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List of works by Kiichiro Tsuchiya

Advances in balloon endoscopes

scientific article published on 23 April 2014

Analysis of interferon signaling by infectious hepatitis C virus clones with substitutions of core amino acids 70 and 91

scientific article

Atonal homolog 1 protein stabilized by tumor necrosis factor α induces high malignant potential in colon cancer cell line

scientific article

Case of severe ulcerative colitis successfully treated with intravenous cyclosporine without high dose corticosteroid

scientific article published on 01 January 2007

Caudal type homeobox 2 expression induced by leukocytapheresis might be associated with mucosal healing in ulcerative colitis

scientific article published on 11 November 2016

Colitogenic CD4+ effector-memory T cells actively recirculate in chronic colitic mice

scientific article published in December 2008

Comparison of HCV-associated gene expression and cell signaling pathways in cells with or without HCV replicon and in replicon-cured cells

scientific article

Continuous generation of colitogenic CD4(+) T cells in persistent colitis

scientific article published in May 2008

Crosstalk between Wnt and Notch signaling in intestinal epithelial cell fate decision.

scientific article published on 25 September 2007

Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine

scientific article

Development of plaque assays for hepatitis C virus-JFH1 strain and isolation of mutants with enhanced cytopathogenicity and replication capacity

scientific article published on 22 October 2007

Distinct expression patterns of Notch ligands, Dll1 and Dll4, in normal and inflamed mice intestine

scientific article

Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel's diverticulum: a case report

scientific article published on 28 September 2012

Establishment of a system to evaluate the therapeutic effect and the dynamics of an investigational drug on ulcerative colitis using human colonic organoids

scientific article published on 01 January 2019

FTY720 suppresses the development of colitis in lymphoid-null mice by modulating the trafficking of colitogenic CD4+ T cells in bone marrow

scientific article

Flagellin stimulation suppresses IL-7 secretion of intestinal epithelial cells

scientific article

Fluorescent labelling of intestinal epithelial cells reveals independent long-lived intestinal stem cells in a crypt

scientific article published on 29 October 2014

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell

scientific article published on 11 March 2012

HADHA, the alpha subunit of the mitochondrial trifunctional protein, is involved in long-chain fatty acid-induced autophagy in intestinal epithelial cells

scientific article published on 30 January 2017

Hes1 promotes the IL-22-mediated antimicrobial response by enhancing STAT3-dependent transcription in human intestinal epithelial cells.

scientific article published on 14 December 2013

IL-2 is positively involved in the development of colitogenic CD4+ IL-7R alpha high memory T cells in chronic colitis

scientific article published in September 2010

IL-6-mediated intersubgenotypic variation of interferon sensitivity in hepatitis C virus genotype 2a/2b chimeric clones.

scientific article published on 25 August 2010

IL-7 Is essential for the development and the persistence of chronic colitis

scientific article published on 01 April 2007

IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice

scientific article published on 18 November 2004

IL-7 is essential for lymphopenia-driven turnover of colitogenic CD4(+) memory T cells in chronic colitis

scientific article published in October 2009

IL-7 promotes long-term in vitro survival of unique long-lived memory subset generated from mucosal effector memory CD4+ T cells in chronic colitis mice.

scientific article published on 23 September 2013

IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome.

scientific article

Immunosenescent colitogenic CD4(+) T cells convert to regulatory cells and suppress colitis

scientific article published on 01 May 2008

Increase of Bone Marrow–Derived Secretory Lineage Epithelial Cells During Regeneration in the Human Intestine

scientific article published on 01 June 2005

Indispensable role of Notch ligand-dependent signaling in the proliferation and stem cell niche maintenance of APC-deficient intestinal tumors.

scientific article published on 7 December 2016

Inhibitory effect of a triterpenoid compound, with or without alpha interferon, on hepatitis C virus infection

scientific article

Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells.

scientific article

Intestinal lamina propria retaining CD4+CD25+ regulatory T cells is a suppressive site of intestinal inflammation

scientific article published on 01 April 2007

Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm

scientific article published on 04 December 2020

Lineage-specific expression of bestrophin-2 and bestrophin-4 in human intestinal epithelial cells

scientific article

Long-lived colitogenic CD4+ memory T cells residing outside the intestine participate in the perpetuation of chronic colitis

scientific article published on 28 September 2009

Longitudinal cell formation in the entire human small intestine is correlated with the localization of Hath1 and Klf4 ⬇️

scientific article published on December 3, 2010

Luminal CD4⁺ T cells penetrate gut epithelial monolayers and egress from lamina propria to blood circulation

scientific article published on 26 August 2011

Magnetic resonance enterocolonography is useful for simultaneous evaluation of small and large intestinal lesions in Crohn's disease

scientific article published on 25 October 2010

Modified single-operator method for double-balloon endoscopy

scientific article published on 01 November 2012

Musashi-1 suppresses expression of Paneth cell-specific genes in human intestinal epithelial cells

scientific article

MyD88-dependent pathway in T cells directly modulates the expansion of colitogenic CD4+ T cells in chronic colitis

scientific article published in April 2008

Negative feedback regulation of colitogenic CD4+ T cells by increased granulopoiesis

scientific article published in November 2008

Novel CD200 homologues iSEC1 and iSEC2 are gastrointestinal secretory cell-specific ligands of inhibitory receptor CD200R.

scientific article published on 7 November 2016

PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells

scientific article

Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer

scientific article published on 12 February 2008

RANK-RANKL signaling pathway is critically involved in the function of CD4+CD25+ regulatory T cells in chronic colitis

scientific article published in May 2009

RIPK3 regulates p62-LC3 complex formation via the caspase-8-dependent cleavage of p62.

scientific article published on 24 November 2014

Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro

scientific article published on 7 February 2012

Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer.

scientific article

Reduced Human α-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease

scientific article

Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186.

scientific article published on 6 July 2016

Requirement of Notch activation during regeneration of the intestinal epithelia

scientific article published on 20 November 2008

Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis

scientific article

Single-operator double-balloon endoscopy (DBE) is as effective as dual-operator DBE.

scientific article

Studies on virus kinetics using infectious fluorescence-tagged hepatitis C virus cell culture

scientific article published on 30 January 2011

Suppressing TGFβ signaling in regenerating epithelia in an inflammatory microenvironment is sufficient to cause invasive intestinal cancer

scientific article published on February 2015

Suppression of hath1 gene expression directly regulated by hes1 via notch signaling is associated with goblet cell depletion in ulcerative colitis

scientific article published on 6 January 2011

Systemic, but not intestinal, IL-7 is essential for the persistence of chronic colitis

scientific article published on 01 January 2008

TNFAIP3 promotes survival of CD4 T cells by restricting MTOR and promoting autophagy

scientific article

TP53 Mutation by CRISPR System Enhances the Malignant Potential of Colon Cancer

scientific article published on 15 April 2019

Th1/Th17-mediated interstitial pneumonia in chronic colitis mice independent of intestinal microbiota.

scientific article

The acquisition of malignant potential in colon cancer is regulated by the stabilization of Atonal homolog 1 protein.

scientific article published on 16 January 2013

The development of colitogenic CD4(+) T cells is regulated by IL-7 in collaboration with NK cell function in a murine model of colitis

scientific article published on 13 February 2012

The intestinal epithelial stem cells and cancer stem cells

scientific article

The ubiquitin hybrid gene UBA52 regulates ubiquitination of ribosome and sustains embryonic development

scientific article published on 10 November 2016

Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication

scientific article published on 20 July 2008

Upregulated IL-7 receptor α expression on colitogenic memory CD4+ T cells may participate in the development and persistence of chronic colitis

scientific article published on 7 January 2011

[110th Scientific Meeting of the Japanese Society of Internal Medicine: Symposium: 2. Diseases originated from stem cell abnormalities; 4) The intestinal epithelial stem cells and cancer stem cells].

scientific article

[A case report: Severe bone marrow suppression caused by 6-mercaptopurin in Crohn's disease patient]

scientific article published on 01 September 2006

[Functional gastrointestinal disorders (FGID): progress in diagnosis and treatments. Topic I. Basic knowledge of functional gastrointestinal disorders (FGID); 4. The significance of infectious disease and microbiota in FGID]

scientific article published on 01 January 2013

[Genetic and immunological basis for ulcerative colitis]

scientific article published on 01 May 2005

[Regulation of epithelial cell differentiation and regeneration in IBD]

scientific article published on 01 August 2007

[Remodeling of cancer stem cells in gastrointestinal cancer].

scientific article published in May 2015

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