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List of works by Nicolas Winssinger

A General and Highly Efficient Solid Phase Synthesis of Oligosaccharides. Total Synthesis of a Heptasaccharide Phytoalexin Elicitor (HPE)

article by K. C. Nicolaou et al published January 1997 in Journal of the American Chemical Society

A LecA ligand identified from a galactoside-conjugate array inhibits host cell invasion by Pseudomonas aeruginosa

scientific article

A highly efficient azide-based protecting group for amines and alcohols

scientific article published on 05 May 2007

A novel HSP90 inhibitor with reduced hepatotoxicity synergizes with radiotherapy to induce apoptosis, abrogate clonogenic survival, and improve tumor control in models of colorectal cancer

scientific article published on June 2016

Accelerating Turnover Frequency in Nucleic Acid Templated Reactions.

scientific article published on 27 November 2017

Activation of Cell-Penetrating Peptides with Ionpair-π Interactions and Fluorophiles

scientific article

Allosterically Regulated Phosphatase Activity from Peptide-PNA Conjugates Folded Through Hybridization

scientific article

Applications of laser-polarized 129Xe to biomolecular assays.

scientific article

Assembly of PNA-tagged small molecules, peptides, and carbohydrates onto DNA templates: programming the combinatorial pairing and inter-ligand distance.

scientific article

Asymmetric synthesis of pochonin E and F, revision of their proposed structure, and their conversion to potent Hsp90 inhibitors

scientific article published on 13 June 2012

Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process

scientific journal article

Azidopeptide nucleic acid. An alternative strategy for solid-phase peptide nucleic acid (PNA) synthesis

scientific article published on 01 November 2003

Biography of Professor Nicolaou: a journey to the extremes of molecular complexity.

scientific article

Cell-Penetrating Streptavidin: A General Tool for Bifunctional Delivery with Spatiotemporal Control, Mediated by Transport Systems Such as Adaptive Benzopolysulfane Networks

scientific article published on 28 February 2020

Chemistry and biology of resorcylic acid lactones

scientific article (publication date: 2007)

Chemistry, Biology, and Medicine of the Glycopeptide Antibiotics

scientific article published on August 1999

Clickable peptide nucleic acids (cPNA) with tunable affinity

scientific article published on 23 June 2010

Combinatorial self-assembly of glycan fragments into microarrays

scientific article published on 01 January 2011

Concise modular asymmetric synthesis of deguelin, tephrosin and investigation into their mode of action

scientific article published on August 2010

Concise synthesis of pochonin A, an HSP90 inhibitor

scientific article published on 01 December 2005

Coupling of DNA Circuit and Templated Reactions for Quadratic Amplification and Release of Functional Molecules

scientific article published on 02 October 2019

Covalent inhibitors: an opportunity for rational target selectivity

scientific article published on 10 June 2017

Critical Analysis of Rate Constants and Turnover Frequency in Nucleic Acid-Templated Reactions: Reaching Terminal Velocity.

scientific article published on 18 January 2017

Cysteine mapping in conformationally distinct kinase nucleotide binding sites: application to the design of selective covalent inhibitors.

scientific article published on 15 February 2011

DNA display of PNA-tagged ligands: a versatile strategy to screen libraries and control geometry of multidentate ligands

scientific article

DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules

scientific article published on 22 September 2014

DNA display of glycoconjugates to emulate oligomeric interactions of glycans

scientific article published in 2015

DNA-templated homo- and heterodimerization of peptide nucleic acid encoded oligosaccharides that mimick the carbohydrate epitope of HIV.

scientific article

DNA-templated release of functional molecules with an azide-reduction-triggered immolative linker

scientific article published on 03 March 2011

Design, synthesis, and biological evaluation of HSP90 inhibitors based on conformational analysis of radicicol and its analogues

scientific article published in May 2005

Detection of miRNA in live cells by using templated RuII-catalyzed unmasking of a fluorophore.

scientific article published on 30 April 2013

Development of a functionalized xenon biosensor.

scientific article published in November 2004

Discovery of an entropically-driven small molecule streptavidin binder from nucleic acid-encoded libraries.

scientific article

Divergent syntheses of resorcylic acid lactones: L-783277, LL-Z1640-2, and hypothemycin

scientific article published in November 2009

Divergent synthesis and identification of the cellular targets of deoxyelephantopins.

scientific article published on 19 August 2016

Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor

scientific article

Diversity-oriented synthesis of diverse polycyclic scaffolds inspired by the logic of sesquiterpene lactones biosynthesis

scientific article published on 19 April 2012

Diversity-oriented synthesis of novel polycyclic scaffolds using polymer-bound reagents

scientific article published on 28 July 2008

Diversity-oriented synthesis of pochonins and biological evaluation against a panel of kinases

scientific article

Duplex formation and secondary structure of γ-PNA observed by NMR and CD. ⬇️

scientific article published on 14 September 2015

Dynamic Cooperative Glycan Assembly Blocks the Binding of Bacterial Lectins to Epithelial Cells

scientific article

Expanding the scope of PNA-encoded synthesis (PES): Mtt-protected PNA fully orthogonal to fmoc chemistry and a broad array of robust diversity-generating reactions.

scientific article

Facile access to modified and functionalized PNAs through Ugi-based solid phase oligomerization

scientific article published on 14 June 2017

Fluorescence-based detection of single nucleotide permutation in DNA via catalytically templated reaction

scientific article published in October 2007

Following the Lead from Nature with Covalent Inhibitors.

scientific article

From Split-Pool Libraries to Spatially Addressable Microarrays and Its Application to Functional Proteomic Profiling

scientific article published on 01 September 2001

HSP90 inhibition as a means of radiosensitizing resistant, aggressive soft tissue sarcomas

scientific article published on June 2015

High Spatial Resolution Imaging of Endogenous Hydrogen Peroxide in Living Cells by Solid-State Fluorescence.

scientific article published on 7 June 2016

Identification of Covalent Bromodomain Binders through DNA Display of Small Molecules

scientific article published on 13 March 2015

Identification of immunodominant linear epitopes from SARS-CoV-2 patient plasma

scientific article published on 09 September 2020

In cellulo protein labelling with Ru-conjugate for luminescence imaging and bioorthogonal photocatalysis.

scientific article published on October 2015

Inhibition of HSP90 with pochoximes: SAR and structure-based insights

scientific article

Kinase-templated abiotic reaction

scientific article published on 24 May 2017

Ligand dimerization programmed by hybridization to study multimeric ligand-receptor interactions.

scientific article

Luciferase-Induced Photouncaging: Bioluminolysis

scientific article published on 20 September 2019

Luciferase-induced photoreductive uncaging of small-molecule effectors

scientific article published in Nature Communications

Lysosome-targeted photoactivation reveals local sphingosine metabolism signatures

scientific article published on 26 December 2018

Microarray-based functional protein profiling using peptide nucleic acid-encoded libraries

scientific article published in December 2005

Mitochondria-specific photoactivation to monitor local sphingosine metabolism and function

scientific article

Modular asymmetric synthesis of aigialomycin D, a kinase-inhibitory scaffold

scientific article published on 01 June 2006

Modular asymmetric synthesis of pochonin C

scientific article published on 01 June 2004

Modular synthesis of radicicol A and related resorcylic acid lactones, potent kinase inhibitors

scientific article published on 01 January 2007

Molecular editing of kinase-targeting resorcylic acid lactones (RAL): Fluoroenone RAL.

scientific article published in May 2010

Multiple simultaneous synthesis of phenolic libraries.

scientific article published on September 1995

New Selenium-Based Safety-Catch Linkers: Solid-Phase Semisynthesis of Vancomycin We thank Drs. D. H. Huang and G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. This work was financially supported by the National Inst

scientific article published on 01 March 2000

Novel PTP1B inhibitors identified by DNA display of fragment pairs.

scientific article published on 28 November 2015

Novel strategies for the solid phase synthesis of substituted indolines and indoles

scientific article

Nucleic Acid Templated Chemical Reaction in a Live Vertebrate

scientific article

Nucleic acid encoding to program self-assembly in chemical biology.

scientific article published on 17 April 2008

Nucleic acid templated uncaging of fluorophores using Ru-catalyzed photoreduction with visible light

scientific article published on 29 December 2011

Nucleic acid-tagged peptides: encoding libraries and controlling dimerization and conformation

scientific article

Nucleic acid-templated energy transfer leading to a photorelease reaction and its application to a system displaying a nonlinear response

scientific article published on 21 October 2011

One-Step Derivatization of Reducing Oligosaccharides for Rapid and Live-Cell-Compatible Chelation-Assisted CuAAC Conjugation

scientific article published on 8 February 2016

PNA as a Biosupramolecular Tag for Programmable Assemblies and Reactions

scientific article published on May 2015

PNA encoding (PNA=peptide nucleic acid): from solution-based libraries to organized microarrays

scientific article published in November 2005

PNA-encoded chemical libraries

scientific article published on 23 January 2015

PNA-encoded protease substrate microarrays.

scientific article

PNA-encoded synthesis (PES) of a 10 000-member hetero-glycoconjugate library and microarray analysis of diverse lectins

scientific article

Peptide nucleic acid-templated selenocystine-selenoester ligation enables rapid miRNA detection.

scientific article published on 22 November 2017

Photoreductive uncaging of fluorophore in response to protein oligomers by templated reaction in vitro and in cellulo.

scientific article published on 30 November 2012

Picture perfect: DNA-templated photoaffinity labeling.

scientific article

Polyubiquitination of transforming growth factor β (TGFβ)-associated kinase 1 mediates nuclear factor-κB activation in response to different inflammatory stimuli.

scientific article

Pseudo-Complementary G:C Base Pair for Mixed Sequence dsDNA Invasion and Its Applications in Diagnostics (SARS-CoV-2 Detection)

scientific article published in 2023

Rapid miRNA imaging in cells using fluorogenic templated Staudinger reaction between PNA-based probes

scientific article published in January 2014

Reactions templated by nucleic acids: more ways to translate oligonucleotide-based instructions into emerging function.

scientific article published on 12 June 2013

Ruthenium-based Photocatalysis in Templated Reactions

scientific article published on 01 April 2018

Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

scientific article

Selection of bead-displayed, PNA-encoded chemicals

scientific article

Self-assembled antibody multimers through peptide nucleic acid conjugation.

scientific article published on 21 December 2012

Self-assembled small-molecule microarrays for protease screening and profiling

scientific article

Self-assembly of PNA-encoded peptides into microarrays

scientific article published in January 2009

Site-Specific Glycoconjugation of Protein via Bioorthogonal Tetrazine Cycloaddition with a Genetically Encoded trans-Cyclooctene or Bicyclononyne

scientific article

Small-Molecule Modulators of the ATPase VCP/p97 Affect Specific p97 Cellular Functions

scientific article published on 18 December 2019

Smartphone DNA or RNA Sensing Using Semisynthetic Luciferase-Based Logic Device

scientific article published on 13 March 2020

Solid Phase Synthesis of Macrocycles by an Intramolecular Ketophosphonate Reaction. Synthesis of a (dl)-Muscone Library

scientific article published in 1998

Solid phase synthesis of glycopeptides using Shoda's activation of unprotected carbohydrates

scientific article published on 24 July 2013

Solid-Phase Synthesis of Macrocyclic Systems by a Cyclorelease Strategy: Application of the Stille Coupling to a Synthesis of (S)-Zearalenone.

scientific article published in October 1998

Solid-Phase Synthesis of Oligosaccharides: Construction of a Dodecasaccharide

scientific article published on 01 June 1998

Solution- and solid-phase synthesis of radicicol (monorden) and pochonin C.

scientific article published in August 2005

Substrate screening identifies a novel target sequence for the proteasomal activity regulated by ionizing radiation.

scientific article

Synthesis and biological evaluation of vancomycin dimers with potent activity against vancomycin-resistant bacteria: target-accelerated combinatorial synthesis.

scientific article

Synthesis of a resorcylic acid lactone (RAL) library using fluorous-mixture synthesis and profile of its selectivity against a panel of kinases

scientific article

Synthesis of deguelin-biotin conjugates and investigation into deguelin's interactions

scientific article

Synthesis of deoxyelephantopin analogues

scientific article published in November 2017

Synthesis of pochoxime prodrugs as potent HSP90 inhibitors

scientific article published on 17 April 2009

Synthesis of sesquiterpene-inspired derivatives designed for covalent binding and their inhibition of the NF-κB pathway.

scientific article

Target-Accelerated Combinatorial Synthesis and Discovery of Highly Potent Antibiotics Effective Against Vancomycin-Resistant Bacteria

scientific article published on 01 November 2000

The HSP90 binding mode of a radicicol-like E-oxime determined by docking, binding free energy estimations, and NMR 15N chemical shifts

scientific article published on 15 April 2009

The molecular chaperone Hsp90α is required for meiotic progression of spermatocytes beyond pachytene in the mouse

scientific article

The novel Hsp90 inhibitor NXD30001 induces tumor regression in a genetically engineered mouse model of glioblastoma multiforme

scientific article published on 19 July 2010

Total synthesis of 16-desmethylepothilone B, epothilone B10, epothilone F, and related side chain modified epothilone B analogues

scientific article published in August 2000

Turn On of a Ruthenium(II) Photocatalyst by DNA-Templated Ligation

scientific article published on 19 November 2018

Visible Light Photoredox Catalysis Using Ruthenium Complexes in Chemical Biology

scientific article published on 20 February 2019

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