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List of works by Stefan Kubicek

A Domino 10-Step Total Synthesis of FR252921 and Its Analogues, Complex Macrocyclic Immunosuppressants

scientific article published on 22 August 2019

A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.

scientific article published on 21 June 2017

A cellular screen identifies ponatinib and pazopanib as inhibitors of necroptosis.

scientific article

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse

scientific article

A combinatorial screen of the CLOUD uncovers a synergy targeting the androgen receptor

scientific article published on 22 May 2017

A crack in histone lysine methylation.

scientific article

A histone-mimicking interdomain linker in a multidomain protein modulates multivalent histone binding.

scientific article published in September 2017

A kinase-independent role for CDK8 in BCR-ABL1+ leukemia

scientific article published on 18 October 2019

A selective inhibitor and probe of the cellular functions of Jumonji C domain-containing histone demethylases

scientific article

A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element

scientific article

A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs

scientific article published on 09 March 2020

Acquired nintedanib resistance in FGFR1-driven small cell lung cancer: role of endothelin-A receptor-activated ABCB1 expression

scientific article

An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation

scientific article published on 25 August 2021

An integrated chemical biology approach identifies specific vulnerability of Ewing's sarcoma to combined inhibition of Aurora kinases A and B.

scientific article published on 18 July 2011

Artemisinins Target GABAA Receptor Signaling and Impair α Cell Identity

scientific article

CDK6 Antagonizes p53-Induced Responses during Tumorigenesis

article

Cdk6 contributes to cytoskeletal stability in erythroid cells.

scientific article published on 2 March 2017

Cell-surface SLC nucleoside transporters and purine levels modulate BRD4-dependent chromatin states

scientific article published on 10 May 2021

Chromatin-targeting small molecules cause class-specific transcriptional changes in pancreatic endocrine cells.

scientific article published on 20 March 2012

Combined chemosensitivity and chromatin profiling prioritizes drug combinations in CLL

scientific article published on 28 January 2019

Connecting Small Molecules with Similar Assay Performance Profiles Leads to New Biological Hypotheses

scientific article

Consensus criteria for diagnosis, staging, and treatment response assessment of T-cell prolymphocytic leukemia

scientific article published on 10 July 2019

DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling

scientific article

Epigenome mapping reveals distinct modes of gene regulation and widespread enhancer reprogramming by the oncogenic fusion protein EWS-FLI1.

scientific article

Exploiting epigenetic vulnerabilities for cancer therapeutics

scientific article published on 12 February 2014

FASIL-MS: An Integrated Proteomic and Bioinformatic Workflow To Universally Quantitate In Vivo-Acetylated Positional Isomers.

scientific article published on 15 June 2016

First-in-human response of BCL-2 inhibitor venetoclax in T-cell prolymphocytic leukemia.

scientific article published on 27 September 2017

GW8510 increases insulin expression in pancreatic alpha cells through activation of p53 transcriptional activity

scientific article

Global survey of the immunomodulatory potential of common drugs.

scientific article

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions.

scientific article

Heterochromatin formation in Drosophila is initiated through active removal of H3K4 methylation by the LSD1 homolog SU(VAR)3-3

scientific article

High activation of STAT5A drives peripheral T-cell lymphoma and leukemia

scientific article published on 31 January 2020

Image-based ex-vivo drug screening for patients with aggressive haematological malignancies: interim results from a single-arm, open-label, pilot study

scientific article published on 15 November 2017

Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells

scientific journal article

Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells

scientific article published on 25 April 2024

MTHFD1 interaction with BRD4 links folate metabolism to transcriptional regulation

scientific article published on 27 May 2019

Mapping the Human Kinome in Response to DNA Damage

scientific article published on 01 January 2019

Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk

scientific article

Mapping the perturbome network of cellular perturbations

scientific article published on 13 November 2019

NOTCH1 activation in breast cancer confers sensitivity to inhibition of SUMOylation

scientific article published on 29 September 2014

New Rebek imide-type receptors for adenine featuring acetylene-linked pi-stacking platforms.

scientific article published on 10 June 2004

PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis

scientific article

Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6.

scientific article published on 20 April 2016

Partitioning and plasticity of repressive histone methylation states in mammalian chromatin

scientific article (publication date: December 2003)

Pdx1 is post-translationally modified in vivo and serine 61 is the principal site of phosphorylation

scientific article (publication date: 2012)

Pharmacologic inhibition of STAT5 in acute myeloid leukemia

scientific article published on 2 February 2018

Pharmacological treats for SUMO addicts

scientific article published on 24 January 2016

Pooled protein tagging, cellular imaging, and in situ sequencing for monitoring drug action in real time

scientific article published on 17 November 2020

Quantitative-proteomic comparison of alpha and Beta cells to uncover novel targets for lineage reprogramming

scientific article (publication date: 2014)

Recruitment of PRC1 function at the initiation of X inactivation independent of PRC2 and silencing

scientific article

Reduced histone biosynthesis and chromatin changes arising from a damage signal at telomeres ⬇️

scientific article published on October 3, 2010

Repair of UV-Induced DNA Damage Independent of Nucleotide Excision Repair Is Masked by MUTYH.

scientific article published in November 2017

Repression of p53 activity by Smyd2-mediated methylation

scientific article

Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase

scientific article

STAT5BN642H is a driver mutation for T cell neoplasia

scientific article published on 4 December 2017

Single-cell transcriptomes reveal characteristic features of human pancreatic islet cell types

scientific article published on 21 December 2015

Small-molecule inducers of insulin expression in pancreatic alpha-cells.

scientific article

Stimulating translational research: several European life science institutions put their heads together

scientific article published on 5 August 2015

Su(var) genes regulate the balance between euchromatin and heterochromatin in Drosophila

scientific article

Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin

scientific article (publication date: 15 July 2003)

Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers

scientific article published on 19 August 2019

TKI rotation-induced persistent deep molecular response in multi-resistant blast crisis of Ph+ CML

scientific article

Targeting a cell state common to triple-negative breast cancers

scientific article

The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease

The methyltransferase Setdb2 mediates virus-induced susceptibility to bacterial superinfection.

scientific article

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

scientific article published on 27 July 2014

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