List of works - Harry Mellor

A synthetic peptide substrate for initiation factor-2 kinases

scientific article (publication date: 31 July 1991)

Actin stress fibres

scientific article published on October 2007

Brefeldin A inhibits protein synthesis through the phosphorylation of the α-subunit of eukaryotic initiation factor-2

scientific article published on 01 August 1994

Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1)

scientific article published on 01 September 2001

Cell motility: Golgi signalling shapes up to ship out.

scientific article published on June 2004

Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

scientific article published in November 1994

Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression

scientific journal article

Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human

scientific article

Cloning and characterization of complementary and genomic DNAs encoding the epsilon-subunit of rat translation initiation factor-2B.

scientific article published on July 1996

Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules

scientific article published in May 2002

Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA

scientific article

Cyclic-AMP Increases Nuclear Actin Monomer Which Promotes Proteasomal Degradation of RelA/p65 Leading to Anti-Inflammatory Effects

scientific article published on 21 April 2022

Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus

scientific article published on 30 July 2020

Direct Activation of NADPH Oxidase 2 by 2-Deoxyribose-1-Phosphate Triggers Nuclear Factor Kappa B-Dependent Angiogenesis.

scientific article

Escherichia coli isolated from bovine mastitis invade mammary cells by a modified endocytic pathway

scholarly article by Samantha L Passey et al published July 2008 in Veterinary Microbiology

Evolution of the Human Rho GTPase Family

Expression of RND proteins in human myometrium

scientific article

Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase

scientific article

Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis.

scientific article published on 30 August 2008

Functional coupling of rat metabotropic glutamate 1a receptors to phospholipase D in CHO cells: involvement of extracellular Ca2+, protein kinase C, tyrosine kinase and Rho-A.

scientific article published in January 2002

Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP

scientific article (publication date: December 2002)

Imaging protein kinase Calpha activation in cells

scientific article published on March 1999

In Vitro Coculture Assays of Angiogenesis

scientific article

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression.

scientific article published on 4 June 2018

Modular phosphoinositide-binding domains--their role in signalling and membrane trafficking.

scientific article

Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif

scientific article

PRK1 is targeted to endosomes by the small GTPase, RhoB

scientific article

Platelet Rho GTPases-a focus on novel players, roles and relationships.

scientific article

Purification and characterisation of an initiation-factor-2 kinase from uninduced mouse erythroleukaemia cells

scientific article published on 01 February 1993

Purification and characterization of eukaryotic translational initiation factor eIF-2B from liver

scientific article published on 01 December 1994

RNA interference approaches to examine Golgi function in animal cell culture

scientific article published on January 2013

Raftlin is recruited by neuropilin-1 to the activated VEGFR2 complex to control proangiogenic signaling

scientific article published on 09 April 2020

Regulation of endocytic traffic by Rho GTPases.

scientific article

Regulation of endocytic traffic by rho family GTPases.

scientific article

Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB

scientific article

Rho GTPase activation assays

scientific article published on March 2008

Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase

scientific article (publication date: 14 April 2000)

Rho-dependence of Schizosaccharomyces pombe Pck2

scientific article published on 01 January 2000

RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane

scientific article published on December 2004

RhoBTB Proteins in Cancer

article published in 2009

RhoBTB2 in breast cancer.

scientific article

RhoG protein regulates platelet granule secretion and thrombus formation in mice.

scientific article published on 08 October 2013

Role of translation initiation factor eIF-2B in the regulation of protein synthesis in mammalian cells

scientific article published on January 1996

S1P and LPA trigger Schwann cell actin changes and migration.

scientific article

Scanning Electron Microscopy of Cell Surface Morphology

article published in 2007

Site recognition and substrate screens for PKN family proteins

scientific article

Small interfering RNAs as a tool to assign Rho GTPase exchange-factor function in vivo

scientific article published in September 2002

Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides

scientific article

Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy

scientific article

Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B

scientific article

Synergistic roles for the Map and Tir effector molecules in mediating uptake of enteropathogenic Escherichia coli (EPEC) into non-phagocytic cells.

scientific article

The Coculture Organotypic Assay of Angiogenesis

The Formin FMNL3 Controls Early Apical Specification in Endothelial Cells by Regulating the Polarized Trafficking of Podocalyxin

scientific article

The Rho GTPase family: a Racs to Wrchs story.

scientific article

The Rho family GTPase Rif induces filopodia through mDia2.

scientific article published on January 2005

The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction

scientific article published on 7 February 2015

The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells

scientific article

The extended protein kinase C superfamily ⬇️

scientific article published on June 1, 1998

The formin FMNL3 is a cytoskeletal regulator of angiogenesis

scientific article

The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements

scientific article

The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation

scientific article (publication date: 13 December 2002)

The role of formins in filopodia formation

scientific article published on 03 January 2009

The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells

scientific article published on 16 March 2010

The small GTPase Rif is dispensable for platelet filopodia generation in mice

scientific article (publication date: 2013)

The small Rho GTPase Rif and actin cytoskeletal remodelling

scientific article published on February 2012

The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B.

scientific article

Translocation of the cell-penetrating Tat peptide across artificial bilayers and into living cells

scientific article published in January 2005

Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor

scientific article published on 14 February 2007

Uses of the in vitro endothelial-fibroblast organotypic co-culture assay in angiogenesis research

scientific article published on December 2011

VEGF receptor trafficking in angiogenesis

scientific article published in December 2009

VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment

scientific article published on 25 April 2006

VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching

scientific article published in June 2009

What is in a filopodium? Starfish versus hedgehogs.

scientific article published in December 2004

eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast

scientific article

List of works by Harry Mellor

A synthetic peptide substrate for initiation factor-2 kinases

Actin stress fibres

Brefeldin A inhibits protein synthesis through the phosphorylation of the α-subunit of eukaryotic initiation factor-2

Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1)

Cell motility: Golgi signalling shapes up to ship out.

Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase

Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression

Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human

Cloning and characterization of complementary and genomic DNAs encoding the epsilon-subunit of rat translation initiation factor-2B.

Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules

Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA

Cyclic-AMP Increases Nuclear Actin Monomer Which Promotes Proteasomal Degradation of RelA/p65 Leading to Anti-Inflammatory Effects

Dimethyl-2-oxoglutarate improves redox balance and mitochondrial function in muscle pericytes of individuals with diabetes mellitus

Direct Activation of NADPH Oxidase 2 by 2-Deoxyribose-1-Phosphate Triggers Nuclear Factor Kappa B-Dependent Angiogenesis.

Escherichia coli isolated from bovine mastitis invade mammary cells by a modified endocytic pathway

Evolution of the Human Rho GTPase Family

Expression of RND proteins in human myometrium

Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase

Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis.

Functional coupling of rat metabotropic glutamate 1a receptors to phospholipase D in CHO cells: involvement of extracellular Ca2+, protein kinase C, tyrosine kinase and Rho-A.

Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP

Imaging protein kinase Calpha activation in cells

In Vitro Coculture Assays of Angiogenesis

Live imaging of wound angiogenesis reveals macrophage orchestrated vessel sprouting and regression.

Modular phosphoinositide-binding domains--their role in signalling and membrane trafficking.

Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif

PRK1 is targeted to endosomes by the small GTPase, RhoB

Platelet Rho GTPases-a focus on novel players, roles and relationships.

Purification and characterisation of an initiation-factor-2 kinase from uninduced mouse erythroleukaemia cells

Purification and characterization of eukaryotic translational initiation factor eIF-2B from liver

RNA interference approaches to examine Golgi function in animal cell culture

Raftlin is recruited by neuropilin-1 to the activated VEGFR2 complex to control proangiogenic signaling

Regulation of endocytic traffic by Rho GTPases.

Regulation of endocytic traffic by rho family GTPases.

Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB

Rho GTPase activation assays

Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase

Rho-dependence of Schizosaccharomyces pombe Pck2

RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane

RhoBTB Proteins in Cancer

RhoBTB2 in breast cancer.

RhoG protein regulates platelet granule secretion and thrombus formation in mice.

Role of translation initiation factor eIF-2B in the regulation of protein synthesis in mammalian cells

S1P and LPA trigger Schwann cell actin changes and migration.

Scanning Electron Microscopy of Cell Surface Morphology

Site recognition and substrate screens for PKN family proteins

Small interfering RNAs as a tool to assign Rho GTPase exchange-factor function in vivo

Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides

Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy

Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B

Synergistic roles for the Map and Tir effector molecules in mediating uptake of enteropathogenic Escherichia coli (EPEC) into non-phagocytic cells.

The Coculture Organotypic Assay of Angiogenesis

The Formin FMNL3 Controls Early Apical Specification in Endothelial Cells by Regulating the Polarized Trafficking of Podocalyxin

The Rho GTPase family: a Racs to Wrchs story.

The Rho family GTPase Rif induces filopodia through mDia2.

The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction

The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells

The extended protein kinase C superfamily ⬇️

The formin FMNL3 is a cytoskeletal regulator of angiogenesis

The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements

The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation

The role of formins in filopodia formation

The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells

The small GTPase Rif is dispensable for platelet filopodia generation in mice

The small Rho GTPase Rif and actin cytoskeletal remodelling

The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B.

Translocation of the cell-penetrating Tat peptide across artificial bilayers and into living cells

Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor

Uses of the in vitro endothelial-fibroblast organotypic co-culture assay in angiogenesis research

VEGF receptor trafficking in angiogenesis

VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment

VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching

What is in a filopodium? Starfish versus hedgehogs.

eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast

siRNA approaches in cell biology