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List of works by Lynn A Raymond

Alterations in STriatal-Enriched protein tyrosine Phosphatase expression, activation, and downstream signaling in early and late stages of the YAC128 Huntington's disease mouse model

scientific article

Alterations in synaptic function and plasticity in Huntington disease

scientific article published on 06 June 2019

Altered NMDA receptor trafficking in a yeast artificial chromosome transgenic mouse model of Huntington's disease.

scientific article published on April 2007

Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

scientific article published on 20 July 2011

An Automated Home-Cage System to Assess Learning and Performance of a Skilled Motor Task in a Mouse Model of Huntington's Disease

scientific article published on 18 September 2017

An enhanced Q175 knock-in mouse model of Huntington disease with higher mutant huntingtin levels and accelerated disease phenotypes

scientific article

Bidirectional control of postsynaptic density-95 (PSD-95) clustering by Huntingtin

scientific article published on 17 December 2013

Calpain and STriatal-Enriched protein tyrosine phosphatase (STEP) activation contribute to extrasynaptic NMDA receptor localization in a Huntington's disease mouse model

scientific article

Caudate volume as an outcome measure in clinical trials for Huntington's disease: a pilot study

scientific article published on December 2003

Cause or compensation?-Altered neuronal Ca2+ handling in Huntington's disease.

scientific article published on 9 February 2018

Chronic blockade of extrasynaptic NMDA receptors ameliorates synaptic dysfunction and pro-death signaling in Huntington disease transgenic mice

scientific article published on 19 November 2013

Cleavage at the 586 amino acid caspase-6 site in mutant huntingtin influences caspase-6 activation in vivo.

scientific article

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

scientific article published in June 2006

Clinical-Genetic Associations in the Prospective Huntington at Risk Observational Study (PHAROS): Implications for Clinical Trials

scientific article

Competition between phasic and asynchronous release for recovered synaptic vesicles at developing hippocampal autaptic synapses.

scientific article

Corticostriatal synaptic function in mouse models of Huntington's disease: early effects of huntingtin repeat length and protein load

scientific article

Differential changes in thalamic and cortical excitatory synapses onto striatal spiny projection neurons in a Huntington disease mouse model

scientific article published on 24 November 2015

Differential regulation of synaptic and extra-synaptic NMDA receptors

scientific article published in September 2002

Differential susceptibility to excitotoxic stress in YAC128 mouse models of Huntington disease between initiation and progression of disease

scientific article published on February 2009

Dysfunctional striatal dopamine signaling in Huntington's disease

scientific article published on 15 July 2019

Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice

scientific article

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

scientific article published on 17 September 2010

Endocannabinoid-Specific Impairment in Synaptic Plasticity in Striatum of Huntington's Disease Mouse Model

scientific article

Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease

scientific article published on 7 July 2004

Extrasynaptic NMDA receptor involvement in central nervous system disorders

scientific article

Genetic rescue of CB1 receptors on medium spiny neurons prevents loss of excitatory striatal synapses but not motor impairment in HD mice

scientific article

Impaired development of cortico-striatal synaptic connectivity in a cell culture model of Huntington's disease

scientific article

Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease

scientific article published in March 2002

Influence of cortical synaptic input on striatal neuronal dendritic arborization and sensitivity to excitotoxicity in corticostriatal coculture

scientific article published on 27 April 2016

Inhibition of the mitochondrial pyruvate carrier protects from excitotoxic neuronal death

scientific article published on 2 March 2017

Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease.

scientific article

Interaction of postsynaptic density protein-95 with NMDA receptors influences excitotoxicity in the yeast artificial chromosome mouse model of Huntington's disease.

scientific article

It's not necessarily all about the delivery in Huntington's disease

scientific article published in July 2014

LRRK2 overexpression alters glutamatergic presynaptic plasticity, striatal dopamine tone, postsynaptic signal transduction, motor activity and memory

scientific article

Levels of mutant huntingtin influence the phenotypic severity of Huntington disease in YAC128 mouse models

scientific article published on 17 October 2005

Mechanisms of synaptic dysfunction and excitotoxicity in Huntington's disease

scientific article published on 03 March 2014

Mechanisms underlying NMDA receptor synaptic/extrasynaptic distribution and function

scientific article

Memory and synaptic deficits in Hip14/DHHC17 knockout mice.

scientific article

Mitigation of augmented extrasynaptic NMDAR signaling and apoptosis in cortico-striatal co-cultures from Huntington's disease mice

scientific article published on 2 June 2012

Mitochondrial sensitivity and altered calcium handling underlie enhanced NMDA-induced apoptosis in YAC128 model of Huntington's disease.

scientific article

Motor onset and diagnosis in Huntington disease using the diagnostic confidence level

scientific article

Mutant huntingtin enhances excitotoxic cell death.

scientific article

N-methyl-D-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

scientific article published on 22 December 2006

N-methyl-D-aspartate receptor subunit- and neuronal-type dependence of excitotoxic signaling through post-synaptic density 95.

scientific article published on 28 September 2010

NMDA receptor desensitization regulated by direct binding to PDZ1-2 domains of PSD-95

scientific article published on 9 April 2008

Opposing roles of synaptic and extrasynaptic NMDA receptor signaling in cocultured striatal and cortical neurons

scientific article published on March 2012

P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease

scientific article

Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function

scientific article

Pathophysiology of Huntington's disease: time-dependent alterations in synaptic and receptor function.

scientific article published on 27 August 2011

PiDose: an open-source system for accurate and automated oral drug administration to group-housed mice

scientific article published on 14 July 2020

Polyglutamine-modulated striatal calpain activity in YAC transgenic huntington disease mouse model: impact on NMDA receptor function and toxicity

scientific article published in November 2008

Potentiation of NMDA receptor-mediated excitotoxicity linked with intrinsic apoptotic pathway in YAC transgenic mouse model of Huntington's disease

scientific article published in March 2004

Progranulin deficiency decreases gross neural connectivity but enhances transmission at individual synapses

scientific journal article

Protective up-regulation of CK2 by mutant huntingtin in cells co-expressing NMDA receptors

scientific article published on 30 October 2007

Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models

scientific article

Refining the diagnosis of Huntington disease: the PREDICT-HD study

scientific article published on 2 April 2013

Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease

scientific article published on December 2003

Selective neuronal degeneration in Huntington's disease

scientific article published on January 2006

Striatal neuronal apoptosis is preferentially enhanced by NMDA receptor activation in YAC transgenic mouse model of Huntington disease

scientific article published on 13 September 2005

Striatal synaptic dysfunction and altered calcium regulation in Huntington disease

scientific article

Striatal synaptic dysfunction and hippocampal plasticity deficits in the Hu97/18 mouse model of Huntington disease

scientific article

Synaptic dysfunction in progranulin-deficient mice

scientific article published on 25 October 2011

Treatment of Huntington Disease and Comorbid Trichotillomania With Aripiprazole

scientific article published in January 2015

Wild-type huntingtin protects neurons from excitotoxicity

scientific article published on 17 January 2006

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