List of works - Jari Yli-Kauhaluoma

(+)-Dehydroabietic acid, an abietane-type diterpene, inhibits Staphylococcus aureus biofilms in vitro

scientific article published on 5 June 2013

A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.

scientific article

A modification of the Hammett equation for predicting ionisation constants of p-vinyl phenols.

scientific article published in July 2005

A new insight into solid-state conformation of macrolide antibiotics

scientific article published on 29 September 2007

Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi.

scientific article published on 5 February 2016

Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.

scientific article

Adenosine analogs bearing phosphate isosteres as human MDO1 ligands

scientific article published on 13 February 2018

Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent

scientific article

Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry.

scientific article published on 20 April 2005

Anti-leishmanial activity of betulin derivatives

scientific article

Antibacterial profiling of abietane-type diterpenoids.

scientific article

Antinociception by spinal and systemic oxycodone: why does the route make a difference? In vitro and in vivo studies in rats.

scientific article published in October 2006

Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania donovani and Trypanosoma cruzi

Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays

scientific article

Asymmetry in catalysis by membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor

scientific article published on 22 May 2019

Azulene-based compounds for targeting orexin receptors

scientific article published on 20 July 2018

Benzo[cd]azulene skeleton: azulene, heptafulvene, and tropone derivatives.

scientific article

Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo.

scientific article published on 14 January 2016

Betulin derivatives impair Leishmania braziliensis viability and host-parasite interaction

scientific article

Betulin-derived compounds as inhibitors of alphavirus replication

scientific article published in November 2009

Biosynthesis of the Bis-Prenylated Alkaloids Muscoride A and B

scientific article published on 19 November 2019

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells.

scientific article published on 8 March 2018

Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9.

scientific article published on 19 August 2011

Brain-derived neurotrophic factor controls activity-dependent maturation of CA1 synapses by downregulating tonic activation of presynaptic kainate receptors.

scientific article published in September 2009

C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells

scientific article

C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure-activity relationships and biological activities

scientific article

Catalytic antibodies: the rerouting of chemical reactions. Towards electrophilic aromatic substitution by carbon dioxide

scientific article published on 01 October 1996

Catalytic, Tunable, One-Step Bismuth(III) Triflate Reaction with Alcohols: Dehydration Versus Dimerization

scientific article published on 9 August 2018

Chemical profiles of birch and alder bark by ambient mass spectrometry

scientific article published on 23 October 2019

Chiral distinction between the enantiomers of bicyclic alcohols by UDP-glucuronosyltransferases 2B7 and 2B17

scientific article published on 01 April 2006

Combined Effect of Naturally-Derived Biofilm Inhibitors and Differentiated HL-60 Cells in the Prevention of Staphylococcus aureus Biofilm Formation

scientific article published on 09 November 2020

Conditioned Reward of Opioids, but not Psychostimulants, is Impaired in GABA-A Receptor δ Subunit Knockout Mice

scientific article published on 09 July 2018

Conformation study of 2-arylbenzimidazoles as inhibitors of Chlamydia pneumoniae growth.

scientific article published on 23 May 2012

Current status and future prospects of C1 domain ligands as drug candidates

scientific article published on January 2011

Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1

scientific article published in Scientific Reports

Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae

scientific article

Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C.

scientific article

Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors.

scientific article

Determination of neutral carbohydrates by CZE with direct UV detection

scientific article published on 01 August 2007

Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A

scientific article published on 13 November 2018

Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12)

scientific article (publication date: 2014)

Electrospray ionization mass spectrometry and tandem mass spectrometry of clodronate and related bisphosphonate and phosphonate compounds

scientific article published in February 2002

Eudismic analysis of tricyclic sesquiterpenoid alcohols: lead structures for the design of potent inhibitors of the human UDP-glucuronosyltransferase 2B7

scientific article published on 15 August 2007

Exploring marine resources for bioactive compounds.

scientific article

Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction

scientific article published in September 2005

Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs

scientific article published on 29 September 2017

Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases

scientific article

HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition

scientific article

Identification of free and conjugated metabolites of mesocarb in human urine by LC-MS/MS.

scientific article published on 23 May 2010

Inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium Chlamydia pneumoniae.

scientific article published on 06 July 2010

Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma

scientific article

In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells

scientific article

Isoform-selective inhibition of the human UDP-glucuronosyltransferase 2B7 by isolongifolol derivatives

scientific article published on 03 May 2007

Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites

scientific article published on 25 June 2019

Mass-tag enhanced immuno-laser desorption/ionization mass spectrometry for sensitive detection of intact protein antigens.

scientific article published on 30 April 2015

Mechanism of the Oxidation of Heptafulvenes to Tropones Studied by Online Mass Spectrometry and Density Functional Theory Calculations

scientific article published on 21 October 2019

Methadone increases intracellular calcium in SH-SY5Y and SH-EP1-halpha7 cells by activating neuronal nicotinic acetylcholine receptors

scientific article published on 5 July 2005

Microplate screening assay for binding of ligands to bovine or reindeer beta-lactoglobulins

scientific article published on 01 August 2006

Microwave-assisted synthesis of imidazoles: reaction of p-toluenesulfonylmethyl isocyanide and polymer-bound imines

scientific article published in August 2005

Morphine, Oxycodone, Methadone and Its Enantiomers in Different Models of Nociception in the Rat

article

Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner

scientific article published on 04 May 2018

New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity

scientific article published on 21 July 2015

Nucleophilic Substitution of Hydrogen Facilitated by Quinone Methide Moieties in Benzo[cd]azulen-3-ones

scientific article published on 5 April 2017

On the hydrolytic behavior of tinidazole, metronidazole, and ornidazole

scientific article published in April 2003

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

scientific article

Optimization of a High-Throughput 384-Well Plate-Based Screening Platform with Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 15442 Biofilms

scientific article published on 25 April 2020

Pharmacological characterization of noroxymorphone as a new opioid for spinal analgesia

scientific article

Pharmacological properties of the ubiquitous natural product betulin

scientific article (publication date: September 2006)

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts

scientific article

Polyketide derivatives active against Botrytis cinerea in Gerbera hybrida.

scientific article published on 28 September 2010

Potent inhibitors of the human UDP-glucuronosyltransferase 2B7 derived from the sesquiterpenoid alcohol longifolol

scientific article published on 01 June 2007

Preparation and Characterization of Dentin Phosphophoryn-Derived Peptide-Functionalized Lignin Nanoparticles for Enhanced Cellular Uptake

scientific article published on 06 May 2019

Protein kinases as drug targets.

scientific article

Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo

scientific article published on 29 April 2019

Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells

scientific article published on 12 December 2016

Recent advances in 1,3-dipolar cycloaddition reactions on solid supports

scientific article

Regioselective sulfonation of dopamine by SULT1A3 in vitro provides a molecular explanation for the preponderance of dopamine-3-O-sulfate in human blood circulation

scientific article published on 10 May 2007

Rigorous computational study reveals what docking overlooks: Double trouble from membrane association in protein kinase C modulators

scientific article published on 11 September 2020

Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C.

scientific article published on 11 April 2018

Screening and characterisation of antimicrobial properties of semisynthetic betulin derivatives

scientific article (publication date: 2014)

Screening of FDA-Approved Drugs Using a 384-Well Plate-Based Biofilm Platform: The Case of Fingolimod

scientific article published on 21 November 2020

Selective hepatitis B and D virus entry inhibitors from the group of pentacyclic lupane-type betulin-derived triterpenoids

scientific article published on 10 December 2020

Simple 3D printed stainless steel microreactors for online mass spectrometric analysis

scientific article published on 02 July 2019

Solid-Phase Synthesis of Pyrazolopyridines from Polymer-Bound Alkyne and Azomethine Imines

scientific article published on 01 May 2006

Solid-phase synthesis of 1,2,3-triazoles via 1,3-dipolar cycloaddition

scientific article

Solid-phase synthesis of amino acid derived N-unsubstituted pyrazoles via sydnones

scientific article published on 01 May 2009

Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds

scientific article published on 09 July 2018

Stereochemical and steric control of the UDP-glucuronosyltransferase-catalyzed conjugation reaction: a rational approach for the design of inhibitors for the human UGT2B7.

scientific article published in December 2007

Stereochemical sensitivity of the human UDP-glucuronosyltransferases 2B7 and 2B17

scientific article published on 01 March 2006

Stereoselective aza Diels-Alder reaction on solid phase: a facile synthesis of hexahydrocinnoline derivatives

scientific article published in March 2007

Strategies to Prevent Biofilm Infections on Biomaterials: Effect of Novel Naturally-Derived Biofilm Inhibitors on a Competitive Colonization Model of Titanium by Staphylococcus aureus and SaOS-2 Cells

scientific article published on 29 February 2020

Structural Isosteres of Phosphate Groups in the Protein Data Bank

scientific article

Structure-Activity Relationships of 1-Benzoylazulenes at the OX1 and OX2 Orexin Receptors

scientific article published on 02 April 2019

Surface-Shaving Proteomics of Mycobacterium marinum Identifies Biofilm Subtype-Specific Changes Affecting Virulence, Tolerance, and Persistence

scientific article published on 22 June 2021

Synthesis and Anti-Proliferative Activity of Sulfanyltriazolylnaphthalenols and Sulfanyltriazolylnaphthalene-1,4-diones.

scientific article published on 12 July 2016

Synthesis and Antiproliferative Activity of Marine Bromotyrosine Purpurealidin I and Its Derivatives

Synthesis and Biological Evaluation of 2-Aminobenzothiazole and Benzimidazole Analogs Based on the Clathrodin Structure

scientific article published on 28 December 2015

Synthesis and anti-leishmanial activity of heterocyclic betulin derivatives

scientific article

Synthesis and biological evaluation of 2-arylbenzimidazoles targeting Leishmania donovani

scientific article

Synthesis and biological evaluation of new oxadiazoline-substituted naphthalenyl acetates as anticancer agents

scientific article

Synthesis and characterization of hydroxylated mesocarb metabolites for doping control

scientific article

Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease

scientific article

Synthesis and tautomerization of benzo[cd]azulen-3-ones

scientific article published on 03 March 2011

Synthesis of 1,3,6-Trisubstituted Azulenes

scientific article published on 11 November 2015

Synthesis of 7β-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors

scientific article published in May 2018

Synthesis of aminophosphonate haptens for an aminoacylation reaction between methyl glucoside and a beta-alanyl ester

scientific article published on 01 August 2000

Synthesis of novel purpurealidin analogs and evaluation of their effect on the cancer-relevant potassium channel KV10.1.

scientific article published on 8 December 2017

Synthesis, Identification, and Structure-Activity Relationship Analysis of GATA4 and NKX2-5 Protein-Protein Interaction Modulators

scientific article published on 03 September 2019

Synthesis, structure characterization, and enzyme screening of clenbuterol glucuronides.

scientific article published on 15 May 2009

The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

scientific article published on 3 May 2013

The Diels-Alder reaction between deactivated dienes and electron-deficient dienophiles on solid support: stereoselective synthesis of hexahydro-1,3-dioxoisoindoles

scientific article published on 01 March 2004

The binding of synthetic retinoids to lipocalin beta-lactoglobulins

scientific article published in January 2010

Tissue-specific study across the stem reveals the chemistry and transcriptome dynamics of birch bark

scientific article published on 07 March 2019

Total synthesis of bistramide A and its 36(Z) isomers: differential effect on cell division, differentiation, and apoptosis

scientific article published on 26 April 2012

Toxicity of betulin derivatives and in vitro effect on promastigotes and amastigotes of Leishmania infantum and L. donovani

scientific article published on 27 April 2011

Tricyclic Benzo[cd]azulenes selectively inhibit activities of Pim kinases and restrict growth of Epstein-Barr virus-transformed cells

scientific article

Trisubstituted barbiturates and thiobarbiturates: Synthesis and biological evaluation as xanthine oxidase inhibitors, antioxidants, antibacterial and anti-proliferative agents.

scientific article published on 27 November 2017

Twisted alpha-keto amides as transition-state analogues for acyl-transfer reactions: synthesis of the immunoconjugates

scientific article published in June 1994

UDP-glucuronic acid binds first and the aglycone substrate binds second to form a ternary complex in UGT1A9-catalyzed reactions, in both the presence and absence of bovine serum albumin

scientific article published on 21 August 2012

UDP-glucuronosyltransferases (UGTs) 2B7 and UGT2B17 display converse specificity in testosterone and epitestosterone glucuronidation, whereas UGT2A1 conjugates both androgens similarly

scientific article published on 20 November 2008

Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

scientific article

List of works by Jari Yli-Kauhaluoma

(+)-Dehydroabietic acid, an abietane-type diterpene, inhibits Staphylococcus aureus biofilms in vitro

A Developability-Focused Optimization Approach Allows Identification of in Vivo Fast-Acting Antimalarials: N-[3-[(Benzimidazol-2-yl)amino]propyl]amides.

A modification of the Hammett equation for predicting ionisation constants of p-vinyl phenols.

A new insight into solid-state conformation of macrolide antibiotics

Abietane-Type Diterpenoid Amides with Highly Potent and Selective Activity against Leishmania donovani and Trypanosoma cruzi.

Acetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.

Adenosine analogs bearing phosphate isosteres as human MDO1 ligands

Albumin stimulates the activity of the human UDP-glucuronosyltransferases 1A7, 1A8, 1A10, 2A1 and 2B15, but the effects are enzyme and substrate dependent

Analysis of small molecules by ultra thin-layer chromatography-atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry.

Anti-leishmanial activity of betulin derivatives

Antibacterial profiling of abietane-type diterpenoids.

Antinociception by spinal and systemic oxycodone: why does the route make a difference? In vitro and in vivo studies in rats.

Antiprotozoal activity of dehydroabietic acid derivatives against Leishmania donovani and Trypanosoma cruzi

Assessing the data quality in predictive toxicology using a panel of cell lines and cytotoxicity assays

Asymmetry in catalysis by membrane-bound pyrophosphatase demonstrated by a nonphosphorus allosteric inhibitor

Azulene-based compounds for targeting orexin receptors

Benzo[cd]azulene skeleton: azulene, heptafulvene, and tropone derivatives.

Betulin Derivatives Effectively Suppress Inflammation in Vitro and in Vivo.

Betulin derivatives impair Leishmania braziliensis viability and host-parasite interaction

Betulin-derived compounds as inhibitors of alphavirus replication

Biosynthesis of the Bis-Prenylated Alkaloids Muscoride A and B

Biotransformation of Cyclodextrine-Complexed Semisynthetic Betulin Derivatives by Plant Cells.

Bovine serum albumin decreases Km values of human UDP-glucuronosyltransferases 1A9 and 2B7 and increases Vmax values of UGT1A9.

Brain-derived neurotrophic factor controls activity-dependent maturation of CA1 synapses by downregulating tonic activation of presynaptic kainate receptors.

C1 Domain-targeted isophthalate derivatives induce cell elongation and cell cycle arrest in HeLa cells

C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure-activity relationships and biological activities

Catalytic antibodies: the rerouting of chemical reactions. Towards electrophilic aromatic substitution by carbon dioxide

Catalytic, Tunable, One-Step Bismuth(III) Triflate Reaction with Alcohols: Dehydration Versus Dimerization

Chemical profiles of birch and alder bark by ambient mass spectrometry

Chiral distinction between the enantiomers of bicyclic alcohols by UDP-glucuronosyltransferases 2B7 and 2B17

Combined Effect of Naturally-Derived Biofilm Inhibitors and Differentiated HL-60 Cells in the Prevention of Staphylococcus aureus Biofilm Formation

Conditioned Reward of Opioids, but not Psychostimulants, is Impaired in GABA-A Receptor δ Subunit Knockout Mice

Conformation study of 2-arylbenzimidazoles as inhibitors of Chlamydia pneumoniae growth.

Current status and future prospects of C1 domain ligands as drug candidates

Dehydroabietic oximes halt pancreatic cancer cell growth in the G1 phase through induction of p27 and downregulation of cyclin D1

Design and synthesis of 2-arylbenzimidazoles and evaluation of their inhibitory effect against Chlamydia pneumoniae

Design, synthesis, and biological activity of isophthalic acid derivatives targeted to the C1 domain of protein kinase C.

Design, synthesis, and biological activity of urea derivatives as anaplastic lymphoma kinase inhibitors.

Determination of neutral carbohydrates by CZE with direct UV detection

Discovery of 12-Thiazole Abietanes as Selective Inhibitors of the Human Metabolic Serine Hydrolase hABHD16A

Discovery of triterpenoids as reversible inhibitors of α/β-hydrolase domain containing 12 (ABHD12)

Electrospray ionization mass spectrometry and tandem mass spectrometry of clodronate and related bisphosphonate and phosphonate compounds

Eudismic analysis of tricyclic sesquiterpenoid alcohols: lead structures for the design of potent inhibitors of the human UDP-glucuronosyltransferase 2B7

Exploring marine resources for bioactive compounds.

Exploring the scope of the 29G12 antibody catalyzed 1,3-dipolar cycloaddition reaction

Functionalization of carboxylated lignin nanoparticles for targeted and pH-responsive delivery of anticancer drugs

Glucuronidation of psilocin and 4-hydroxyindole by the human UDP-glucuronosyltransferases

HIV-1 Tat-peptide inhibits protein kinase C and protein kinase A through substrate competition

Identification of free and conjugated metabolites of mesocarb in human urine by LC-MS/MS.

Inhibitory effect of the natural product betulin and its derivatives against the intracellular bacterium Chlamydia pneumoniae.

Interaction between retinoid acid receptor-related orphan receptor alpha (RORA) and neuropeptide S receptor 1 (NPSR1) in asthma

In vitro evaluation of biodegradable lignin-based nanoparticles for drug delivery and enhanced antiproliferation effect in cancer cells

Isoform-selective inhibition of the human UDP-glucuronosyltransferase 2B7 by isolongifolol derivatives

Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites

Mass-tag enhanced immuno-laser desorption/ionization mass spectrometry for sensitive detection of intact protein antigens.

Mechanism of the Oxidation of Heptafulvenes to Tropones Studied by Online Mass Spectrometry and Density Functional Theory Calculations

Methadone increases intracellular calcium in SH-SY5Y and SH-EP1-halpha7 cells by activating neuronal nicotinic acetylcholine receptors

Microplate screening assay for binding of ligands to bovine or reindeer beta-lactoglobulins

Microwave-assisted synthesis of imidazoles: reaction of p-toluenesulfonylmethyl isocyanide and polymer-bound imines

Morphine, Oxycodone, Methadone and Its Enantiomers in Different Models of Nociception in the Rat

Natural Stilbenoids Have Anti-Inflammatory Properties in Vivo and Down-Regulate the Production of Inflammatory Mediators NO, IL6, and MCP1 Possibly in a PI3K/Akt-Dependent Manner

New derivatives of dehydroabietic acid target planktonic and biofilm bacteria in Staphylococcus aureus and effectively disrupt bacterial membrane integrity

Nucleophilic Substitution of Hydrogen Facilitated by Quinone Methide Moieties in Benzo[cd]azulen-3-ones

On the hydrolytic behavior of tinidazole, metronidazole, and ornidazole

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

Optimization of a High-Throughput 384-Well Plate-Based Screening Platform with Staphylococcus aureus ATCC 25923 and Pseudomonas aeruginosa ATCC 15442 Biofilms

Pharmacological characterization of noroxymorphone as a new opioid for spinal analgesia

Pharmacological properties of the ubiquitous natural product betulin

Pim Kinases Promote Migration and Metastatic Growth of Prostate Cancer Xenografts

Polyketide derivatives active against Botrytis cinerea in Gerbera hybrida.

Potent inhibitors of the human UDP-glucuronosyltransferase 2B7 derived from the sesquiterpenoid alcohol longifolol

Preparation and Characterization of Dentin Phosphophoryn-Derived Peptide-Functionalized Lignin Nanoparticles for Enhanced Cellular Uptake

Protein kinases as drug targets.

Pyrazine-Fused Triterpenoids Block the TRPA1 Ion Channel in Vitro and Inhibit TRPA1-Mediated Acute Inflammation in Vivo

Quercetin-Based Modified Porous Silicon Nanoparticles for Enhanced Inhibition of Doxorubicin-Resistant Cancer Cells

Recent advances in 1,3-dipolar cycloaddition reactions on solid supports

Regioselective sulfonation of dopamine by SULT1A3 in vitro provides a molecular explanation for the preponderance of dopamine-3-O-sulfate in human blood circulation

Rigorous computational study reveals what docking overlooks: Double trouble from membrane association in protein kinase C modulators

Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C.