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List of works by Jörg Huwyler

5-hydroxyindole-2-carboxylic acid amides: novel histamine-3 receptor inverse agonists for the treatment of obesity.

scientific article

9H-Xanthene-9-carboxylic acid [1,2,4]oxadiazol-3-yl- and (2H-tetrazol-5-yl)-amides as potent, orally available mGlu1 receptor enhancers.

scientific article

A Method To Determine the Kinetics of Solute Mixing in Liquid/Liquid Formulation Dual-Chamber Syringes

scientific article published on 11 August 2016

A binary ant colony optimization classifier for molecular activities.

scientific article published on 14 September 2011

A cell-based, multiparametric sensor approach characterises drug-induced cytotoxicity in human liver HepG2 cells

scientific article published on 14 February 2013

A combined mathematical model linking the formation of amorphous solid dispersions with hot-melt-extrusion process parameters

scientific article published on 19 September 2018

A potentiometric titration method for the crystallization of drug-like organic molecules

scientific article published on 21 May 2007

An Impedance-Based Method to Determine Reconstitution Time for Freeze-Dried Pharmaceuticals

scientific article published on 8 April 2015

Application of the extended clearance concept classification system (ECCCS) to predict the victim drug-drug interaction potential of statins

scientific article

Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors

scientific article

Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists

scientific article published on 24 January 2006

Assessing the Risk of Drug-Induced Cholestasis Using Unbound Intrahepatic Concentrations

scientific article

Be Aggressive! Amorphous Excipients Enabling Single-Step Freeze-Drying of Monoclonal Antibody Formulations

scientific article published on 17 November 2019

Biocompatible polymer-Peptide hybrid-based DNA nanoparticles for gene delivery.

scientific article published on 5 May 2015

Bioinspired Molecular Factories with Architecture and In Vivo Functionalities as Cell Mimics

scientific article published on 09 January 2020

Biomimetic artificial organelles with in vitro and in vivo activity triggered by reduction in microenvironment.

scientific article published on 19 March 2018

Brain drug delivery of small molecules using immunoliposomes

scientific article

By-passing of P-glycoprotein using immunoliposomes

scientific article

Characterization of Surface Properties of Glass Vials Used as Primary Packaging Material for Parenterals

scientific article published on 10 January 2018

Characterization of new functionalized calcium carbonate-polycaprolactone composite material for application in geometry-constrained drug release formulation development

scientific article published on 8 May 2017

CombiCap: A novel drug formulation for the basel phenotyping cocktail

scientific article published on 23 August 2016

Combinatorial QSAR modeling of human intestinal absorption

scientific article published on 29 December 2010

Compaction of functionalized calcium carbonate, a porous and crystalline microparticulate material with a lamellar surface

scientific article published on 12 March 2014

Comparative Evaluation of Two Methods for Preparative Fractionation of Proteinaceous Subvisible Particles--Differential Centrifugation and FACS.

scientific article

Comparative safety evaluation of silica-based particles.

scientific article published on 3 October 2015

Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery

scientific article published in April 2003

Computational aqueous solubility prediction for drug-like compounds in congeneric series

scientific article published on 06 May 2007

Computational prediction of blood-brain barrier permeability using decision tree induction.

scientific article published on 31 August 2012

Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations

scientific article published on 3 April 2017

Cytokine signaling in the human brain capillary endothelial cell line hCMEC/D3.

scientific article published on 6 August 2010

Design, Synthesis, and Characterization of a Paclitaxel Formulation Activated by Extracellular MMP9

scientific article published on 10 January 2020

Determination of the Density of Protein Particles Using a Suspended Microchannel Resonator

scientific article published on 07 September 2015

Development and validation of a liquid chromatography and ion spray tandem mass spectrometry method for the quantification of artesunate, artemether and their major metabolites dihydroartemisinin and dihydroartemisinin-glucuronide in sheep plasma.

scientific article

Development and validation of a liquid chromatography/mass spectrometry method for pharmacokinetic studies of OZ78, a fasciocidal drug candidate

scientific article published on 21 August 2010

Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots

scientific article published on 22 October 2015

Directing Nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake.

scientific article published on 10 January 2018

Discovery of potent and selective histamine H3 receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold

scientific article published on 6 August 2010

Drug interaction potential of resveratrol.

scientific article published on August 2012

Drug loading into porous calcium carbonate microparticles by solvent evaporation

scientific article published on 22 February 2014

Drug targeting using OX7-immunoliposomes: correlation between Thy1.1 antigen expression and tissue distribution in the rat

scientific article published on 01 February 2008

Drug transport to brain with targeted liposomes

scientific article

Duloxetine inhibits effects of MDMA ("ecstasy") in vitro and in humans in a randomized placebo-controlled laboratory study

scientific article

Effects of ivermectin and oxantel pamoate on tribendimidine: and drug-drug interaction study

scientific article published on 21 December 2018

Efficacy and Safety of Ivermectin Against Trichuris trichiura in Preschool- and School-Aged Children: A Randomized Controlled Dose-Finding Trial

scientific article published on 30 March 2018

Efficacy and Safety of Moxidectin, Synriam, Synriam-Praziquantel versus Praziquantel against Schistosoma haematobium and S. mansoni Infections: A Randomized, Exploratory Phase 2 Trial

scientific article

Efficacy and pharmacokinetics of OZ78 and MT04 against a natural infection with Fasciola hepatica in sheep

scientific article published on 14 August 2013

Efficacy and safety of albendazole plus ivermectin, albendazole plus mebendazole, albendazole plus oxantel pamoate, and mebendazole alone against Trichuris trichiura and concomitant soil-transmitted helminth infections: a four-arm, randomised contro

scientific article

Efficacy and safety of oxantel pamoate in school-aged children infected with Trichuris trichiura on Pemba Island, Tanzania: a parallel, randomised, controlled, dose-ranging study

scientific article published on 17 September 2015

Efficacy and safety of tribendimidine, tribendimidine plus ivermectin, tribendimidine plus oxantel pamoate, and albendazole plus oxantel pamoate against hookworm and concomitant soil-transmitted helminth infections in Tanzania and Côte d'Ivoire: a r

scientific article published on 29 August 2017

Efficacy and tolerability of moxidectin alone and in co-administration with albendazole and tribendimidine versus albendazole plus oxantel pamoate against Trichuris trichiura infections: a randomised, non-inferiority, single-blind trial

scientific article published on 29 May 2018

Efficacy and tolerability of triple drug therapy with albendazole, pyrantel pamoate, and oxantel pamoate compared with albendazole plus oxantel pamoate, pyrantel pamoate plus oxantel pamoate, and mebendazole plus pyrantel pamoate and oxantel pamoate

scientific article

Efficacy of moxidectin versus ivermectin against Strongyloides stercoralis infections: a randomized controlled non-inferiority trial

scientific article

Efficacy, safety and pharmacokinetics of 1,2,4-trioxolane OZ78 against an experimental infection with Fasciola hepatica in sheep

scientific article published on 25 June 2010

Engineered nanomaterial uptake and tissue distribution: from cell to organism

scientific article

Evaluation of Glass Delamination Risk in Pharmaceutical 10 mL/10R Vials

scientific article

Evaluation of the NR2B-selective NMDA receptor antagonist Ro 63-1908 on rodent behaviour: evidence for an involvement of NR2B NMDA receptors in response inhibition

scientific article published in March 2003

Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with Fasciola hepatica

scientific article

Excipients for Room Temperature Stable Freeze-Dried Monoclonal Antibody Formulations

scientific article published on 14 October 2019

Exposure to the chlorofluorocarbon substitute 2,2-dichloro-1,1,1- trifluoroethane and the anesthetic agent halothane is associated with transient protein adduct formation in the heart

scientific article published in May 1992

Extensive Chemical Modifications in the Primary Protein Structure of IgG1 Subvisible Particles Are Necessary for Breaking Immune Tolerance.

scientific article

Factors Governing the Accuracy of Subvisible Particle Counting Methods

scientific article published on 8 June 2016

Factors Governing the Precision of Subvisible Particle Measurement Methods - A Case Study with a Low-Concentration Therapeutic Protein Product in a Prefilled Syringe.

scientific article published on 16 October 2015

Floating gastroretentive drug delivery systems: Comparison of experimental and simulated dissolution profiles and floatation behavior

scientific article published on 02 April 2014

Functionalized calcium carbonate as a novel pharmaceutical excipient for the preparation of orally dispersible tablets

scientific article

Functionalized calcium carbonate microparticles for the delivery of proteins

scientific article

Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro

scientific article published in June 1992

Hepatocyte targeting using pegylated asialofetuin-conjugated liposomes

scientific article published on 13 December 2013

High-throughput viscosity measurement using capillary electrophoresis instrumentation and its application to protein formulation

scientific article published on 14 July 2014

Human cytokines activate JAK-STAT signaling pathway in porcine ocular tissue

scientific article

Imaging Techniques to Characterize Cake Appearance of Freeze-Dried Products

scientific article published on 10 July 2018

Immobilization of Enzymes on PLGA Sub-Micrometer Particles by Crosslinked Layer-by-Layer Deposition

scientific article published on 07 April 2017

Immunoliposome targeting to mesangial cells: a promising strategy for specific drug delivery to the kidney

scientific article published on 21 September 2005

Impact of Insoluble Separation Layer Mechanical Properties on Disintegration and Dissolution Kinetics of Multilayer Tablets

scientific article published on 29 May 2020

Impact of Solutol HS 15 on the pharmacokinetic behaviour of colchicine upon intravenous administration to male Wistar rats

scientific article published on 01 May 2003

Impact of Vial Capping on Residual Seal Force and Container Closure Integrity.

scientific article

Impact of Vial Washing and Depyrogenation on Surface Properties and Delamination Risk of Glass Vials

scientific article published on 23 May 2018

Impact of dextran on thermal properties, product quality attributes, and monoclonal antibody stability in freeze-dried formulations

scientific article published on 19 December 2019

Impact of non-ideal analyte behavior on the separation of protein aggregates by asymmetric flow field-flow fractionation.

scientific article published on 25 April 2018

Improved oral bioavailability of cyclosporin A in male Wistar rats. Comparison of a Solutol HS 15 containing self-dispersing formulation and a microsuspension

scientific article published in October 2002

In Vivo Stability of Therapeutic Proteins

scientific article published on 03 January 2020

In silico and in vitro methods to optimize the performance of experimental gastroretentive floating mini-tablets

scientific article published on 26 August 2015

In silico prediction of brain and CSF permeation of small molecules using PLS regression models

scientific article published on 26 November 2007

In vitro assessment of the formation of ceftriaxone-calcium precipitates in human plasma

scientific article published on 19 January 2011

In vitro characterization and mouthfeel study of functionalized calcium carbonate in orally disintegrating tablets

scientific article

In vitro-in vivo extrapolation method to predict human renal clearance of drugs.

scientific article published on 13 January 2014

Induction of cytochrome P450 3A4 and P-glycoprotein by the isoxazolyl-penicillin antibiotic flucloxacillin

scientific article published in February 2006

Influence of Different Container Closure Systems and Capping Process Parameters on Product Quality and Container Closure Integrity (CCI) in GMP Drug Product Manufacturing

scientific article published on 21 January 2016

Insights into possibilities for grouping and read-across for nanomaterials in EU chemicals legislation

scientific article published on 05 September 2018

Interaction of the antiviral drug telaprevir with renal and hepatic drug transporters

scientific article

Interactions between silica nanoparticles and phospholipid membranes

scientific article published on 24 June 2016

LC-MS/MS method for the determination of two metabolites of tribendimidine, deacylated amidantel and its acetylated metabolite in plasma, blood and dried blood spots.

scientific article

Leukotriene B4 formation upon halothane-induced lipid peroxidation in liver membrane fractions under low O2 concentrations in vitro

scientific article published in January 1994

Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery

scientific article published on 02 April 2019

Loading of Porous Functionalized Calcium Carbonate Microparticles: Distribution Analysis with Focused Ion Beam Electron Microscopy and Mercury Porosimetry

scientific article published on 15 January 2019

Low volume aseptic filling: Impact of pump systems on shear stress

scientific article published on 10 December 2019

Marker-ion analysis for quantification of mucoadhesivity of microparticles in particle-retention assays.

scientific article published on 13 April 2015

Measuring Subvisible Particles in Protein Formulations Using a Modified Light Obscuration Sensor with Improved Detection Capabilities

scientific article published on 02 June 2015

Measuring tissue back-pressure--in vivo injection forces during subcutaneous injection

scientific article

Mechanisms of halothane toxicity: novel insights

scientific article published on January 1993

Mechanisms of increased bioavailability through amorphous solid dispersions: a review

scientific article published on 01 December 2020

Mechanistic insights into effect of surfactants on oral bioavailability of amorphous solid dispersions

scientific article published on 21 January 2020

Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1-(4-fluorophenyl)-2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases

scientific article published on 2 February 2015

Microdosed midazolam for the determination of cytochrome P450 3A activity: Development and clinical evaluation of a buccal film

scientific article published on 16 May 2019

Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces

scholarly article by Reiji Yokoyama et al published 3 December 2018 in Pharmaceutics

Modulation of transendothelial permeability and expression of ATP-binding cassette transporters in cultured brain capillary endothelial cells by astrocytic factors and cell-culture conditions

scientific article published on 12 September 2003

Mucoadhesive microparticles for local treatment of gastrointestinal diseases

scientific article published on 11 June 2016

Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications

scientific article published on 26 December 2014

New IVIVE method for the prediction of total human clearance and relative elimination pathway contributions from in vitro hepatocyte and microsome data.

scientific article

New Processes for Freeze-Drying in Dual-Chamber Systems

scientific article published on 9 February 2016

On-line identification of P-glycoprotein substrates by monitoring of extracellular acidification and respiration rates in living cells.

scientific article published on 22 March 2011

Optimization-by-design of hepatotropic lipid nanoparticles targeting the sodium-taurocholate cotransporting polypeptide

scientific article published on 23 July 2019

Oral delivery of vancomycin by tetraether lipid liposomes.

scientific article published on 14 July 2017

Oxantel pamoate-albendazole for Trichuris trichiura infection

scientific article

PDMS-b-PMOXA polymersomes for hepatocyte targeting and assessment of toxicity.

scientific article published on 15 July 2017

PEG-PCL-based nanomedicines: A biodegradable drug delivery system and its application.

scientific article published on 20 May 2017

Pediatric Dispersible Tablets: a Modular Approach for Rapid Prototyping

scientific article published on June 2016

Pharmacokinetic Study of Praziquantel Enantiomers and Its Main Metabolite R-trans-4-OH-PZQ in Plasma, Blood and Dried Blood Spots in Opisthorchis viverrini-Infected Patients

scientific article

Pharmacokinetics and phenotyping properties of the Basel phenotyping cocktail combination capsule in healthy male adults

scientific article published on 12 December 2019

Pharmacokinetics of a Pediatric Tribendimidine Dose-Finding Study To Treat Hookworm Infection in African Children

scientific article published on 27 August 2018

Pharmacokinetics of the Antischistosomal Lead Ozonide OZ418 in Uninfected Mice Determined by Liquid Chromatography-Tandem Mass Spectrometry

scientific article published on 03 October 2016

Pharmacokinetics of the fasciocidal drug candidates MT04 and OZ78 in uninfected rats and in vitro pharmacodynamic studies

scientific article published on 14 April 2012

Pharmacological characterization of designer cathinones in vitro ⬇️

scientific article published on January 1, 2013

Poly(Sarcosine) Surface Modification Imparts Stealth-Like Properties to Liposomes

scientific article published on 13 November 2019

Polymersomes conjugated to 83-14 monoclonal antibodies: in vitro targeting of brain capillary endothelial cells

scientific article

Polymersomes containing quantum dots for cellular imaging

scientific article

Pooled Population Pharmacokinetic Analysis of Tribendimidine for the Treatment of Infections

scientific article published on 27 March 2019

Preclinical hazard evaluation strategy for nanomedicines

scientific article published on 05 September 2018

Prediction of organic anion-transporting polypeptide 1B1- and 1B3-mediated hepatic uptake of statins based on transporter protein expression and activity data

scientific article

Rapid and highly automated determination of morphine and morphine glucuronides in plasma by on-line solid-phase extraction and column liquid chromatography

scientific article published in December 1995

Rapid optimization of liposome characteristics using a combined microfluidics and design-of-experiment approach

article

Regulation of BCRP (ABCG2) and P-glycoprotein (ABCB1) by cytokines in a model of the human blood-brain barrier

scientific article

Report from the EPAA workshop: in vitro ADME in safety testing used by EPAA industry sectors.

scientific article published on 15 December 2010

Rheological characterization and injection forces of concentrated protein formulations: an alternative predictive model for non-Newtonian solutions

scientific article published on 18 February 2014

Scientific Basis for Regulatory Decision-Making of Nanomaterials Report on the Workshop, 20-21 January 2014, Center of Applied Ecotoxicology, Dübendorf

scientific article published in February 2015

Secreted Matrix Metalloproteinase-9 of Proliferating Smooth Muscle Cells as a Trigger for Drug Release from Stent Surface Polymers in Coronary Arteries

scientific article published on 30 May 2016

Selective Oxidation of Methionine and Tryptophan Residues in a Therapeutic IgG1 Molecule

scientific article published on 25 May 2015

Selective stimulation of the JAK/STAT signaling pathway by silica nanoparticles in human endothelial cells

scientific article

Shedding Light on Metal-Based Nanoparticles in Zebrafish by Computed Tomography with Micrometer Resolution

scientific article published on 22 June 2020

Single-Ascending-Dose Pharmacokinetic Study of Tribendimidine in Opisthorchis viverrini-Infected Patients

scientific article published on 18 July 2016

Single-step organic extraction of leukotrienes and related compounds and their simultaneous analysis by high-performance liquid chromatography

scientific article published in August 1990

Spontaneous In Situ Formation of Liposomes from Inert Porous Microparticles for Oral Drug Delivery

scientific article published on 15 August 2020

Stability investigation of FCC-based tablets for oral suspension with caffeine and oxantel pamoate as model drugs

scientific article published on 17 October 2018

Sterile Filtration of Highly Concentrated Protein Formulations: Impact of Protein Concentration, Formulation Composition, and Filter Material.

scientific article

Study of drug particle distributions within mini-tablets using synchrotron X-ray microtomography and superpixel image clustering

scientific article published on 19 November 2019

Subvisible Particulate Contamination in Cell Therapy Products-Can We Distinguish?

scientific article published on 12 September 2019

Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists

scientific article published on 21 October 2010

Targeting of daunomycin using biotinylated immunoliposomes: pharmacokinetics, tissue distribution and in vitro pharmacological effects

scientific article

Targeting of skeletal muscle in vitro using biotinylated immunoliposomes

scientific article published on January 2004

Targeting of the photocytotoxic compound AlPcS4 to Hela cells by transferrin conjugated PEG-liposomes

scientific article

Technology, Applications, and Process Challenges of Dual Chamber Systems

scientific article published on 13 January 2016

The Effect of Formulation, Process, and Method Variables on the Reconstitution Time in Dual Chamber Syringes

scientific article published in January 2016

The Pharmaceutical Capping Process-Correlation between Residual Seal Force, Torque Moment, and Flip-off Removal Force.

scientific article published on 21 January 2016

The kidney as a novel target tissue for protein adduct formation associated with metabolism of halothane and the candidate chlorofluorocarbon replacement 2,2-dichloro-1,1,1-trifluoroethane.

scientific article published in July 1992

The norepinephrine transporter inhibitor reboxetine reduces stimulant effects of MDMA ("ecstasy") in humans

scientific article (publication date: August 2011)

The pharmaceutical vial capping process: Container closure systems, capping equipment, regulatory framework, and seal quality tests

scientific article

The use of 4-Hexylresorcinol as antibiotic adjuvant

scientific article published on 22 September 2020

Transferrin-conjugated liposome targeting of photosensitizer AlPcS4 to rat bladder carcinoma cells.

scientific article published in November 2004

Transformation of 5-hydroperoxyeicosatetraenoic acid into dihydroxy- and cysteinyl-leukotrienes by rat hepatocytes: effects of glutathione ⬇️

scientific article published on March 1, 1991

Transport of clonidine across cultured brain microvessel endothelial cells ⬇️

scientific article published on July 1, 1997

Variable asialoglycoprotein receptor 1 expression in liver disease: Implications for therapeutic intervention.

scientific article

Zebrafish as a preclinical in vivo screening model for nanomedicines

scientific article published on 04 January 2019

Zebrafish as a predictive screening model to assess macrophage clearance of liposomes in vivo

scientific article published on 17 January 2019

Zebrafish as an early stage screening tool to study the systemic circulation of nanoparticulate drug delivery systems in vivo

scientific article published on 26 August 2017

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