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List of works by Dirk Geerts

A competitive cell growth assay for the detection of subtle effects of gene transduction on cell proliferation.

scientific article

Acid Sphingomyelinase-Derived Ceramide Regulates ICAM-1 Function during T Cell Transmigration across Brain Endothelial Cells

scientific article published on 23 November 2015

Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly

scientific article

Binding of integrin alpha6beta4 to plectin prevents plectin association with F-actin but does not interfere with intermediate filament binding

scientific article

Brain endothelial barrier passage by monocytes is controlled by the endothelin system

scientific article

CIP75 (connexin43-interacting protein of 75 kDa) mediates the endoplasmic reticulum dislocation of connexin43

scientific article published on 01 February 2014

Cardiomyocyte Progenitor Cells as a Functional Gene Delivery Vehicle for Long-Term Biological Pacing

article

Comparison of RNAi efficiency mediated by tetracycline-responsive H1 and U6 promoter variants in mammalian cell lines

scientific article published on 10 April 2007

Cyclin D1 is a direct transcriptional target of GATA3 in neuroblastoma tumor cells

DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma

scientific article published on 21 February 2013

Defective IL-1A expression in patients with Crohn's disease is related to attenuated MAP3K4 signaling.

scientific article

Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients

scientific article published on 15 October 2014

Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits

scientific article

Domain-wide regulation of gene expression in the human genome

scientific article

Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs

scientific article published on 12 August 2013

Essential function in chloroplast recognition of the ferredoxin transit peptide processing region

Establishment of Primary Transgenic Human Airway Epithelial Cell Cultures to Study Respiratory Virus-Host Interactions

scientific article published on 13 August 2019

Expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in neuroblastoma: correlation with clinical features, cellular localization, and cerulenin-mediated apoptosis regulation

scientific article published on November 2007

FHL2 protein is a novel co-repressor of nuclear receptor Nur77.

scientific article published on 2 November 2011

Focal-adhesion targeting links caveolin-1 to a Rac1-degradation pathway

scientific article published on 11 May 2010

HOXA/PBX3 knockdown impairs growth and sensitizes cytogenetically normal acute myeloid leukemia cells to chemotherapy

scientific article published on 28 March 2013

Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180

scientific article

Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains

scientific article (publication date: 26 February 1999)

In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma

scientific article published on September 2010

Inactivation of CDK2 is synthetically lethal to MYCN over-expressing cancer cells

scholarly article

Inflammation-induced endothelial to mesenchymal transition promotes brain endothelial cell dysfunction and occurs during multiple sclerosis pathophysiology

scientific article published on 18 January 2019

Inhibition of HIV-1 replication with stable RNAi-mediated knockdown of autophagy factors

scientific article

Integrin cytoplasmic domain-associated protein-1 (ICAP-1) interacts with the ROCK-I kinase at the plasma membrane

scientific article (publication date: September 2006)

Interaction of BP180 and α6β4

scientific article published on 01 May 1999

Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus

scientific article

LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation

scientific article

Ligand-independent role of the β4 integrin subunit in the formation of hemidesmosomes ⬇️

scientific article published on June 1, 1998

Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors

scientific article published on 18 November 2010

MEIS and PBX homeobox proteins in ovarian cancer.

scientific article published on 18 October 2007

MEIS homeobox genes in neuroblastoma

scientific article

MEIS transcription factors in development and disease

scientific article published on 15 August 2019

MSX1 induces the Wnt pathway antagonist genes DKK1, DKK2, DKK3, and SFRP1 in neuroblastoma cells, but does not block Wnt3 and Wnt5A signalling to DVL3.

scientific article published on 7 October 2009

MYCN-regulated miRNA-92 inhibits secretion of the tumor suppressor DICKKOPF-3 (DKK3) in neuroblastoma

scientific article published on 13 May 2011

Myc-associated zinc finger protein (MAZ) is regulated by miR-125b and mediates VEGF-induced angiogenesis in glioblastoma

scientific article published on 13 March 2012

Myeloid ecotropic viral integration site 1 (MEIS) 1 involvement in embryonic implantation

scientific article published on 11 April 2008

Nod2 improves barrier function of intestinal epithelial cells via enhancement of TLR responses

article

Notch signaling is impaired during inflammation in a Lunatic Fringe-dependent manner

scientific article published on 28 December 2017

Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation

scientific article

P-glycoprotein regulates trafficking of CD8(+) T cells to the brain parenchyma

scientific article published on 16 January 2014

PEA-15 potentiates H-Ras-mediated epithelial cell transformation through phospholipase D

scientific article published on 21 November 2011

PEA15 impairs cell migration and correlates with clinical features predicting good prognosis in neuroblastoma

scientific article

PRAF2 stimulates cell proliferation and migration and predicts poor prognosis in neuroblastoma

scientific article published on 21 February 2013

Pluripotency induction in HEK293T cells by concurrent expression of STELLA, OCT4 and NANOS2.

scientific article published on 26 October 2016

Polyamine synthesis as a target of MYC oncogenes

scientific article published in Journal of Biological Chemistry

Pre-B-cell leukemia homeobox interacting protein 1 is overexpressed in astrocytoma and promotes tumor cell growth and migration

scientific article

Rac1 acts in conjunction with Nedd4 and dishevelled-1 to promote maturation of cell-cell contacts

scientific article

Reduced expression of PGC-1α partly underlies mitochondrial changes and correlates with neuronal loss in multiple sclerosis cortex

scientific article

Regulation of endometrial receptivity by the highly expressed HOXA9, HOXA11 and HOXD10 HOX-class homeobox genes

scientific article published on 18 February 2014

Retinoic acid induces blood-brain barrier development.

scientific article published on January 2013

Rho GAPs and GEFs: controling switches in endothelial cell adhesion

scientific article

Silencing GFAP isoforms in astrocytoma cells disturbs laminin-dependent motility and cell adhesion

scientific article published on 2 April 2014

Silencing of SPRY1 triggers complete regression of rhabdomyosarcoma tumors carrying a mutated RAS gene

scientific article

Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier

scientific article

Subcellular distribution and expression of prenylated Rab acceptor 1 domain family, member 2 (PRAF2) in malignant glioma: Influence on cell survival and migration

scientific article published on 19 March 2010

Synergistic drug combination GC7/DFMO suppresses hypusine/spermidine-dependent eIF5A activation and induces apoptotic cell death in neuroblastoma

scientific article published on 2 January 2018

The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB.

scientific article

The F-BAR Protein PACSIN2 Regulates Epidermal Growth Factor Receptor Internalization ⬇️

scientific article published on November 5, 2012

The LIM-only protein DRAL/FHL2 binds to the cytoplasmic domain of several alpha and beta integrin chains and is recruited to adhesion complexes

scientific article

The MSX1 homeobox transcription factor is a downstream target of PHOX2B and activates the Delta-Notch pathway in neuroblastoma

scientific article published on 16 January 2008

The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits

scientific article (publication date: March 2002)

The Rho-guanine nucleotide exchange factor Trio controls leukocyte transendothelial migration by promoting docking structure formation.

scientific article

The human minor histocompatibility antigen 1 is a RhoGAP

scientific article

The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification

scientific article

The role of the MEIS homeobox genes in neuroblastoma

scientific article

The tyrosine phosphatase SHP2 regulates recovery of endothelial adherens junctions through control of β-catenin phosphorylation

scientific article

Tumorigenic and anti-proliferative properties of the TALE-transcription factors MEIS2D and MEIS2A in neuroblastoma

scientific article

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