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List of works by Shamshad Cockcroft

14-3-3 protein and ATRAP bind to the soluble class IIB phosphatidylinositol transfer protein RdgBβ at distinct sites.

scientific article published on April 2012

A modified procedure for thin-layer chromatography of phospholipids

scientific article published in December 1982

A new family of StART domain proteins at membrane contact sites has a role in ER-PM sterol transport.

scientific article

A unique phosphatidylinositol 4-phosphate 5-kinase is activated by ADP-ribosylation factor in Plasmodium falciparum.

scientific article published on 10 January 2009

ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I.

scientific article published in July 1999

ADP-ribosylation factor 1-regulated phospholipase D activity is localized at the plasma membrane and intracellular organelles in HL60 cells.

scientific article published on December 1996

ADP-ribosylation factor and Rho proteins mediate fMLP-dependent activation of phospholipase D in human neutrophils

scientific article published on 01 May 1998

ADP-ribosylation-factor-regulated phospholipase D activity localizes to secretory vesicles and mobilizes to the plasma membrane following N-formylmethionyl-leucyl-phenylalanine stimulation of human neutrophils.

scientific article published on August 1997

ARF and PITP restore GTPγS-stimulated protein secretion from cytosol-depleted HL60 cells by promoting PIP2 synthesis

scientific article published on 01 June 1996

ARF-regulated phospholipase D: a potential role in membrane traffic

scientific article published on May 1996

ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts

scientific article published on December 1998

ARF1(2-17) does not specifically interact with ARF1-dependent pathways. Inhibition by peptide of phospholipases C beta, D and exocytosis in HL60 cells

scientific article published on 01 July 1994

ARF1-regulated phospholipase D in human neutrophils is enhanced by PMA and MgATP

scientific article published on 01 September 1994

ATP induces nucleotide permeability in rat mast cells

scientific journal article

ATP stimulates secretion in human neutrophils and HL60 cells via a pertussis toxin-sensitive guanine nucleotide-binding protein coupled to phospholipase C

scientific article published on 01 March 1989

Activation and inhibition of calcium-dependent histamine secretion by ATP ions applied to rat mast cells ⬇️

scientific article published on November 1, 1979

Activation of exocytosis by cross-linking of the IgE receptor is dependent on ADP-ribosylation factor 1-regulated phospholipase D in RBL-2H3 mast cells: evidence that the mechanism of activation is via regulation of phosphatidylinositol [...]

scientific journal article

Acyl chain-based molecular selectivity for HL60 cellular phosphatidylinositol and of phosphatidylcholine by phosphatidylinositol transfer protein alpha.

scientific article

An essential role for phosphatidylinositol transfer protein in phospholipase C-Mediated inositol lipid signaling

scientific article published on 01 September 1993

Biochemical and biological functions of class I phosphatidylinositol transfer proteins

scientific article published on 4 April 2007

Breakdown and synthesis of polyphosphoinositides in fMetLeuPhe-stimulated neutrophils

scientific article published on 01 February 1985

Bromoenol lactone, an inhibitor of Group V1A calcium-independent phospholipase A2 inhibits antigen-stimulated mast cell exocytosis without blocking Ca2+ influx

scientific article published on 18 July 2006

Ca2+-dependent conversion of phosphatidylinositol to phosphatidate in neutrophils stimulated with fMet-Leu-Phe or ionophore A23187

scientific article published on 01 August 1984

Characterization of fMet-Leu-Phe-stimulated phospholipase C in streptolysin-O-permeabilised cells

scientific article published on April 1991

Chemotactic peptide stimulation of arachidonic acid release in HL60 cells, an interaction between G protein and phospholipase C mediated signal transduction

scientific article published on 01 October 1991

Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in the formylmethionyl-leucylphenylalanine-dependent production of phosphatidylinositol 3,4,5-trisphosphate in human neutrophils

scientific article published on July 1997

Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in vitro

scientific article published on January 2002

Compartmentalized signalling in neurons

scientific article published on 01 October 2007

Continual production of phosphatidic acid by phospholipase D is essential for antigen-stimulated membrane ruffling in cultured mast cells

scientific article

Contrasting roles for receptor-stimulated inositol lipid metabolism in secretory cells ⬇️

scientific article published on 01 December 1984

Correlation between secretion and phospholipase D activation in differentiated HL60 cells.

scientific article

Crystallization and preliminary X-ray diffraction studies on ADP-ribosylation factor 1

scientific article (publication date: 16 December 1994)

Current thoughts on the phosphatidylinositol transfer protein family

scientific article

Deletion of 24 amino acids from the C-terminus of phosphatidylinositol transfer protein causes loss of phospholipase C-mediated inositol lipid signalling

scientific article published on May 1997

Didecanoyl phosphatidylcholine is a superior substrate for assaying mammalian phospholipase D.

scientific article published on November 1996

Differential control of azurophilic and specific granule exocytosis in Sendai-virus-permeabilized rabbit neutrophils

scientific article

Differential expression of a C-terminal splice variant of phosphatidylinositol transfer protein beta lacking the constitutive-phosphorylated Ser262 that localizes to the Golgi compartment.

scientific article published in September 2006

Dual role for guanine nucleotides in stimulus-secretion coupling

scientific article published on 01 June 1986

Dynamics of lipid transfer by phosphatidylinositol transfer proteins in cells

scientific article published on 9 July 2008

EGF regulation of PITP dynamics is blocked by inhibitors of phospholipase C and of the Ras-MAP kinase pathway

scientific article published on 01 January 2003

Early events in the activation of Ca2+ dependent secretion: studies with rat peritoneal mast cells

scientific article published on 01 September 1980

Effect of H-ras proteins on the activity of polyphosphoinositide phospholipase C in HL60 membranes

scientific article published on January 1990

Endogenous phospholipase D2 localizes to the plasma membrane of RBL-2H3 mast cells and can be distinguished from ADP ribosylation factor-stimulated phospholipase D1 activity by its specific sensitivity to oleic acid

scientific article published on January 2003

Essential synergy between Ca2+ and guanine nucleotides in exocytotic secretion from permeabilized rat mast cells

scientific article published on July 1987

Evidence for a role of phosphatidylinositol turnover in stimulus–secretion coupling. Studies with rat peritoneal mast cells ⬇️

scientific article published on March 15, 1979

Fluoxetine elevates allopregnanolone in female rat brain but inhibits a steroid microsomal dehydrogenase rather than activating an aldo-keto reductase.

scientific article

Function of the phosphatidylinositol transfer protein gene family: is phosphatidylinositol transfer the mechanism of action?

scientific article published on 31 January 2011

Guanine nucleotides stimulate polyphosphoinositide phosphodiesterase and exocytotic secretion from HL60 cells permeabilized with streptolysin O.

scientific article

Human ITPK1: a reversible inositol phosphate kinase/phosphatase that links receptor-dependent phospholipase C to Ca2+-activated chloride channels

scientific article

Identification of a Plasmodium falciparum phospholipid transfer protein

scientific article (publication date: November 2013)

Identification of a novel cytosolic poly-phosphoinositide-specific phospholipase C (PLC-86) as the major G-protein-regulated enzyme ⬇️

scientific article published on September 1, 1991

Identification of phospholipase B from Dictyostelium discoideum reveals a new lipase family present in mammals, flies and nematodes, but not yeast

scientific article

Inositol lipid metabolism in human T lymphocytes activated via the T3 complex

scientific article published on 01 February 1987

Insulin uptake across the luminal membrane of the rat proximal tubule in vivo and in vitro.

scientific article

Ionomycin stimulates mast cell histamine secretion by forming a lipid-soluble calcium complex ⬇️

scientific article published on December 20, 1979

Is phospholipase A2 activation regulated by G-proteins? ⬇️

scientific article published on April 1, 1991

Ligand and membrane-binding behavior of the phosphatidylinositol transfer proteins PITPα and PITPβ.

scientific article published on 18 April 2016

Mammalian PITPs at the Golgi and ER-Golgi Membrane Contact Sites

Mammalian phosphatidylinositol transfer proteins: emerging roles in signal transduction and vesicular traffic.

scientific article

Measurement of phosphatidylinositol and phosphatidylcholine binding and transfer activity of the lipid transport protein PITP

scientific article published on 01 January 2009

Measurement of phospholipase C by monitoring inositol phosphates using [3H]inositol-labeling protocols in permeabilized cells.

scientific article published in January 2006

Measurement of phospholipase C by monitoring inositol phosphates using [³H]inositol labeling protocols in permeabilized cells

scientific article

Measurement of phospholipase C by monitoring inositol phosphates using [³H]inositol-labeling protocols in permeabilized cells

scientific article published on January 2005

Mechanism of ADP ribosylation factor-stimulated phosphatidylinositol 4,5-bisphosphate synthesis in HL60 cells

scientific article published on 14 December 2001

Membrane targeting and activation of the Lowe syndrome protein OCRL1 by rab GTPases

scientific article

Mitochondrial CDP-diacylglycerol synthase activity is due to the peripheral protein, TAMM41 and not due to the integral membrane protein, CDP-diacylglycerol synthase 1.

scientific article published on 15 December 2017

Monomeric IgE stimulates NFAT translocation into the nucleus, a rise in cytosol Ca2+, degranulation, and membrane ruffling in the cultured rat basophilic leukemia-2H3 mast cell line

scientific article published on April 2004

PA binding of phosphatidylinositol 4-phosphate 5-kinase

scientific article

Phorbol ester inhibits polyphosphoinositide phosphodiesterase activity stimulated by either Ca2+, fluoride or GTP analogue in HL60 membranes and in permeabilized HL60 cells

scientific article published on 01 January 1989

Phorbol esters inhibit inositol phosphate and diacylglycerol formation in proliferating HL60 cells. Relationship to differentiation

scientific article published on 01 June 1988

Phosphatidic acid regulation of phosphatidylinositol 4-phosphate 5-kinases

scientific article published on 17 March 2009

Phosphatidylinositol binding of Saccharomyces cerevisiae Pdr16p represents an essential feature of this lipid transfer protein to provide protection against azole antifungals

scientific article published on 25 July 2014

Phosphatidylinositol metabolism in mast cells and neutrophils ⬇️

scientific article published on October 1, 1982

Phosphatidylinositol transfer protein beta displays minimal sphingomyelin transfer activity and is not required for biosynthesis and trafficking of sphingomyelin

scientific article published on August 2002

Phosphatidylinositol transfer protein dictates the rate of inositol trisphosphate production by promoting the synthesis of PIP2 ⬇️

scientific article published on July 1, 1995

Phosphatidylinositol transfer protein, cytoplasmic 1 (PITPNC1) binds and transfers phosphatidic acid

scientific journal article

Phosphatidylinositol transfer protein-α in platelets is inconsequential for thrombosis yet is utilized for tumor metastasis

scientific article published on 31 October 2017

Phosphatidylinositol transfer proteins: a requirement in signal transduction and vesicle traffic ⬇️

scientific article published on May 1, 1998

Phosphatidylinositol transfer proteins: an essential requirement in inositol lipid signalling

scientific article published on November 1997

Phosphatidylinositol transfer proteins: requirements in phospholipase C signaling and in regulated exocytosis ⬇️

scientific article published on June 23, 1997

Phosphatidylinositol- and phosphatidylcholine-transfer activity of PITPbeta is essential for COPI-mediated retrograde transport from the Golgi to the endoplasmic reticulum

scientific article published on 23 March 2010

Phospholipase D: Regulation by GTPases and protein kinase C and physiological relevance ⬇️

scientific article published on December 1, 1996

Phospholipase D: a downstream effector of ARF in granulocytes

scientific article published in Science

Phospholipid transport protein function at organelle contact sites

article published in 2018

Phosphorylation of a distinct structural form of phosphatidylinositol transfer protein alpha at Ser166 by protein kinase C disrupts receptor-mediated phospholipase C signaling by inhibiting delivery of phosphatidylinositol to membranes

scientific article

Pitpnc1a Regulates Zebrafish Sleep and Wake Behavior through Modulation of Insulin-like Growth Factor Signaling

Plasma-membrane location of phosphatidylinositol hydrolysis in rabbit neutrophils stimulated with formylmethionyl-leucylphenylalanine

scientific article published on December 1982

Potential role for phosphatidylinositol transfer protein (PITP) family in lipid transfer during phospholipase C signalling

scientific article published on 21 July 2013

Potentiation and inhibition of secretion from neutrophils by phorbol ester

scientific article published in May 1986

Protein and diacylglycerol phosphorylation in the stimulus-secretion coupling of rat mast cells

scientific article published on 01 June 1987

Purification and cloning of phosphatidylinositol transfer proteins from Dictyostelium discoideum: homologues of both mammalian PITPs and Saccharomyces cerevisiae sec14p are found in the same cell

scientific article

Purification of phosphatidylinositol transfer protein from brain cytosol for reconstituting G-protein-regulated phosphoinositide-specific phospholipase C-beta isozymes

scientific article published on 01 January 1994

RDGBα, a PtdIns-PtdOH transfer protein, regulates G-protein-coupled PtdIns(4,5)P2 signalling during Drosophila phototransduction

scientific article

Rat mast cells permeabilized with ATP secrete histamine in response to calcium ions buffered in the micromolar range

scientific article published on 01 August 1981

Reconstitution System Based on Cytosol-Depleted Cells to Study the Regulation of Phospholipases C and D

scientific article published on 01 January 1998

Reconstitution of GTPγS-Induced NADPH Oxidase Activity in Streptolysin-O-Permeabilized Neutrophils by Specific Cytosol Fractions

scientific article published on 01 November 1999

Reconstitution system based on cytosol-depleted cells to study the regulation of phospholipase D.

scientific article published on January 2006

Regulation of PI3K signalling by the phosphatidylinositol transfer protein PITPalpha during axonal extension in hippocampal neurons

scientific article published on 19 February 2008

Regulation of cytosolic phosphoinositide-phospholipase C by G-protein, Gp.

scientific article

Regulation of inositol lipid-specific phospholipase cdelta by changes in Ca2+ ion concentrations

scientific article published on October 1997

Requirement for phosphatidylinositol transfer protein in epidermal growth factor signaling

scientific article

Resynthesis of phosphatidylinositol in permeabilized neutrophils following phospholipase Cbeta activation: transport of the intermediate, phosphatidic acid, from the plasma membrane to the endoplasmic reticulum for phosphatidylinositol resynthesis i

scientific article published in July 1999

Reversible bleb formation in mast cells stimulated with antigen is Ca2+/calmodulin-dependent and bleb size is regulated by ARF6.

scientific article published on 14 December 2009

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

scientific article published in Nature

Signalling role for ARF and phospholipase D in mast cell exocytosis stimulated by crosslinking of the high affinity FcepsilonR1 receptor.

scientific article

Signalling roles of mammalian phospholipase D1 and D2 ⬇️

scientific article published on October 1, 2001

Signalling through phospholipase C interferes with clathrin-mediated endocytosis

scientific article published on 6 June 2006

Special issue on phospholipase D

scientific article published on 01 September 2009

Spermine increases phosphatidylinositol 4,5-bisphosphate content in permeabilized and nonpermeabilized HL60 cells

scientific article

Stimulated neutrophils from patients with autosomal recessive chronic granulomatous disease fail to phosphorylate a Mr-44,000 protein

scientific article published in August 1985

Stimulus–secretion coupling in rabbit neutrophils is not mediated by phosphatidylinositol breakdown

scientific article published in Nature

Structure-function analysis of human [corrected] phosphatidylinositol transfer protein alpha bound to phosphatidylinositol

scientific article

Subcellular localisation of inositol lipid kinases in rat liver

scientific article published in May 1985

The ATP4- receptor of rat mast cells

scientific article published on June 1980

The Ca2+-activated polyphosphoinositide phosphodiesterase of human and rabbit neutrophil membranes ⬇️

scientific article published on July 15, 1984

The Concise Guide to PHARMACOLOGY 2013/14: overview

scientific article

The Diverse Functions of Phosphatidylinositol Transfer Proteins ⬇️

scientific article published on January 1, 2012

The Drosophila photoreceptor as a model system for studying signalling at membrane contact sites

scientific article published on April 2016

The dependence on Ca2+ of phosphatidylinositol breakdown and enzyme secretion in rabbit neutrophils stimulated by formylmethionyl-leucylphenylalanine or ionomycin

scientific article published in December 1981

The differentiating agent, retinoic acid, causes an early inhibition of inositol lipid-specific phospholipase C activity in HL-60 cells

scientific article published on 01 January 1991

The fatty acid composition of 1,2-diacylglycerol and polyphosphoinositides from human erythrocyte membranes

scientific article published on August 1983

The latest phospholipase C, PLCeta, is implicated in neuronal function

scientific article

The phosphatidylinositol transfer protein RdgBβ binds 14-3-3 via its unstructured C-terminus, whereas its lipid-binding domain interacts with the integral membrane protein ATRAP (angiotensin II type I receptor-associated protein)

scientific article published in 2011

The receptors for ATP and fMetLeuPhe are independently coupled to phospholipases C and A2 via G-protein(s). Relationship between phospholipase C and A2 activation and exocytosis in HL60 cells and human neutrophils

scientific article published in November 1989

The yeast and mammalian isoforms of phosphatidylinositol transfer protein can all restore phospholipase C-mediated inositol lipid signaling in cytosol-depleted RBL-2H3 and HL-60 cells

scientific article published on June 1996

Thyroid-stimulating hormone stimulates increases in inositol phosphates as well as cyclic AMP in the FRTL-5 rat thyroid cell line

scientific article published on November 1987

Topological organisation of the phosphatidylinositol 4,5-bisphosphate-phospholipase C resynthesis cycle: PITPs bridge the ER-PM gap.

scientific article published on December 2016

Trafficking of phosphatidylinositol by phosphatidylinositol transfer proteins

scientific article published on January 2007

Two G-proteins act in series to control stimulus-secretion coupling in mast cells: use of neomycin to distinguish between G-proteins controlling polyphosphoinositide phosphodiesterase and exocytosis

scientific article published on December 1987

Two roles for guanine nucleotides in the stimulus-secretion sequence of neutrophils

scientific article published in February 1986

Type I phosphatidylinositol 4-phosphate 5-kinase directly interacts with ADP-ribosylation factor 1 and is responsible for phosphatidylinositol 4,5-bisphosphate synthesis in the golgi compartment.

scientific article

Undifferentiated HL60 cells respond to extracellular ATP and UTP by stimulating phospholipase C activation and exocytosis

scientific article published on 01 March 1990

Use of cytochalasin B to distinguish between early and late events in neutrophil activation

scientific article published on 01 October 1980

Use of cytosol-depleted HL-60 cells for reconstitution studies of G-protein-regulated phosphoinositide-specific phospholipase C-beta isozymes

scientific article published on January 1994

Vesicular transport. Sticky fingers grab a lipid

scientific article

Yeast Sec14p deficient in phosphatidylinositol transfer activity is functional in vivo.

scientific article

f-MetLeuPhe-induced phosphatidylinositol turnover in rabbit neutrophils is dependent on extracellular calcium

scientific article published on 01 January 1980

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