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List of works by Martin Pule

2B4 (CD244) signaling by recombinant antigen-specific chimeric receptors costimulates natural killer cell activation to leukemia and neuroblastoma cells

scientific article

2B4 (CD244) signaling via chimeric receptors costimulates tumor-antigen specific proliferation and in vitro expansion of human T cells

scientific article published on 10 April 2009

A Rapamycin-Activated Caspase 9-Based Suicide Gene.

scientific article published on 9 March 2018

A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

scientific article published on 23 June 2005

A dual-color far-red to near-infrared firefly luciferin analogue designed for multiparametric bioluminescence imaging

scientific article published on 29 September 2014

A highly compact epitope-based marker/suicide gene for easier and safer T-cell therapy

scientific article published on 26 June 2014

Acute promyelocytic leukaemia presenting with a myeloid sarcoma of the tongue

scientific article published on 27 March 2008

Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells

scientific article published on 17 August 2006

Adoptive T-cell therapy for cancer in the United kingdom: a review of activity for the British Society of Gene and Cell Therapy annual meeting 2015.

scientific article published on May 2015

An APRIL based chimeric antigen receptor for dual targeting of BCMA and TACI in Multiple Myeloma.

scientific article published on 28 December 2017

An Optimized GD2-Targeting Retroviral Cassette for More Potent and Safer Cellular Therapy of Neuroblastoma and Other Cancers

scientific article

An inducible caspase 9 safety switch for T-cell therapy

scientific article published on 22 February 2005

Anti-CD1a CAR T cells to selectively target T-ALL

scientific article published on 01 May 2019

Antitumor activity and long-term fate of chimeric antigen receptor-positive T cells in patients with neuroblastoma

scientific article published on 7 October 2011

Antitumor activity without on-target off-tumor toxicity of GD2-chimeric antigen receptor T cells in patients with neuroblastoma

scientific article published on 01 November 2020

Artemisinin therapy and severe delayed haemolysis

scientific article published on July 2013

Assessing the safety of cytotoxic T lymphocytes transduced with a dominant negative transforming growth factor-beta receptor.

scientific article published in May 2006

Autologous stem cell transplantation outcomes in elderly patients with B cell Non-Hodgkin Lymphoma.

scientific article published on 26 June 2015

Automated manufacturing of chimeric antigen receptor T cells for adoptive immunotherapy using CliniMACS prodigy

scientific article published on August 2016

CAR T-cell Integration of Multiple Input Signals Allows for Precise Targeting of Cancer

scientific article published on 01 August 2018

CAR–T cells and solid tumors: tuning T cells to challenge an inveterate foe ⬇️

scientific article published on May 19, 2012

CD19 chimeric antigen receptor T cell therapy for haematological malignancies

scientific article

Chimeric antigen receptor T cells for ALL

scientific article published on 13 October 2014

Clonal expansion of T memory stem cells determines early anti-leukemic responses and long-term CAR T cell persistence in patients

scientific article published on 24 May 2021

Co-expression of cytokine and suicide genes to enhance the activity and safety of tumor-specific cytotoxic T lymphocytes.

scientific article

Comparison of different suicide-gene strategies for the safety improvement of genetically manipulated T cells.

scientific article published on December 2012

Complement-fixing CD45 monoclonal antibodies to facilitate stem cell transplantation in mouse and man.

scientific article published in May 2003

Cytotoxic T cells transduced with chimeric anti-CD19 receptors prevent engraftment of primary lymphoblastic leukemia in vivo

Development of cellular immune responses against PAX5, a novel target for cancer immunotherapy

scientific article published in October 2008

Enhanced CAR T cell expansion and prolonged persistence in pediatric patients with ALL treated with a low-affinity CD19 CAR

scientific article published on 02 September 2019

Enhanced tumor trafficking of GD2 chimeric antigen receptor T cells by expression of the chemokine receptor CCR2b.

scientific article published on October 2010

Evolving adoptive cellular therapies in urological malignancies

scientific article published on June 2017

Fc Effector Function Contributes to the Activity of Human Anti-CTLA-4 Antibodies.

scientific article

Fc-Optimized Anti-CD25 Depletes Tumor-Infiltrating Regulatory T Cells and Synergizes with PD-1 Blockade to Eradicate Established Tumors

scientific article

Flow-Based Single Cell Deposition for High-Throughput Screening of Protein Libraries

scientific article

Fluorescence-guided development of a tricistronic vector encoding bimodal optical and nuclear genetic reporters for in vivo cellular imaging

scientific article

Functional characterization of alloreactive T cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy.

scientific article published on 4 November 2009

Generation of EBV-specific cytotoxic T cells that are resistant to calcineurin inhibitors for the treatment of posttransplantation lymphoproliferative disease

scientific article published on 21 September 2009

Generation of a neutralizing antibody against RD114-pseudotyped viral vectors

scientific article published on 08 November 2019

Genetic Regulation of Fate Decisions in Therapeutic T Cells to Enhance Tumor Protection and Memory Formation

scientific article published on 22 April 2015

Genetically engineered T-cells for adoptive immunotherapy.

scientific article

Hematopoietic and immunomodulatory effects of lytic CD45 monoclonal antibodies in patients with hematologic malignancy

scientific article published on 01 April 2003

Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis.

scientific article published on 15 February 2005

Imaging of X-Ray-Excited Emissions from Quantum Dots and Biological Tissue in Whole Mouse

scientific article published on 16 December 2019

Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression.

scientific article

In Vitro Comparison of Three Different Chimeric Receptor-modified Effector T-cell Populations for Leukemia Cell Therapy ⬇️

scientific article published on July 1, 2011

In vitro characterization of genetically expressed absorbing proteins using photoacoustic spectroscopy

scientific article

Increased angiogenesis in bone marrow of children with acute lymphoblastic leukaemia has no prognostic significance

scientific article published on 01 September 2002

Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma

scientific article published on 19 January 2021

Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients

scientific article

Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells

scientific article published in January 2017

Molecular transfer of CD40 and OX40 ligands to leukemic human B cells induces expansion of autologous tumor-reactive cytotoxic T lymphocytes

scientific article published on 9 November 2004

Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies

scientific article

Near-infrared dual bioluminescence imaging in mouse models of cancer using infraluciferin

scientific article published on 15 October 2019

Quantitative in vivo dual-color bioluminescence imaging in the mouse brain

scientific article published on 01 April 2019

Radiographic viewing conditions at Johannesburg Hospital ⬇️

scientific article published on April 2008

Rapid generation of EBV-specific cytotoxic T lymphocytes resistant to calcineurin inhibitors for adoptive immunotherapy

scientific article published on 8 October 2013

Red-emitting luciferases for bioluminescence reporter and imaging applications.

scientific article

T lymphocytes redirected against the kappa light chain of human immunoglobulin efficiently kill mature B lymphocyte-derived malignant cells

scientific article published on 22 August 2006

T-helper cell receptors from long-term survivors after telomerase cancer vaccination for use in adoptive cell therapy

scientific article published on 24 October 2016

TALEN-Mediated Inactivation of PD-1 in Tumor-Reactive Lymphocytes Promotes Intratumoral T-cell Persistence and Rejection of Established Tumors

scientific article published on April 2016

TALEN-mediated genetic inactivation of the glucocorticoid receptor in cytomegalovirus-specific T cells

scientific article

Target antigen expression on a professional antigen-presenting cell induces superior proliferative antitumor T-cell responses via chimeric T-cell receptors

scientific article published on January 2006

Targeting the T cell receptor β-chain constant region for immunotherapy of T cell malignancies

scientific article published on 13 November 2017

The p53 regulatory gene MDM2 is a direct transcriptional target of MYCN in neuroblastoma.

scientific article

Towards gene therapy for EBV-associated posttransplant lymphoma with genetically modified EBV-specific cytotoxic T cells

scientific article

Transient redirection of T cells for adoptive cell therapy with telomerase-specific T helper cell receptors isolated from long term survivors after cancer vaccination

scientific article published on 19 January 2019

Transiently redirected T cells for adoptive transfer.

scientific article published on 21 December 2010

Treatment of diffuse large B-cell lymphoma with secondary central nervous system involvement: encouraging efficacy using CNS-penetrating R-IDARAM chemotherapy

scientific article published on 18 December 2015

Vaccination to improve the persistence of CD19CAR gene-modified T cells in relapsed pediatric acute lymphoblastic leukemia

scientific article published on 27 January 2017

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