Search filters

List of works by Clare L Hawkins

8-Chloroadenosine Alters the Metabolic Profile and Downregulates Antioxidant and DNA Damage Repair Pathways in Macrophages

scientific article published on 16 December 2019

8-Chloroadenosine induces apoptosis in human coronary artery endothelial cells through the activation of the unfolded protein response

scientific article published on 10 July 2019

A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity

scientific article published on 19 November 2016

A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation

scientific article published on 16 May 2019

A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid

scientific article published on 31 January 2018

A therapeutic role for selenoprotein T in reducing ischaemia/reperfusion injury in the heart?

scientific article published on 17 June 2018

Ability of hypochlorous acid and N-chloramines to chlorinate DNA and its constituents

scientific article published in July 2010

Acetaminophen (paracetamol) inhibits myeloperoxidase-catalyzed oxidant production and biological damage at therapeutically achievable concentrations

scientific article published on 5 December 2009

Amino acid, peptide, and protein hydroperoxides and their decomposition products modify the activity of the 26S proteasome

scientific article published on 25 November 2010

Assessing the Efficacy of Dietary Selenomethionine Supplementation in the Setting of Cardiac Ischemia/Reperfusion Injury

scientific article published on 13 November 2019

Bilirubin scavenges chloramines and inhibits myeloperoxidase-induced protein/lipid oxidation in physiologically relevant hyperbilirubinemic serum.

scientific article published on 6 June 2015

CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis.

scientific article

Catalytic oxidant scavenging by selenium-containing compounds: Reduction of selenoxides and N-chloramines by thiols and redox enzymes.

scientific article published on 19 April 2017

Cellular effects of peptide and protein hydroperoxides

scientific article

Cellular effects of photogenerated oxidants and long-lived, reactive, hydroperoxide photoproducts

scientific article published on 12 August 2010

Cellular targets of the myeloperoxidase-derived oxidant hypothiocyanous acid (HOSCN) and its role in the inhibition of glycolysis in macrophages

scientific article published on 17 February 2016

Changes in mitochondrial homeostasis and redox status in astronauts following long stays in space

scientific article published on 16 December 2016

Characterization of the cellular effects of myeloperoxidase-derived oxidants on H9c2 cardiac myoblasts

scientific article published on 11 March 2019

Chasing great paths of Helmut Sies "Oxidative Stress".

scientific article

Comparative reactivity of myeloperoxidase-derived oxidants with mammalian cells

scientific article published on 13 March 2014

Comparative reactivity of the myeloperoxidase-derived oxidants HOCl and HOSCN with low-density lipoprotein (LDL): Implications for foam cell formation in atherosclerosis

scientific article

Comparative reactivity of the myeloperoxidase-derived oxidants hypochlorous acid and hypothiocyanous acid with human coronary artery endothelial cells

scientific article published on 10 October 2013

Cross-linking of lens crystallin proteins induced by tryptophan metabolites and metal ions: implications for cataract development

scientific article published on 7 July 2016

Degradation of Hyaluronic Acid, Poly- and Mono-Saccharides, and Model Compounds by Hypochlorite: Evidence for Radical Intermediates and Fragmentation

article

Detection and characterisation of radicals in biological materials using EPR methodology

scientific article published on 06 April 2013

Detection, identification, and quantification of oxidative protein modifications

scientific article published on 31 October 2019

Direct detection and identification of radicals generated during the hydroxyl radical-induced degradation of hyaluronic acid and related materials

scientific article published on 01 January 1996

EPR spin trapping of protein radicals

scientific article published on May 2004

Generation and propagation of radical reactions on proteins.

scientific article

Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction

scientific article

High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase

article

Human Indoleamine 2,3-Dioxygenase 1 Is an Efficient Mammalian Nitrite Reductase

scientific article published on 23 January 2019

Hypochlorite and superoxide radicals can act synergistically to induce fragmentation of hyaluronan and chondroitin sulphates

scientific article published on July 2004

Hypochlorite- and hypobromite-mediated radical formation and its role in cell lysis.

scientific article

Hypochlorite-Mediated Fragmentation of Hyaluronan, Chondroitin Sulfates, and RelatedN-Acetyl Glycosamines: Evidence for Chloramide Intermediates, Free Radical Transfer Reactions, and Site-Specific Fragmentation ⬇️

scientific article published on November 12, 2003

Hypochlorite-induced damage to DNA, RNA, and polynucleotides: formation of chloramines and nitrogen-centered radicals

scientific article published in January 2002

Hypochlorite-induced damage to nucleosides: formation of chloramines and nitrogen-centered radicals.

scientific article published in August 2001

Hypochlorite-induced oxidation of amino acids, peptides and proteins.

scientific article published on 29 July 2003

Hypochlorite-induced oxidation of proteins in plasma: formation of chloramines and nitrogen-centred radicals and their role in protein fragmentation

scientific article published in June 1999

Hypochlorite-induced oxidation of thiols: Formation of thiyl radicals and the role of sulfenyl chlorides as intermediates

scientific article published on 01 December 2000

Hypochlorous acid oxidizes methionine and tryptophan residues in myoglobin

scientific article published on 19 June 2008

Hypochlorous acid-mediated oxidation of lipid components and antioxidants present in low-density lipoproteins: absolute rate constants, product analysis, and computational modeling

scientific article published in April 2003

Hypochlorous acid-mediated protein oxidation: how important are chloramine transfer reactions and protein tertiary structure?

scientific article

Hypochlorous acid-modified extracellular matrix contributes to the behavioral switching of human coronary artery smooth muscle cells

scientific article published on 01 February 2019

Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid

scientific article

Hypothiocyanous acid: benign or deadly?

scientific article

Identification of plasma proteins that are susceptible to thiol oxidation by hypochlorous acid and N-chloramines

scientific article published on 13 August 2008

Identification of proteins susceptible to thiol oxidation in endothelial cells exposed to hypochlorous acid and N-chloramines

article

In Vitro Stimulation and Visualization of Extracellular Trap Release in Differentiated Human Monocyte-derived Macrophages

scientific article published on 01 November 2019

Inactivation of protease inhibitors and lysozyme by hypochlorous acid: role of side-chain oxidation and protein unfolding in loss of biological function

scientific article published in October 2005

Inactivation of thiol-dependent enzymes by hypothiocyanous acid: role of sulfenyl thiocyanate and sulfenic acid intermediates

scientific article

Inhibition of myeloperoxidase- and neutrophil-mediated oxidant production by tetraethyl and tetramethyl nitroxides

scientific article published on 22 February 2014

Low-density lipoprotein modified by myeloperoxidase oxidants induces endothelial dysfunction

scientific article

Mammalian heme peroxidases: from molecular mechanisms to health implications

scientific article published on July 2008

Manganese superoxide dismutase promotes interaction of actin, S100A4 and Talin, and enhances rat gastric tumor cell invasion.

scientific article

Modification of Cys residues in human thioredoxin-1 by p-benzoquinone causes inhibition of its catalytic activity and activation of the ASK1/p38-MAPK signalling pathway

scientific article published on 06 December 2019

Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3β Axis.

scientific article

Myeloperoxidase Modulates Hydrogen Peroxide Mediated Cellular Damage in Murine Macrophages

scientific article published on 10 December 2020

Myeloperoxidase-derived oxidants modify apolipoprotein A-I and generate dysfunctional high-density lipoproteins: comparison of hypothiocyanous acid (HOSCN) with hypochlorous acid (HOCl).

scientific article

Nitric Oxide Storage and Transport in Cells Are Mediated by Glutathione S-Transferase P1-1 and Multidrug Resistance Protein 1 via Dinitrosyl Iron Complexes ⬇️

scientific article published on November 14, 2011

Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1.

scholarly article

Oxidation of human plasma fibronectin by inflammatory oxidants perturbs endothelial cell function

scientific article published on 05 April 2019

Oxidative damage to collagen and related substrates by metal ion/hydrogen peroxide systems: random attack or site-specific damage?

scientific article published on 01 February 1997

Photo-oxidation of cells generates long-lived intracellular protein peroxides

scientific article published in March 2003

Protein carbamylation: a key driver of vascular calcification during chronic kidney disease

scientific article published on 01 July 2018

Quantification of protein modification by oxidants

scientific article published on 21 January 2009

Reaction of protein chloramines with DNA and nucleosides: evidence for the formation of radicals, protein-DNA cross-links and DNA fragmentation

scientific article published on August 2002

Reactions and reactivity of myeloperoxidase-derived oxidants: differential biological effects of hypochlorous and hypothiocyanous acids

scientific article published on 23 April 2012

Reactivity of selenium-containing compounds with myeloperoxidase-derived chlorinating oxidants: Second-order rate constants and implications for biological damage

scientific article

Reduced circulating oxidized LDL is associated with hypocholesterolemia and enhanced thiol status in Gilbert syndrome

scientific article

Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function

scientific article published on 8 February 2017

Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?

scientific article

Role of cyanate in the induction of vascular dysfunction during uremia: more than protein carbamylation?

scientific article published on 01 November 2014

Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation

scientific article published on 04 September 2018

Selenomethionine supplementation reduces lesion burden, improves vessel function and modulates the inflammatory response within the setting of atherosclerosis

scientific article published on 16 December 2019

Sensitizer-mediated photooxidation of histidine residues: evidence for the formation of reactive side-chain peroxides

scientific article published on 12 December 2005

Separation, detection, and quantification of hydroperoxides formed at side-chain and backbone sites on amino acids, peptides, and proteins

scientific article

Singlet oxygen-mediated protein oxidation: evidence for the formation of reactive peroxides

article

Singlet oxygen-mediated protein oxidation: evidence for the formation of reactive side chain peroxides on tyrosine residues

scientific article

Singlet-oxygen-mediated amino acid and protein oxidation: formation of tryptophan peroxides and decomposition products

scientific article published on 16 April 2009

Special issue on “Peroxidase”

scientific article published on 27 May 2015

The iron complex of Dp44mT is redox-active and induces hydroxyl radical formation: an EPR study.

scientific article published on 23 July 2010

The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages

scientific article

The potent and novel thiosemicarbazone chelators di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone and 2-benzoylpyridine-4,4-dimethyl-3-thiosemicarbazone affect crucial thiol systems required for ribonucleotide reductase activity.

scientific article published on 9 March 2011

The role of aromatic amino acid oxidation, protein unfolding, and aggregation in the hypobromous acid-induced inactivation of trypsin inhibitor and lysozyme.

scientific article

The role of hypothiocyanous acid (HOSCN) in biological systems.

scientific article published on December 2009

The role of reactive N-bromo species and radical intermediates in hypobromous acid-induced protein oxidation

scientific article

Tryptophan oxidation in proteins exposed to thiocyanate-derived oxidants

scientific article published on 27 August 2014

Tryptophan residues are targets in hypothiocyanous acid-mediated protein oxidation

scientific article published in December 2008

What are the plasma targets of the oxidant hypochlorous acid? A kinetic modeling approach

scientific article

β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia.

scientific article published on 19 February 2016

Paulina is supported by:

About Paulina

Help