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List of works by Helen Griffiths

8-Hydroxydeoxyguanosine. A marker of oxidative DNA damage in systemic lupus erythematosus

scientific article published on 01 July 1994

A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y.

scientific article published on 31 October 2007

A novel silicon membrane-based biosensing platform using distributive sensing strategy and artificial neural networks for feature analysis.

scientific article

Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention.

scientific article published on March 2010

Activation of the neutrophil respiratory burst by plasma from periodontitis patients is mediated by pro-inflammatory cytokines

scientific article published on 21 October 2010

Alpha tocopherol supplementation elevates plasma apolipoprotein A1 isoforms in normal healthy subjects

scientific article published in March 2006

An almond-enriched diet increases plasma α-tocopherol and improves vascular function but does not affect oxidative stress markers or lipid levels.

scientific article

An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression.

scientific article

Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH.

scientific article published on 10 December 2006

Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells.

scientific article published on 25 November 2011

Are lipid ratios less susceptible to change with systemic inflammation than individual lipid components in patients with rheumatoid arthritis?

scientific article published on 3 August 2010

Ascorbate and α-tocopherol differentially modulate reactive oxygen species generation by neutrophils in response to FcγR and TLR agonists

scientific article published on 21 August 2012

Ascorbic acid in the 21st century - more than a simple antioxidant.

scientific article published on September 2001

Binding of anti-DNA antibodies to oxidatively damaged DNA in spouses and relatives of patients with systemic lupus erythematosus

scientific article published on 01 July 1994

Biomarkers.

scientific article

C-reactive protein mediates CD11b expression in monocytes through the non-receptor tyrosine kinase, Syk, and calcium mobilization but not through cytosolic peroxides

scientific article published on December 2005

CD4(+) T cell surface alpha enolase is lower in older adults.

scientific article

Cell passage-associated transient high oxygenation causes a transient decrease in cellular glutathione and affects T cell responses to apoptotic and mitogenic stimuli

scientific article published on 27 December 2006

Ceramide induces a loss in cytosolic peroxide levels in mononuclear cells

scientific article published on November 2003

Ceramides reduce CD36 cell surface expression and oxidised LDL uptake by monocytes and macrophages

article

Chemiluminescence determination of hydroperoxides following radiolysis and photolysis of free amino acids

scientific article published on 01 July 1998

Deoxycytidine glyoxal: lesion induction and evidence of repair following vitamin C supplementation in vivo.

scientific article published in January 2003

Designing liposomal adjuvants for the next generation of vaccines.

scientific article

Dietary habits are major determinants of the plasma antioxidant status in healthy elderly subjects

scientific article published in November 2005

Dietary protein insufficiency: an important consideration in fatty liver disease?

scientific article published on 29 November 2019

Direct modulatory effect of C-reactive protein on primary human monocyte adhesion to human endothelial cells

scientific article published on 01 November 2002

Dose-dependent modulation of the T cell proteome by ascorbic acid

scientific article

Downstream effects on human low density lipoprotein of homocysteine exported from endothelial cells in an in vitro system.

scientific article published in December 2004

Effects of oral vitamin C on monocyte: endothelial cell adhesion in healthy subjects

scientific article

Evidence for sensitisation of DNA to oxidative damage during isolation.

scientific article

Free radical reaction products and antioxidant capacity in beating heart coronary artery surgery compared to conventional bypass

scientific article

Free radicals and redox signalling in T-cells during chronic inflammation and ageing

scientific article published in October 2011

Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variant

scientific article published on 19 November 2007

Gravity spun polycaprolactone fibers for applications in vascular tissue engineering: proliferation and function of human vascular endothelial cells

scientific article published in January 2006

Healthy ageing and depletion of intracellular glutathione influences T cell membrane thioredoxin-1 levels and cytokine secretion.

scientific article

Immunochemical detection of UV-induced DNA damage and repair

scientific article published in September 2003

Immunochemical detection of glyoxal DNA damage

scientific article published on 01 May 1999

Immunochemical detection of sequence-specific modifications to DNA induced by UV light.

scientific article published on November 1994

Immunogenic and antigenic epitopes of immunoglobulin—XX. Denaturation of human IgG3 by free radicals

scientific article published on 01 November 1987

In vivo vitamin C supplementation increases phosphoinositol transfer protein expression in peripheral blood mononuclear cells from healthy individuals

scientific article

Innovative biomarkers for predicting type 2 diabetes mellitus: relevance to dietary management of frailty in older adults.

scientific article published on 20 February 2016

Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease?

scientific article published on 05 May 2008

LDL-lipids from patients with hypercholesterolaemia and Alzheimer's disease are inflammatory to microvascular endothelial cells: mitigation by statin intervention

scientific article published on 23 September 2015

Lack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study.

scientific article published on 17 December 2008

Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?

scientific article

Macular Pigment Optical Density is Related to Blood Glutathione Levels in Healthy Individuals

scientific article published on 23 August 2011

Metabolic memory effect of the saturated fatty acid, palmitate, in monocytes

scientific article

Mitochondrial superoxide anion radicals mediate induction of apoptosis in cardiac myoblasts exposed to chronic hypoxia.

scientific article published on 29 October 2010

Molecular and cellular effects of ultraviolet light-induced genotoxicity

scientific article published in June 1998

Monocytes in coronary artery disease and atherosclerosis: where are we now?

scientific article

Neurotoxicity of 1,2,3,4-tetrahydro-2-methyl-4,6,7-isoquinolinetriol (TMIQ) and effects on catecholamine homeostasis in SH-SY5Y cells ⬇️

scientific article published on August 15, 1996

Novel ageing-biomarker discovery using data-intensive technologies

scientific article

Novel repair action of vitamin C upon in vivo oxidative DNA damage

scientific article published on 20 November 1998

Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species

scientific article published on 22 August 2013

Oxidation of protein in human low-density lipoprotein exposed to peroxyl radicals facilitates uptake by monocytes; protection by antioxidants in vitro.

scientific article published on January 2004

Oxidative LDL modification is increased in vascular dementia and is inversely associated with cognitive performance.

scientific article published in March 2010

Oxidative and inflammatory status in Type 2 diabetes patients with periodontitis.

scientific article published on 24 August 2011

Oxidative modification of a specific apolipoprotein B lysine residue confers altered receptor specificity on LDL

scientific article published on 01 January 1999

Oxidative stress in diabetes - circulating advanced glycation end products, lipid oxidation and vascular disease.

scientific article

Oxygen radical induced alterations in polyclonal IgG

scientific article published on 01 March 1988

Oxygen radical induced fluorescence in proteins; identification of the fluorescent tryptophan metabolite, N-formyl kynurenine, as a biological index of radical damage.

scientific article published in June 1992

Oxygen tension modulates the cytokine response of oral epithelium to periodontal bacteria.

scientific article published on 18 October 2010

Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis.

scientific article published on 26 May 2012

Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia

scientific article

Plasma levels of HDL and carotenoids are lower in dementia patients with vascular comorbidities.

scientific article

Probing molecular changes induced in DNA by reactive oxygen species with monoclonal antibodies

scientific article published on 01 October 1992

Proteomic analysis of a noninvasive human model of acute inflammation and its resolution: the twenty-one day gingivitis model

scientific article published in September 2010

Proteomic analysis of the anti‐inflammatory action of minocycline ⬇️

scientific article published on December 6, 2010

Serum α-Tocopherol Has a Nonlinear Inverse Association with Periodontitis among US Adults.

scientific article

Stabilising cysteinyl thiol oxidation and nitrosation for proteomic analysis.

scientific article published on 21 June 2013

Statin use in rheumatoid arthritis in relation to actual cardiovascular risk: evidence for substantial undertreatment of lipid-associated cardiovascular risk?

scientific article published on 23 October 2009

Studies on the neurotoxicity of 6,7-dihydroxy-1-methyl-1,2,3,4-tetrahydroisoquinoline (salsolinol) in SH-SY5Y cells.

scientific article published in December 1995

Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitro

scientific article published on 24 June 2013

Terminal galactose residues on transferrin are increased in midlife adults compared to young adults.

scientific article published on 12 October 2012

The C1q binding activity of IgG is modified in vitro by reactive oxygen species: implications for rheumatoid arthritis

scientific article published on 01 June 1996

The Effects of Vitamin C Supplementation on Protein Oxidation in Healthy Volunteers

scientific article published on 01 July 2000

The anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species

scientific article published on February 2003

The antioxidant enzyme peroxiredoxin-2 is depleted in lymphocytes seven days after ultra-endurance exercise.

scientific article published on 19 August 2013

The dual role of ROS in autoimmune and inflammatory diseases: Evidence from preclinical models

scientific article published on 14 March 2018

The effects of oxygen free radicals on the carbohydrate moiety of IgG

scientific article published on 01 March 1989

The presence of ascorbate induces expression of brain derived neurotrophic factor in SH-SY5Y neuroblastoma cells after peroxide insult, which is associated with increased survival.

scientific article

The role of monocytes in atherosclerotic coronary artery disease.

scientific article published on September 2010

The selective protection afforded by ebselen against lipid peroxidation in an ROS-dependent model of inflammation

scientific article published on 01 May 1992

The use of proteomic techniques to explore the holistic effects of nutrients in vivo

scientific article published on December 2006

Thiol redox homeostasis in neurodegenerative disease

scientific article published on 22 April 2015

Urinary 8-oxo-2'-deoxyguanosine: redox regulation of DNA repair in vivo?

scientific article

Validation of a novel ELISA for measurement of MDA-LDL in human plasma.

scientific article published in September 2003

Vitamin C exhibits pro-oxidant properties.

scientific article published in April 1998

Vitamin C supplementation in normal subjects reduces constitutive ICAM-1 expression.

scientific article published in August 2003

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