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List of works by Xosé R. Bustelo

3D structure of Syk kinase determined by single-particle electron microscopy

scientific article

A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition

scientific article

A transcriptional cross-talk between RhoA and c-Myc inhibits the RhoA/Rock-dependent cytoskeleton

scientific article published on 10 May 2010

A transcriptional cross–talk between RhoA and c–Myc inhibits the RhoA/Rock–dependent cytoskeleton ⬇️

scientific article published on July 1, 2010

Activating mutations and translocations in the guanine exchange factor VAV1 in peripheral T-cell lymphomas

scientific article published on 06 January 2017

Activation of Vav by the gammaherpesvirus M2 protein contributes to the establishment of viral latency in B lymphocytes

scientific article

Activation of Vav/Rho GTPase signaling by CXCL12 controls membrane-type matrix metalloproteinase-dependent melanoma cell invasion

scientific article published on January 2006

An unexpected tumor suppressor role for VAV1a

scientific article published on 23 February 2018

CANCERTOOL: A Visualization and Representation Interface to Exploit Cancer Datasets

scientific article published on 19 September 2018

CD147 inhibits the nuclear factor of activated T-cells by impairing Vav1 and Rac1 downstream signaling

scientific article published on 26 December 2007

Cancer-associated mutations in VAV1 trigger variegated signaling outputs and T-cell lymphomagenesis

scientific article published on 07 October 2021

Characterization of Novel Molecular Mechanisms Favoring Rac1 Membrane Translocation

scientific article

Chronic sympathoexcitation through loss of Vav3, a Rac1 activator, results in divergent effects on metabolic syndrome and obesity depending on diet

scientific article published in August 2013

Conformational rearrangements upon Syk auto-phosphorylation

scientific article

Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome

scientific article

Contribution of the R-Ras2 GTP-binding protein to primary breast tumorigenesis and late-stage metastatic disease

scientific article published on 14 May 2014

Control of lymphocyte shape and the chemotactic response by the GTP exchange factor Vav.

scientific article published on 23 December 2004

Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation.

scientific article

Coronin1 proteins dictate rac1 intracellular dynamics and cytoskeletal output

scientific article published on 30 June 2014

Cytochrome c oxidase subunit II mRNA levels during T-lymphocyte proliferation and liver regeneration

scientific article published on 01 April 1991

Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis

scientific article published on 30 July 2018

Drug Vulnerabilities and Disease Prognosis Linked to the Stem Cell-Like Gene Expression Program Triggered by the RHO GTPase Activator VAV2 in Hyperplastic Keratinocytes and Head and Neck Cancer

scientific article published on 03 September 2020

Efficient fractionation and analysis of ribosome assembly intermediates in human cells

scientific article published in 2021

Essential function for the GTPase TC21 in homeostatic antigen receptor signaling.

scientific article

Exchange factors of the RasGRP family mediate Ras activation in the Golgi

scientific article published on 2 June 2003

Expression of VAV1 in the tumour microenvironment of glioblastoma multiforme.

scientific article published on 4 August 2012

F-actin-dependent translocation of the Rap1 GDP/GTP exchange factor RasGRP2.

scientific article published on 26 February 2004

Focal accumulation of preribosomes outside the nucleolus during metaphase-anaphase in budding yeast

scientific article published on 06 June 2017

Functional characterization of Pwp2, a WD family protein essential for the assembly of the 90 S pre-ribosomal particle

scientific article

GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo

scientific article

Genetic dissection of the vav2-rac1 signaling axis in vascular smooth muscle cells

scientific article

Genomic and Functional Regulation of TRIB1 Contributes to Prostate Cancer Pathogenesis

scientific article published on 11 September 2020

Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3.

scientific article

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences

scientific article published on 21 November 2016

HERC Ubiquitin Ligases in Cancer

scientific article published on 22 June 2020

How Vav proteins discriminate the GTPases Rac1 and RhoA from Cdc42.

scientific article published in December 2001

Human Proteinpedia enables sharing of human protein data

scientific article

Identification of a Vav2-dependent mechanism for GDNF/Ret control of mesolimbic DAT trafficking

scientific article

Identification of distinct maturation steps involved in human 40S ribosomal subunit biosynthesis

scientific article published on 09 January 2020

Identification of the Rock-dependent transcriptome in rodent fibroblasts

scientific article

Immunosuppression-Independent Role of Regulatory T Cells against Hypertension-Driven Renal Dysfunctions

scientific article

In Silico Analysis of the Age-Dependent Evolution of the Transcriptome of Mouse Skin Stem Cells

scientific article published on 09 January 2020

Intratumoral stages of metastatic cells: A synthesis of ontogeny, Rho/Rac GTPases, epithelial‐mesenchymal transitions, and more ⬇️

scientific article published on June 18, 2012

Inverted signaling hierarchy between RAS and RAC in T-lymphocytes.

scientific article

Involvement of the Rho/Rac family member RhoG in caveolar endocytosis

scientific article

Isolation and characterization of thymosin β9Met from pork spleen

scientific article published on 01 September 1989

K-RasV14I recapitulates Noonan syndrome in mice

scientific article

Loss of Vav2 proto-oncogene causes tachycardia and cardiovascular disease in mice

scientific article published on 3 January 2007

Lung regeneration after toxic injury is improved in absence of dioxin receptor.

scientific article published on 12 October 2017

Mechanistic analysis of the amplification and diversification events induced by Vav proteins in B-lymphocytes.

scientific article

New avenue to inhibit Ras signaling

scientific article published on December 2014

New insights into the Vav1 activation cycle in lymphocytes

scientific article published in February 2018

Nuclear Vav3 is required for polycomb repression complex-1 activity in B-cell lymphoblastic leukemogenesis

scientific article published on 01 June 2022

Overexpression of the VAV proto-oncogene product is associated with B-cell chronic lymphocytic leukaemia displaying loss on 13q.

scientific article

Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.

scientific article published on 18 January 2007

Phosphatidylinositol Monophosphates Regulate Optimal Vav1 Signaling Output

scientific article published on 16 December 2019

Phylogenetic conservation of the regulatory and functional properties of the Vav oncoprotein family.

scientific article

Plk1 regulates contraction of postmitotic smooth muscle cells and is required for vascular homeostasis

scientific article

R-Ras2 is required for germinal center formation to aid B cells during energetically demanding processes

scientific article published on 29 May 2018

RAS GTPase-dependent pathways in developmental diseases: old guys, new lads, and current challenges

scholarly article

RAS at the Golgi antagonizes malignant transformation through PTPRκ-mediated inhibition of ERK activation

scientific article published in Nature Communications

Rac1 function is required for Src-induced transformation. Evidence of a role for Tiam1 and Vav2 in Rac activation by Src.

scientific article published on 16 June 2003

RasGRF2, a guanosine nucleotide exchange factor for Ras GTPases, participates in T-cell signaling responses

scientific article

Reduction of NADPH-oxidase activity ameliorates the cardiovascular phenotype in a mouse model of Williams-Beuren Syndrome

scientific article (publication date: February 2012)

Regulatory and signaling properties of the Vav family

scientific article

Rho guanosine nucleotide exchange factors are not such bad guys after all in cancera

scientific article

Ribosome biogenesis and cancer: basic and translational challenges

scientific article published on 26 October 2017

Role of Src homology domain binding in signaling complexes assembled by the murid γ-herpesvirus M2 protein

scientific article published on 20 December 2012

Role of chimaerins, a group of Rac-specific GTPase activating proteins, in T-cell receptor signaling

scientific article published on 28 December 2007

S. typhimurium encodes an activator of Rho GTPases that induces membrane ruffling and nuclear responses in host cells.

scientific article

Signaling through the leukocyte integrin LFA-1 in T cells induces a transient activation of Rac-1 that is regulated by Vav and PI3K/Akt-1.

scientific article published on 11 February 2004

Specific phosphorylation of p120-catenin regulatory domain differently modulates its binding to RhoA.

scientific article published on 28 December 2006

Structural basis for the signaling specificity of RhoG and Rac1 GTPases

scientific article (publication date: 26 September 2003)

Structural determinants for the biological activity of Vav proteins.

scientific article

T cell receptor internalization from the immunological synapse is mediated by TC21 and RhoG GTPase-dependent phagocytosis

scientific article

The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.

scientific article

The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins

scientific article published on 15 April 2014

The Gammaherpesvirus m2 protein manipulates the Fyn/Vav pathway through a multidocking mechanism of assembly

scientific article

The Ras-like protein R-Ras2/TC21 is important for proper mammary gland development

scientific article

The Rho exchange factors Vav2 and Vav3 favor skin tumor initiation and promotion by engaging extracellular signaling loops

scientific article (publication date: July 2013)

The Rho guanosine nucleotide exchange factors Vav2 and Vav3 modulate epidermal stem cell function

scientific article published on 09 May 2022

The Rho/Rac exchange factor Vav2 controls nitric oxide-dependent responses in mouse vascular smooth muscle cells.

scientific article

The Vav GEF Family: An Evolutionary and Functional Perspective.

scientific article

The Vav-Rac1 pathway in cytotoxic lymphocytes regulates the generation of cell-mediated killing

scientific article

The dioxin receptor has tumor suppressor activity in melanoma growth and metastasis.

scientific article published on 10 July 2013

The dioxin receptor regulates the constitutive expression of the vav3 proto-oncogene and modulates cell shape and adhesion.

scientific article published on 21 January 2009

The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathway-specific signaling defects

scientific article

The levels of cytochrome c oxidase subunit II mRNA change during the rat T-cell development

scientific article published on 01 December 1989

The rho exchange factors vav2 and vav3 control a lung metastasis-specific transcriptional program in breast cancer cells.

scientific article

The use of knockout mice reveals a synergistic role of the Vav1 and Rasgrf2 gene deficiencies in lymphomagenesis and metastasis

scientific article

Transcript levels of thymosin β4, an actin-sequestering peptide, in cell proliferation

scientific article published on 01 March 1993

Transcriptional factor aryl hydrocarbon receptor (Ahr) controls cardiovascular and respiratory functions by regulating the expression of the Vav3 proto-oncogene

scientific article

Transcriptomal profiling of site-specific Ras signals

scientific article

Transcriptomal profiling of the cellular transformation induced by Rho subfamily GTPases

scientific article published on 8 January 2007

Tyrosine phosphorylation mediates both activation and downmodulation of the biological activity of Vav

scientific article

Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

scientific journal article

Understanding Rho/Rac biology in T-cells using animal models

scientific article

VAV2 signaling promotes regenerative proliferation in both cutaneous and head and neck squamous cell carcinoma

scientific article published on 22 September 2020

VAV3 mediates resistance to breast cancer endocrine therapy.

scientific article

Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity

scientific article published on December 2016

Vav family exchange factors: an integrated regulatory and functional view

scientific article

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

scientific article published on July 2003

Vav mediates Ras stimulation by direct activation of the GDP/GTP exchange factor Ras GRP1

scientific article published on 01 March 2019

Vav proteins maintain epithelial traits in breast cancer cells using miR-200c-dependent and independent mechanisms

scientific article published on 07 August 2018

Vav proteins, adaptors and cell signaling.

scientific article

Vav1 and Rac control chemokine-promoted T lymphocyte adhesion mediated by the integrin alpha4beta1

scientific article

Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis

scientific article published on 16 November 2020

Vav2 pharmaco-mimetic mice reveal the therapeutic value and caveats of the catalytic inactivation of a Rho exchange factor

scientific article published on 11 June 2020

Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation, and survival

scientific article

Vav3 is involved in GABAergic axon guidance events important for the proper function of brainstem neurons controlling cardiovascular, respiratory, and renal parameters.

scientific article

Vav3 proto-oncogene deficiency leads to sympathetic hyperactivity and cardiovascular dysfunction

scientific article

Vav3-deficient mice exhibit a transient delay in cerebellar development

scientific article

Vav3-induced cytoskeletal dynamics contribute to heterotypic properties of endothelial barriers

scientific article published on 01 June 2018

Walking pathways at Heidelberg. Conference on oncogenes and growth control

scientific article published in November 2002

Wound healing defect of Vav3-/- mice due to impaired {beta}2-integrin-dependent macrophage phagocytosis of apoptotic neutrophils

scientific article published on 15 January 2009

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