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List of works by Oliver Ottmann

A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia

scientific article published on 03 July 2003

A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias

scientific article

A phase I dose-escalation study of MSC1992371A, an oral inhibitor of aurora and other kinases, in advanced hematologic malignancies

scientific article published on 5 June 2013

A phase I trial investigating the Aurora B kinase inhibitor BI 811283 in combination with cytarabine in patients with acute myeloid leukaemia

scientific article published on 19 November 2018

A randomized multicenter open label phase II study to determine the safety and efficacy of induction therapy with imatinib (Glivec, formerly STI571) in comparison with standard induction chemotherapy in elderly (>55 years) patients with Philadelphia

scientific article

A randomized, open-label, phase I/II trial to investigate the maximum tolerated dose of the Polo-like kinase inhibitor BI 2536 in elderly patients with refractory/relapsed acute myeloid leukaemia

scientific article published on 16 August 2013

Activity of the multitargeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL-positive leukemic cells

scientific article published on 14 June 2010

Acute lymphoblastic leukemia

scientific article published on 01 January 2002

Acute lymphoblastic leukemia with the (4;11) translocation: combined cytogenetic, immunological and molecular genetic analyses

scholarly article by C Schardt et al published May 1992 in Leukemia

Allosteric inhibition enhances the efficacy of ABL kinase inhibitors to target unmutated BCR-ABL and BCR-ABL-T315I

scientific article

Alteration of c-mpl-mediated signal transduction in CD34(+) cells from patients with myelodysplastic syndromes

scientific article

Alternating versus concurrent schedules of imatinib and chemotherapy as front-line therapy for Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL)

scientific article published on 25 April 2006

An immunological method for the detection of BCR-ABL fusion protein and monitoring its activation

scientific article published on 26 December 2007

An international study to standardize the detection and quantitation of BCR-ABL transcripts from stabilized peripheral blood preparations by quantitative RT-PCR.

scientific article published in July 2007

Analysis of NUP98/NSD1 translocations in adult AML and MDS patients

article

Antiproliferative efficacy of the third-generation bisphosphonate, zoledronic acid, combined with other anticancer drugs in leukemic cell lines

scientific article published on January 2004

Assignment of the human histone deacetylase 6 gene (HDAC6) to X chromosome p11.23 by in situ hybridization.

scientific article

BCR-ABL mediates arsenic trioxide-induced apoptosis independently of its aberrant kinase activity

scientific article published on 01 July 2000

Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

scholarly article

Blockade of thymic stromal lymphopoietin (TSLP) receptor inhibits TSLP-driven proliferation and signalling in lymphoblasts from a subset of B-precursor ALL patients

scientific article published on 22 October 2015

Bone marrow changes in chronic myelogenous leukaemia after long-term treatment with the tyrosine kinase inhibitor STI571: an immunohistochemical study on 75 patients

scientific article published in May 2005

CRISPR-mediated TCR replacement generates superior anticancer transgenic T cells

scientific article published on 9 November 2017

Changes in erythroid progenitor cell and accessory cell compartments in patients with myelodysplastic syndromes during treatment with all-trans retinoic acid and haemopoietic growth factors

scientific article published on 01 March 1995

Changes in the haematopoietic progenitor cell compartment in the acquired immunodeficiency syndrome

scientific article published on 01 March 1990

Characterization of ZC3H15 as a potential TRAF-2-interacting protein implicated in the NFκB pathway and overexpressed in AML.

scientific article published on 29 April 2013

Characterization of defective megakaryocytic development in patients with myelodysplastic syndromes.

scientific article

Clinical and functional implications of microRNA mutations in a cohort of 935 patients with myelodysplastic syndromes and acute myeloid leukemia

scientific article published on 31 December 2014

Clinical effects of recombinant human interleukin-3.

scientific article

Clinical pharmacokinetics of the BCR-ABL tyrosine kinase inhibitor nilotinib

scientific article published on 18 November 2009

Clinical use of recombinant human hematopoietic growth factors (GM-CSF, IL-3, EPO) in patients with myelodysplastic syndrome.

scientific article published in January 1991

Comparison of TaqMan real-time PCR and p24 Elisa for quantification of in vitro HIV-1 replication

scientific article published on February 2003

Comparison of toxicity and outcome in patients with acute myeloid leukemia treated with high-dose cytosine arabinoside consolidation after induction with a regimen containing idarubicin or daunorubicin ⬇️

scientific article published on March 1, 1998

Compensatory PI3-kinase/Akt/mTor activation regulates imatinib resistance development

scientific article published in October 2005

Concomitant granulocyte colony-stimulating factor and induction chemoradiotherapy in adult acute lymphoblastic leukemia: a randomized phase III trial

scientific article published in July 1995

Constitutive NF-κB/Rel Activation in Philadelphia Chromosome Positive (Ph+) Acute Lymphoblastic Leukemia (ALL)

scientific article published on 01 June 2004

Coordination of cell growth in cocultures by a genetic proliferation control system

scientific article published on May 2002

Current status of growth factors in the treatment of acute myeloid and lymphoblastic leukemia.

scientific article published on July 2007

Cytokine therapy for myelodysplastic syndrome.

scientific article

Dasatinib and low-intensity chemotherapy in elderly patients with Philadelphia chromosome-positive ALL

scientific article published on 27 April 2016

Dasatinib induces complete hematologic and cytogenetic responses in patients with imatinib-resistant or -intolerant chronic myeloid leukemia in blast crisis

scientific article published on 21 December 2006

Dasatinib induces rapid hematologic and cytogenetic responses in adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia with resistance or intolerance to imatinib: interim results of a phase 2 study

scientific article

Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation

scientific article published on 01 February 2007

Decreased haematopoietic colony growth in long-term bone marrow cultures of HIV-positive patients

article

Demonstration of the Th1 to Th2 cytokine shift during the course of HIV-1 infection using cytoplasmic cytokine detection on single cell level by flow cytometry

article

Development of hygromas or severe edema during treatment with the tyrosine kinase inhibitor STI571 is not associated with platelet-derived growth factor receptor (PDGFR) gene polymorphisms

scientific article published in November 2004

Differential effects of selective inhibitors targeting the PI3K/AKT/mTOR pathway in acute lymphoblastic leukemia.

scientific article published on 14 November 2013

Differential expression of class II MHC antigens in subpopulations of human hematopoietic progenitor cells

scientific article published on 01 October 1988

Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL-positive B-lineage acute lymphoblastic leukemia.

scientific article published on 27 November 2013

Differential proliferative effects of transforming growth factor-beta on human hematopoietic progenitor cells.

scientific article published on April 1988

Do G-CSF and GM-CSF contribute to the management of acute lymphoblastic leukemia?

scientific article published on 01 July 1996

Down-stream regions of the POZ-domain influence the interaction of the t(11;17)-associated PLZF/RARalpha fusion protein with the histone-deacetylase recruiting co-repressor complex.

scientific article published in January 2001

Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon alpha/ara-C.

scientific article published in December 2003

Early minimal residual disease (MRD) analysis during treatment of Philadelphia chromosome/Bcr-Abl-positive acute lymphoblastic leukemia with the Abl-tyrosine kinase inhibitor imatinib (STI571).

scientific article published on 22 August 2002

Early molecular response to posttransplantation imatinib determines outcome in MRD+ Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL).

scientific article published on 7 April 2005

Early prediction of response in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL) treated with imatinib

scientific article published on 23 October 2003

Effect of combination therapy with all-trans-retinoic acid and recombinant human granulocyte colony-stimulating factor in patients with myelodysplastic syndromes

scientific article published on 01 March 1994

Effect of histone deacetylase inhibitor valproic acid on progenitor cells of acute myeloid leukemia

scientific article published on April 2007

Effect of long-term treatment with recombinant human interleukin-3 in patients with myelodysplastic syndromes

scientific article

Effect of recombinant human transforming growth factor beta and tumor necrosis factor alpha on bone marrow progenitor cells of HIV-infected persons.

scientific article

Effect of treatment with amifostine used as a single agent in patients with refractory anemia on clinical outcome and serum tumor necrosis factor α levels

scientific article published on 01 May 2000

Effects of recombinant human IL-7 on blast cell proliferation in acute lymphoblastic leukemia.

scientific article published in August 1990

Effects of recombinant human interleukin-3 in patients with normal hematopoiesis and in patients with bone marrow failure

scientific article

Effects of the tyrosine kinase inhibitor imatinib mesylate (STI571) on bone marrow features in patients with chronic myelogenous leukemia.

scientific article published in October 2004

Efficacy and safety of imatinib mesylate (Glivec) in combination with interferon-alpha (IFN-alpha) in Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL).

scientific article published in October 2003

Endoplasmic reticulum protein GliPR1 regulates G protein signaling and the cell cycle and is overexpressed in AML.

scientific article published on 04 September 2013

Establishment and cytogenetic characterization of a human acute lymphoblastic leukemia cell line (ALL-VG) with ETV6/ABL1 rearrangement

scientific article

Expression of interleukin‐18 and its monokine‐directed function in rheumatoid arthritis

scientific article published on 01 March 2001

FLT3-ITD-, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment

scientific article published on 22 November 2005

First-line treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia in adults.

scientific article published on June 2009

Folinic acid antagonizes methotrexate-induced differentiation of monocyte progenitors.

scientific article

Frequency and prognostic impact of mutations in SRSF2, U2AF1, and ZRSR2 in patients with myelodysplastic syndromes

scientific article published on 2 March 2012

Gamma-catenin contributes to leukemogenesis induced by AML-associated translocation products by increasing the self-renewal of very primitive progenitor cells.

scientific article

Genomic CDKN2A/2B deletions in adult Ph+ ALL are adverse despite allogeneic stem cell transplantation

scientific article published on 18 January 2018

Genomic imprinting of insulin-like growth factor 2 (IGF-2) in chronic synovitis

scientific article published on 21 June 2007

Growth factors in the treatment of acute lymphoblastic leukemia

scientific article published on 01 December 1998

HIV-1 infection suppresses expression of host cell cycle-associated gene PDS5A

scientific article published on August 25, 2011

Hematologic and cytogenetic remission by STI571 (Glivec) in a patient relapsing with accelerated phase CML after second allogeneic stem cell transplantation

scientific article published on October 2001

Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia

scientific article published in February 2002

Hematopoietic stem cell involvement in BCR-ABL1-positive ALL as potential mechanism of resistance to blinatumomab therapy.

scientific article

Heterogeneity in detecting Abl kinase mutations and better sensitivity using circulating plasma RNA

scientific article published on 24 August 2006

High efficiency gene transfer to human hematopoietic SCID-repopulating cells under serum-free conditions

article

High-performance liquid chromatography method with ultraviolet detection for the quantification of the BCR-ABL inhibitor nilotinib (AMN107) in plasma, urine, culture medium and cell preparations

scientific article published on 26 January 2007

Histamine Release from Basophils after in vivo Application of Recombinant Human Interleukin-3 in Man ⬇️

scientific article published on January 1, 1990

IDH1 mutations in patients with myelodysplastic syndromes are associated with an unfavorable prognosis.

scientific article

IL-18 activates STAT3 in the natural killer cell line 92, augments cytotoxic activity, and mediates IFN-gamma production by the stress kinase p38 and by the extracellular regulated kinases p44erk-1 and p42erk-21

scientific article published in August 2000

Identification of defects in the transcriptional program during lineage-specific in vitro differentiation of CD34(+) cells selected from patients with both low- and high-risk myelodysplastic syndrome

scientific article published on June 2010

Imatinib combined with mitoxantrone/etoposide and cytarabine is an effective induction therapy for patients with chronic myeloid leukemia in myeloid blast crisis

scientific article published on 01 April 2007

Imatinib in the treatment of Philadelphia chromosome-positive acute lymphoblastic leukaemia: current status and evolving concepts.

scientific article

Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study

scientific article published in March 2002

Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study.

scientific article published in May 2002

Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP rs11554137 is an adverse prognostic factor

scientific article

Impact of leukapheresis on early death rate in adult acute myeloid leukemia presenting with hyperleukocytosis

scientific article published on 01 October 2007

Improved multilineage response of hematopoiesis in patients with myelodysplastic syndromes to a combination therapy with all- trans -retinoic acid, granulocyte colony-stimulating factor, erythropoietin and α-tocopherol

article

In vitro culture of common acute lymphoblastic leukemia blasts: effects of interleukin-3, interleukin-7, and accessory cells ⬇️

scientific article published on June 15, 1992

In vitro improvement of bone marrow-derived hematopoietic colony formation in HIV-positive patients by alpha-D-tocopherol and erythropoietin.

scientific article published in October 1994

Induction of TNF-α in patients with myelodysplastic syndromes undergoing treatment with interleukin-3

scientific article published on 01 August 1993

Induction of soluble IL-2 receptor in patients with myelodysplastic syndromes undergoing high-dose interleukin-3 treatment

scientific article published in April 1994

Infection of granulocyte/monocyte progenitor cells with HIV1

article

Influence of human recombinant interferon-alpha and interferon-gamma on bone marrow progenitor cells of HIV-positive individuals.

scientific article

Inhibition of phosphotyrosine phosphatase 1B causes resistance in BCR-ABL-positive leukemia cells to the ABL kinase inhibitor STI571.

scientific article published on April 2006

Intensive chemotherapy with idarubicin, cytarabine, etoposide, and G-CSF priming in patients with advanced myelodysplastic syndrome and high-risk acute myeloid leukemia

scientific article

Interleukin 3 Improves the Ex Vivo Expansion of Primitive Human Cord Blood Progenitor Cells and Maintains the Engraftment Potential of SCID Repopulating Cells

scientific article published on 01 January 2001

Interleukin 3 and interleukin 3/GM-CSF combination therapy--clinical implications

scientific article published on November 1993

Interleukin-10 expression: is there a neglected contribution of CD8+ T cells in rheumatoid arthritis joints?

scientific article

Interleukin-18 stimulates HIV-1 replication in a T-cell line

scientific article

Interleukin-3 in the treatment of myelodysplastic syndromes

scientific article published on 01 January 1992

Kinase domain mutations of BCR-ABL frequently precede imatinib-based therapy and give rise to relapse in patients with de novo Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL)

article

Kleine-Levin and Munchausen syndromes in a patient with recurrent acromegaly

scientific article published in February 1999

Klinischer Einsatz hämatopoetischer Wachstumsfaktoren

scientific article published on 01 December 1997

Knockdown of ERM Family Member Moesin in Host Cells Increases HIV Type 1 Replication

article

Leukemia-associated translocation products able to activate RAS modify PML and render cells sensitive to arsenic-induced apoptosis.

scientific article published in October 2003

Liquid chromatographic method for detection and quantitation of STI-571 and its main metabolite N-desmethyl-STI in plasma, urine, cerebrospinal fluid, culture medium and cell preparations

scientific article

Long-term culture of primary human lymphoblastic leukemia cells in the absence of serum or hematopoietic growth factors

scientific article published on 9 January 2009

Long-term efficacy and safety of dasatinib in patients with chronic myeloid leukemia in accelerated phase who are resistant to or intolerant of imatinib

scholarly article by Oliver Ottmann et al published 3 September 2018 in Blood Cancer Journal

Long-term results of a prospective randomized trial evaluating G-CSF priming in intensive induction chemotherapy followed by autologous stem cell transplantation in elderly patients with acute myeloid leukemia.

scientific article

MK-0457, an Aurora kinase and BCR-ABL inhibitor, is active in patients with BCR-ABL T315I leukemia.

scientific article

Management of Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL).

scientific article published in January 2009

Mechanisms of Bcr-Abl-mediated NF-kappaB/Rel activation

scientific article

Mechanisms of resistance to natural killer cell-mediated cytotoxicity in acute lymphoblastic leukemia.

scientific article published on March 2005

Megakaryocytic growth in patients with refractory anemia is suppressed by treatment with interferon alpha

scientific article published on 01 May 1999

Methodologic and biological variability of quantitative real-time polymerase chain reaction analysis of Bcr-Abl expression in Philadelphia chromosome-positive acute lymphoblastic leukemia

scientific article published on 01 September 2003

Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1.

scientific article published on 11 August 2014

Mobilization and transduction of CD34(+) peripheral blood stem cells in patients with X-linked chronic granulomatous disease

scientific article published in August 2002

Modulation of vincristine cytotoxicity by dexverapamil in sensitive and resistant HL-60 cell lines as a function of extracellular protein binding

scientific article published on 01 February 1998

Molecular cytogenetic monitoring from CD34+ peripheral blood cells in myelodysplastic syndromes: first results from a prospective multicenter German diagnostic study

scientific article published on 25 April 2013

Murine M2-10B4 and SL/SL cell lines differentially affect the balance between CD34+ cell expansion and maturation

scientific article

Myelodysplastic syndromes: clinical features

scientific article published on July 1996

Nilotinib (formerly AMN107), a highly selective BCR-ABL tyrosine kinase inhibitor, is active in patients with imatinib-resistant or -intolerant accelerated-phase chronic myelogenous leukemia

scientific article

Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

scientific article (publication date: 15 June 2006)

Nilotinib in imatinib-resistant or imatinib-intolerant patients with chronic myeloid leukemia in chronic phase: 48-month follow-up results of a phase II study.

scientific article

Nilotinib is effective in imatinib-resistant or -intolerant patients with chronic myeloid leukemia in blastic phase.

scientific article

Nilotinib is effective in patients with chronic myeloid leukemia in chronic phase after imatinib resistance or intolerance: 24-month follow-up results

scientific article published on 22 November 2010

Oligomerization inhibition, combined with allosteric inhibition, abrogates the transformation potential of T315I-positive BCR/ABL.

scientific article published on October 2009

PF-114, a potent and selective inhibitor of native and mutated BCR/ABL is active against Philadelphia chromosome-positive (Ph+) leukemias harboring the T315I mutation.

scientific article

PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia

scientific article

Ph(+) acute lymphoblastic leukemia resistant to the tyrosine kinase inhibitor STI571 has a unique BCR-ABL gene mutation

scientific article published in March 2002

Pharmacokinetics and cellular uptake of imatinib and its main metabolite CGP74588.

scientific article

Phase 1 study of INNO-406, a dual Abl/Lyn kinase inhibitor, in Philadelphia chromosome-positive leukemias after imatinib resistance or intolerance

scientific article

Phase 1/1B trial of the heat shock protein 90 inhibitor NVP-AUY922 as monotherapy or in combination with bortezomib in patients with relapsed or refractory multiple myeloma.

scientific article published on 24 March 2015

Phase 2 study of oral panobinostat (LBH589) with or without erythropoietin in heavily transfusion-dependent IPSS low or int-1 MDS patients.

scientific article published on 4 November 2013

Phase I dose-escalation trial investigating volasertib as monotherapy or in combination with cytarabine in patients with relapsed/refractory acute myeloid leukaemia

scientific article published on 08 June 2018

Phase II study of nilotinib in patients with relapsed or refractory Philadelphia chromosome--positive acute lymphoblastic leukemia

scientific article

Phase Ia/II, two-arm, open-label, dose-escalation study of oral panobinostat administered via two dosing schedules in patients with advanced hematologic malignancies.

scientific article

Phospho-CRKL monitoring for the assessment of BCR-ABL activity in imatinib-resistant chronic myeloid leukemia or Ph+ acute lymphoblastic leukemia patients treated with nilotinib

scientific article published on 26 March 2008

Phosphorylation levels of BCR-ABL, CrkL, AKT and STAT5 in imatinib-resistant chronic myeloid leukemia cells implicate alternative pathway usage as a survival strategy

scientific article published on 27 September 2007

Polo-like kinases in AML.

scientific article published on 6 June 2012

Preclinical and clinical evaluation of interleukin 3

scientific article published on December 1, 1991

Prediction of outcomes in patients with Ph+ chronic myeloid leukemia in chronic phase treated with nilotinib after imatinib resistance/intolerance.

scientific article

Prednisolone induces interleukin-18 expression in mononuclear blood and myeloid progenitor cells.

scientific article published in September 2002

Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin Lymphoma.

scientific article published on 5 August 2009

Presence of the BCR-ABL mutation Glu255Lys prior to STI571 (imatinib) treatment in patients with Ph+ acute lymphoblastic leukemia

scientific article published on 27 March 2003

Prevalence and dynamics of bcr-abl kinase domain mutations during imatinib treatment differ in patients with newly diagnosed and recurrent bcr-abl positive acute lymphoblastic leukemia.

scientific article published on 9 January 2012

Prognostic significance of ASXL1 mutations in patients with myelodysplastic syndromes

scientific article

Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes

scientific article published on 10 April 2012

Proliferative effects of a recombinant human granulocyte colony-stimulating factor (rG-CSF) on highly enriched hematopoietic progenitor cells

scientific article published in January 1987

Prospective randomized trial to evaluate two delayed granulocyte colony stimulating factor administration schedules after high-dose cytarabine therapy in adult patients with acute lymphoblastic leukemia

scientific article published on 17 October 2002

Quantification of human interleukin 18 mRNA expression by competitive reverse transcriptase polymerase chain reaction

scientific article published on June 1999

Randomized comparison of prophylactic and minimal residual disease-triggered imatinib after allogeneic stem cell transplantation for BCR-ABL1-positive acute lymphoblastic leukemia

scientific article published on 5 December 2012

Rapid automated detection of ABL kinase domain mutations in imatinib-resistant patients

scientific article

Recombinant human granulocyte-macrophage colony-stimulating factor and low-dose cytosine arabinoside in patients with myelodysplastic syndrome. A pilot study

scientific article

Recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes--a phase I/II trial

scientific article

Recombinant human interleukin-3 in patients with hematopoietic failure

scientific article published on January 1991

Regulation of early hematopoiesis in serum-deprived cultures of mafosfamide-treated and untreated CD34-enriched bone marrow cells

article

Regulation of human IL-18 gene expression: interaction of PU.1 with GC-box binding protein is involved in human IL-18 expression in myeloid cells

scientific article published on March 2004

Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study

scientific article published on February 2002

Response to imatinib in patients who relapse after allogeneic stem cell transplantation for chronic myeloid leukemia

scientific article published in September 2003

Restoration of impaired cytokine secretion from monocytes of patients with myelodysplastic syndromes after in vivo treatment with GM-CSF or IL-3

scientific article published on 01 November 1993

Retrovirally expressed anti-HIV ribozymes confer a selective survival advantage on CD4+ T cells in vitro

scientific article published in March 2000

Rho family small GTPases control migration of hematopoietic progenitor cells into multicellular spheroids of bone marrow stroma cells

scientific article published on 01 October 2002

Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate.

scientific article published in October 2003

SETBP1 mutation analysis in 944 patients with MDS and AML.

scientific article published on 7 May 2013

Sequential in vivo treatment with two recombinant human hematopoietic growth factors (interleukin-3 and granulocyte-macrophage colony-stimulating factor) as a new therapeutic modality to stimulate hematopoiesis: results of a phase I study.

scientific article

Serial minimal residual disease (MRD) analysis as a predictor of response duration in Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL) during imatinib treatment

scientific article published in September 2003

Simultaneous administration of granulocyte colony-stimulating factor (Filgrastim) and induction chemotherapy in acute lymphoblastic leukemia. A pilot study

scientific article published on October 1993

Simultaneous production of tumor necrosis factor-alpha and lymphotoxin by normal T cells after induction with IL-2 and anti-T3.

scientific article published in April 1988

Single nucleotide polymorphism in the mutational hotspot of WT1 predicts a favorable outcome in patients with cytogenetically normal acute myeloid leukemia

scientific article published on 28 December 2009

Smoothened inhibitor erismodegib combined with nilotinib in patients with chronic myeloid leukemia resistant/intolerant to at least one prior tyrosine kinase inhibitor: a phase 1b study

scientific article published on 06 November 2020

Sorafenib in combination with intensive chemotherapy in elderly patients with acute myeloid leukemia: results from a randomized, placebo-controlled trial

scientific article published on 29 July 2013

Stable molecular remission induced by imatinib mesylate (STI571) in a patient with CML lymphoid blast crisis relapsing after allogeneic stem cell transplantation

scientific article published in April 2003

Stimulation of human hematopoietic progenitor cell proliferation and differentiation by recombinant human interleukin 3. Comparison and interactions with recombinant human granulocyte-macrophage and granulocyte colony-stimulating factors

scientific article published in February 1989

Suppression of the DNA damage response in acute myeloid leukemia versus myelodysplastic syndrome

scientific article published on 27 April 2009

Synergistic inhibition of human marrow granulocyte-macrophage progenitor cells by prostaglandin E and recombinant interferon-alpha, -beta, and -gamma and an effect mediated by tumor necrosis factor

scientific article published on 01 January 1988

TGF beta-induced SMAD2 phosphorylation predicts inhibition of thymidine incorporation in CD34+ cells from healthy donors, but not from patients with AML after MDS.

scientific article published in June 2001

TIBO R82913, A New HIV-1 Inhibiting Agent, Does Not Inhibit Hematopoietic Progenitor Cells ⬇️

scientific article published on December 1, 1991

Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy-refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival.

scientific article published on 16 May 2011

Targeting of the N-terminal coiled coil oligomerization interface of BCR interferes with the transformation potential of BCR-ABL and increases sensitivity to STI571.

scientific article

Targeting the oligomerization domain of ETO interferes with RUNX1/ETO oncogenic activity in t(8;21)-positive leukemic cells

scientific article published on March 2007

Targeting the phosphoinositide 3-kinase pathway in hematologic malignancies

scientific article

Telomerase Inhibitor Imetelstat in Patients with Essential Thrombocythemia.

scientific article

The DAC system and associations with acute leukemias and myelodysplastic syndromes

scientific article

The German competence network ‘Acute and chronic leukemias’

article

The effect of recombinant human granulocyte-macrophage colony-stimulating factor on neutropenia and related morbidity in chronic severe neutropenia

scientific article published in December 1989

The effect of the dual Src/Abl kinase inhibitor AZD0530 on Philadelphia positive leukaemia cell lines

scientific article

The functional interplay between the t(9;22)-associated fusion proteins BCR/ABL and ABL/BCR in Philadelphia chromosome-positive acute lymphatic leukemia

scientific article published on 28 April 2015

The gatekeeper mutation T315I confers resistance against small molecules by increasing or restoring the ABL-kinase activity accompanied by aberrant transphosphorylation of endogenous BCR, even in loss-of-function mutants of BCR/ABL.

scientific article published on 16 April 2009

The integrity of the charged pocket in the BTB/POZ domain is essential for the phenotype induced by the leukemia-associated t(11;17) fusion protein PLZF/RARalpha.

scientific article published in July 2005

The third-generation bisphosphonate zoledronate synergistically augments the anti-Ph+ leukemia activity of imatinib mesylate

scientific article published on 22 May 2003

The tyrosine kinase inhibitor AMN107 (Nilotinib) exhibits off-target effects in lymphoblastic cell lines

scientific article

Therapy of Philadelphia chromosome positive acute lymphatic leukemia (Ph+ ALL) with an inhibitor of abl-tyrosine kinase (Glivec)

scientific article published in January 2002

Therapy with imatinib mesylate (Glivec) preceding allogeneic stem cell transplantation (SCT) in relapsed or refractory Philadelphia-positive acute lymphoblastic leukemia (Ph+ALL).

scientific article published in December 2002

Transcriptional profiling of human hematopoiesis during in vitro lineage-specific differentiation.

scientific article

Transforming growth factor-beta1 interferes with thrombopoietin-induced signal transduction in megakaryoblastic and erythroleukemic cells

scientific article published in May 2001

Treatment of Philadelphia chromosome-positive acute lymphoblastic leukemia

scientific article published in January 2005

Treatment of myelodysplastic syndromes with cytokines and cytotoxic drugs

scientific article published on April 1, 1992

Treatment of patients with advanced cancer with the natural killer cell line NK-92.

scientific article published on October 2013

Treatment of patients with low-risk myelodysplastic syndromes using a combination of all- trans retinoic acid, interferon alpha, and granulocyte colony-stimulating factor

scientific article published on 01 March 1999

Treatment of poor-risk myelodysplastic syndromes and acute myeloid leukemia with a combination of 5-azacytidine and valproic acid ⬇️

scientific article published on April 8, 2011

Tyrosine kinase inhibitors improve long-term outcome of allogeneic hematopoietic stem cell transplantation for adult patients with Philadelphia chromosome positive acute lymphoblastic leukemia

scientific article

UGT1A1 promoter polymorphism increases risk of nilotinib-induced hyperbilirubinemia

scientific article published on 05 July 2007

Use of a novel histone deacetylase inhibitor to induce apoptosis in cell lines of acute lymphoblastic leukemia.

scientific article published on April 2004

Valproic acid stimulates proliferation and self-renewal of hematopoietic stem cells

scientific article

Zoledronate synergises with imatinib mesylate to inhibit Ph primary leukaemic cell growth

scientific article published in August 2005

[Growth factors in oncology: effectiveness and prospects]

scientific article published on 01 September 1998

p185(BCR/ABL) has a lower sensitivity than p210(BCR/ABL) to the allosteric inhibitor GNF-2 in Philadelphia chromosome-positive acute lymphatic leukemia.

scientific article

p53-independent anti-tumor effects of the nitrogen-containing bisphosphonate zoledronic acid

scientific article published in February 2004

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