulations

The impact of surface- and nano-crystallisation on the detected amorphous content and the dissolution behaviour of amorphous indomethacin

The influence of lysozyme on mannitol polymorphism in freeze-dried and spray-dried formulations depends on the selection of the drying process

The significance of the amorphous potential energy landscape for dictating glassy dynamics and driving solid-state crystallisation

The use of molecular descriptors in the development of co-amorphous formulations.

Towards a robust water content determination of freeze-dried samples by near-infrared spectroscopy

Transformations between Co-Amorphous and Co-Crystal Systems and Their Influence on the Formation and Physical Stability of Co-Amorphous Systems

Undesired co-amorphisation of indomethacin and arginine during combined storage at high humidity conditions