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List of works by Zhiyuan Zhong

A Smart Nano-Prodrug Platform with Reactive Drug Loading, Superb Stability, and Fast Responsive Drug Release for Targeted Cancer Therapy

scientific article published on 2 May 2017

A newly developed chemically crosslinked dextran-poly(ethylene glycol) hydrogel for cartilage tissue engineering

scientific article

ATN-161 Peptide Functionalized Reversibly Cross-Linked Polymersomes Mediate Targeted Doxorubicin Delivery into Melanoma-Bearing C57BL/6 Mice

scientific article published on 22 December 2016

Advanced drug and gene delivery systems based on functional biodegradable polycarbonates and copolymers

scientific article published on 21 May 2014

Anisamide-Decorated pH-Sensitive Degradable Chimaeric Polymersomes Mediate Potent and Targeted Protein Delivery to Lung Cancer Cells.

scientific article published on 12 May 2015

Anisamide-functionalized intelligent polymersomes mediate targeted delivery of methotrexate into lung cancer cells

scientific article published on 19 August 2015

Apolipoprotein E Peptide-Directed Chimeric Polymersomes Mediate an Ultrahigh-Efficiency Targeted Protein Therapy for Glioblastoma

scientific article published on 08 November 2018

Apolipoprotein E Peptide-Guided Disulfide-Cross-Linked Micelles for Targeted Delivery of Sorafenib to Hepatocellular Carcinoma

scientific article published on 06 December 2019

Biodegradable Micelles Based on Poly(ethylene glycol)-b-polylipopeptide Copolymer: A Robust and Versatile Nanoplatform for Anticancer Drug Delivery.

scientific article published on 07 August 2017

Biodegradable chimaeric polymersomes mediate highly efficient delivery of exogenous proteins into cells.

scientific article

Biodegradable micelles with sheddable poly(ethylene glycol) shells for triggered intracellular release of doxorubicin

scientific article

Biomacromolecules for Emerging Biological and Medical Science and Technology

scientific article published on 01 December 2019

Bioresponsive and fluorescent hyaluronic acid-iodixanol nanogels for targeted X-ray computed tomography imaging and chemotherapy of breast tumors

scientific article published on 24 August 2016

Boosting RNAi therapy for orthotopic glioblastoma with nontoxic brain-targeting chimaeric polymersomes

scientific article published on 05 November 2018

Branched polyethylenimine derivatives with reductively cleavable periphery for safe and efficient in vitro gene transfer.

scientific article published on 18 February 2011

CD44-Specific A6 Short Peptide Boosts Targetability and Anticancer Efficacy of Polymersomal Epirubicin to Orthotopic Human Multiple Myeloma

scientific article published on 27 September 2019

CD44-Targeted Multifunctional Nanomedicines Based on a Single-Component Hyaluronic Acid Conjugate with All-Natural Precursors: Construction and Treatment of Metastatic Breast Tumors in Vivo

scientific article published on 18 September 2019

Cancer Nanomedicines Based on Synthetic Polypeptides

scientific article published on 07 November 2019

Chimaeric polymersomes based on poly(ethylene glycol)-b-poly(l-leucine)-b-poly(l-glutamic acid) for efficient delivery of doxorubicin hydrochloride into drug-resistant cancer cells

scientific article published on 19 August 2015

Chiral salan aluminium ethyl complexes and their application in lactide polymerization

scientific article published in September 2009

Click hydrogels, microgels and nanogels: emerging platforms for drug delivery and tissue engineering.

scientific article published on 24 March 2014

Construction of Small-Sized, Robust, and Reduction-Responsive Polypeptide Micelles for High Loading and Targeted Delivery of Chemotherapeutics

scientific article published on 01 August 2018

Controlled and stereoselective polymerization of lactide: kinetics, selectivity, and microstructures.

scientific article

Core-crosslinked pH-sensitive degradable micelles: A promising approach to resolve the extracellular stability versus intracellular drug release dilemma

scientific article published on 16 July 2012

Cyclic RGD-Peptide-Functionalized Polylipopeptide Micelles for Enhanced Loading and Targeted Delivery of Monomethyl Auristatin E

scientific article published on 27 September 2018

Cyclo(RGD)-Decorated Reduction-Responsive Nanogels Mediate Targeted Chemotherapy of Integrin Overexpressing Human Glioblastoma In Vivo

scientific article published on 16 November 2016

Disulfide-containing poly(beta-amino ester)s for gene delivery

scientific article published on 01 November 2006

Dual and multi-stimuli responsive polymeric nanoparticles for programmed site-specific drug delivery ⬇️

scientific article published on February 14, 2013

Dually Active Targeting Nanomedicines Based on a Direct Conjugate of Two Purely Natural Ligands for Potent Chemotherapy of Ovarian Tumors

scientific article published on 09 December 2019

EGFR and CD44 Dual-Targeted Multifunctional Hyaluronic Acid Nanogels Boost Protein Delivery to Ovarian and Breast Cancers In Vitro and In Vivo

scientific article published on 4 July 2017

EGFR-targeted multifunctional polymersomal doxorubicin induces selective and potent suppression of orthotopic human liver cancer in vivo

scientific article

Efficacious delivery of protein drugs to prostate cancer cells by PSMA-targeted pH-responsive chimaeric polymersomes.

scientific article published on 5 September 2015

Efficient and Targeted Suppression of Human Lung Tumor Xenografts in Mice with Methotrexate Sodium Encapsulated in All-Function-in-One Chimeric Polymersomes

scientific article published on 6 July 2016

Endosomal pH-activatable poly(ethylene oxide)-graft-doxorubicin prodrugs: synthesis, drug release, and biodistribution in tumor-bearing mice.

scientific article

Enzymatically and reductively degradable α-amino acid-based poly(ester amide)s: synthesis, cell compatibility, and intracellular anticancer drug delivery

scientific article published on 17 January 2015

Enzymatically crosslinked dextran-tyramine hydrogels as injectable scaffolds for cartilage tissue engineering

scientific article published in August 2010

Enzyme-mediated fast in situ formation of hydrogels from dextran-tyramine conjugates

scientific article published on 25 February 2007

Exogenous vitamin C boosts the antitumor efficacy of paclitaxel containing reduction-sensitive shell-sheddable micelles in vivo

scientific article

Facile Synthesis of Reductively Degradable Biopolymers Using Cystamine Diisocyanate as a Coupling Agent

scientific article published on 26 January 2016

Facile construction of dual-bioresponsive biodegradable micelles with superior extracellular stability and activated intracellular drug release.

scientific article published on 15 May 2015

Future Directions at the Frontier of Polymer Science and Biology

scientific article published on 01 January 2019

GE11-Directed Functional Polymersomal Doxorubicin as an Advanced Alternative to Clinical Liposomal Formulation for Ovarian Cancer Treatment.

scientific article published on 23 March 2018

Galactose-decorated cross-linked biodegradable poly(ethylene glycol)-b-poly(ε-caprolactone) block copolymer micelles for enhanced hepatoma-targeting delivery of paclitaxel

scientific article published on 14 July 2011

Galactose-decorated reduction-sensitive degradable chimaeric polymersomes as a multifunctional nanocarrier to efficiently chaperone apoptotic proteins into hepatoma cells.

scientific article published on 16 July 2013

Galactose-installed photo-crosslinked pH-sensitive degradable micelles for active targeting chemotherapy of hepatocellular carcinoma in mice

scientific article

Glutathione-Sensitive Hyaluronic Acid-Mercaptopurine Prodrug Linked via Carbonyl Vinyl Sulfide: A Robust and CD44-Targeted Nanomedicine for Leukemia

scientific article

Glutathione-Sensitive Hyaluronic Acid-SS-Mertansine Prodrug with a High Drug Content: Facile Synthesis and Targeted Breast Tumor Therapy

scientific article published on 10 October 2016

Glyco-nanoparticles with sheddable saccharide shells: a unique and potent platform for hepatoma-targeting delivery of anticancer drugs.

scientific article

Granzyme B-loaded, cell-selective penetrating and reduction-responsive polymersomes effectively inhibit progression of orthotopic human lung tumor in vivo

scientific article published on 10 October 2018

HER2-Specific Reduction-Sensitive Immunopolymersomes with High Loading of Epirubicin for Targeted Treatment of Ovarian Tumor

scientific article published on 30 September 2019

Hyaluronic Acid-Shelled Disulfide-Cross-Linked Nanopolymersomes for Ultrahigh-Efficiency Reactive Encapsulation and CD44-Targeted Delivery of Mertansine Toxin

scientific article published on 22 December 2017

Hyaluronic acid coated PLGA nanoparticulate docetaxel effectively targets and suppresses orthotopic human lung cancer

scientific article published on 24 December 2016

Hyaluronic acid shell and disulfide-crosslinked core micelles for in vivo targeted delivery of bortezomib for the treatment of multiple myeloma

scientific article published on 19 September 2018

In Situ Forming Hydrogels via Catalyst-Free and Bioorthogonal “Tetrazole–Alkene” Photo-Click Chemistry ⬇️

scientific article published on July 12, 2013

In situ forming reduction-sensitive degradable nanogels for facile loading and triggered intracellular release of proteins.

scientific article published on 21 March 2013

In vitro and in vivo protein delivery from in situ forming poly(ethylene glycol)-poly(lactide) hydrogels

scientific article published on 31 March 2007

In-situ formation of biodegradable hydrogels by stereocomplexation of PEG-(PLLA)8 and PEG-(PDLA)8 star block copolymers

scientific article

Injectable biodegradable hybrid hydrogels based on thiolated collagen and oligo(acryloyl carbonate)-poly(ethylene glycol)-oligo(acryloyl carbonate) copolymer for functional cardiac regeneration

scientific article published on 26 December 2014

Injectable chitosan-based hydrogels for cartilage tissue engineering.

scientific article published on 26 January 2009

Innovative Polymers for Controlled Release Applications

scientific article published in November 2017

Integrated Multifunctional Micelles Co-Self-Assembled from Polypeptides Conjugated with Natural Ferulic Acid and Lipoic Acid for Efficient and Bioresponsive Doxorubicin Delivery

scientific article published on 9 January 2018

Intracellular release of doxorubicin from core-crosslinked polypeptide micelles triggered by both pH and reduction conditions ⬇️

scientific article published on April 6, 2013

Iodine-Rich Polymersomes Enable Versatile SPECT/CT Imaging and Potent Radioisotope Therapy for Tumor in Vivo

scientific article published on 15 May 2019

Linear poly(amido amine)s with secondary and tertiary amino groups and variable amounts of disulfide linkages: synthesis and in vitro gene transfer properties

scientific article published on 23 September 2006

Lipopepsomes: A novel and robust family of nano-vesicles capable of highly efficient encapsulation and tumor-targeted delivery of doxorubicin hydrochloride in vivo

scientific article published on 17 January 2018

Lipoyl Ester Terminated Star PLGA as a Simple and Smart Material for Controlled Drug Delivery Application

scientific article published on 22 March 2018

Low-toxicity transferrin-guided polymersomal doxorubicin for potent chemotherapy of orthotopic hepatocellular carcinoma in vivo

scientific article published on 15 May 2019

Lung cancer specific and reduction-responsive chimaeric polymersomes for highly efficient loading of pemetrexed and targeted suppression of lung tumor in vivo.

scientific article published on 2 February 2018

Methylglyoxal-derived advanced glycation end products contribute to negative cardiac remodeling and dysfunction post-myocardial infarction

scientific article published in September 2017

Micelles Based on Acid Degradable Poly(acetal urethane): Preparation, pH-Sensitivity, and Triggered Intracellular Drug Release

scientific article

Morphology of a highly asymmetric double crystallizable poly(epsilon-caprolactone-b-ethylene oxide) block copolymer

scientific article published on 01 January 2007

Nanoagents Based on Poly(ethylene glycol)-b-Poly(l-thyroxine) Block Copolypeptide for Enhanced Dual-Modality Imaging and Targeted Tumor Radiotherapy

scientific article published on 20 September 2019

Nanopolymersomes with an Ultrahigh Iodine Content for High-Performance X-Ray Computed Tomography Imaging In Vivo

scientific article published on 5 January 2017

Non-viral gene transfection in vitro using endosomal pH-sensitive reversibly hydrophobilized polyethylenimine.

scientific article

Novel bioreducible poly(amido amine)s for highly efficient gene delivery

scientific article published on 01 January 2007

Novel injectable biodegradable glycol chitosan-based hydrogels crosslinked by Michael-type addition reaction with oligo(acryloyl carbonate)-b-poly(ethylene glycol)-b-oligo(acryloyl carbonate) copolymers.

scientific article published in September 2011

Novel reversibly crosslinked chimaeric polypeptide polymersomes for active loading and intracellular release of doxorubicin hydrochloride

scientific article published on 19 August 2015

Oncoprotein Inhibitor Rigosertib Loaded in ApoE-Targeted Smart Polymersomes Reveals High Safety and Potency against Human Glioblastoma in Mice

scientific article published on 12 July 2019

Organocatalytic ring-opening copolymerization of trimethylene carbonate and dithiolane trimethylene carbonate: Impact of organocatalysts on copolymerization kinetics and copolymer microstructures.

scientific article

PEG-PLLA and PEG-PDLA multiblock copolymers: synthesis and in situ hydrogel formation by stereocomplexation

scientific article published on 01 November 2006

Peptide-decorated polymeric nanomedicines for precision cancer therapy

scientific article published on 02 October 2018

Photo-crosslinked biodegradable micelles for paclitaxel release

scientific article published in November 2011

Poly(ethylene oxide) grafted with low molecular weight polyethylenimines for non-viral gene transfer.

scientific article published in November 2011

Polymerization of Lactide Using Achiral Bis(pyrrolidene) Schiff Base Aluminum Complexes

Polymers at the Interface with Biology

scientific article published on 01 August 2018

Polymers from Nature and for Nature

scientific article published on 01 June 2018

Polytyrosine nanoparticles enable ultra-high loading of doxorubicin and rapid enzyme-responsive drug release

scientific article published on 01 May 2018

Preface: The Fourth Symposium on Innovative Polymers for Controlled Delivery, September 23-26, 2016, Suzhou, China.

scientific article published in August 2017

Preparation of collagen/hydroxyapatite/alendronate hybrid hydrogels as potential scaffolds for bone regeneration.

scientific article published on 11 March 2016

Professor Jan Feijen: a pioneer in biomedical polymers and controlled drug release

scientific article published in May 2015

Protein Nanotherapeutics as an Emerging Modality for Cancer Therapy

scientific article published on 21 September 2018

Protein Toxin Chaperoned by LRP-1-Targeted Virus-Mimicking Vesicles Induces High-Efficiency Glioblastoma Therapy In Vivo

scientific article published on 11 June 2018

Protein release from injectable stereocomplexed hydrogels based on PEG-PDLA and PEG-PLLA star block copolymers

scientific article published on 01 November 2006

Random and block copolymers of bioreducible poly(amido amine)s with high- and low-basicity amino groups: study of DNA condensation and buffer capacity on gene transfection

scientific article published on 21 July 2007

Rapidly in situ forming biodegradable robust hydrogels by combining stereocomplexation and photopolymerization

scientific article published on 24 July 2007

Rapidly in situ-forming degradable hydrogels from dextran thiols through Michael addition

scientific article published on 11 April 2007

Rapidly pH-responsive degradable polymersomes for triggered release of hydrophilic and hydrophobic anticancer drugs

scientific article published on 01 November 2011

Rapidly photo-crosslinked functional biodegradable hydrogels

scientific article published in November 2011

Redox-Sensitive and Intrinsically Fluorescent Photoclick Hyaluronic Acid Nanogels for Traceable and Targeted Delivery of Cytochrome c to Breast Tumor in Mice

scientific article published on 10 August 2016

Reducible poly(amido ethylenediamine) for hypoxia-inducible VEGF delivery

scientific article published on 28 December 2006

Reducible poly(amido ethylenimine) directed to enhance RNA interference

scientific article published on 10 January 2007

Reduction and pH dual-bioresponsive crosslinked polymersomes for efficient intracellular delivery of proteins and potent induction of cancer cell apoptosis.

scientific article

Reduction-responsive cationic biodegradable micelles based on PDMAEMA-SS-PCL-SS-PDMAEMA triblock copolymers for gene delivery ⬇️

scientific article published on November 30, 2011

Reduction-responsive disassemblable core-cross-linked micelles based on poly(ethylene glycol)-b-poly(N-2-hydroxypropyl methacrylamide)-lipoic acid conjugates for triggered intracellular anticancer drug release.

scientific article

Reduction-responsive polymeric micelles and vesicles for triggered intracellular drug release.

scientific article

Reduction-responsive shell-sheddable biodegradable micelles for intracellular doxorubicin delivery ⬇️

scientific article published on November 30, 2011

Reduction-sensitive degradable micellar nanoparticles as smart and intuitive delivery systems for cancer chemotherapy.

scientific article published on 22 March 2013

Reduction-sensitive polymeric nanomedicines: An emerging multifunctional platform for targeted cancer therapy

scientific article published on 24 May 2018

Reduction-sensitive reversibly crosslinked biodegradable micelles for triggered release of doxorubicin.

scientific article published in December 2009

Reductively cleavable polymer-drug conjugates based on dendritic polyglycerol sulfate and monomethyl auristatin E as anticancer drugs

scientific article published on 19 February 2019

Reductively degradable α-amino acid-based poly(ester amide)-graft-galactose copolymers: facile synthesis, self-assembly, and hepatoma-targeting doxorubicin delivery.

scientific article published on 8 April 2015

Release of model proteins and basic fibroblast growth factor from in situ forming degradable dextran hydrogels

scientific article published on 22 June 2007

Reversibly cross-linked polyplexes enable cancer-targeted gene delivery via self-promoted DNA release and self-diminished toxicity.

scientific article published on 19 March 2015

Reversibly crosslinked poly(vinyl alcohol) nanoparticles for triggered release of doxorubicin

scientific article published on 01 November 2011

Reversibly shielded DNA polyplexes based on bioreducible PDMAEMA-SS-PEG-SS-PDMAEMA triblock copolymers mediate markedly enhanced nonviral gene transfection.

scientific article

Reversibly stabilized multifunctional dextran nanoparticles efficiently deliver doxorubicin into the nuclei of cancer cells

scientific article

Robust, Responsive, and Targeted PLGA Anticancer Nanomedicines by Combination of Reductively Cleavable Surfactant and Covalent Hyaluronic Acid Coating.

scientific article published on 12 January 2017

Robust, active tumor-targeting and fast bioresponsive anticancer nanotherapeutics based on natural endogenous materials

scientific article published on 27 August 2016

Robust, tumor-homing and redox-sensitive polymersomal doxorubicin: A superior alternative to Doxil and Caelyx?

scientific article

Saporin-loaded CD44 and EGFR dual-targeted nanogels for potent inhibition of metastatic breast cancer in vivo

scientific article published on 27 January 2019

Selective Cell Penetrating Peptide-Functionalized Polymersomes Mediate Efficient and Targeted Delivery of Methotrexate Disodium to Human Lung Cancer In Vivo

scientific article published on 27 December 2017

Self-crosslinkable and intracellularly decrosslinkable biodegradable micellar nanoparticles: A robust, simple and multifunctional nanoplatform for high-efficiency targeted cancer chemotherapy.

scientific article published on 28 May 2016

Shell-sheddable micelles based on dextran-SS-poly(epsilon-caprolactone) diblock copolymer for efficient intracellular release of doxorubicin

scientific article

Small, Traceable, Endosome-Disrupting, and Bioresponsive Click Nanogels Fabricated via Microfluidics for CD44-Targeted Cytoplasmic Delivery of Therapeutic Proteins

scientific article published on 13 June 2019

Smart polymersomes dually functionalized with cRGD and fusogenic GALA peptides enable specific and high-efficiency cytosolic delivery of apoptotic proteins

scientific article published on 18 October 2018

Systemic Delivery of NAC-1 siRNA by Neuropilin-Targeted Polymersomes Sensitizes Antiangiogenic Therapy of Metastatic Triple-Negative Breast Cancer

scientific article published on 11 November 2020

Tailor-Making Fluorescent Hyaluronic Acid Microgels via Combining Microfluidics and Photoclick Chemistry for Sustained and Localized Delivery of Herceptin in Tumor

scientific article published on 5 January 2018

Targeted glioma chemotherapy by cyclic RGD peptide-functionalized reversibly core-crosslinked multifunctional poly(ethylene glycol)-b-poly(ε-caprolactone) micelles

scientific article published on 5 January 2017

Targeted hepatoma chemotherapy in vivo using galactose-decorated crosslinked pH-sensitive degradable micelles

scientific article published on 19 August 2015

The Second Symposium on Innovative Polymers for Controlled Delivery, September 11–14, 2012, Suzhou, China ⬇️

scientific article published on April 24, 2013

The Third Symposium on Innovative Polymers for Controlled Delivery, September 16-19, 2014, Suzhou, China. Preface

scientific article published in May 2015

The highly efficient delivery of exogenous proteins into cells mediated by biodegradable chimaeric polymersomes.

scientific article

Timing underpins the benefits associated with injectable collagen biomaterial therapy for the treatment of myocardial infarction

scientific article

Transferrin-binding peptide functionalized polymersomes mediate targeted doxorubicin delivery to colorectal cancer in vivo

scientific article published on 07 January 2020

Virus-Mimicking Chimaeric Polymersomes Boost Targeted Cancer siRNA Therapy In Vivo.

scientific article published on 29 September 2017

Vitamin E-Oligo(methyl diglycol l-glutamate) as a Biocompatible and Functional Surfactant for Facile Preparation of Active Tumor-Targeting PLGA Nanoparticles.

scientific article published on 15 June 2016

Water-soluble cationic poly(ferrocenylsilane): an efficient DNA condensation and transfection agent

scientific article published on 01 November 2006

cRGD-decorated biodegradable polytyrosine nanoparticles for robust encapsulation and targeted delivery of doxorubicin to colorectal cancer in vivo

scientific article published on 18 March 2019

cRGD-directed, NIR-responsive and robust AuNR/PEG-PCL hybrid nanoparticles for targeted chemotherapy of glioblastoma in vivo

scientific article

cRGD-functionalized reduction-sensitive shell-sheddable biodegradable micelles mediate enhanced doxorubicin delivery to human glioma xenografts in vivo.

scientific article

cRGD/TAT Dual-Ligand Reversibly Cross-Linked Micelles Loaded with Docetaxel Penetrate Deeply into Tumor Tissue and Show High Antitumor Efficacy in Vivo

scientific article

pH and reduction dual-bioresponsive polymersomes for efficient intracellular protein delivery.

scientific article

pH-Responsive chimaeric pepsomes based on asymmetric poly(ethylene glycol)-b-poly(l-leucine)-b-poly(l-glutamic acid) triblock copolymer for efficient loading and active intracellular delivery of doxorubicin hydrochloride.

scientific article

pH-Sensitive Coiled-Coil Peptide-Crosslinked Hyaluronic Acid Nanogels: Synthesis and Targeted Intracellular Protein Delivery to CD44 Positive Cancer Cells

scientific article

pH-Sensitive degradable polymersomes for triggered release of anticancer drugs: a comparative study with micelles

scientific article published on 3 October 2009

pH-sensitive degradable chimaeric polymersomes for the intracellular release of doxorubicin hydrochloride ⬇️

scientific article published on July 12, 2012

α-Amino acid containing degradable polymers as functional biomaterials: rational design, synthetic pathway, and biomedical applications.

scientific article published on 26 April 2011

α3β1 Integrin-Targeting Polymersomal Docetaxel as an Advanced Nanotherapeutic for Nonsmall Cell Lung Cancer Treatment

scientific article published on 18 March 2020

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