List of works - Spencer B. Gibson

A matter of balance between life and death: Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy ⬇️

scientific article published on October 16, 2010

Adhesion of ZAP-70+ chronic lymphocytic leukemia cells to stromal cells is enhanced by cytokines and blocked by inhibitors of the PI3-kinase pathway

scientific article

Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death

scientific article published on December 2007

Association of interleukin-6 and interleukin-8 with poor prognosis in elderly patients with chronic lymphocytic leukemia

article

Autophagy in clear cell ovarian cancer, a potential marker for hypoxia and poor prognosis?# ⬇️

scientific article published on December 1, 2012

BNIP3 (Bcl-2 19 kDa interacting protein) acts as transcriptional repressor of apoptosis-inducing factor expression preventing cell death in human malignant gliomas

scientific article published on April 2009

BNIP3 acts as transcriptional repressor of death receptor-5 expression and prevents TRAIL-induced cell death in gliomas

scientific article published on 11 April 2013

BNIP3 interacting with LC3 triggers excessive mitophagy in delayed neuronal death in stroke

scientific article

BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF.

scientific article

Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway

scientific article

Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway

scientific article published on October 2005

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

scientific article published on March 1998

Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B leukemic cells.

scientific article

Cyclin D expression in chronic lymphocytic leukemia

scientific article published on September 2005

Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabinein vitro

scientific article published on 01 December 2008

Death receptor-4 (DR4) expression is regulated by transcription factor NF-kappaB in response to etoposide treatment

scientific article

Differential cellular responses induced by dorsomorphin and LDN-193189 in chemotherapy-sensitive and chemotherapy-resistant human epithelial ovarian cancer cells.

scientific article

Differential expression and function of CD27 in chronic lymphocytic leukemia cells expressing ZAP-70.

scientific article published on 2 May 2015

Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents

scientific article published on April 1999

Epidermal growth factor and trail interactions in epithelial-derived cells.

scientific article published on January 2004

Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation

scientific article published on June 1999

Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer

scientific article

Estrogen regulation of anti-apoptotic Bcl-2 family member Mcl-1 expression in breast cancer cells

scientific article

Expression and function of phosphoinositide 3-kinase delta in mesenchymal stromal cells from normal and leukaemic bone marrow

scientific article published on 14 March 2019

Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells

scientific article published on 21 August 2017

Frequent occurrence of highly expanded but unrelated B-cell clones in patients with multiple myeloma.

scientific article

Functional LCK Is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy.

scientific article published on 24 May 2018

Herceptin sensitizes ErbB2-overexpressing cells to apoptosis by reducing antiapoptotic Mcl-1 expression

scientific article published on February 2006

High incidence of chronic lymphocytic leukemia (CLL) diagnosed by immunophenotyping: A population-based Canadian cohort

article

Identification and Characterization of Novel Receptor-Interacting Serine/Threonine-Protein Kinase 2 Inhibitors Using Structural Similarity Analysis.

scientific article published on 19 March 2018

Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study

scientific article published on 16 July 2013

Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis.

scientific article published on December 2010

Investigating the role of reactive oxygen species in regulating autophagy.

scientific article published on January 2013

Investigation of an NQO1 polymorphism as a possible risk and prognostic factor for chronic lymphocytic leukemia

scientific article published on 3 August 2008

Lysophosphatidic acid (LPA) induces the expression of VEGF leading to protection against apoptosis in B-cell derived malignancies

scientific article

Lysophosphatidic acid (LPA) protects primary chronic lymphocytic leukemia cells from apoptosis through LPA receptor activation of the anti-apoptotic protein AKT/PKB.

scientific article published on 23 December 2004

Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.

scientific article published on 11 April 2008

Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression

scientific article published on December 2009

Lysophosphatidylcholine Stimulates Activator Protein 1 and the c-Jun N-terminal Kinase Activity

scientific article published in Journal of Biological Chemistry

Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels

scientific article published on 17 September 2019

Lysosomes as Oxidative Targets for Cancer Therapy

scientific article

MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton

scientific article published in April 1999

MEKK1-induced apoptosis is mediated by Smac/Diablo release from the mitochondria

scientific journal article

Methods for detecting autophagy and determining autophagy-induced cell death.

scientific article published on March 2010

Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species

scientific article published on December 2007

On-target effect of FK866, a nicotinamide phosphoribosyl transferase inhibitor, by apoptosis-mediated death in chronic lymphocytic leukemia cells

scientific article published on 29 August 2014

Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells

scientific article

Phosphatidylinositol-3,4-Bisphosphate and Its Binding Protein Lamellipodin Regulate Chemotaxis of Malignant B Lymphocytes.

scientific article published on 22 December 2015

Poly(ADP-ribose) polymerase-1 causes mitochondrial damage and neuron death mediated by Bnip3.

scientific article published in November 2014

Primary del 17 chronic lymphocytic leukaemia lymphocytes are hypersensitive to dasatinib in vitro

scientific article published on 02 September 2009

RNA species generated in vaccinia virus infected cells activate cell type-specific MDA5 or RIG-I dependent interferon gene transcription and PKR dependent apoptosis

scientific article published on 26 February 2011

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment ⬇️

scientific article published on July 20, 2012

Regulation of apoptosis in fibroblast-like synoviocytes by the hypoxia-induced Bcl-2 family member Bcl-2/adenovirus E1B 19-kd protein–interacting protein 3

scientific article published on 01 September 2007

Regulation of autophagy in hematological malignancies: role of reactive oxygen species.

scientific article published on 08 September 2011

Reovirus-induced apoptosis is mediated by TRAIL

scientific article

Role of BNIP3 in proliferation and hypoxia-induced autophagy: implications for personalized cancer therapies.

scientific article published on October 2010

Role of myeloid cell factor-1 (Mcl-1) in chronic lymphocytic leukemia

scientific article published in October 2004

Role of the TRAIL/APO2-L death receptors in chlorambucil- and fludarabine-induced apoptosis in chronic lymphocytic leukemia

scientific article published in November 2003

Single-agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia.

scientific article published on 28 December 2010

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation ⬇️

scientific article published on September 19, 2012

Superoxide is the major reactive oxygen species regulating autophagy

scientific article published on May 2009

Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B

scientific article published on 18 October 2013

TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia

scientific article

Targeting metabolism and autophagy in the context of haematologic malignancies

scientific article published on 8 July 2012

The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation

scientific article published in PLoS ONE

The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer

scientific article published on July 2005

The TRAIL apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary chronic lymphocytic leukemia cells

scientific article published on July 2006

The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia

scientific article published on April 2006

The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death.

scientific article published on 09 January 2009

Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1.

scientific article

Truncated forms of BNIP3 act as dominant negatives inhibiting hypoxia-induced cell death.

scientific article

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFkappaB activation in epithelial derived cell lines

scientific article

Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells.

scientific article

ZAP70 expression directly promotes chronic lymphocytic leukaemia cell adhesion to bone marrow stromal cells.

scientific article

List of works by Spencer B. Gibson

A matter of balance between life and death: Targeting reactive oxygen species (ROS)-induced autophagy for cancer therapy ⬇️

Adhesion of ZAP-70+ chronic lymphocytic leukemia cells to stromal cells is enhanced by cytokines and blocked by inhibitors of the PI3-kinase pathway

Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death

Association of interleukin-6 and interleukin-8 with poor prognosis in elderly patients with chronic lymphocytic leukemia

Autophagy in clear cell ovarian cancer, a potential marker for hypoxia and poor prognosis?# ⬇️

BNIP3 (Bcl-2 19 kDa interacting protein) acts as transcriptional repressor of apoptosis-inducing factor expression preventing cell death in human malignant gliomas

BNIP3 acts as transcriptional repressor of death receptor-5 expression and prevents TRAIL-induced cell death in gliomas

BNIP3 interacting with LC3 triggers excessive mitophagy in delayed neuronal death in stroke

BNIP3 plays a role in hypoxic cell death in human epithelial cells that is inhibited by growth factors EGF and IGF.

Brevinin-2R(1) semi-selectively kills cancer cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway

Cancer-specific toxicity of apoptin is independent of death receptors but involves the loss of mitochondrial membrane potential and the release of mitochondrial cell-death mediators by a Nur77-dependent pathway

Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signals

Cucurbitacin-I (JSI-124) activates the JNK/c-Jun signaling pathway independent of apoptosis and cell cycle arrest in B leukemic cells.

Cyclin D expression in chronic lymphocytic leukemia

Dasatinib sensitizes primary chronic lymphocytic leukaemia lymphocytes to chlorambucil and fludarabinein vitro

Death receptor-4 (DR4) expression is regulated by transcription factor NF-kappaB in response to etoposide treatment

Differential cellular responses induced by dorsomorphin and LDN-193189 in chemotherapy-sensitive and chemotherapy-resistant human epithelial ovarian cancer cells.

Differential expression and function of CD27 in chronic lymphocytic leukemia cells expressing ZAP-70.

Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents

Epidermal growth factor and trail interactions in epithelial-derived cells.

Epidermal growth factor protects epithelial cells against Fas-induced apoptosis. Requirement for Akt activation

Epidermal growth factor regulates Mcl-1 expression through the MAPK-Elk-1 signalling pathway contributing to cell survival in breast cancer

Estrogen regulation of anti-apoptotic Bcl-2 family member Mcl-1 expression in breast cancer cells

Expression and function of phosphoinositide 3-kinase delta in mesenchymal stromal cells from normal and leukaemic bone marrow

Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells

Frequent occurrence of highly expanded but unrelated B-cell clones in patients with multiple myeloma.

Functional LCK Is required for optimal CD28-mediated activation of the TEC family tyrosine kinase EMT/ITK.

Guidelines for the use and interpretation of assays for monitoring autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Harnessing Oxidative Stress as an Innovative Target for Cancer Therapy.

Herceptin sensitizes ErbB2-overexpressing cells to apoptosis by reducing antiapoptotic Mcl-1 expression

High incidence of chronic lymphocytic leukemia (CLL) diagnosed by immunophenotyping: A population-based Canadian cohort

Identification and Characterization of Novel Receptor-Interacting Serine/Threonine-Protein Kinase 2 Inhibitors Using Structural Similarity Analysis.

Increased risk of second malignancies in chronic lymphocytic leukaemia patients as compared with follicular lymphoma patients: a Canadian population-based study

Inhibition of constitutive activation of STAT3 by curcurbitacin-I (JSI-124) sensitized human B-leukemia cells to apoptosis.

Investigating the role of reactive oxygen species in regulating autophagy.

Investigation of an NQO1 polymorphism as a possible risk and prognostic factor for chronic lymphocytic leukemia

Lysophosphatidic acid (LPA) induces the expression of VEGF leading to protection against apoptosis in B-cell derived malignancies

Lysophosphatidic acid (LPA) protects primary chronic lymphocytic leukemia cells from apoptosis through LPA receptor activation of the anti-apoptotic protein AKT/PKB.

Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.

Lysophosphatidic acid receptor expression in chronic lymphocytic leukemia leads to cell survival mediated though vascular endothelial growth factor expression

Lysophosphatidylcholine Stimulates Activator Protein 1 and the c-Jun N-terminal Kinase Activity

Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels

Lysosomes as Oxidative Targets for Cancer Therapy

MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton

MEKK1-induced apoptosis is mediated by Smac/Diablo release from the mitochondria

Methods for detecting autophagy and determining autophagy-induced cell death.

Mitochondrial electron-transport-chain inhibitors of complexes I and II induce autophagic cell death mediated by reactive oxygen species

On-target effect of FK866, a nicotinamide phosphoribosyl transferase inhibitor, by apoptosis-mediated death in chronic lymphocytic leukemia cells

Oxidative stress induces autophagic cell death independent of apoptosis in transformed and cancer cells

Phosphatidylinositol-3,4-Bisphosphate and Its Binding Protein Lamellipodin Regulate Chemotaxis of Malignant B Lymphocytes.

Poly(ADP-ribose) polymerase-1 causes mitochondrial damage and neuron death mediated by Bnip3.

Primary del 17 chronic lymphocytic leukaemia lymphocytes are hypersensitive to dasatinib in vitro

RNA species generated in vaccinia virus infected cells activate cell type-specific MDA5 or RIG-I dependent interferon gene transcription and PKR dependent apoptosis

Reactive oxygen species regulation of autophagy in cancer: Implications for cancer treatment ⬇️

Regulation of apoptosis in fibroblast-like synoviocytes by the hypoxia-induced Bcl-2 family member Bcl-2/adenovirus E1B 19-kd protein–interacting protein 3

Regulation of autophagy in hematological malignancies: role of reactive oxygen species.

Reovirus-induced apoptosis is mediated by TRAIL

Role of BNIP3 in proliferation and hypoxia-induced autophagy: implications for personalized cancer therapies.

Role of myeloid cell factor-1 (Mcl-1) in chronic lymphocytic leukemia

Role of the TRAIL/APO2-L death receptors in chlorambucil- and fludarabine-induced apoptosis in chronic lymphocytic leukemia

Single-agent lenalidomide in the treatment of previously untreated chronic lymphocytic leukemia.

Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation ⬇️

Superoxide is the major reactive oxygen species regulating autophagy

Synergistic apoptotic response between valproic acid and fludarabine in chronic lymphocytic leukaemia (CLL) cells involves the lysosomal protease cathepsin B

TAPP2 links phosphoinositide 3-kinase signaling to B-cell adhesion through interaction with the cytoskeletal protein utrophin: expression of a novel cell adhesion-promoting complex in B-cell leukemia

Targeting metabolism and autophagy in the context of haematologic malignancies

The BH3 only Bcl-2 family member BNIP3 regulates cellular proliferation

The S100A7-c-Jun activation domain binding protein 1 pathway enhances prosurvival pathways in breast cancer

The TRAIL apoptotic pathway mediates proteasome inhibitor induced apoptosis in primary chronic lymphocytic leukemia cells

The pro-cell death Bcl-2 family member, BNIP3, is localized to the nucleus of human glial cells: Implications for glioblastoma multiforme tumor cell survival under hypoxia

The role of Bcl-2 family member BNIP3 in cell death and disease: NIPping at the heels of cell death.

Transcription factor NF-kappaB differentially regulates death receptor 5 expression involving histone deacetylase 1.

Truncated forms of BNIP3 act as dominant negatives inhibiting hypoxia-induced cell death.

Tumor necrosis factor-related apoptosis inducing ligand (TRAIL) up-regulates death receptor 5 (DR5) mediated by NFkappaB activation in epithelial derived cell lines

Valproic acid enhances fludarabine-induced apoptosis mediated by ROS and involving decreased AKT and ATM activation in B-cell-lymphoid neoplastic cells.

ZAP70 expression directly promotes chronic lymphocytic leukaemia cell adhesion to bone marrow stromal cells.