List of works - David A Robinson

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

scientific article published on 12 September 2018

Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors

scientific article

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

scientific article published on 2 October 2017

Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design

scientific article published in February 2006

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.

scientific article published on 10 November 2017

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

scientific article

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

scientific article

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.

scientific article published on 23 September 2015

Discovery of a Novel Class of Orally Active Trypanocidal N -Myristoyltransferase Inhibitors

scientific article

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

scientific article

Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase

scientific article published on 21 April 2015

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

scientific article published in January 2019

Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis

scientific article

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

scientific article published on 20 March 2019

Mechanism of Enzymatic Fluorination in Streptomyces c attleya

scientific article

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

scientific article

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus

scientific article published on 27 February 2015

Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking

scientific article

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

scientific article

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

scientific article

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae.

scientific article

Structure-guided design of alpha-amino acid-derived Pin1 inhibitors

scientific article

Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates

scientific article published on 8 March 2006

Targeting a critical step in fungal hexosamine biosynthesis

scientific article published on 27 April 2020

The fluorinase from Streptomyces cattleya is also a chlorinase

scientific article

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution.

scientific article

Type II dehydroquinase: molecular replacement with many copies

scientific article published on 05 December 2007

List of works by David A Robinson

A Molecular Hybridization Approach for the Design of Potent, Highly Selective, and Brain-Penetrant N-Myristoyltransferase Inhibitors

Bisubstrate UDP–peptide conjugates as human O-GlcNAc transferase inhibitors

Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani

Crystal structures of Helicobacter pylori type II dehydroquinase inhibitor complexes: new directions for inhibitor design

Design and Synthesis of Brain Penetrant Trypanocidal N-Myristoyltransferase Inhibitors.

Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.

Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase

Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode.

Discovery of a Novel Class of Orally Active Trypanocidal N -Myristoyltransferase Inhibitors

Discovery of cell-active phenyl-imidazole Pin1 inhibitors by structure-guided fragment evolution

Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase

Identification of inhibitors of an unconventional Trypanosoma brucei kinetochore kinase.

Lead optimization of a pyrazole sulfonamide series of Trypanosoma brucei N-myristoyltransferase inhibitors: identification and evaluation of CNS penetrant compounds as potential treatments for stage 2 human African trypanosomiasis

Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis

Mechanism of Enzymatic Fluorination in Streptomyces c attleya

N-myristoyltransferase inhibitors as new leads to treat sleeping sickness

N-myristoyltransferase is a cell wall target in Aspergillus fumigatus

Novel Ligands for a Purine Riboswitch Discovered by RNA-Ligand Docking

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

One Scaffold, Three Binding Modes: Novel and Selective Pteridine Reductase 1 Inhibitors Derived from Fragment Hits Discovered by Virtual Screening

Phosphorylation of Sli15 by Ipl1 is important for proper CPC localization and chromosome stability in Saccharomyces cerevisiae.

Structure-guided design of alpha-amino acid-derived Pin1 inhibitors

Substrate specificity in enzymatic fluorination. The fluorinase from Streptomyces cattleya accepts 2'-deoxyadenosine substrates

Targeting a critical step in fungal hexosamine biosynthesis

The fluorinase from Streptomyces cattleya is also a chlorinase

The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution.

Type II dehydroquinase: molecular replacement with many copies