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List of works by William Couet

A microcomputer program to determine the precision of elimination rate constant and half-life estimates when sampling time is short

scientific article published in January 1993

A new approach for early assessment of the epileptogenic potential of quinolones

scientific article

A pharmacokinetic/pharmacodynamic approach to show that not all fluoroquinolones exhibit similar sensitivity toward the proconvulsant effect of biphenyl acetic acid in rats

scientific article published in December 2001

A preclinical pharmacokinetic modeling approach to the biopharmaceutical characterization of immediate and microsphere-based sustained release pulmonary formulations of rifampicin.

scientific article published on 16 November 2012

A simple and sensitive liquid chromatography-tandem mass spectrometry assay for the quantification of ertapenem in microdialysate

scientific article published on 17 November 2007

A survey on the use of gentamicin in infective endocarditis

scientific article published on 29 October 2011

Aerosol therapy with colistin methanesulfonate: a biopharmaceutical issue illustrated in rats.

scientific article published on 14 June 2010

Antagonistic interaction between the convulsant activities of pefloxacin and its main metabolite norfloxacin in rats

scientific article published in December 1999

Anticancer drug delivery with transferrin targeted polymeric chitosan vesicles.

scientific article published on January 2004

Assay of colistin and colistin methanesulfonate in plasma and urine by liquid chromatography-tandem mass spectrometry

scientific article published on 22 February 2010

Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats. 4. Aztreonam.

scientific article

Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 3. Tobramycin.

scientific article published on 3 August 2015

Biopharmaceutical Characterization of Nebulized Antimicrobial Agents in Rats: 5. Oseltamivir Carboxylate

scientific article published on 13 June 2016

Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 1. Ciprofloxacin, moxifloxacin, and grepafloxacin.

scientific article

Biopharmaceutical characterization of nebulized antimicrobial agents in rats: 2. Colistin

scientific article

Brain delivery of vasoactive intestinal peptide (VIP) following nasal administration to rats.

scientific article published in April 2003

Brain microdialysis distribution study of cefotaxime in a patient with traumatic brain injury

scientific article published in November 2012

Brain microdialysis study of meropenem in two patients with acute brain injury

scientific article published on June 2010

Characterization of colistin tissue pharmacokinetics by microdialysis.

scientific article

Ciprofloxacin-Loaded Inorganic-Organic Composite Microparticles To Treat Bacterial Lung Infection.

scientific article published on 7 December 2015

Colistin distribution in the peritoneal fluid of a patient with severe peritonitis.

scientific article published on 30 April 2012

Colistin in critically ill patients

scientific article published on December 17, 2012

Colistin pharmacokinetics: the fog is lifting

scientific article published on 11 October 2011

Comparative Cerebrospinal Fluid Diffusion of Imipenem and Meropenem in Rats

scientific article published in September 2000

Comparison of intrapulmonary and systemic pharmacokinetics of colistin methanesulfonate (CMS) and colistin after aerosol delivery and intravenous administration of CMS in critically ill patients.

scientific article

Consistent Global Approach on Reporting of Colistin Doses to Promote Safe and Effective Use

scientific article published on 8 October 2013

Convulsions and apnoea in a patient infected with New Delhi metallo-β-lactamase-1 Escherichia coli treated with colistin.

scientific article

Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats

scientific article published in July 1998

Distinguishing Antimicrobial Models with Different Resistance Mechanisms via Population Pharmacodynamic Modeling

scientific article

Dose ranging pharmacokinetics and brain distribution of norfloxacin using microdialysis in rats

scientific article published in December 2003

Dose-dependent bioavailability and metabolism of salicylamide in dogs

scientific article published in July 1984

Dose-ranging pharmacokinetics of colistin methanesulphonate (CMS) and colistin in rats following single intravenous CMS doses

scientific article published on 27 May 2010

Effect of Tamoxifen on the Pharmacokinetics of Theophylline in Rats

scientific article published in January 1997

Effect of experimentally induced hypovolemia on ertapenem tissue distribution using microdialysis in rats

scientific article

Effect of ponsinomycin on cyclosporin pharmacokinetics

scientific article published in August 1990

Effect of ponsinomycin on single-dose kinetics and metabolism of carbamazepine

scientific article published in March 1990

Effect of ponsinomycin on the pharmacokinetics of dihydroergotamine administered orally

scientific article published in February 1991

Enhanced MRI of tumors utilizing a new nitroxyl spin label contrast agent.

scientific article published on January 1985

Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded lipid nanocapsules

scientific article

Extension of the isobolographic approach to interactions studies between more than two drugs: illustration with the convulsant interaction between pefloxacin, norfloxacin, and theophylline in rats

scientific article published in March 2004

Factors affecting nitroxide reduction in ascorbate solution and tissue homogenates.

scientific article

Formulation and in vitro characterization of inhalable rifampicin-loaded PLGA microspheres for sustained lung delivery

scientific article published in July 2011

Formulation of rifampicin-cyclodextrin complexes for lung nebulization

scientific article

Framework for optimisation of the clinical use of colistin and polymyxin B: the Prato polymyxin consensus

scientific article published on 21 October 2014

High-throughput hydrophilic interaction chromatography coupled to tandem mass spectrometry for the optimized quantification of the anti-Gram-negatives antibiotic colistin A/B and its pro-drug colistimethate

scientific article published on 2 October 2014

Ignoring pharmacokinetics may lead to isoboles misinterpretation: illustration with the norfloxacin-theophylline convulsant interaction in rats

scientific article published in February 2002

Impact of colistin sulfate treatment of broilers on the presence of resistant bacteria and resistance genes in stored or composted manure

scientific article published on 17 November 2015

Impact of two different colistin dosing strategies on healthy piglet fecal microbiota

scientific article published on 8 June 2016

In situ nasal absorption of midazolam in rats.

scientific article

In vitro and in vivo investigations on fluoroquinolones; effects of the P-glycoprotein efflux transporter on brain distribution of sparfloxacin.

scientific article

In vitro comparative studies of two marketed transdermal nicotine delivery systems: Nicopatch and Nicorette

scientific article

Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity

scientific article published in 1999

Investigation of oral bioavailability and brain distribution of the Ind(8)-Val conjugate of indinavir in rodents.

scientific article published in April 2005

Kinetic profiles of tianeptine and its MC5 metabolite in plasma, blood and brain after single and chronic intraperitoneal administration in the rat.

scientific article published in January 1990

Kinetics of imipenem distribution into the peritoneal fluid of patients with severe peritonitis studied by microdialysis.

scientific article published in May 2010

LC-MS/MS determination of the HIV-1 protease inhibitor indinavir in brain and testis of mice.

scientific article

Lack of effect of experimental hypovolemia on imipenem muscle distribution in rats assessed by microdialysis

scientific article published on December 2005

Lack of effect of extracorporeal membrane oxygenation on tigecycline pharmacokinetics

scientific article published on 29 December 2011

Lack of effect of ponsinomycin on the pharmacokinetics of nicoumalone enantiomers

scientific article published on October 1990

Lack of effect of ponsinomycin on the plasma pharmacokinetics of theophylline

scientific article published in 1989

Lung microdialysis study of levofloxacin in rats following intravenous infusion at steady state.

scientific article published on 30 June 2008

Metronidazole and hydroxymetronidazole central nervous system distribution: 1. microdialysis assessment of brain extracellular fluid concentrations in patients with acute brain injury.

scientific article

Metronidazole and hydroxymetronidazole central nervous system distribution: 2. cerebrospinal fluid concentration measurements in patients with external ventricular drain.

scientific article published on 25 November 2013

Microdialysis as a way to measure antibiotics concentration in tissues

scientific article published on 10 June 2016

Microdialysis study of cefotaxime cerebral distribution in patients with acute brain injury.

scientific article published on 09 April 2013

Microdialysis study of imipenem distribution in muscle and lung extracellular fluids of infected rats

scientific article

Microdialysis study of imipenem distribution in skeletal muscle and lung extracellular fluids of Acinetobacter baumannii-infected rats

scientific article

Microdialysis study of imipenem distribution in skeletal muscle and lung extracellular fluids of noninfected rats

scientific article published on June 2005

Microdialysis study of imipenem distribution in the intraperitoneal fluid of rats with or without experimental peritonitis.

scientific article published on January 2006

Microdialysis study of imipenem distribution in the peritoneal fluid of rats with experimental acute pancreatitis

scientific article published on 14 January 2008

Microdialysis study of meropenem cerebral distribution in patients with acute brain injury.

scientific article published in March 2010

Modeling Approach To Characterize Intraocular Doripenem Pharmacokinetics after Intravenous Administration to Rabbits, with Tentative Extrapolation to Humans ⬇️

scientific article published on April 23, 2012

Nefopam pharmacokinetics in patients with end-stage renal disease.

scientific article published on November 2010

New colistin population pharmacokinetic data in critically ill patients suggesting an alternative loading dose rationale.

scientific article

Niosomes and polymeric chitosan based vesicles bearing transferrin and glucose ligands for drug targeting.

scientific article

Norfloxacin blood-brain barrier transport in rats is not affected by probenecid coadministration

scientific article published in January 2006

Ofloxacin pharmacokinetics in renal failure

scientific article published in June 1987

P-glycoprotein-mediated transport of moxifloxacin in a Calu-3 lung epithelial cell model.

scientific article published on 2 February 2009

Passive and active strategies for transdermal delivery using co-encapsulating nanostructured lipid carriers: in vitro vs. in vivo studies.

scientific article published on 11 December 2013

Pharmacokinetic modeling of free amoxicillin concentrations in rat muscle extracellular fluids determined by microdialysis

scientific article

Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of fluoroquinolones in rats

scientific article published on June 1999

Pharmacokinetic-pharmacodynamic contributions to the convulsant activity of pefloxacin and norfloxacin in rats.

scientific article published on February 1997

Pharmacokinetic-pharmacodynamic modeling of the electroencephalogram effect of norfloxacin in rats.

scientific article

Pharmacokinetic-pharmacodynamic modelling of the convulsant interaction between norfloxacin and biphenyl acetic acid in rats.

scientific article

Pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of imipenem in rats with experimental hypovolaemia or endotoxaemia.

scientific article

Pharmacokinetic/pharmacodynamic studies in the CMI.

scientific article

Pharmacokinetics and metabolic fate of two nitroxides potentially useful as contrast agents for magnetic resonance imaging

scientific article published in September 1984

Pharmacokinetics of Colistin Methansulphonate (CMS) and Colistin after CMS Nebulisation in Baboon Monkeys.

scientific article published on 4 June 2015

Pharmacokinetics of Colistin and Colistimethate Sodium After a Single 80-mg Intravenous Dose of CMS in Young Healthy Volunteers

scientific article published on May 4, 2011

Pharmacokinetics of Meropenem Determined by Microdialysis in the Peritoneal Fluid of Patients With Severe Peritonitis Associated With Septic Shock

scientific article published on 08 August 2007

Pharmacokinetics of daptomycin in a patient with severe renal failure not receiving dialysis

scientific article published in April 2013

Pharmacokinetics of ertapenem following intravenous and subcutaneous infusions in patients.

scientific article published on 23 November 2009

Pharmacokinetics of oral cefatrizine in patients with impaired renal function.

scientific article

Pharmacokinetics of prazosin administered as gastro-intestinal-therapeutic-systems to 24 healthy volunteers

scientific article published on 01 March 1993

Pharmacokinetics of quinine and doxycycline in patients with acute falciparum malaria: a study in Africa

scientific article published in November 1991

Pharmacokinetics of two prototype nitroxide spin labels for contrast enhancement in magnetic resonance imaging

scientific article published in March 1985

Photodegradation study of a new activator of the cystic fibrosis chloride channel, the 6-hydroxy-10-chlorobenzo[c]quinolizinium chloride (MPB-07).

scientific article published on February 2002

Plasma levels of oxybutynine chloride in children

scientific article published in February 1994

Population Pharmacokinetics of Amitriptyline After Intrathecal, Epidural, and Intravenous Administration in Sheep

scientific article

Population Pharmacokinetics of Colistin Methanesulfonate and Colistin in Critically Ill Patients with Acute Renal Failure Requiring Intermittent Hemodialysis.

scientific article published on 4 January 2016

Potential Radiosensitizing Effectin Vivoof Nitroxyl Spin Labels

scientific article published in January 1985

Pulmonary delivery of pyrazinamide-loaded large porous particles.

scientific article published on 30 May 2015

Pulmonary pharmacokinetics of levofloxacin in rats after aerosolization of immediate-release chitosan or sustained-release PLGA microspheres

scientific article published on 13 August 2016

Relative contributions of active mediated transport and passive diffusion of fluoroquinolones with various lipophilicities in a Calu-3 lung epithelial cell model

scientific article published on 12 October 2009

Removal of colistin during intermittent haemodialysis in two critically ill patients

scientific article published on 25 May 2010

Saturable rate of cefatrizine absorption after oral administration to humans

scientific article published on February 1990

Simulated antibiotic exposures in an in vitro hollow-fiber infection model influence toxin gene expression and production in community-associated methicillin-resistant Staphylococcus aureus strain MW2.

scientific article published on 7 November 2011

Simultaneous central nervous system distribution and pharmacokinetic-pharmacodynamic modelling of the electroencephalogram effect of norfloxacin administered at a convulsant dose in rats.

scientific article published on May 2004

Specific and non-specific contrast media for MRI of tumors. Experimental study of human breast carcinoma

scientific article

Steady-state bioavailability and pharmacokinetics of ambroxol and clenbuterol administered alone and combined in a new oral formulation

scientific article published in September 1989

Steady-state trough serum and epithelial lining fluid concentrations of teicoplanin 12 mg/kg per day in patients with ventilator-associated pneumonia

scientific article published on 21 March 2006

Tissue distribution of indinavir administered as solid lipid nanocapsule formulation in mdr1a (+/+) and mdr1a (-/-) CF-1 mice

scientific article published in November 2005

[Influence of food intake on the bioavailability of ponsinomycin administered in a syrup form]

scientific article published in May 1989

[Pharmacokinetics of ponsinomycin administered in a syrup form in single 400-800 and 1200 mg doses in healthy volunteers]

scientific article published in May 1989

[Pharmacokinetics of ponsinomycine with repeated ingestion in healthy volunteers]

scientific article published on 01 March 1990

[Pharmacokinetics of sulindac in aged patients presenting with inflammatory joint disease]

scientific article published on 01 July 1989

[Physiologic compatibility of compartment models used in pharmacokinetics]

scientific article published on 01 November 1986

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