List of works - Charles R. Mackay

A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout

scientific article published on June 2015

A fully humanized IgG-like bispecific antibody for effective dual targeting of CXCR3 and CCR6.

scientific article

A fundamental role for interleukin-21 in the generation of T follicular helper cells

scientific article

A large proportion of bovine T cells express the gamma delta T cell receptor and show a distinct tissue distribution and surface phenotype

scientific article published on 01 January 1989

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion

scientific article

Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges.

scientific article published on 11 July 2016

B-Cell cross-presentation of autologous antigen precipitates diabetes. Diabetes 2012;61:2893–2905.

scientific article published on 17 January 2013

B-cell cross-presentation of autologous antigen precipitates diabetes.

scientific article

BAFF and MyD88 signals promote a lupuslike disease independent of T cells

scientific article

BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice

scientific article published on 16 February 2014

BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders

scientific article published on 01 October 2005

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis

scientific article published on 11 December 2017

CXCR3⁺CCR5⁺ T cells and autoimmune diseases: guilty as charged?

scientific article

CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses

scientific article published on 6 April 2011

Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control.

scientific article published on 26 September 2011

Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice.

scientific article

Clues to asthma pathogenesis from microarray expression studies

scientific article

Commensal flora and the regulation of inflammatory and autoimmune responses.

scientific article published on 02 February 2011

Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microglia.

scientific article

Contribution of stromal cells to the migration, function and retention of plasma cells in human spleen: potential roles of CXCL12, IL-6 and CD54.

scientific article published in March 2005

Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2K(d) -specific CD8+ T cells

scientific article published on 29 November 2013

Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

scientific article published on 10 July 2019

Diet, gut microbiota and immune responses

scientific article

Diet, metabolites, and "western-lifestyle" inflammatory diseases

scientific article

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells.

scientific article published on 18 January 2017

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways.

scientific article published in June 2016

Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases

scientific article

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

scientific article published on 23 June 2015

Expression of human CD4 in transgenic mice does not confer sensitivity to human immunodeficiency virus infection

scientific article published in December 1992

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

scientific article published on 4 November 2016

Follicular B helper T cells in antibody responses and autoimmunity.

scientific article

G Protein-Coupled Receptor 43 Modulates Neutrophil Recruitment during Acute Inflammation

scientific article (publication date: 22 September 2016)

GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases

scientific article published on October 2015

Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody.

scientific article

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

scientific article published on 6 June 2016

Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses

scientific article published on 16 July 2009

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

scientific article

Gαs-coupled GPCRs GPR65 and GPR174. Downers for immune responses.

scientific article

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice.

scientific article

IL-21 enhances the potential of human γδ T cells to provide B-cell help

scientific article published on 12 December 2011

Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes

scientific article published on 21 June 2006

Inflammation and lymphopenia trigger autoimmunity by suppression of IL-2-controlled regulatory T cell and increase of IL-21-mediated effector T cell expansion.

scientific article published on 22 October 2014

Lineage specification and heterogeneity of T follicular helper cells

scientific article

MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

scientific article published on 01 June 2010

Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice

scientific article

Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

scientific article published on 24 March 2020

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.

scientific article published on April 2015

Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling

scientific article

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases.

scientific article published on January 2012

Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

scientific article published on 22 July 2019

Moving targets: cell migration inhibitors as new anti-inflammatory therapies

scientific article published on September 2008

Overlapping gene expression profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines interleukin-1 beta and tumor necrosis factor

scientific article

Polymorphism in the 5' regulatory region of the B-lymphocyte activating factor gene is associated with the Ro/La autoantibody response and serum BAFF levels in primary Sjogren's syndrome

scientific article published on 10 July 2008

Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1.

scientific article published on 12 February 2006

Protection against Nippostrongylus brasiliensis infection in mice is independent of GM-CSF

scientific article published on 16 August 2011

Rapid-onset clinical and mechanistic effects of anti-C5aR treatment in the mouse collagen-induced arthritis model

scientific article published on July 2014

Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice.

scientific article published on 26 November 2012

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

scientific journal article

Specific expression of GPR56 by human cytotoxic lymphocytes.

scientific article

Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.

scientific article

The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction.

scientific article

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

scientific article

The Role of Follicular Helper T Cell Molecules and Environmental Influences in Autoantibody Production and Progression to Inflammatory Arthritis in Mice

article

The functional plasticity of T cell subsets

scientific article

The nutrition-gut microbiome-physiology axis and allergic diseases.

scientific article published on July 2017

The role of short-chain fatty acids in health and disease.

scientific article

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

scientific article published on 23 July 2009

Therapeutic blockade of CXCR2 rapidly clears inflammation in arthritis and atopic dermatitis models: demonstration with surrogate and humanized antibodies

scientific article published on 01 January 2020

Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model

scientific article published on 27 April 2015

c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses

scientific article published on April 2017

List of works by Charles R. Mackay

A Role for Gut Microbiota and the Metabolite-Sensing Receptor GPR43 in a Murine Model of Gout

A fully humanized IgG-like bispecific antibody for effective dual targeting of CXCR3 and CCR6.

A fundamental role for interleukin-21 in the generation of T follicular helper cells

A large proportion of bovine T cells express the gamma delta T cell receptor and show a distinct tissue distribution and surface phenotype

An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion

Avenues to autoimmune arthritis triggered by diverse remote inflammatory challenges.

B-Cell cross-presentation of autologous antigen precipitates diabetes. Diabetes 2012;61:2893–2905.

B-cell cross-presentation of autologous antigen precipitates diabetes.

BAFF and MyD88 signals promote a lupuslike disease independent of T cells

BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice

BAFF-R, the major B cell-activating factor receptor, is expressed on most mature B cells and B-cell lymphoproliferative disorders

C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis

CXCR3⁺CCR5⁺ T cells and autoimmune diseases: guilty as charged?

CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses

Chemotherapy induces intratumoral expression of chemokines in cutaneous melanoma, favoring T-cell infiltration and tumor control.

Chlamydia muridarum lung infection in infants alters hematopoietic cells to promote allergic airway disease in mice.

Clues to asthma pathogenesis from microarray expression studies

Commensal flora and the regulation of inflammatory and autoimmune responses.

Complexity in human immunodeficiency virus type 1 (HIV-1) co-receptor usage: roles of CCR3 and CCR5 in HIV-1 infection of monocyte-derived macrophages and brain microglia.

Contribution of stromal cells to the migration, function and retention of plasma cells in human spleen: potential roles of CXCL12, IL-6 and CD54.

Cyclophosphamide treatment induces rejection of established P815 mastocytoma by enhancing CD4 priming and intratumoral infiltration of P1E/H-2K(d) -specific CD8+ T cells

Decreased maternal serum acetate and impaired fetal thymic and regulatory T cell development in preeclampsia

Diet, gut microbiota and immune responses

Diet, metabolites, and "western-lifestyle" inflammatory diseases

Diet-Derived Short Chain Fatty Acids Stimulate Intestinal Epithelial Cells To Induce Mucosal Tolerogenic Dendritic Cells.

Dietary Fiber and Bacterial SCFA Enhance Oral Tolerance and Protect against Food Allergy through Diverse Cellular Pathways.

Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases

Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites

Expression of human CD4 in transgenic mice does not confer sensitivity to human immunodeficiency virus infection

Fermentable carbohydrate stimulates FFAR2-dependent colonic PYY cell expansion to increase satiety

Follicular B helper T cells in antibody responses and autoimmunity.

G Protein-Coupled Receptor 43 Modulates Neutrophil Recruitment during Acute Inflammation

GPR43 - A Prototypic Metabolite Sensor Linking Metabolic and Inflammatory Diseases

Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody.

Genetic Coding Variant in GPR65 Alters Lysosomal pH and Links Lysosomal Dysfunction with Colitis Risk

Guidance of B cells by the orphan G protein-coupled receptor EBI2 shapes humoral immune responses

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Gαs-coupled GPCRs GPR65 and GPR174. Downers for immune responses.

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice.

IL-21 enhances the potential of human γδ T cells to provide B-cell help

Immune cell transcriptome datasets reveal novel leukocyte subset-specific genes and genes associated with allergic processes

Inflammation and lymphopenia trigger autoimmunity by suppression of IL-2-controlled regulatory T cell and increase of IL-21-mediated effector T cell expansion.

Lineage specification and heterogeneity of T follicular helper cells

MEDI-563, a humanized anti–IL-5 receptor α mAb with enhanced antibody-dependent cell-mediated cytotoxicity function

Macrophage migration inhibitory factor regulates neutrophil chemotactic responses in inflammatory arthritis in mice

Maternal carriage of Prevotella during pregnancy associates with protection against food allergy in the offspring

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome.

Mice deficient in GEM GTPase show abnormal glucose homeostasis due to defects in beta-cell calcium handling

Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases.

Microbiota-derived acetate protects against respiratory syncytial virus infection through a GPR43-type 1 interferon response

Moving targets: cell migration inhibitors as new anti-inflammatory therapies

Overlapping gene expression profiles in rheumatoid fibroblast-like synoviocytes induced by the proinflammatory cytokines interleukin-1 beta and tumor necrosis factor

Polymorphism in the 5' regulatory region of the B-lymphocyte activating factor gene is associated with the Ro/La autoantibody response and serum BAFF levels in primary Sjogren's syndrome

Positive regulation of immune cell function and inflammatory responses by phosphatase PAC-1.

Protection against Nippostrongylus brasiliensis infection in mice is independent of GM-CSF

Rapid-onset clinical and mechanistic effects of anti-C5aR treatment in the mouse collagen-induced arthritis model

Real-time interactive two-photon photoconversion of recirculating lymphocytes for discontinuous cell tracking in live adult mice.

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Specific expression of GPR56 by human cytotoxic lymphocytes.

Targeting dual-specificity phosphatases: manipulating MAP kinase signalling and immune responses.

The C5a receptor (C5aR) C5L2 is a modulator of C5aR-mediated signal transduction.

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

The Role of Follicular Helper T Cell Molecules and Environmental Influences in Autoantibody Production and Progression to Inflammatory Arthritis in Mice

The functional plasticity of T cell subsets

The nutrition-gut microbiome-physiology axis and allergic diseases.

The role of short-chain fatty acids in health and disease.

The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment

Therapeutic blockade of CXCR2 rapidly clears inflammation in arthritis and atopic dermatitis models: demonstration with surrogate and humanized antibodies

Treatment with anti-C5aR mAb leads to early-onset clinical and mechanistic effects in the murine delayed-type hypersensitivity arthritis model

c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody Responses