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List of works by Oscar Llorca

3D architecture of DNA Pol α reveals the functional core of multi-subunit replicative polymerases

scientific article

3D structure of Syk kinase determined by single-particle electron microscopy

scientific article

3D structure of the C3bB complex provides insights into the activation and regulation of the complement alternative pathway convertase.

scholarly article

A humanized antibody that regulates the alternative pathway convertase: potential for therapy of renal disease associated with nephritic factors

scientific article

A novel antibody against human factor B that blocks formation of the C3bB proconvertase and inhibits complement activation in disease models.

scientific article

A physicochemical characterization of the interaction between DC-Chol/DOPE cationic liposomes and DNA.

scientific article

A theoretical and experimental approach to the compaction process of DNA by dioctadecyldimethylammonium bromide/zwitterionic mixed liposomes.

scientific article

ATP Binding Induces Large Conformational Changes in the Apical and Equatorial Domains of the Eukaryotic Chaperonin Containing TCP-1 Complex

scientific article published in Journal of Biological Chemistry

ATP hydrolysis induces an intermediate conformational state in GroEL

scientific article published on 01 January 1999

Addition of electrophilic lipids to actin alters filament structure.

scientific article published on 12 September 2006

Advances on the Structure of the R2TP/Prefoldin-like Complex

scientific article published on 01 January 2018

Aggregation phenomena on the ternary ionic-nonionic surfactant system: didodecyldimethylammonium bromide/octyl-beta-D-glucopyranoside/water. Mixed microaggregates, vesicles, and micelles

scientific article published on March 2005

Analysis of the interaction between the eukaryotic chaperonin CCT and its substrates actin and tubulin

scientific article (publication date: August 2001)

Architecture of the mycobacterial type VII secretion system

scientific article published on 09 October 2019

Architecture of the pontin/reptin complex, essential in the assembly of several macromolecular complexes

scientific article

Assembly and regulation of the membrane attack complex based on structures of C5b6 and sC5b9.

scientific article

Assembly of the asymmetric human γ-tubulin ring complex by RUVBL1-RUVBL2 AAA ATPase

scientific article published on 18 December 2020

Author Correction: RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

scientific article published in Nature Communications

Biochemical Characterization of Symmetric GroEL-GroES Complexes

scientific article published in Journal of Biological Chemistry

C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation

scientific article published on June 2013

Cationic prevesicle and vesicle nanoaggregates: an experimental and theoretical study

scientific article

Caveolar domain organization and trafficking is regulated by Abl kinases and mDia1.

scientific article published on 27 March 2012

Coexistence of closed and open conformations of complement factor B in the alternative pathway C3bB(Mg2+) proconvertase

scientific article published on 4 November 2009

Compaction process of calf thymus DNA by mixed cationic-zwitterionic liposomes: a physicochemical study.

scientific article published on 26 January 2008

Conformational Changes Generated in GroEL during ATP Hydrolysis as Seen by Time-resolved Infrared Spectroscopy

scientific article published in Journal of Biological Chemistry

Conformational changes in the GroEL oligomer during the functional cycle.

scientific article

Conformational rearrangements upon Syk auto-phosphorylation

scientific article

CryoEM of RUVBL1-RUVBL2-ZNHIT2, a complex that interacts with pre-mRNA-processing-splicing factor 8

scientific article published on 01 January 2022

Cyclopentenone prostaglandins with dienone structure promote cross-linking of the chemoresistance-inducing enzyme glutathione transferase P1-1.

scientific article published on 14 July 2010

Effects of the Inter-ring Communication in GroEL Structural and Functional Asymmetry

scientific article published in Journal of Biological Chemistry

Electrochemical, Microscopic, and Spectroscopic Characterization of Prevesicle Nanostructures and Vesicles on Mixed Cationic Surfactant Systems

scientific article published on 01 April 2006

Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA

scientific article published on 01 June 2003

Electron microscopy of Xrcc4 and the DNA ligase IV-Xrcc4 DNA repair complex.

scientific article published in December 2009

Electron microscopy studies on DNA recognition by DNA-PK.

scientific article

Energetics and geometry of FtsZ polymers: nucleated self-assembly of single protofilaments

scientific article

Eukaryotic chaperonin CCT stabilizes actin and tubulin folding intermediates in open quasi-native conformations

scientific article

Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies

scientific article

Flexible tethering of primase and DNA Pol in the eukaryotic primosome

Flexible tethering of primase and DNA Pol α in the eukaryotic primosome.

scientific article

Functional and structural characterization of four mouse monoclonal antibodies to complement C3 with potential therapeutic and diagnostic applications.

scientific article published on 13 January 2017

Global conformational rearrangements during the activation of the GDP/GTP exchange factor Vav3.

scientific article

GroEL under Heat-Shock

scientific article published in Journal of Biological Chemistry

HYDROMIC: prediction of hydrodynamic properties of rigid macromolecular structures obtained from electron microscopy images

scientific article published on 01 October 2001

How novel structures inform understanding of complement function

scientific article published on 14 August 2017

Human nonsense-mediated mRNA decay factor UPF2 interacts directly with eRF3 and the SURF complex

scientific article published on 5 January 2016

Ionic tethering contributes to the conformational stability and function of complement C3b.

scientific article published on 27 February 2017

Iterative elastic 3D-to-2D alignment method using normal modes for studying structural dynamics of large macromolecular complexes.

scientific article published on 6 February 2014

Lessons from functional and structural analyses of disease-associated genetic variants in the complement alternative pathway.

scientific article

Long Noncoding RNA NIHCOLE Promotes Ligation Efficiency of DNA Double-Strand Breaks in Hepatocellular Carcinoma

publication published on 28 July 2021

Modeling of a 14 kDa RUVBL2-Binding Domain with Medium Resolution Cryo-EM Density

scientific article published on 20 March 2020

Modulation of the chaperone DnaK allosterism by the nucleotide exchange factor GrpE.

scientific article published on 4 March 2015

Molecular architecture and structural transitions of a Clostridium thermocellum mini-cellulosome

scientific article published on 15 February 2011

Partial Occlusion of Both Cavities of the Eukaryotic Chaperonin with Antibody Has No Effect upon the Rates of β-Actin or α-Tubulin Folding

scientific article published in Journal of Biological Chemistry

Plasmid replication initiator RepB forms a hexamer reminiscent of ring helicases and has mobile nuclease domains

scientific article

Point mutations in a hinge linking the small and large domains of beta-actin result in trapped folding intermediates bound to cytosolic chaperonin CCT

scientific article (publication date: August 2001)

Prediction of the structure of GroES and its interaction with GroEL.

scientific article

RPAP3 C-Terminal Domain: A Conserved Domain for the Assembly of R2TP Co-Chaperone Complexes

scientific article published on 06 May 2020

RPAP3 provides a flexible scaffold for coupling HSP90 to the human R2TP co-chaperone complex

scientific article published on 16 April 2018

Reconstitution of the Escherichia coli cell division ZipA-FtsZ complexes in nanodiscs as revealed by electron microscopy.

scientific article published on 19 September 2012

Recurrent Germline DLST Mutations in Individuals with Multiple Pheochromocytomas and Paragangliomas

scientific article published on 28 March 2019

Regulation of RUVBL1-RUVBL2 AAA-ATPases by the nonsense-mediated mRNA decay factor DHX34, as evidenced by Cryo-EM

scientific article published on 18 November 2020

Role of the amino terminal domain in GroES oligomerization

scientific article published on 01 January 1997

Self-Organization of FtsZ Polymers in Solution Reveals Spacer Role of the Disordered C-Terminal Tail.

scientific article

Structural analysis of tobacco etch potyvirus HC-pro oligomers involved in aphid transmission.

scientific article published on March 2005

Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling

scientific article

Structural and functional characterization of an influenza virus RNA polymerase-genomic RNA complex

scientific article

Structural basis for the stabilization of the complement alternative pathway C3 convertase by properdin.

scientific article

Structural basis of Focal Adhesion Kinase activation on lipid membranes

scientific article published on 11 August 2020

Structural comparison of prokaryotic and eukaryotic chaperonins.

scientific article published in January 2001

Structural insights into nonsense-mediated mRNA decay (NMD) by electron microscopy ⬇️

scientific article published on October 23, 2012

Structural insights on complement activation.

scientific article published on 07 August 2015

Structural mechanism for regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP co-chaperone revealed by cryo-EM

scientific article published on 01 May 2019

Structural model for the mannose receptor family uncovered by electron microscopy of Endo180 and the mannose receptor

scientific article published in February 2006

Structural model of full-length human Ku70-Ku80 heterodimer and its recognition of DNA and DNA-PKcs

scientific article

Structural model of human endoglin, a transmembrane receptor responsible for hereditary hemorrhagic telangiectasia.

scientific article published on 12 October 2006

Structure of TOR and Its Complex with KOG1

scientific article published on 01 August 2007

Structure of Yin Yang 1 oligomers that cooperate with RuvBL1-RuvBL2 ATPases

scientific article

Structure of human complement C8, a precursor to membrane attack

scientific article

Structure of the Hsp110:Hsc70 nucleotide exchange machine

scientific article

Structure of the TELO2-TTI1-TTI2 complex and its function in TOR recruitment to the R2TP chaperone

scientific article

Structures of SMG1-UPFs complexes: SMG1 contributes to regulate UPF2-dependent activation of UPF1 in NMD.

scientific article

The 'sequential allosteric ring' mechanism in the eukaryotic chaperonin-assisted folding of actin and tubulin

scientific article

The AAA+ proteins Pontin and Reptin enter adult age: from understanding their basic biology to the identification of selective inhibitors

scientific article

The C-terminal SH3 domain contributes to the intramolecular inhibition of Vav family proteins

scientific article published on 15 April 2014

The RNA helicase DHX34 functions as a scaffold for SMG1-mediated UPF1 phosphorylation

scientific article

The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System

scientific article

The antibacterial cell division inhibitor PC190723 is an FtsZ polymer-stabilizing agent that induces filament assembly and condensation.

scientific article published on 8 March 2010

The cryo-EM structure of the UPF-EJC complex shows UPF1 poised toward the RNA 3' end.

scientific article

The formation of symmetrical GroEL-GroES complexes in the presence of ATP.

scientific article

The molecular and structural bases for the association of complement C3 mutations with atypical hemolytic uremic syndrome.

scientific article

The nonsense-mediated mRNA decay SMG-1 kinase is regulated by large-scale conformational changes controlled by SMG-8.

scientific article

The structures of cytosolic and plastid-located glutamine synthetases fromMedicago truncatulareveal a common and dynamic architecture

scientific article

The three-dimensional structure of an eukaryotic glutamine synthetase: Functional implications of its oligomeric structure

scientific article published on 21 June 2006

Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

Three-dimensional interplay among the ligand-binding domains of the urokinase-plasminogen-activator-receptor-associated protein, Endo180.

scientific article published on 4 July 2003

Three-dimensional model for the isolated recombinant influenza virus polymerase heterotrimer

scientific article published on 21 May 2007

Three-dimensional reconstruction of a recombinant influenza virus ribonucleoprotein particle

scientific article published on April 2001

Three-dimensional structure and regulation of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs).

scientific article published on February 2005

Topology of the components of the DNA packaging machinery in the phage phi29 prohead.

scientific article published in May 2000

Transition of human γ-tubulin ring complex into a closed conformation during microtubule nucleation

scientific article published on 02 February 2024

TubZ filament assembly dynamics requires the flexible C-terminal tail

scientific article

Unique structure of iC3b resolved at a resolution of 24 Å by 3D-electron microscopy

scientific article

Visualization of DNA-induced conformational changes in the DNA repair kinase DNA-PKcs

scientific article published on November 2003

pH-controlled quaternary states of hexameric DnaB helicase

scientific article published on 01 October 2000

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