List of works - Yingying Le

A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses.

scientific article published on 3 March 2010

A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression

scientific article

A novel monoclonal antibody against the N-terminus of Aβ1-42 reduces plaques and improves cognition in a mouse model of Alzheimer's disease

scientific article

Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease

scientific article published in December 2009

Amyloid-β Induces Hepatic Insulin Resistance In Vivo via JAK2 ⬇️

scientific article published on December 6, 2012

Androgen alleviates neurotoxicity of β-amyloid peptide (Aβ) by promoting microglial clearance of Aβ and inhibiting microglial inflammatory response to Aβ.

scientific article

Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor

scientific article

Associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy Chinese.

scientific article

Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.

scientific article

Biologically active peptides interacting with the G protein-coupled formylpeptide receptor.

scientific article published on January 2007

Chronic Low-Dose Cadmium Exposure Impairs Cutaneous Wound Healing With Defective Early Inflammatory Responses After Skin Injury.

scientific article published on 29 June 2017

Chronic exposure to nicotine enhances insulin sensitivity through α7 nicotinic acetylcholine receptor-STAT3 pathway

scientific article

Deficiency in Fpr2 results in reduced numbers of Lin-cKit+Sca1+ myeloid progenitor cells

scientific article published on 17 July 2018

Desensitization of chemokine receptor CCR5 in dendritic cells at the early stage of differentiation by activation of formyl peptide receptors

scientific article published in June 2001

Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT.

scientific article published on 31 July 2015

Exogenous porcine surfactants increase the infiltration of leukocytes in the lung of rats

scientific article published on 01 June 2009

Expression of functional formyl peptide receptors by human astrocytoma cell lines.

scientific article published in November 2000

Fatty acids induce amylin expression and secretion by pancreatic beta-cells.

scientific article

Formyl-peptide receptors revisited

scientific article (publication date: November 2002)

Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells

scientific article published on 24 August 2015

Formylpeptide receptor FPR and the rapid growth of malignant human gliomas

scientific article published on June 2005

Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis.

scientific article published on April 2013

Formylpeptide receptors mediate rapid neutrophil mobilization to accelerate wound healing

scientific article

Fpr2 Deficiency Alleviates Diet-Induced Insulin Resistance Through Reducing Body Weight Gain and Inhibiting Inflammation Mediated by Macrophage Chemotaxis and M1 Polarization

scientific article published on 12 March 2019

HCV peptide (C5A), an amphipathic α-helical peptide of hepatitis virus C, is an activator of N-formyl peptide receptor in human phagocytes.

scientific article published on 12 January 2011

Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor α.

scientific article

High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol.

scientific article published on 9 January 2012

Identification of functional domains in the formyl peptide receptor-like 1 for agonist-induced cell chemotaxis.

scientific article published on February 2005

Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway

scientific article published on 12 December 2012

Luteolin-7-glucoside Promotes Human Epidermal Stem Cell Proliferation by Upregulating β-Catenin, c-Myc, and Cyclin Expression

scientific article published on 02 June 2019

MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2

scientific article published in 2011

Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells

scientific article published on 25 October 2007

MicroRNA-451 Negatively Regulates Hepatic Glucose Production and Glucose Homeostasis by Targeting Glycerol Kinase-Mediated Gluconeogenesis

scientific article published on 5 August 2016

N36, a synthetic N-terminal heptad repeat domain of the HIV-1 envelope protein gp41, is an activator of human phagocytes.

scientific article

Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme.

scientific article published on September 2010

PP2A mediated AMPK inhibition promotes HSP70 expression in heat shock response

scientific article

Proinflammatory stimulants promote the expression of a promiscuous G protein-coupled receptor, mFPR2, in microvascular endothelial cells.

scientific article published on April 2012

RNA interference as a novel and powerful tool in immunopharmacological research.

scientific article published on 22 January 2007

Receptor "hijacking" by malignant glioma cells: a tactic for tumor progression

scientific article

Regulation of Fasting Fuel Metabolism by Toll-Like Receptor 4 ⬇️

scientific article published on September 20, 2010

Resveratrol protects vascular endothelial cells from high glucose-induced apoptosis through inhibition of NADPH oxidase activation-driven oxidative stress

scientific article published on 3 June 2013

Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer disease

scientific article

Sesamin inhibits bacterial formylpeptide-induced inflammatory responses in a murine air-pouch model and in THP-1 human monocytes.

scientific article

Signal relay by CC chemokine receptor 2 (CCR2) and formylpeptide receptor 2 (Fpr2) in the recruitment of monocyte-derived dendritic cells in allergic airway inflammation

scientific article published on 19 April 2013

Silencing the formylpeptide receptor FPR by short-interfering RNA.

scientific article published on 16 July 2004

TNF-α acutely upregulates amylin expression in murine pancreatic beta cells

scientific article

The formylpeptide receptor 2 (Fpr2) and its endogenous ligand cathelin-related antimicrobial peptide (CRAMP) promote dendritic cell maturation.

scientific article

The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor FPR.

scientific article

The immunopharmacological properties of transforming growth factor beta.

scientific article

The synthetic peptide WKYMVm attenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1.

scientific article

Toll-like receptors in inflammation of the central nervous system

scientific article published on 18 May 2011

Up-regulation of FPR2, a chemotactic receptor for amyloid beta 1-42 (A beta 42), in murine microglial cells by TNF alpha

scientific article published on August 2002

Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic β-cells by MCP-1 (CCL2) ⬇️

scientific article published on August 22, 2011

List of works by Yingying Le

A critical role for the g protein-coupled receptor mFPR2 in airway inflammation and immune responses.

A non-secretory form of FAM3B promotes invasion and metastasis of human colon cancer cells by upregulating Slug expression

A novel monoclonal antibody against the N-terminus of Aβ1-42 reduces plaques and improves cognition in a mouse model of Alzheimer's disease

Amyloid deposition and inflammation in APPswe/PS1dE9 mouse model of Alzheimer's disease

Amyloid-β Induces Hepatic Insulin Resistance In Vivo via JAK2 ⬇️

Androgen alleviates neurotoxicity of β-amyloid peptide (Aβ) by promoting microglial clearance of Aβ and inhibiting microglial inflammatory response to Aβ.

Antishock effect of anisodamine involves a novel pathway for activating alpha7 nicotinic acetylcholine receptor

Associations of amylin with inflammatory markers and metabolic syndrome in apparently healthy Chinese.

Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages.

Biologically active peptides interacting with the G protein-coupled formylpeptide receptor.

Chronic Low-Dose Cadmium Exposure Impairs Cutaneous Wound Healing With Defective Early Inflammatory Responses After Skin Injury.

Chronic exposure to nicotine enhances insulin sensitivity through α7 nicotinic acetylcholine receptor-STAT3 pathway

Deficiency in Fpr2 results in reduced numbers of Lin-cKit+Sca1+ myeloid progenitor cells

Desensitization of chemokine receptor CCR5 in dendritic cells at the early stage of differentiation by activation of formyl peptide receptors

Discovery of Novel Inhibitors and Fluorescent Probe Targeting NAMPT.

Exogenous porcine surfactants increase the infiltration of leukocytes in the lung of rats

Expression of functional formyl peptide receptors by human astrocytoma cell lines.

Fatty acids induce amylin expression and secretion by pancreatic beta-cells.

Formyl-peptide receptors revisited

Formylpeptide receptor 1 mediates the tumorigenicity of human hepatocellular carcinoma cells

Formylpeptide receptor FPR and the rapid growth of malignant human gliomas

Formylpeptide receptor-2 contributes to colonic epithelial homeostasis, inflammation, and tumorigenesis.

Formylpeptide receptors mediate rapid neutrophil mobilization to accelerate wound healing

Fpr2 Deficiency Alleviates Diet-Induced Insulin Resistance Through Reducing Body Weight Gain and Inhibiting Inflammation Mediated by Macrophage Chemotaxis and M1 Polarization

HCV peptide (C5A), an amphipathic α-helical peptide of hepatitis virus C, is an activator of N-formyl peptide receptor in human phagocytes.

Hepatic ATF6 Increases Fatty Acid Oxidation to Attenuate Hepatic Steatosis in Mice Through Peroxisome Proliferator-Activated Receptor α.

High glucose induces renal mesangial cell proliferation and fibronectin expression through JNK/NF-κB/NADPH oxidase/ROS pathway, which is inhibited by resveratrol.

Identification of functional domains in the formyl peptide receptor-like 1 for agonist-induced cell chemotaxis.

Knockdown of FAM3B triggers cell apoptosis through p53-dependent pathway

Luteolin-7-glucoside Promotes Human Epidermal Stem Cell Proliferation by Upregulating β-Catenin, c-Myc, and Cyclin Expression

MCP-1 upregulates amylin expression in murine pancreatic β cells through ERK/JNK-AP1 and NF-κB related signaling pathways independent of CCR2

Mechanisms of glucose-induced expression of pancreatic-derived factor in pancreatic beta-cells

MicroRNA-451 Negatively Regulates Hepatic Glucose Production and Glucose Homeostasis by Targeting Glycerol Kinase-Mediated Gluconeogenesis

N36, a synthetic N-terminal heptad repeat domain of the HIV-1 envelope protein gp41, is an activator of human phagocytes.

Norepinephrine promotes microglia to uptake and degrade amyloid beta peptide through upregulation of mouse formyl peptide receptor 2 and induction of insulin-degrading enzyme.

PP2A mediated AMPK inhibition promotes HSP70 expression in heat shock response

Proinflammatory stimulants promote the expression of a promiscuous G protein-coupled receptor, mFPR2, in microvascular endothelial cells.

RNA interference as a novel and powerful tool in immunopharmacological research.

Receptor "hijacking" by malignant glioma cells: a tactic for tumor progression

Regulation of Fasting Fuel Metabolism by Toll-Like Receptor 4 ⬇️

Resveratrol protects vascular endothelial cells from high glucose-induced apoptosis through inhibition of NADPH oxidase activation-driven oxidative stress

Role of formyl peptide receptor-like 1 (FPRL1/FPR2) in mononuclear phagocyte responses in Alzheimer disease

Sesamin inhibits bacterial formylpeptide-induced inflammatory responses in a murine air-pouch model and in THP-1 human monocytes.

Signal relay by CC chemokine receptor 2 (CCR2) and formylpeptide receptor 2 (Fpr2) in the recruitment of monocyte-derived dendritic cells in allergic airway inflammation

Silencing the formylpeptide receptor FPR by short-interfering RNA.

TNF-α acutely upregulates amylin expression in murine pancreatic beta cells

The formylpeptide receptor 2 (Fpr2) and its endogenous ligand cathelin-related antimicrobial peptide (CRAMP) promote dendritic cell maturation.

The green tea polyphenol (-)-epigallocatechin-3-gallate inhibits leukocyte activation by bacterial formylpeptide through the receptor FPR.

The immunopharmacological properties of transforming growth factor beta.

The synthetic peptide WKYMVm attenuates the function of the chemokine receptors CCR5 and CXCR4 through activation of formyl peptide receptor-like 1.

Toll-like receptors in inflammation of the central nervous system

Up-regulation of FPR2, a chemotactic receptor for amyloid beta 1-42 (A beta 42), in murine microglial cells by TNF alpha

Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic β-cells by MCP-1 (CCL2) ⬇️