Search filters

List of works by Francisco Sobrino

A DNA vaccine encoding foot-and-mouth disease virus B and T-cell epitopes targeted to class II swine leukocyte antigens protects pigs against viral challenge

scientific article published on 26 July 2011

A DNA vaccine expressing the E2 protein of classical swine fever virus elicits T cell responses that can prime for rapid antibody production and confer total protection upon viral challenge.

scientific article published on May 2005

A RT-PCR assay for the differential diagnosis of vesicular viral diseases of swine

scientific article published on 01 June 1998

A Single Dose of Dendrimer B2T Peptide Vaccine Partially Protects Pigs against Foot-and-Mouth Disease Virus Infection

scientific article published on 10 January 2020

A T-cell epitope on NS3 non-structural protein enhances the B and T cell responses elicited by dendrimeric constructions against CSFV in domestic pigs

scientific article published on 17 August 2012

A bivalent B-cell epitope dendrimer peptide can confer long-lasting immunity in swine against foot-and-mouth disease

scientific article published on 28 January 2020

A bivalent dendrimeric peptide bearing a T-cell epitope from foot-and-mouth disease virus protein 3A improves humoral response against classical swine fever virus.

scientific article published on 29 May 2017

A computer program for the design of PCR primers for diagnosis of highly variable genomes.

scientific article

A procedure for detecting selection in highly variable viral genomes: evidence of positive selection in antigenic regions of capsid protein VP1 of foot-and-mouth disease virus.

scientific article published in October 1998

A recombinant DNA vaccine protects mice deficient in the alpha/beta interferon receptor against lethal challenge with Usutu virus

scientific article published on 15 March 2016

A single amino acid substitution in nonstructural protein 3A can mediate adaptation of foot-and-mouth disease virus to the guinea pig.

scientific article published on April 2001

A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid lability and confer resistance to acid-dependent uncoating inhibition

scientific article

A single amino acid substitution in the capsid of foot-and-mouth disease virus can increase acid resistance

scientific article published on 22 December 2010

Acid-dependent viral entry.

scientific article published on 07 June 2012

Activation of peritoneal macrophages during the prediabetic phase in low-dose streptozotocin-treated mice

scientific article published on 01 July 1993

Allergen-dependent CD14 modulation and apoptosis in monocytes from allergic patients

scientific article published on 01 October 2003

An increase in acid resistance of foot-and-mouth disease virus capsid is mediated by a tyrosine replacement of the VP2 histidine previously associated with VP0 cleavage.

scientific article

Analysis of the B and T cell response in guinea pigs induced with recombinant vaccinia expressing foot-and-mouth disease virus structural proteins

scientific article published in January 1998

Analysis of the immune response against mixotope peptide libraries from a main antigenic site of foot-and-mouth disease virus

scientific article published in April 2005

Antigenic specificity of porcine T cell response against foot-and-mouth disease virus structural proteins: identification of T helper epitopes in VP1.

scientific article

Association of Porcine Swine Leukocyte Antigen (SLA) Haplotypes with B- and T-Cell Immune Response to Foot-and-Mouth Disease Virus (FMDV) Peptides

scientific article published on 08 September 2020

Association of bovine DRB3 alleles with immune response to FMDV peptides and protection against viral challenge

article

Attenuated Foot-and-Mouth Disease Virus RNA Carrying a Deletion in the 3' Noncoding Region Can Elicit Immunity in Swine

scientific article

B epitope multiplicity and B/T epitope orientation influence immunogenicity of foot-and-mouth disease peptide vaccines

scientific article published on 03 December 2013

Cell density-dependent expression of viral antigens during persistence of foot-and-mouth disease virus in cell culture

scientific article

Characterization of Calcineurin in Human Neutrophils

scientific article published in Journal of Biological Chemistry

Characterization of a nuclear localization signal in the foot-and-mouth disease virus polymerase

scientific article published on 22 July 2013

Combined administration of synthetic RNA and a conventional vaccine improves immune responses and protection against foot-and-mouth disease virus in swine.

scientific article published on 15 March 2017

Contribution of a Multifunctional Polymerase Region of Foot-and-Mouth Disease Virus to Lethal Mutagenesis

scientific article published on 26 September 2018

Cyclosporin A antagonizes phenylephrine, oxytocin and angiotensin effects on glucose metabolism in rat thymus lymphocytes.

scientific article

DNA immunization of pigs with foot-and-mouth disease virus minigenes: from partial protection to disease exacerbation

scientific article published on 17 February 2011

DNA immunization with 2C FMDV non-structural protein reveals the presence of an immunodominant CD8+, CTL epitope for Balb/c mice

scientific article published on 21 July 2006

DNA vaccines expressing B and T cell epitopes can protect mice from FMDV infection in the absence of specific humoral responses

article

Delivery of synthetic RNA can enhance the immunogenicity of vaccines against foot-and-mouth disease virus (FMDV) in mice

scientific article published on 13 July 2013

Dendrimeric peptides can confer protection against foot-and-mouth disease virus in cattle.

scientific article published on 26 September 2017

Dendritic cell internalization of foot-and-mouth disease virus: influence of heparan sulfate binding on virus uptake and induction of the immune response

scientific article

Design and construction of African swine fever virus chimeras incorporating foreign viral epitopes.

scientific article published on January 1999

Designing Functionally Versatile, Highly Immunogenic Peptide-Based Multiepitopic Vaccines against Foot-and-Mouth Disease Virus

scientific article published on 22 July 2020

Different signaling pathways inhibit DNA methylation activity and up-regulate IFN- in human lymphocytes

scientific article published on 4 October 2005

Differential distribution of non-structural proteins of foot-and-mouth disease virus in BHK-21 cells

scientific article published on 19 April 2006

Discriminating foot-and-mouth disease virus-infected and vaccinated animals by use of beta-galactosidase allosteric biosensors.

scientific article published on 24 June 2009

Effect of thimerosal and other sulfhydryl reagents on calcium permeability in thymus lymphocytes

scientific article published in January 1995

Elevated secretion of myeloperoxidase by neutrophils from asthmatic patients: the effect of immunotherapy.

scientific article published in April 2001

Enhanced mucosal immunoglobulin A response and solid protection against foot-and-mouth disease virus challenge induced by a novel dendrimeric peptide.

scientific article

Enhanced response to antibody binding in engineered beta-galactosidase enzymatic sensors.

scientific article

Enhancement of Antigen-specific functional responses by neutrophils from allergic patients.

scientific article published on June 1996

Equine Rhinitis A Virus Mutants with Altered Acid Resistance Unveil a Key Role of VP3 and Intrasubunit Interactions in the Control of the pH Stability of the Aphthovirus Capsid.

scientific article

Estimates by computer simulation of genetic distances from comparisons of RNAse A mismatch cleavage patterns

article

Evidence of the coevolution of antigenicity and host cell tropism of foot-and-mouth disease virus in vivo

scientific article

Evolution of foot-and-mouth disease virus

scientific article

Exploring IRES region accessibility by interference of foot-and-mouth disease virus infectivity

scientific article

Expression of the transcription factor NFAT2 in human neutrophils: IgE-dependent, Ca2+- and calcineurin-mediated NFAT2 activation

scientific article published on 01 July 2007

First Complete Coding Sequence of a Spanish Isolate of Swine Vesicular Disease Virus

scientific article published on 3 March 2016

Foot-and-mouth disease virus

scientific article

Foot-and-mouth disease virus particles inactivated with binary ethylenimine are efficiently internalized into cultured cells.

scientific article published on 24 October 2011

Foot-and-mouth disease virus: biology and prospects for disease control

scientific article

Full protection of swine against foot-and-mouth disease by a bivalent B-cell epitope dendrimer peptide

scientific article published on 5 March 2016

Gene expression profiles in the cerebellum of transgenic mice over expressing the human FMR1 gene with CGG repeats in the normal range

scientific article published in March 2012

Genetic and phenotypic variability during replication of foot-and-mouth disease virus in swine

scientific article published on December 1990

Genomic and antigenic characterization of viruses from the 1993 Italian foot-and-mouth disease outbreak

article

Glucocorticoids inhibit fructose 2,6-bisphosphate synthesis in rat thymocytes. Opposite effect of cycloheximide

scientific article published on 01 January 1991

Guinea pig-adapted foot-and-mouth disease virus with altered receptor recognition can productively infect a natural host

scientific article published on 23 May 2007

Heme oxygenase-1 expression is down-regulated by angiotensin II and under hypertension in human neutrophils

scientific article published on 30 May 2008

Heterotypic inhibition of foot-and-mouth disease virus infection by combinations of RNA transcripts corresponding to the 5' and 3' regions

scientific article

Hormonal regulation of fructose 2,6-bisphosphate levels in epididymal adipose tissue of rat

scientific article published on 01 March 1985

Host sphingomyelin increases West Nile virus infection in vivo

scientific article published on 13 January 2016

Human neutrophils synthesize IL-8 in an IgE-mediated activation.

scientific article

Identification of T-cell epitopes in nonstructural proteins of foot-and-mouth disease virus.

scientific article published on April 2001

IgE-dependent release of myeloperoxidase by neutrophils from allergic patients

scientific article published on 01 June 2001

IgE-mediated downregulation of L-selectin (CD62L) on lymphocytes from asthmatic patients

scientific article published on 01 February 2001

Immune Response and Partial Protection against Heterologous Foot-and-Mouth Disease Virus Induced by Dendrimer Peptides in Cattle.

scientific article published on 18 April 2018

Immunogenicity and T cell recognition in swine of foot-and-mouth disease virus polymerase 3D.

scientific article published in May 2004

Immunomodulatory effect of swine CCL20 chemokine in DNA vaccination against CSFV.

scientific article published on 26 May 2011

Inclusion of a specific T cell epitope increases the protection conferred against foot-and-mouth disease virus in pigs by a linear peptide containing an immunodominant B cell site

scientific article

Inhibition of Porcine Viruses by Different Cell-Targeted Antiviral Drugs

scientific article published on 14 August 2019

Inhibition of enveloped virus infection of cultured cells by valproic acid

scientific article

Inhibition of herpes virus infection in oligodendrocyte cultured cells by valproic acid

scientific article published on 21 January 2016

Inhibition of multiplication of the prototypic arenavirus LCMV by valproic acid.

scientific article published on 2 June 2013

Inhibitory effect of albumin-derived advanced glycosylation products on PMA-induced superoxide anion production by rat macrophages

scientific article published on 01 January 1997

Innate immune sensor LGP2 is cleaved by the Leader protease of foot-and-mouth disease virus

scientific article published on 29 June 2018

Inoculation of newborn mice with non-coding regions of foot-and-mouth disease virus RNA can induce a rapid, solid and wide-range protection against viral infection.

scientific article published on 13 October 2011

Intermediate alleles at the FRAXA and FRAXE loci in Parkinson's disease

scientific article published on 22 January 2011

Internalization of swine vesicular disease virus into cultured cells: a comparative study with foot-and-mouth disease virus.

scientific article

Interspecies major histocompatibility complex-restricted Th cell epitope on foot-and-mouth disease virus capsid protein VP4.

scientific article

MDA5 cleavage by the Leader protease of foot-and-mouth disease virus reveals its pleiotropic effect against the host antiviral response

scientific article published on 02 September 2020

Macrophage inducible nitric oxide synthase gene expression is blocked by a benzothiophene derivative with anti-HIV properties.

scientific article

Membrane topology and cellular dynamics of foot-and-mouth disease virus 3A protein

scientific article published on 2 October 2014

Methylation-dependent gene silencing induced by interleukin 1beta via nitric oxide production

scientific journal article

Modification of the Host Cell Lipid Metabolism Induced by Hypolipidemic Drugs Targeting the Acetyl Coenzyme A Carboxylase Impairs West Nile Virus Replication

scientific article published on 26 October 2015

Modulation of IgE-dependent COX-2 gene expression by reactive oxygen species in human neutrophils.

scientific article

Modulation of foot-and-mouth disease virus pH threshold for uncoating correlates with differential sensitivity to inhibition of cellular Rab GTPases and decreases infectivity in vivo.

scientific article

Modulation of phorbol ester-induced respiratory burst by vanadate, genistein, and phenylarsine oxide in mouse macrophages

scientific article published in February 1995

Molecular epidemiology of classical swine fever in Cuba.

scientific article published on October 1999

Multifunctionality of a picornavirus polymerase domain: nuclear localization signal and nucleotide recognition

scientific article published on 22 April 2015

Mutations that hamper dimerization of foot-and-mouth disease virus 3A protein are detrimental for infectivity

scientific article

NO induces a cGMP-independent release of cytochrome c from mitochondria which precedes caspase 3 activation in insulin producing RINm5F cells.

scientific article published on October 1999

Negatively charged amino acids at the foot-and-mouth disease virus capsid reduce the virion-destabilizing effect of viral RNA at acidic pH

scientific article published on 03 February 2020

Nicotinamide inhibits inducible nitric oxide synthase enzyme activity in macrophages by allowing nitric oxide to inhibit its own formation

scientific article published on 01 January 1997

Nitric oxide and superoxide anion production decrease with age in resident and activated rat peritoneal macrophages

scientific article published on 01 April 1996

Nitric oxide-induced carbonylation of Bcl-2, GAPDH and ANT precedes apoptotic events in insulin-secreting RINm5F cells.

scientific article published in February 2004

Origin and evolution of viruses causing classical swine fever in Cuba.

scientific article

Oxidative stress is a critical mediator of the angiotensin II signal in human neutrophils: involvement of mitogen-activated protein kinase, calcineurin, and the transcription factor NF-kappaB.

scientific article published on 27 March 2003

Partial protection against classical swine fever virus elicited by dendrimeric vaccine-candidate peptides in domestic pigs

scientific article published on 13 April 2011

Peptide vaccine candidates against classical swine fever virus: T cell and neutralizing antibody responses of dendrimers displaying E2 and NS2-3 epitopes

scientific article published on 2 September 2010

Peptides Interfering 3A Protein Dimerization Decrease FMDV Multiplication

scientific article published on 27 October 2015

Phenylarsine Oxide Increases Intracellular Calcium Mobility and Inhibits Ca2+-Dependent ATPase Activity in Thymocytes

scientific article published in November 1999

Plasma membrane phosphatidylinositol 4,5 bisphosphate is required for internalization of foot-and-mouth disease virus and vesicular stomatitis virus

scientific article

Preserved immunogenicity of an inactivated vaccine based on foot-and-mouth disease virus particles with improved stability.

scientific article published on 30 March 2017

Primer design for specific diagnosis by PCR of highly variable RNA viruses: typing of foot-and-mouth disease virus

scientific article published in July 1992

Productive entry of type C foot-and-mouth disease virus into susceptible cultured cells requires clathrin and is dependent on the presence of plasma membrane cholesterol

scientific article published on 21 August 2007

Protection against Rift Valley fever virus infection in mice upon administration of interferon-inducing RNA transcripts from the FMDV genome

scientific article published on 25 June 2014

Protection against West Nile virus infection in mice after inoculation with type I interferon-inducing RNA transcripts.

scientific article

Protection of a single dose west nile virus recombinant subviral particle vaccine against lineage 1 or 2 strains and analysis of the cross-reactivity with Usutu virus

scientific article

RNA immunization can protect mice against foot-and-mouth disease virus

article by Miguel Rodríguez Pulido et al published March 2010 in Antiviral Research

RNA structural domains in noncoding regions of the foot-and-mouth disease virus genome trigger innate immunity in porcine cells and mice

scientific article published on 27 April 2011

Raccoons (Procyon lotor) in the Madrid region of Spain are carriers of antimicrobial-resistant Escherichia coli and enteropathogenic E. coli

scientific article published on 23 November 2020

Rational dissection of binding surfaces for mimicking of discontinuous antigenic sites.

scientific article

Recent advances in the development of recombinant vaccines against classical swine fever virus: cellular responses also play a role in protection

scientific article published on 04 September 2007

Recombinant viruses expressing the foot-and-mouth disease virus capsid precursor polypeptide (P1) induce cellular but not humoral antiviral immunity and partial protection in pigs

scientific article published in June 1999

Recovery of infectious foot-and-mouth disease virus from suckling mice after direct inoculation with in vitro-transcribed RNA.

scientific article

Respiratory burst in neutrophils from asthmatic patients.

scientific article published in October 2002

Response to retreatment with interferon-alpha plus ribavirin in chronic hepatitis C patients is independent of the NS5A gene nucleotide sequence

scientific article published in September 1999

Skewed X inactivation of the normal allele in fully mutated female carriers determines the levels of FMRP in blood and the fragile X phenotype

scientific article published in January 2005

Sodium nitroprusside-induced mitochondrial apoptotic events in insulin-secreting RINm5F cells are associated with MAP kinases activation.

scientific article

Specific allergens enhance elastase release in stimulated neutrophils from asthmatic patients

scientific article published on 01 July 2003

Stable expression of antisense RNAs targeted to the 5' non-coding region confers heterotypic inhibition to foot-and-mouth disease virus infection

scientific article published on February 2003

Stimulators of AMP-activated protein kinase inhibit the respiratory burst in human neutrophils.

scientific article

Streptozotocin-induced diabetes increases fructose 2,6-bisphosphate levels and glucose metabolism in rat macrophages.

scientific article published in December 1993

Subcellular distribution of swine vesicular disease virus proteins and alterations induced in infected cells: a comparative study with foot-and-mouth disease virus and vesicular stomatitis virus

scientific article published on 14 February 2008

Susceptibility to viral infection is enhanced by stable expression of 3A or 3AB proteins from foot-and-mouth disease virus

scientific article

Synthetic RNAs Mimicking Structural Domains in the Foot-and-Mouth Disease Virus Genome Elicit a Broad Innate Immune Response in Porcine Cells Triggered by RIG-I and TLR Activation

scientific article published on 17 July 2015

Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models

scientific article published on 01 January 2019

The Amino Acid Substitution Q65H in the 2C Protein of Swine Vesicular Disease Virus Confers Resistance to Golgi Disrupting Drugs.

scientific article published on 27 April 2016

The composition of West Nile virus lipid envelope unveils a role of sphingolipid metabolism in flavivirus biogenesis.

scientific article

The pH Stability of Foot-and-Mouth Disease Virus Particles Is Modulated by Residues Located at the Pentameric Interface and in the N Terminus of VP1.

scientific article

Tolerance to mutations in the foot-and-mouth disease virus integrin-binding RGD region is different in cultured cells and in vivo and depends on the capsid sequence context

scientific article published on October 2008

Towards a multi-site synthetic vaccine to foot-and-mouth disease: addition of discontinuous site peptide mimic increases the neutralization response in immunized animals

article

Transcription of liver X receptor is down-regulated by 15-deoxy-Δ(12,14)-prostaglandin J(2) through oxidative stress in human neutrophils

scientific article

p53 transactivation of the HIV-1 long terminal repeat is blocked by PD 144795, a calcineurin-inhibitor with anti-HIV properties.

scientific article published on March 1998

β-Naphthylamine induces anion superoxide production in rat peritoneal macrophages ⬇️

scientific article published on April 15, 1992

Paulina is supported by:

About Paulina

Help