List of works - Rune Hartmann

2'-5' oligoadenylate synthetase shares active site architecture with the archaeal CCA-adding enzyme

scientific article published in August 2008

2'3'-cGAMP triggers a STING- and NF-κB-dependent broad antiviral response in <i>Drosophila</i>

scientific article published on 01 December 2020

2′-Adenylated derivatives of Ap3A activate RNase L

scientific article published on 01 August 1999

A conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane.

scientific article

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

scientific article published on 30 April 2006

Activation of 2'-5' oligoadenylate synthetase by single-stranded and double-stranded RNA aptamers

scientific article

An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity

scientific journal article

Antiviral Activities of Different Interferon Types and Subtypes against Hepatitis E Virus Replication

scientific article published on 19 January 2016

Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor

scientific article published on 12 June 2014

Ap3A and Ap4A are primers for oligoadenylate synthesis catalyzed by interferon-inducible 2-5A synthetase

scientific article published on May 1997

Author Correction: STEEP mediates STING ER exit and activation of signaling

scientific article published on 14 September 2020

B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation

scientific article published on 06 December 2021

Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression.

scientific article published on 16 February 2016

Conformational diversity in prion protein variants influences intermolecular beta-sheet formation

scientific article

Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

scientific article published on 01 December 2021

Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21R

scientific article

Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase

scientific article

Differential regulation of the OASL and OAS1 genes in response to viral infections

scientific article

Disparate temperature-dependent virus – host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

scientific article published on 28 April 2020

Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

scientific article published on 29 March 2021

Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses

scientific article published on May 2006

Ectodermal dysplasia with immunodeficiency caused by a branch-point mutation in IKBKG/NEMO.

scientific article published on 29 June 2016

Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential

scientific article

Erratum: Corrigendum: Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

scientific article published in Nature Communications

Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity

scientific article published on 15 September 2010

Frequently used bioinformatics tools overestimate the damaging effect of allelic variants.

scientific article published on 4 December 2017

Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

scientific article

Gene structure and function of the 2'-5'-oligoadenylate synthetase family.

scientific article

Gene structure of the murine 2'-5'-oligoadenylate synthetase family

scientific article published on July 2002

Guarding the frontiers: the biology of type III interferons

scientific article published on July 2015

HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6

scientific article

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

scientific article published on 27 May 2016

Human interferon-lambda3 is a potent member of the type III interferon family.

scientific article

IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis

scientific article published on 10 April 2017

IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment.

scientific article published on 11 August 2016

Identification of essential regulatory elements responsible for the explicit expression of IL-28Rα and their effect on critical SNPs using in-Silico methods.

scientific article

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.

scientific article published on 19 February 2016

Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions

scientific article

Inhibition of SARS-CoV-2 by type I and type III interferons

scientific article published on 25 June 2020

Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1

scientific article (publication date: February 2004)

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses

scientific article published on 29 October 2013

Interferon- Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family

scientific article

Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin

scientific article published on 18 March 2019

Lambda Interferons: New Cytokines with Old Functions

scientific article

Length dependent activation of OAS proteins by dsRNA

scientific article published on 17 October 2019

Modular structure of PACT: distinct domains for binding and activating PKR

scientific article

Natural mutations in a 2'-5' oligoadenylate synthetase transgene revealed residues essential for enzyme activity

scientific journal article

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

scientific article published on 18 July 2014

Pandemic H1N1 2009 influenza A virus induces weak cytokine responses in human macrophages and dendritic cells and is highly sensitive to the antiviral actions of interferons.

scientific article

Rapid Uptake and Inhibition of Viral Propagation by Extracellular OAS1.

scientific article published on 17 December 2014

Rational design of interleukin-21 antagonist through selective elimination of the gammaC binding epitope

scientific article

Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

scientific article published on 23 December 2014

SARS-CoV-2 evades immune detection in alveolar macrophages

scientific article published on 28 October 2020

STEEP mediates STING ER exit and activation of signaling

scientific article published on 20 July 2020

Selection of a Novel and Highly Specific Tumor Necrosis Factor (TNF ) Antagonist: INSIGHT FROM THE CRYSTAL STRUCTURE OF THE ANTAGONIST-TNF COMPLEX

scientific article

Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap(3)A and Ap(4)A, by two specific human dinucleoside polyphosphate hydrolases.

scientific article

Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling

scientific article published on 29 April 2015

The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation.

scientific article published on October 2014

The crystal structure of zebrafish IL-22 reveals an evolutionary, conserved structure highly similar to that of human IL-22

scientific article

The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein. ⬇️

scientific article published on 2 March 2018

The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities

scientific article

The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain

scientific article

The role of IFN in the development of NAFLD and NASH

article

The structure of human interferon lambda and what it has taught us.

scientific article published on August 2010

The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains

scientific article published on 28 August 2009

Transcriptome analysis reveals a classical interferon signature induced by IFNλ4 in human primary cells.

scientific article

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

scientific article

Type III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases

scientific article published on 16 May 2007

Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1.

scientific article

What makes the hepatitis C virus evolve? ⬇️

scientific article published on 03 September 2019

cGAS is activated by DNA in a length-dependent manner.

scientific article published on 10 August 2017

p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family ⬇️

scientific article published on September 15, 1998

List of works by Rune Hartmann

2'-5' oligoadenylate synthetase shares active site architecture with the archaeal CCA-adding enzyme

2'3'-cGAMP triggers a STING- and NF-κB-dependent broad antiviral response in <i>Drosophila</i>

2′-Adenylated derivatives of Ap3A activate RNase L

A conserved sugar bridge connected to the WSXWS motif has an important role for transport of IL-21R to the plasma membrane.

A structural basis for discriminating between self and nonself double-stranded RNAs in mammalian cells.

Activation of 2'-5' oligoadenylate synthetase by single-stranded and double-stranded RNA aptamers

An important role for type III interferon (IFN-lambda/IL-28) in TLR-induced antiviral activity

Antiviral Activities of Different Interferon Types and Subtypes against Hepatitis E Virus Replication

Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor

Ap3A and Ap4A are primers for oligoadenylate synthesis catalyzed by interferon-inducible 2-5A synthetase

Author Correction: STEEP mediates STING ER exit and activation of signaling

B Cell Intrinsic STING Signaling Is Not Required for Autoreactive Germinal Center Participation

Cellular Mechanism for Impaired Hepatitis C Virus Clearance by Interferon Associated with IFNL3 Gene Polymorphisms Relates to Intrahepatic Interferon-λ Expression.

Conformational diversity in prion protein variants influences intermolecular beta-sheet formation

Cross-species analysis of viral nucleic acid interacting proteins identifies TAOKs as innate immune regulators

Crystal Structure of Interleukin-21 Receptor (IL-21R) Bound to IL-21 Reveals That Sugar Chain Interacting with WSXWS Motif Is Integral Part of IL-21R

Crystal structure of the 2'-specific and double-stranded RNA-activated interferon-induced antiviral protein 2'-5'-oligoadenylate synthetase

Differential regulation of the OASL and OAS1 genes in response to viral infections

Disparate temperature-dependent virus – host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

Disparate temperature-dependent virus-host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

Double-stranded RNA is produced by positive-strand RNA viruses and DNA viruses but not in detectable amounts by negative-strand RNA viruses

Ectodermal dysplasia with immunodeficiency caused by a branch-point mutation in IKBKG/NEMO.

Efficient replication of the novel human betacoronavirus EMC on primary human epithelium highlights its zoonotic potential

Erratum: Corrigendum: Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

Extracellular 2'-5' oligoadenylate synthetase stimulates RNase L-independent antiviral activity: a novel mechanism of virus-induced innate immunity

Frequently used bioinformatics tools overestimate the damaging effect of allelic variants.

Functional IRF3 deficiency in a patient with herpes simplex encephalitis.

Gene structure and function of the 2'-5'-oligoadenylate synthetase family.

Gene structure of the murine 2'-5'-oligoadenylate synthetase family

Guarding the frontiers: the biology of type III interferons

HSV infection induces production of ROS, which potentiate signaling from pattern recognition receptors: role for S-glutathionylation of TRAF3 and 6

HSV-1 ICP27 targets the TBK1-activated STING signalsome to inhibit virus-induced type I IFN expression

Human interferon-lambda3 is a potent member of the type III interferon family.

IFN-λ3, not IFN-λ4, likely mediates IFNL3-IFNL4 haplotype-dependent hepatic inflammation and fibrosis

IFNλ is a potent anti-influenza therapeutic without the inflammatory side effects of IFNα treatment.

Identification of essential regulatory elements responsible for the explicit expression of IL-28Rα and their effect on critical SNPs using in-Silico methods.

Influenza A virus targets a cGAS-independent STING pathway that controls enveloped RNA viruses.

Inhibition of 2'-5' oligoadenylate synthetase by divalent metal ions

Inhibition of SARS-CoV-2 by type I and type III interferons

Interaction between the 2'-5' oligoadenylate synthetase-like protein p59 OASL and the transcriptional repressor methyl CpG-binding protein 1

Interferon lambda 4 signals via the IFNλ receptor to regulate antiviral activity against HCV and coronaviruses

Interferon- Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family

Interferon-λ enhances adaptive mucosal immunity by boosting release of thymic stromal lymphopoietin

Lambda Interferons: New Cytokines with Old Functions

Length dependent activation of OAS proteins by dsRNA

Modular structure of PACT: distinct domains for binding and activating PKR

Natural mutations in a 2'-5' oligoadenylate synthetase transgene revealed residues essential for enzyme activity

OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids

Pandemic H1N1 2009 influenza A virus induces weak cytokine responses in human macrophages and dendritic cells and is highly sensitive to the antiviral actions of interferons.

Rapid Uptake and Inhibition of Viral Propagation by Extracellular OAS1.

Rational design of interleukin-21 antagonist through selective elimination of the gammaC binding epitope

Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes

SARS-CoV-2 evades immune detection in alveolar macrophages

STEEP mediates STING ER exit and activation of signaling

Selection of a Novel and Highly Specific Tumor Necrosis Factor (TNF ) Antagonist: INSIGHT FROM THE CRYSTAL STRUCTURE OF THE ANTAGONIST-TNF COMPLEX

Selective degradation of 2'-adenylated diadenosine tri- and tetraphosphates, Ap(3)A and Ap(4)A, by two specific human dinucleoside polyphosphate hydrolases.

Structural and functional analysis reveals that human OASL binds dsRNA to enhance RIG-I signaling

The 2'-5'-oligoadenylate synthetase 3 enzyme potently synthesizes the 2'-5'-oligoadenylates required for RNase L activation.

The crystal structure of zebrafish IL-22 reveals an evolutionary, conserved structure highly similar to that of human IL-22

The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi's sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein. ⬇️

The oligoadenylate synthetase family: an ancient protein family with multiple antiviral activities

The p59 oligoadenylate synthetase-like protein possesses antiviral activity that requires the C-terminal ubiquitin-like domain

The role of IFN in the development of NAFLD and NASH

The structure of human interferon lambda and what it has taught us.

The two groups of zebrafish virus-induced interferons signal via distinct receptors with specific and shared chains

Transcriptome analysis reveals a classical interferon signature induced by IFNλ4 in human primary cells.

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

Type III interferon (IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases

Unraveling the molecular mechanism governing the tissue specific expression of IFNλR1.

What makes the hepatitis C virus evolve? ⬇️

cGAS is activated by DNA in a length-dependent manner.

p59OASL, a 2'-5' oligoadenylate synthetase like protein: a novel human gene related to the 2'-5' oligoadenylate synthetase family ⬇️