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List of works by Kevin A Reynolds

1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)

scientific article

A novel alternate anaplerotic pathway to the glyoxylate cycle in streptomycetes ⬇️

scientific article published on August 1, 1997

A novel delta(3),delta(2)-enoyl-CoA isomerase involved in the biosynthesis of the cyclohexanecarboxylic acid-derived moiety of the polyketide ansatrienin A.

scientific article published in June 2000

A pH-stability study of phoslactomycin B and analysis of the acid and base degradation products

scientific article published in September 2005

Acyl-CoA subunit selectivity in the pikromycin polyketide synthase PikAIV: steady-state kinetics and active-site occupancy analysis by FTICR-MS.

scientific article

Alkyl-CoA disulfides as inhibitors and mechanistic probes for FabH enzymes

scientific article

Alteration of the fatty acid profile of Streptomyces coelicolor by replacement of the initiation enzyme 3-ketoacyl acyl carrier protein synthase III (FabH).

scientific article

An O-phosphotransferase catalyzes phosphorylation of hygromycin A in the antibiotic-producing organism Streptomyces hygroscopicus

scientific article published on 21 July 2008

An unexpected interaction between the modular polyketide synthases, erythromycin DEBS1 and pikromycin PikAIV, leads to efficient triketide lactone synthesis

scientific article published in September 2002

Antibacterial targets in fatty acid biosynthesis

scientific article (publication date: October 2007)

Antimalarial activity of natural and synthetic prodiginines

scientific article published on 8 July 2011

Biochemical evidence for an editing role of thioesterase II in the biosynthesis of the polyketide pikromycin

scientific article published on 3 October 2002

Biosynthesis of ansatrienin (mycotrienin) and naphthomycin. Identification and analysis of two separate biosynthetic gene clusters in Streptomyces collinus Tü 1892. ⬇️

scientific article published in April 1999

Biosynthesis of salinosporamides from alpha,beta-unsaturated fatty acids: implications for extending polyketide synthase diversity.

scientific article published on August 2009

Biosynthesis of the Shikimate-derived Starter Unit of the Immunosuppressant Ascomycin: Stereochemistry of the 1,4-Conjugate Elimination ⬇️

scientific article published on 01 August 1997

Biosynthesis of the aminocyclitol subunit of hygromycin A in Streptomyces hygroscopicus NRRL 2388.

scientific article published in November 2009

Biosynthetic origin of hygromycin A.

scientific article

Biosynthetic origins of the natural product, thiolactomycin: a unique and selective inhibitor of type II dissociated fatty acid synthases

scientific article published in August 2003

Branched-chain fatty acid biosynthesis in Escherichia coli

scientific article published in October 2001

Characterization of FabG and FabI of the Streptomyces coelicolor dissociated fatty acid synthase

scientific article published on 6 February 2015

Cloning, expression, and characterization of a type II 3-dehydroquinate dehydratase gene from Streptomyces hygroscopicus.

scientific article

Combinatorial biosynthesis: lesson learned from nature

scientific article

Crotonyl-coenzyme A reductase provides methylmalonyl-CoA precursors for monensin biosynthesis by Streptomyces cinnamonensis in an oil-based extended fermentation

scientific article

Crystal structure of a substrate complex of Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III (FabH) with lauroyl-coenzyme A

scientific journal article

Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A

scientific article published on 28 May 2015

Elucidation of final steps of the marineosins biosynthetic pathway through identification and characterization of the corresponding gene cluster ⬇️

scientific article published on 12 March 2014

Elucidation of the Streptomyces coelicolor pathway to 2-undecylpyrrole, a key intermediate in undecylprodiginine and streptorubin B biosynthesis

scientific article

Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster

scientific article

Ethyl-substituted erythromycin derivatives produced by directed metabolic engineering ⬇️

scientific article published on June 23, 1998

Fatty-acid biosynthesis in a branched-chain alpha-keto acid dehydrogenase mutant of Streptomyces avermitilis

scientific article published in June 2000

Functional characterization of an NADPH dependent 2-alkyl-3-ketoalkanoic acid reductase involved in olefin biosynthesis in Stenotrophomonas maltophilia

scientific article

Functional dissection of a multimodular polypeptide of the pikromycin polyketide synthase into monomodules by using a matched pair of heterologous docking domains

scientific article published on June 2009

Functional modular dissection of DEBS1-TE changes triketide lactone ratios and provides insight into Acyl group loading, hydrolysis, and ACP transfer.

scientific article

Generation of multiple bioactive macrolides by hybrid modular polyketide synthases in Streptomyces venezuelae

scientific article published in February 2002

Generation of novel pikromycin antibiotic products through mutasynthesis

scientific article published on July 2008

Genes encoding acyl-CoA dehydrogenase (AcdH) homologues from Streptomyces coelicolor and Streptomyces avermitilis provide insights into the metabolism of small branched-chain fatty acids and macrolide antibiotic production.

scientific article published in September 1999

Genetic approaches for controlling ratios of related polyketide products in fermentation processes ⬇️

scientific article published on December 1, 2001

Genetic manipulation of the biosynthetic process leading to phoslactomycins, potent protein phosphatase 2A inhibitors.

scientific article

High titer production of tetracenomycins by heterologous expression of the pathway in a Streptomyces cinnamonensis industrial monensin producer strain.

scientific article published on 10 July 2009

Identification and Characterization of FabA from the Type II Fatty Acid Synthase of Streptomyces coelicolor

scientific article published on 5 January 2016

Identification and disruptional analysis of the Streptomyces cinnamonensis msdA gene, encoding methylmalonic acid semialdehyde dehydrogenase ⬇️

scientific article published on 15 November 2005

In vivo analysis of straight-chain and branched-chain fatty acid biosynthesis in three actinomycetes.

scientific article

Isotopically sensitive regioselectivity in the oxidative deamination of a homologous series of diamines catalyzed by diamine oxidase

scientific article published on 01 November 1992

Iterative chain elongation by a pikromycin monomodular polyketide synthase

scientific article published in April 2003

MarH, a Bifunctional Enzyme Involved in the Condensation and Hydroxylation Steps of the Marineosin Biosynthetic Pathway

scientific article published on 08 March 2017

MeaA, a putative coenzyme B12-dependent mutase, provides methylmalonyl coenzyme A for monensin biosynthesis in Streptomyces cinnamonensis. ⬇️

scientific article

Mechanisms of molecular recognition in the pikromycin polyketide synthase

scientific article published in December 2000

Mechanistic studies of two amino acid racemases of broad substrate specificity from Pseudomonas striata and Aeromonas caviae

scientific article published on 01 January 1991

Multiple pathways for acetate assimilation in Streptomyces cinnamonensis ⬇️

scientific article

Polyketide synthase acyl carrier protein (ACP) as a substrate and a catalyst for malonyl ACP biosynthesis

scientific article published in August 1999

Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates

scientific article

Production of Hygromycin A Analogs in Streptomyces hygroscopicus NRRL 2388 through Identification and Manipulation of the Biosynthetic Gene Cluster

scientific article published on 30 July 2006

Production of branched-chain alkylprodiginines in S. coelicolor by replacement of the 3-ketoacyl ACP synthase III initiation enzyme, RedP.

scientific article

Purification and characterization of a novel enoyl coenzyme A reductase from Streptomyces collinus

scientific article

Purification of crotonyl-CoA reductase from Streptomyces collinus and cloning, sequencing and expression of the corresponding gene in Escherichia coli.

scientific article

Separate entrance and exit portals for ligand traffic in Mycobacterium tuberculosis FabH

scientific article

Stenotrophomonas maltophilia OleC-Catalyzed ATP-Dependent Formation of Long-Chain Z-Olefins from 2-Alkyl-3-hydroxyalkanoic Acids

scientific article published on 20 June 2016

Stereospecific synthesis of 23-hydroxyundecylprodiginines and analogues and conversion to antimalarial premarineosins via a Rieske oxygenase catalyzed bicyclization

scientific article

Streptomyces coelicolor RedP and FabH enzymes, initiating undecylprodiginine and fatty acid biosynthesis, exhibit distinct acyl-CoA and malonyl-acyl carrier protein substrate specificities

scientific article published on 04 January 2012

Structural Basis for Binding Specificity between Subclasses of Modular Polyketide Synthase Docking Domains

scientific article

Structural and Stereochemical Analysis of a Modular Polyketide Synthase Ketoreductase Domain Required for the Generation of a cis-Alkene

scientific article

Structure and Function of the RedJ Protein, a Thioesterase from the Prodiginine Biosynthetic Pathway in Streptomyces coelicolor

scientific article

Substrate recognition and channeling of monomodules from the pikromycin polyketide synthase

scientific article published in October 2003

Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials

scientific article published on 25 August 2015

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors

scientific article

Synthesis and biological evaluation of thiazolidine-2-one 1,1-dioxide as inhibitors of Escherichia coli beta-ketoacyl-ACP-synthase III (FabH).

scientific article published on December 2006

The final step of hygromycin A biosynthesis, oxidation of C-5''-dihydrohygromycin A, is linked to a putative proton gradient-dependent efflux

scientific article published on 21 September 2009

The hidden steps of domain skipping: macrolactone ring size determination in the pikromycin modular polyketide synthase

scientific article published in May 2002

The plmS2-encoded cytochrome P450 monooxygenase mediates hydroxylation of phoslactomycin B in Streptomyces sp. strain HK803.

scientific article

Unsymmetric aryl-alkyl disulfide growth inhibitors of methicillin-resistant Staphylococcus aureus and Bacillus anthracis

scientific article published on 17 May 2008

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