List of works - Sarah E. O'Connor

Nicotiana benthamiana as a Transient Expression Host to Produce Auxin Analogs

scientific article published on 20 November 2020

A BAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids.

scientific article published on 13 February 2018

A Pressure Test to Make 10 Molecules in 90 Days: External Evaluation of Methods to Engineer Biology.

scientific article published on 26 February 2018

A microbial supply chain for production of the anti-cancer drug vinblastine

scientific article published in 2022

A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an organ-dependent manner in Catharanthus roseus

scientific article published on 9 October 2013

A role for Old Yellow Enzyme in ergot alkaloid biosynthesis

scientific article published in February 2010

A stereoselective hydroxylation step of alkaloid biosynthesis by a unique cytochrome P450 in Catharanthus roseus ⬇️

scientific article

A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate.

scientific article

A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus

scientific article published on 27 July 2011

An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole.

scientific article published on 13 January 2017

An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis

scientific article

An old yellow enzyme gene controls the branch point between Aspergillus fumigatus and Claviceps purpurea ergot alkaloid pathways ⬇️

scientific article

Aureolic acids: similar antibiotics with different biosynthetic gene clusters

scientific article published in January 2004

Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis

scientific article published on December 2009

Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs

scientific article published on 13 December 2019

Biocatalysts from alkaloid producing plants

scientific article

Biocatalytic Strategies towards [4+2] Cycloadditions

scientific article published on 12 March 2019

Biocatalytic asymmetric formation of tetrahydro-β-carbolines

scientific article published on August 2010

Biocatalytic production of tetrahydroisoquinolines

scientific article published on February 2012

Biosynthesis of an Anti-Addiction Agent from the Iboga Plant

scientific article published on 06 August 2019

Biosynthesis of epothilone intermediates with alternate starter units: engineering polyketide-nonribosomal interfaces.

scientific article published in August 2003

Biosynthesis of strychnine

scholarly article published in 2022

Biosynthesis of the ergot alkaloids

scientific article

Bypassing stereoselectivity in the early steps of alkaloid biosynthesis

scientific article published on 13 August 2009

Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine

scientific article

Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome. ⬇️

scientific article published on 19 August 2015

Chemistry and biology of monoterpene indole alkaloid biosynthesis

scientific article

Chemoselective derivatization of alkaloids in periwinkle

scientific article published on 11 July 2007

Chlorinated Auxins-How Does Arabidopsis Thaliana Deal with Them?

scientific article published on 07 April 2020

Class II Cytochrome P450 Reductase Governs the Biosynthesis of Alkaloids.

scientific article published on 29 September 2016

Controlling a structural branch point in ergot alkaloid biosynthesis

scientific article published on September 2010

Conversion of substrate analogs suggests a Michael cyclization in iridoid biosynthesis

scientific article published on 23 October 2014

Corrigendum to biocatalysts from alkaloid producing plants [Biocatalysts from alkaloid producing plants 31 (2016) 22-30]

scientific article published on 01 June 2018

Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

scientific article published in August 2005

Cyclization of natural products

scientific article published on 01 October 2006

Cytochrome P450 and -methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from

scientific article published in Journal of Biological Chemistry

De novo production of the plant-derived alkaloid strictosidine in yeast

scientific article

Development of transcriptomic resources for interrogating the biosynthesis of monoterpene indole alkaloids in medicinal plant species

scientific article

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation

scientific article published on 21 August 2020

Differential iridoid production as revealed by a diversity panel of 84 cultivated and wild blueberry species

scientific article

Directed Evolution of Piperazic Acid Incorporation by a Nonribosomal Peptide Synthetase**

scientific article published in 2023

Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus

scientific article published on November 2006

Discovery and Reconstitution of the Cycloclavine Biosynthetic Pathway-Enzymatic Formation of a Cyclopropyl Group

scientific article published on 25 February 2015

Discovery and reconstitution of the cycloclavine biosynthetic pathway--enzymatic formation of a cyclopropyl group

scientific article published on 25 February 2015

Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids

scientific article published on 01 May 2015

Discovery of a short chain dehydrogenase from Catharanthus roseus that produces a novel monoterpene indole alkaloid.

scientific article published on 9 February 2018

Diversification of monoterpene indole alkaloid analogs through cross-coupling

scientific article published on 28 May 2013

Dual Catalytic Activity of a Cytochrome P450 Controls Bifurcation at a Metabolic Branch Point of Alkaloid Biosynthesis in Rauwolfia serpentina

scientific article published on 27 June 2017

Editorial overview: Growing the future: synthetic biology in plants

scientific article published on 24 May 2014

Editorial: Modern methods in plant natural products themed issue

scientific article published in April 2013

Editorial: structural aspects of biosynthesis themed issue

scientific article published on 28 August 2012

Engineering of Secondary Metabolism

scientific article published on 21 September 2015

Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces

scientific article published on April 2002

Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus.

scientific article published on 17 March 2011

Folivory elicits a strong defense reaction in Catharanthus roseus: metabolomic and transcriptomic analyses reveal distinct local and systemic responses

scientific article published on 17 January 2017

Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics

scientific article published in January 2002

Gene Discovery in Gelsemium Highlights Conserved Gene Clusters in Monoterpene Indole Alkaloid Biosynthesis

article

Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene indole alkaloid biosynthesis

article

Genome-guided investigation of plant natural product biosynthesis

scientific article published on 11 April 2015

Gerichtete Evolution von Piperazinsäureeinbau durch eine Nichtribosomale Peptidsynthetase**

scientific article published in 2023

Hairy root transformation of Brassica rapa with bacterial halogenase genes and regeneration to adult plants to modify production of indolic compounds

scientific article published on 10 April 2020

Halogenase Engineering for the Generation of New Natural Product Analogues

scientific article published on 10 August 2015

Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis ⬇️

scientific article published on October 18, 2010

Identification and Characterization of the Iridoid Synthase Involved in Oleuropein Biosynthesis in Olive (Olea europaea) Fruits

scientific article published on 26 December 2015

Identification of Iridoid Glucoside Transporters in Catharanthus roseus.

scientific article published in September 2017

Identification of iridoid synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry.

scientific article published on 27 October 2017

Identifying Genes Involved in alkaloid Biosynthesis in Vinca minor Through Transcriptomics and Gene Co-Expression Analysis

scientific article published on 24 November 2020

Identifying Missing Biosynthesis Enzymes of Plant Natural Products

scientific article published on 21 January 2020

Integrating carbon-halogen bond formation into medicinal plant metabolism.

scientific article published on 3 November 2010

Inverted stereocontrol of iridoid synthase in snapdragon.

scientific article published on 12 July 2017

Iridoid Synthase Activity Is Common among the Plant Progesterone 5β-Reductase Family

scientific article published on 19 September 2014

Iridoid synthase activity is common among the plant progesterone 5β-reductase family

scientific article published on 11 December 2014

Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis

scientific article

Mechanistic advances in plant natural product enzymes

scientific article published on 23 July 2009

Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits

scientific article published in 2021

Metabolic reprogramming of periwinkle plant culture

scientific article published on 18 January 2009

Metabolite and Molecular Characterization of Mitragyna speciosa Identifies Developmental and Genotypic Effects on Monoterpene Indole and Oxindole Alkaloid Composition

scientific article published on 13 March 2023

Metabolomics Analysis Reveals Tissue-Specific Metabolite Compositions in Leaf Blade and Traps of Carnivorous Nepenthes Plants

scientific article published on 19 June 2020

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.

scientific article published on 3 May 2018

Natural products from plant cell cultures.

scientific article published on January 2008

New developments in engineering plant metabolic pathways

scientific article

OXIDOSQUALENE CYCLASE 1 and 2 influence triterpene biosynthesis and defense in Nicotiana attenuata

Opportunities for enzyme engineering in natural product biosynthesis

scientific article published on 05 February 2009

Opportunities in metabolic engineering to facilitate scalable alkaloid production

scientific article published on May 2009

PLANT BIOCHEMISTRY. Fighting cancer while saving the mayapple.

scientific article published in September 2015

Plant science. Plant gene clusters and opiates

scientific article published on 01 June 2012

Publisher Correction: Biosynthesis of strychnine

correction of a scholarly article

Raising the BAR of specificity

scientific article published on 27 November 2017

Rapid identification of enzyme variants for reengineered alkaloid biosynthesis in periwinkle

scientific article published on August 2007

Recycling Upstream Redox Enzymes Expands the Regioselectivity of Cycloaddition in Pseudo-Aspidosperma Alkaloid Biosynthesis

scientific article published on 14 October 2022

Redesign of a central enzyme in alkaloid biosynthesis

scientific article published in November 2006

Redesign of a dioxygenase in morphine biosynthesis.

scientific article published in June 2012

Reengineering a tryptophan halogenase to preferentially chlorinate a direct alkaloid precursor

scientific article published on 11 November 2011

Roles of cytochrome P450 monooxygenases in triterpene biosynthesis and their potential impact on growth and development

scientific article published on 25 July 2024

Sarpagan bridge enzyme has substrate-controlled cyclization and aromatization modes

scientific article published on 25 June 2018

Silencing of tryptamine biosynthesis for production of nonnatural alkaloids in plant culture

scholarly article

Standards for plant synthetic biology: a common syntax for exchange of DNA parts.

scientific article

Strategies for engineering plant natural products: the iridoid-derived monoterpene indole alkaloids of Catharanthus roseus.

scientific article

Strictosidine synthase: mechanism of a Pictet-Spengler catalyzing enzyme

scientific article published on 16 January 2008

Structural basis of cycloaddition in biosynthesis of iboga and aspidosperma alkaloids

scientific article published on 17 February 2020

Structural characterization of EasH (Aspergillus japonicus) - an oxidase involved in cycloclavine biosynthesis

scientific article published on 25 November 2016

Structural determinants of reductive terpene cyclization in iridoid biosynthesis.

scientific article published on 9 November 2015

Structural investigation of heteroyohimbine alkaloid synthesis reveals active site elements that control stereoselectivity

scientific article published on 15 July 2016

Substrate specificity and diastereoselectivity of strictosidine glucosidase, a key enzyme in monoterpene indole alkaloid biosynthesis.

scientific article published on 22 November 2007

Substrate specificity of strictosidine synthase

scientific article

Synthesis and biochemical evaluation of des-vinyl secologanin aglycones with alternate stereochemistry

scientific article published on December 2009

Synthesis of (-)-Melodinine K: A Case Study of Efficiency in Natural Product Synthesis

scientific article published on 29 July 2020

Terpene Indole Alkaloid Biosynthesis

The Vinca minor genome highlights conserved evolutionary traits in monoterpene indole alkaloid synthesis

scientific article published in 2022

The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus.

scientific article published on 15 June 2015

The complexity of intercellular localisation of alkaloids revealed by single-cell metabolomics

scientific article published on 20 September 2019

The evolution of function in strictosidine synthase-like proteins

scientific article published on 21 September 2011

The evolutionary origins of the cat attractant nepetalactone in catnip

scientific article published on 13 May 2020

The impact of structural biology on alkaloid biosynthesis research

scientific article published on 21 August 2012

The important ergot alkaloid intermediate chanoclavine-I produced in the yeast Saccharomyces cerevisiae by the combined action of EasC and EasE from Aspergillus japonicus.

scientific article published on 12 August 2014

The progesterone 5β-reductase/iridoid synthase family is a catalytic reservoir for specialized metabolism across land plants

scientific article published on 05 June 2020

Towards the Microbial Production of Plant-Derived Anticancer Drugs

scientific article published on 05 March 2020

Two Tabersonine 6,7-Epoxidases Initiate Lochnericine-Derived Alkaloid Biosynthesis in ⬇️

scientific article published on 22 June 2018

Two bi-functional cytochrome P450 CYP72 enzymes from olive (Olea europaea) catalyze the oxidative C-C bond cleavage in the biosynthesis of secoxy-iridoids - flavor and quality determinants in olive oil

scientific article published on 30 October 2020

Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis.

scientific article published on 10 December 2018

Unlocking the diversity of alkaloids in Catharanthus roseus: nuclear localization suggests metabolic channeling in secondary metabolism

scientific article published on 12 March 2015

Vacuole-Targeted Proteins: Ins and Outs of Subcellular Localization Studies

scientific article published on 01 January 2018

Virus-Induced Gene Silencing: Hush Genes to Make Them Talk

scientific article published on 17 March 2020

List of works by Sarah E. O'Connor

<i>Nicotiana benthamiana</i> as a Transient Expression Host to Produce Auxin Analogs

A BAHD acyltransferase catalyzing 19-O-acetylation of tabersonine derivatives in roots of Catharanthus roseus enables combinatorial synthesis of monoterpene indole alkaloids.

A Pressure Test to Make 10 Molecules in 90 Days: External Evaluation of Methods to Engineer Biology.

A microbial supply chain for production of the anti-cancer drug vinblastine

A pair of tabersonine 16-hydroxylases initiates the synthesis of vindoline in an organ-dependent manner in Catharanthus roseus

A role for Old Yellow Enzyme in ergot alkaloid biosynthesis

A stereoselective hydroxylation step of alkaloid biosynthesis by a unique cytochrome P450 in Catharanthus roseus ⬇️

A three enzyme system to generate the Strychnos alkaloid scaffold from a central biosynthetic intermediate.

A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus

An NPF transporter exports a central monoterpene indole alkaloid intermediate from the vacuole.

An alternative route to cyclic terpenes by reductive cyclization in iridoid biosynthesis

An old yellow enzyme gene controls the branch point between Aspergillus fumigatus and Claviceps purpurea ergot alkaloid pathways ⬇️

Aureolic acids: similar antibiotics with different biosynthetic gene clusters

Aza-tryptamine substrates in monoterpene indole alkaloid biosynthesis

Beyond the semi-synthetic artemisinin: metabolic engineering of plant-derived anti-cancer drugs

Biocatalysts from alkaloid producing plants

Biocatalytic Strategies towards [4+2] Cycloadditions

Biocatalytic asymmetric formation of tetrahydro-β-carbolines

Biocatalytic production of tetrahydroisoquinolines

Biosynthesis of an Anti-Addiction Agent from the Iboga Plant

Biosynthesis of epothilone intermediates with alternate starter units: engineering polyketide-nonribosomal interfaces.

Biosynthesis of strychnine

Biosynthesis of the ergot alkaloids

Bypassing stereoselectivity in the early steps of alkaloid biosynthesis

Characterization of CmaA, an adenylation-thiolation didomain enzyme involved in the biosynthesis of coronatine

Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome. ⬇️

Chemistry and biology of monoterpene indole alkaloid biosynthesis

Chemoselective derivatization of alkaloids in periwinkle

Chlorinated Auxins-How Does Arabidopsis Thaliana Deal with Them?

Class II Cytochrome P450 Reductase Governs the Biosynthesis of Alkaloids.

Controlling a structural branch point in ergot alkaloid biosynthesis

Conversion of substrate analogs suggests a Michael cyclization in iridoid biosynthesis

Corrigendum to biocatalysts from alkaloid producing plants [Biocatalysts from alkaloid producing plants 31 (2016) 22-30]

Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

Cyclization of natural products

Cytochrome P450 and -methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from

De novo production of the plant-derived alkaloid strictosidine in yeast

Development of transcriptomic resources for interrogating the biosynthesis of monoterpene indole alkaloids in medicinal plant species

Developmental Methylome of the Medicinal Plant Catharanthus roseus Unravels the Tissue-Specific Control of the Monoterpene Indole Alkaloid Pathway by DNA Methylation

Differential iridoid production as revealed by a diversity panel of 84 cultivated and wild blueberry species

Directed Evolution of Piperazic Acid Incorporation by a Nonribosomal Peptide Synthetase**

Directed biosynthesis of alkaloid analogs in the medicinal plant Catharanthus roseus

Discovery and Reconstitution of the Cycloclavine Biosynthetic Pathway-Enzymatic Formation of a Cyclopropyl Group

Discovery and reconstitution of the cycloclavine biosynthetic pathway--enzymatic formation of a cyclopropyl group

Discovery of a P450-catalyzed step in vindoline biosynthesis: a link between the aspidosperma and eburnamine alkaloids

Discovery of a short chain dehydrogenase from Catharanthus roseus that produces a novel monoterpene indole alkaloid.

Diversification of monoterpene indole alkaloid analogs through cross-coupling

Dual Catalytic Activity of a Cytochrome P450 Controls Bifurcation at a Metabolic Branch Point of Alkaloid Biosynthesis in Rauwolfia serpentina

Editorial overview: Growing the future: synthetic biology in plants

Editorial: Modern methods in plant natural products themed issue

Editorial: structural aspects of biosynthesis themed issue

Engineering of Secondary Metabolism

Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces

Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus.

Folivory elicits a strong defense reaction in Catharanthus roseus: metabolomic and transcriptomic analyses reveal distinct local and systemic responses

Formation of beta-hydroxy histidine in the biosynthesis of nikkomycin antibiotics

Gene Discovery in Gelsemium Highlights Conserved Gene Clusters in Monoterpene Indole Alkaloid Biosynthesis

Gene discovery in Gelsemium highlights conserved gene clusters in monoterpene indole alkaloid biosynthesis

Genome-guided investigation of plant natural product biosynthesis

Gerichtete Evolution von Piperazinsäureeinbau durch eine Nichtribosomale Peptidsynthetase**

Hairy root transformation of Brassica rapa with bacterial halogenase genes and regeneration to adult plants to modify production of indolic compounds

Halogenase Engineering for the Generation of New Natural Product Analogues

Homolog of tocopherol C methyltransferases catalyzes N methylation in anticancer alkaloid biosynthesis ⬇️

Identification and Characterization of the Iridoid Synthase Involved in Oleuropein Biosynthesis in Olive (Olea europaea) Fruits

Identification of Iridoid Glucoside Transporters in Catharanthus roseus.

Identification of iridoid synthases from Nepeta species: Iridoid cyclization does not determine nepetalactone stereochemistry.

Identifying Genes Involved in alkaloid Biosynthesis in <i>Vinca minor</i> Through Transcriptomics and Gene Co-Expression Analysis

Identifying Missing Biosynthesis Enzymes of Plant Natural Products

Integrating carbon-halogen bond formation into medicinal plant metabolism.

Inverted stereocontrol of iridoid synthase in snapdragon.

Iridoid Synthase Activity Is Common among the Plant Progesterone 5β-Reductase Family

Iridoid synthase activity is common among the plant progesterone 5β-reductase family

Mass spectrometric interrogation of thioester-bound intermediates in the initial stages of epothilone biosynthesis

Mechanistic advances in plant natural product enzymes

Metabolic engineering for plant natural products biosynthesis: new procedures, concrete achievements and remaining limits

Metabolic reprogramming of periwinkle plant culture

Metabolite and Molecular Characterization of Mitragyna speciosa Identifies Developmental and Genotypic Effects on Monoterpene Indole and Oxindole Alkaloid Composition

Metabolomics Analysis Reveals Tissue-Specific Metabolite Compositions in Leaf Blade and Traps of Carnivorous Nepenthes Plants

Missing enzymes in the biosynthesis of the anticancer drug vinblastine in Madagascar periwinkle.