List of works - Eugene Healy

A 2005 survey of clinical academic staff in U.K. dermatology

scientific article published on 01 July 2006

A Mutational Hotspot in the 2B Domain of Human Hair Basic Keratin 6 (hHb6) in Monilethrix Patients

scientific article published on 01 November 1998

A comparison of twice-weekly MPD-PUVA and three times-weekly skin typing-PUVA regimens for the treatment of psoriasis

scientific article published on 01 September 1995

A gene for monilethrix is closely linked to the type II keratin gene cluster at 12q13

article

A pilot randomized controlled trial to examine the feasibility and efficacy of an educational nursing intervention to improve self-management practices in patients with mild-moderate psoriasis.

scientific article published on 28 June 2011

A time for everything and everything in its time - exploring the mechanisms underlying seasonality of COPD exacerbations

scholarly article by Alexander Hicks et al published 5 September 2018 in International Journal of Chronic Obstructive Pulmonary Disease

AIDS, i.v. drug use and mycobacterial disease: the Dublin experience.

scientific article published in November 1992

ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class

scientific article published in September 1999

Allelotypes of primary cutaneous melanoma and benign melanocytic nevi

scientific article published on 01 February 1996

Alpha-melanocyte-stimulating hormone suppresses antigen-induced lymphocyte proliferation in humans independently of melanocortin 1 receptor gene status

scientific article published on October 2005

Antibiotic hypersensitivity mimicking recurrent endocardits--identifying the culprit with the in vitro lymphocyte transformation test

scientific article published on 01 January 2008

Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function

scientific article published on 13 November 2018

Basal cell carcinoma and cystic fibrosis: a report of two cases

scientific article

CD70-CD27 interaction augments CD8+ T-cell activation by human epidermal Langerhans cells.

scientific article published in March 2012

Case 2

scientific article published on 01 January 2003

Characteristics of immunosuppressive regulatory T cells in cutaneous squamous cell carcinomas and role in metastasis

scientific article published in February 2015

Chromosome 9 allele loss occurs in both basal and squamous cell carcinomas of the skin

scientific article

Cost-effectiveness of tacrolimus ointment in adults and children with moderate and severe atopic dermatitis: twice-weekly maintenance treatment vs. standard twice-daily reactive treatment of exacerbations from a third party payer (U.K. National Heal

scientific article

Cutaneous lupus erythematosus--a study of clinical and laboratory prognostic factors in 65 patients

scientific article

Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts

scientific article published on 07 November 2006

Dissociation of Erythema and p53 Protein Expression in Human Skin Following UVB Irradiation, and Induction of p53 Protein and mRNA Following Application of Skin Irritants

scientific article published on 01 October 1994

Distinct molecular signature of human skin Langerhans cells denotes critical differences in cutaneous dendritic cell immune regulation

scientific article published on 4 September 2013

Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response

scholarly article by Greg Crawford et al published August 2018 in Nature Immunology

Epithelial mechanobiology, skin wound healing, and the stem cell niche

scientific article

Evidence for variable selective pressures at MC1R

scientific article

Expression and glycosylation of MUC1 in epidermolysis bullosa-associated and sporadic cutaneous squamous cell carcinomas

scientific article published on 01 September 2004

Expression of PI3K signalling associated with T cells in psoriasis is inhibited by seletalisib, a PI3Kδ inhibitor, and is required for functional activity

scientific article published on 4 January 2018

Faltering of prenatal growth precedes the development of atopic eczema in infancy: cohort study

scientific article published in 2018

First-in-human studies of seletalisib, an orally bioavailable small-molecule PI3Kδ inhibitor for the treatment of immune and inflammatory diseases

scientific article published on 4 February 2017

Fortnightly Review Acne vulgaris

scientific article published in the British Medical Journal

Forty Years of the European Society for Dermatological Research as European Dermatology Goes from Strength to Strength

scientific article published on 01 August 2010

Functional variation of MC1R alleles from red-haired individuals.

scientific article

Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development

scientific article

Growth and hormone profiling in children with congenital melanocytic naevi

scientific article published on 19 August 2015

Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump

scientific article (publication date: 12 April 2000)

High frequency of loss of heterozygosity in actinic keratoses, a usually benign disease

scientific article published in The Lancet

High incidence of skin cancer in the Channel Islands.

scientific article published on 24 September 2012

Human Endothelial Cells Modulate CD4+ T Cell Populations and Enhance Regulatory T Cell Suppressive Capacity.

scientific article published on 23 March 2018

Identification of novel mutations in basic hair keratins hHb1 and hHb6 in monilethrix: implications for protein structure and clinical phenotype.

scientific article

Identification of translational dermatology research priorities in the U.K.: results of an electronic Delphi exercise

scientific article published on 06 July 2015

Immunohistochemical and ultrastructural features of congenital melanocytic naevus cells support a stem-cell phenotype

scientific article published on August 2013

Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis

scientific article published in 2023

In vitro human T cell responses to diphencyprone.

scientific article published in April 2017

In vitrodiagnostic assays are effective during the acute phase of delayed-type drug hypersensitivity reactions

scientific article published on 31 January 2013

Infrequent Mutation of p16INK4 in Sporadic Melanoma

scientific article published on 01 September 1996

Investigation of mechanisms underlying the T-cell response to the hapten 2,4-dinitrochlorobenzene

scientific article published on 28 September 2006

Limited exposure to ambient ultraviolet radiation and 25-hydroxyvitamin D levels: a systematic review

scientific article

Linkage Analyses in British Pedigrees Suggest a Single Locus for Darier Disease and Narrow the Location to the Interval between D12S105 and D12S129

scientific article published on 01 November 1994

Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43.

scientific article

Loss of heterozygosity in sporadic primary cutaneous melanoma

scientific article published on 01 February 1995

Lymphomatoid plaquosis - a CD30+ lymphoproliferative rash exhibiting a predilection for recurrence on the same skin sites.

scientific article

Mapping of monilethrix to the type II keratin gene cluster at chromosome 12q13 in three new families, including one with variable expressivity

scientific article published on 01 September 1997

Maternal stress and psychological distress preconception: association with offspring atopic eczema at age 12 months.

scientific article published on 20 February 2017

Melanocortin 1 receptor variants in an Irish population

scientific article (publication date: July 1998)

Melanocortin 1 receptor variants, pigmentation, and skin cancer susceptibility.

scientific article

Melanocortin receptors, red hair, and skin cancer

scientific article published on August 1997

Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair

scientific article published in The Lancet

Melanoma in situ affecting the penis of a naturist.

scientific article

Microsatellite instability in human non-melanoma and melanoma skin cancer

scientific article published on March 1995

Migration of Immunocytes across the Basement Membrane in Skin: The Role of Basement Membrane Pores

scientific article published on 02 June 2011

Molecular genetic approaches to non-melanoma and melanoma skin cancer

scientific article published on July 1996

Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS

scientific article published on 07 February 2013

Neanderthal man’s MC1R plays fair

scientific article published on 22 April 2008

Neuropeptide alpha-MSH exerts pro-inflammatory effects on Neisseria meningitidis infection in vitro.

scientific article

Nicotinamide as a chemopreventive therapy of skin cancers. Too much of good thing?

scientific article published on 27 February 2019

Nonmelanoma skin cancer in an Irish population: an appraisal of risk factors.

scientific article published on March 1995

OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential.

scientific article published on 31 March 2016

PUVA treatment for alopecia areata--does it work? A retrospective review of 102 cases

scientific article

Peroxisome proliferator-activated receptors and their relevance to dermatology.

scientific article

Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity.

scientific article published on 23 February 2017

Photosensitivity dermatitis/actinic reticuloid syndrome in an Irish population: a review and some unusual features

scientific article published on January 1995

Point mutation in the helix termination peptide (HTP) of human type II hair keratin hHb6 causes monilethrix in five families

scientific article published on 01 August 1999

Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment

scientific article published in July 2008

Prognostic significance of allelic losses in primary melanoma

scientific article published in April 1998

Prognostic value of Ki67 antigen expression in basal cell carcinomas.

scientific article

Protection against UVR involves MC1R-mediated non-pigmentary and pigmentary mechanisms in vivo

scientific article published on 18 March 2010

Proteomic Profiling of Archived Tissue of Primary Melanoma Identifies Proteins Associated with Metastasis

scientific article published on 31 October 2020

Repeated low-dose skin exposure is an effective sensitizing stimulus, a factor to be taken into account in predicting sensitization risk.

scientific article published on September 2009

STAT4 expression and activation is increased during mitosis in vitro and in vivo in skin- and mucosa-derived cell types: implications in neoplastic and inflammatory skin diseases.

scientific article published on 18 May 2017

Self-management experiences in adults with mild-moderate psoriasis: an exploratory study and implications for improved support.

scientific article published in November 2010

Sensitization via healthy skin programs Th2 responses in individuals with atopic dermatitis

scientific article published on 25 March 2013

Subclonal Evolution of Cancer-Related Gene Mutations in p53 Immunopositive Patches in Human Skin.

scientific article

The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma

scientific article published on 01 October 1996

The PROCLIPI international registry of early-stage mycosis fungoides identifies substantial diagnostic delay in most patients

scientific article published on 25 November 2018

The Warthin-Starry stain for detection of cutaneous melanin: more than a historical curiosity

scientific article published on 01 October 2016

The cutaneous biochemical redox barrier: a component of the innate immune defenses against sensitization by highly reactive environmental xenobiotics

scientific article published on 4 November 2009

The spectrum of HIV related skin diseases in an Irish population

scientific article published in November 1993

Treatment of resistant pemphigus vulgaris with an anti-CD20 monoclonal antibody (Rituximab).

scientific article

Tuberculosis verrucosa cutis in association with bovine tuberculosis ⬇️

scholarly article by E Healy & S Rogers published November 1992 in Journal of the Royal Society of Medicine

Under the spotlight: skin therapy for asthma

scientific article published on 01 September 2007

Up-Regulation of p21WAF1/CIP1 in Psoriasis and After the Application of Irritants and Tape Stripping

scientific article published on 01 August 1995

Use of in situ detection of histone mRNA in the assessment of epidermal proliferation: comparison with the Ki67 antigen and BrdU incorporation

scientific article published on March 1995

Variants of the melanocortin-1 receptor: do they matter clinically?

scientific article published on 11 November 2014

Variants of the melanocyte-stimulating hormone receptor gene are associated with red hair and fair skin in humans

scientific article

Yersinia infection and acute abdominal pain

scientific article published on March 1987

alpha-Melanocyte-stimulating hormone protects from ultraviolet radiation-induced apoptosis and DNA damage

scientific article

‘Lambing ears’: a blistering disorder affecting farmers at lambing time

scientific article published on 06 November 2007

List of works by Eugene Healy

A 2005 survey of clinical academic staff in U.K. dermatology

A Mutational Hotspot in the 2B Domain of Human Hair Basic Keratin 6 (hHb6) in Monilethrix Patients

A comparison of twice-weekly MPD-PUVA and three times-weekly skin typing-PUVA regimens for the treatment of psoriasis

A gene for monilethrix is closely linked to the type II keratin gene cluster at 12q13

A pilot randomized controlled trial to examine the feasibility and efficacy of an educational nursing intervention to improve self-management practices in patients with mild-moderate psoriasis.

A time for everything and everything in its time - exploring the mechanisms underlying seasonality of COPD exacerbations

AIDS, i.v. drug use and mycobacterial disease: the Dublin experience.

ATP2A2 mutations in Darier's disease: variant cutaneous phenotypes are associated with missense mutations, but neuropsychiatric features are independent of mutation class

Allelotypes of primary cutaneous melanoma and benign melanocytic nevi

Alpha-melanocyte-stimulating hormone suppresses antigen-induced lymphocyte proliferation in humans independently of melanocortin 1 receptor gene status

Antibiotic hypersensitivity mimicking recurrent endocardits--identifying the culprit with the in vitro lymphocyte transformation test

Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function

Basal cell carcinoma and cystic fibrosis: a report of two cases

CD70-CD27 interaction augments CD8+ T-cell activation by human epidermal Langerhans cells.

Case 2

Characteristics of immunosuppressive regulatory T cells in cutaneous squamous cell carcinomas and role in metastasis

Chromosome 9 allele loss occurs in both basal and squamous cell carcinomas of the skin

Cost-effectiveness of tacrolimus ointment in adults and children with moderate and severe atopic dermatitis: twice-weekly maintenance treatment vs. standard twice-daily reactive treatment of exacerbations from a third party payer (U.K. National Heal

Cutaneous lupus erythematosus--a study of clinical and laboratory prognostic factors in 65 patients

Cysteinyl leukotrienes synergize with growth factors to induce proliferation of human bronchial fibroblasts

Dissociation of Erythema and p53 Protein Expression in Human Skin Following UVB Irradiation, and Induction of p53 Protein and mRNA Following Application of Skin Irritants

Distinct molecular signature of human skin Langerhans cells denotes critical differences in cutaneous dendritic cell immune regulation

Epithelial damage and tissue γδ T cells promote a unique tumor-protective IgE response

Epithelial mechanobiology, skin wound healing, and the stem cell niche

Evidence for variable selective pressures at MC1R

Expression and glycosylation of MUC1 in epidermolysis bullosa-associated and sporadic cutaneous squamous cell carcinomas

Expression of PI3K signalling associated with T cells in psoriasis is inhibited by seletalisib, a PI3Kδ inhibitor, and is required for functional activity

Faltering of prenatal growth precedes the development of atopic eczema in infancy: cohort study

First-in-human studies of seletalisib, an orally bioavailable small-molecule PI3Kδ inhibitor for the treatment of immune and inflammatory diseases

Fortnightly Review Acne vulgaris

Forty Years of the European Society for Dermatological Research as European Dermatology Goes from Strength to Strength

Functional variation of MC1R alleles from red-haired individuals.

Germline melanocortin-1-receptor genotype is associated with severity of cutaneous phenotype in congenital melanocytic nevi: a role for MC1R in human fetal development

Growth and hormone profiling in children with congenital melanocytic naevi

Hailey-Hailey disease is caused by mutations in ATP2C1 encoding a novel Ca(2+) pump

High frequency of loss of heterozygosity in actinic keratoses, a usually benign disease

High incidence of skin cancer in the Channel Islands.

Human Endothelial Cells Modulate CD4+ T Cell Populations and Enhance Regulatory T Cell Suppressive Capacity.

Identification of novel mutations in basic hair keratins hHb1 and hHb6 in monilethrix: implications for protein structure and clinical phenotype.

Identification of translational dermatology research priorities in the U.K.: results of an electronic Delphi exercise

Immunohistochemical and ultrastructural features of congenital melanocytic naevus cells support a stem-cell phenotype

Impaired expression of metallothioneins contributes to allergen-induced inflammation in patients with atopic dermatitis

In vitro human T cell responses to diphencyprone.

In vitrodiagnostic assays are effective during the acute phase of delayed-type drug hypersensitivity reactions

Infrequent Mutation of p16INK4 in Sporadic Melanoma

Investigation of mechanisms underlying the T-cell response to the hapten 2,4-dinitrochlorobenzene

Limited exposure to ambient ultraviolet radiation and 25-hydroxyvitamin D levels: a systematic review

Linkage Analyses in British Pedigrees Suggest a Single Locus for Darier Disease and Narrow the Location to the Interval between D12S105 and D12S129

Localization of a gene (MCUL1) for multiple cutaneous leiomyomata and uterine fibroids to chromosome 1q42.3-q43.

Loss of heterozygosity in sporadic primary cutaneous melanoma

Lymphomatoid plaquosis - a CD30+ lymphoproliferative rash exhibiting a predilection for recurrence on the same skin sites.

Mapping of monilethrix to the type II keratin gene cluster at chromosome 12q13 in three new families, including one with variable expressivity

Maternal stress and psychological distress preconception: association with offspring atopic eczema at age 12 months.

Melanocortin 1 receptor variants in an Irish population

Melanocortin 1 receptor variants, pigmentation, and skin cancer susceptibility.

Melanocortin receptors, red hair, and skin cancer

Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair

Melanoma in situ affecting the penis of a naturist.

Microsatellite instability in human non-melanoma and melanoma skin cancer

Migration of Immunocytes across the Basement Membrane in Skin: The Role of Basement Membrane Pores

Molecular genetic approaches to non-melanoma and melanoma skin cancer

Multiple congenital melanocytic nevi and neurocutaneous melanosis are caused by postzygotic mutations in codon 61 of NRAS

Neanderthal man’s MC1R plays fair

Neuropeptide alpha-MSH exerts pro-inflammatory effects on Neisseria meningitidis infection in vitro.

Nicotinamide as a chemopreventive therapy of skin cancers. Too much of good thing?

Nonmelanoma skin cancer in an Irish population: an appraisal of risk factors.

OX40+ Regulatory T Cells in Cutaneous Squamous Cell Carcinoma Suppress Effector T-Cell Responses and Associate with Metastatic Potential.

PUVA treatment for alopecia areata--does it work? A retrospective review of 102 cases

Peroxisome proliferator-activated receptors and their relevance to dermatology.

Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity.

Photosensitivity dermatitis/actinic reticuloid syndrome in an Irish population: a review and some unusual features

Point mutation in the helix termination peptide (HTP) of human type II hair keratin hHb6 causes monilethrix in five families

Proactive treatment of atopic dermatitis in adults with 0.1% tacrolimus ointment

Prognostic significance of allelic losses in primary melanoma

Prognostic value of Ki67 antigen expression in basal cell carcinomas.

Protection against UVR involves MC1R-mediated non-pigmentary and pigmentary mechanisms in vivo

Proteomic Profiling of Archived Tissue of Primary Melanoma Identifies Proteins Associated with Metastasis

Repeated low-dose skin exposure is an effective sensitizing stimulus, a factor to be taken into account in predicting sensitization risk.

STAT4 expression and activation is increased during mitosis in vitro and in vivo in skin- and mucosa-derived cell types: implications in neoplastic and inflammatory skin diseases.