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List of works by Patricia A. Bradford

A Standard Numbering Scheme for Class C β-Lactamases

scientific article published on 21 February 2020

A Systematic Approach to the Selection of the Appropriate Avibactam Concentration for Use with Ceftazidime in Broth Microdilution Susceptibility Testing

scientific article published on 26 June 2018

A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline

scientific article published on May 2005

AcrAB efflux pump plays a role in decreased susceptibility to tigecycline in Morganella morganii

scientific article published on February 2005

AcrAB multidrug efflux pump is associated with reduced levels of susceptibility to tigecycline (GAR-936) in Proteus mirabilis

scientific article

AdeABC multidrug efflux pump is associated with decreased susceptibility to tigecycline in Acinetobacter calcoaceticus–Acinetobacter baumannii complex

scientific article published on 15 March 2007

Antimicrobial Activity of Exebacase (Lysin CF-301) against the Most Common Causes of Infective Endocarditis

scientific article published on 23 September 2019

Carbapenem-resistant Escherichia coli harboring Klebsiella pneumoniae carbapenemase beta-lactamases associated with long-term care facilities

scientific article

Ceftriaxone-resistant salmonella infection acquired by a child from cattle

scientific article published on April 2000

Characterization and sequence analysis of extended-spectrum-{beta}-lactamase-encoding genes from Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis isolates collected during tigecycline phase 3 clinical trials

scientific article published on 17 November 2008

Characterization of expanded-spectrum cephalosporin resistance in E. coli isolates associated with bovine calf diarrhoeal disease

scientific article published on 01 November 1999

Characterization of β-Lactamase Content of Ceftazidime-Resistant Pathogens Recovered during the Pathogen-Directed Phase 3 REPRISE Trial for Ceftazidime-Avibactam: Correlation of Efficacy against β-Lactamase Producers

scientific article published on 24 May 2019

Comment on: Redefining extended-spectrum -lactamases: balancing science and clinical need

scientific article published on 24 March 2009

Comparative in vitro activities of AC98-6446, a novel semisynthetic glycopeptide derivative of the natural product mannopeptimycin alpha, and other antimicrobial agents against gram-positive clinical isolates

scientific article

Correlation of β-Lactamase Production and Colistin Resistance among Enterobacteriaceae Isolates from a Global Surveillance Program

scientific article published on 14 December 2015

Determination of MIC Quality Control Ranges for the Novel Gyrase Inhibitor Zoliflodacin

scientific article published on 26 August 2019

Determining incidence of extended spectrum beta-lactamase producing Enterobacteriaceae, vancomycin-resistant Enterococcus faecium and methicillin-resistant Staphylococcus aureus in 38 centres from 17 countries: the PEARLS study 2001-2002.

scientific article

Diagnostic PCR analysis of the occurrence of methicillin and tetracycline resistance genes among Staphylococcus aureus isolates from phase 3 clinical trials of tigecycline for complicated skin and skin structure infections

scientific article

Effect of medium age and supplementation with the biocatalytic oxygen-reducing reagent oxyrase on in vitro activities of tigecycline against recent clinical isolates

scientific article

Efficacy of piperacillin combined with the Penem beta-lactamase inhibitor BLI-489 in murine models of systemic infection

scientific article published on 02 February 2009

Efflux-mediated resistance to tigecycline (GAR-936) in Pseudomonas aeruginosa PAO1.

scientific article

Emergence of carbapenem-resistant Klebsiella species possessing the class A carbapenem-hydrolyzing KPC-2 and inhibitor-resistant TEM-30 beta-lactamases in New York City

scientific article published on 14 June 2004

Epidemiology of β-Lactamase-Producing Pathogens

scientific article published on 26 February 2020

Establishment of in vitro susceptibility testing methodologies and comparative activities of piperacillin in combination with the penem {beta}-lactamase inhibitor BLI-489.

scientific article published on 10 November 2008

Functional, biophysical, and structural bases for antibacterial activity of tigecycline

scientific article

Further evidence that a cell wall precursor [C(55)-MurNAc-(peptide)-GlcNAc] serves as an acceptor in a sorting reaction

scientific article published on April 2002

Genetic Determinants of Tetracycline Resistance and their Effect on Tetracycline and Glycylcycline Antibiotics

scholarly article by C. Jones et al published 1 April 2008 in Anti-Infective Agents in Medicinal Chemistry

Global Dissemination of blaKPC into Bacterial Species beyond Klebsiella pneumoniae and In Vitro Susceptibility to Ceftazidime-Avibactam and Aztreonam-Avibactam

scientific article published on 09 May 2016

Global Escherichia coli Sequence Type 131 Clade with blaCTX-M-27 Gene

scientific article (publication date: November 2016)

Global incidence of carbapenemase-producing Escherichia coli ST131.

scientific article

Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria

scientific article (publication date: July 2004)

Identification and analysis of bacterial protein secretion inhibitors utilizing a SecA-LacZ reporter fusion system

scientific article published on June 2000

Identification and sequence of a tet(M) tetracycline resistance determinant homologue in clinical isolates of Escherichia coli

scientific article

Identification of CTX-M beta-lactamases in Escherichia coli from hospitalized patients and residents of long-term care facilities

scientific article

Identification of plasmid-mediated AmpC beta-lactamases in Escherichia coli, Klebsiella spp., and proteus species can potentially improve reporting of cephalosporin susceptibility testing results

scientific article

In Vitro Activity of AZD0914, a Novel Bacterial DNA Gyrase/Topoisomerase IV Inhibitor, against Clinically Relevant Gram-Positive and Fastidious Gram-Negative Pathogens

scientific article published on 20 July 2015

In Vitro Activity of Aztreonam-Avibactam against Enterobacteriaceae and Pseudomonas aeruginosa Isolated by Clinical Laboratories in 40 Countries from 2012 to 2015.

scientific article published on 19 June 2017

In Vitro Activity of Ceftazidime-Avibactam Against Isolates from Patients in a Phase 3 Clinical Trial for the Treatment of Complicated Intra-Abdominal Infections

scientific article published on 23 April 2018

In Vitro Activity of Ceftazidime-Avibactam and Aztreonam-Avibactam against OXA-48-Carrying Enterobacteriaceae Isolated as Part of the International Network for Optimal Resistance Monitoring (INFORM) Global Surveillance Program from 2012 to 2015.

scientific article published on 26 November 2018

In vitro activity of aztreonam-avibactam against a global collection of Gram-negative pathogens from 2012 and 2013.

scientific article

In vitro activity of omadacycline against pathogens isolated from Mainland China during 2017-2018

scientific article published on 30 April 2020

In vitro activity of tigecycline against Staphylococcus epidermidis growing in an adherent-cell biofilm model

scientific article published on December 2003

In vitro activity of tigecycline against isolates from patients enrolled in phase 3 clinical trials of treatment for complicated skin and skin-structure infections and complicated intra-abdominal infections

scientific article published in September 2005

In vitro activity of tigecycline and occurrence of tetracycline resistance determinants in isolates from patients enrolled in phase 3 clinical trials for community-acquired pneumonia

scientific article published in September 2008

In vitro and in vivo activities of novel 6-methylidene penems as beta-lactamase inhibitors

scientific article published on December 2004

In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant gram-positive pathogens

scientific article

In vitro antibacterial activities of tigecycline and comparative agents by time-kill kinetic studies in fresh Mueller-Hinton broth

scientific article published on 26 July 2007

In vitro antibacterial activities of tigecycline in combination with other antimicrobial agents determined by chequerboard and time-kill kinetic analysis

scientific article published on 23 January 2006

In vitro antibacterial activity of AZD0914, a new spiropyrimidinetrione DNA gyrase/topoisomerase inhibitor with potent activity against Gram-positive, fastidious Gram-Negative, and atypical bacteria

scientific article published on 10 November 2014

In vitro evaluation of tigecycline and comparative agents in 3049 clinical isolates: 2001 to 2002.

scientific article

Inactivation of mprF affects vancomycin susceptibility in Staphylococcus aureus

scientific article published in May 2003

Influence of transcriptional activator RamA on expression of multidrug efflux pump AcrAB and tigecycline susceptibility in Klebsiella pneumoniae

scientific article published on March 2005

Late stage antibacterial drugs in the clinical pipeline

scientific article published on 22 October 2007

Mannopeptimycins, new cyclic glycopeptide antibiotics produced by Streptomyces hygroscopicus LL-AC98: antibacterial and mechanistic activities.

scientific article

MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli

scientific article published on 29 October 2007

Mechanism of action of the mannopeptimycins, a novel class of glycopeptide antibiotics active against vancomycin-resistant gram-positive bacteria

scientific article published on March 2004

Molecular epidemiology of a citywide outbreak of extended-spectrum beta-lactamase-producing Klebsiella pneumoniae infection

scientific article published on 10 September 2002

Molecular β-Lactamase Characterization of Aerobic Gram-Negative Pathogens Recovered from Patients Enrolled in the Ceftazidime-Avibactam Phase 3 Trials for Complicated Intra-abdominal Infections, with Efficacies Analyzed against Susceptible and Resis

scientific article published on 27 March 2017

Molecular β-lactamase characterization of Gram-negative pathogens recovered from patients enrolled in the ceftazidime-avibactam phase 3 trials (RECAPTURE 1 and 2) for complicated urinary tract infections: Efficacies analysed against susceptible and

scholarly article by Rodrigo E. Mendes et al published August 2018 in International Journal of Antimicrobial Agents

Multiple antibiotic-resistant Klebsiella and Escherichia coli in nursing homes.

scientific article

Multiyear, Multinational Survey of the Incidence and Global Distribution of Metallo-β-Lactamase-Producing Enterobacteriaceae and Pseudomonas aeruginosa

scientific article published on 7 December 2015

Occurrence of tetracycline resistance genes among Escherichia coli isolates from the phase 3 clinical trials for tigecycline

scientific article published on 9 July 2007

Pharmacokinetics/pharmacodynamics of a β-lactam and β-lactamase inhibitor combination: a novel approach for aztreonam/avibactam

scientific article published on 29 May 2015

Pyrosequencing using the single-nucleotide polymorphism protocol for rapid determination of TEM- and SHV-type extended-spectrum beta-lactamases in clinical isolates and identification of the novel beta-lactamase genes blaSHV-48, blaSHV-105, and blaT

scientific article published on 15 December 2008

RT-PCR and statistical analyses of adeABC expression in clinical isolates of Acinetobacter calcoaceticus-Acinetobacter baumannii complex

scientific article published in June 2010

RamA, a transcriptional regulator, and AcrAB, an RND-type efflux pump, are associated with decreased susceptibility to tigecycline in Enterobacter cloacae.

scientific article

Real-time PCR and statistical analyses of acrAB and ramA expression in clinical isolates of Klebsiella pneumoniae

scientific article published on 14 July 2008

Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893

scientific article published on 20 June 2016

Structural and sequence analysis of class A β-lactamases with respect to avibactam inhibition: impact of Ω-loop variations

scientific article published on 7 July 2016

Tigecycline MIC testing by broth dilution requires use of fresh medium or addition of the biocatalytic oxygen-reducing reagent oxyrase to standardize the test method

scientific article published on September 2005

Use of ribotyping to retrospectively identify methicillin-resistant Staphylococcus aureus isolates from phase 3 clinical trials for tigecycline that are genotypically related to community-associated isolates

scientific article

Uses of Staphylococcus aureus GeneChips in genotyping and genetic composition analysis

scientific article

Validation and reproducibility assessment of tigecycline MIC determinations by Etest

scientific article published on 23 May 2007

What's New in beta-lactamases?

scientific article

mSphere of Influence: the View from the Microbiologists of the Future.

scientific article published on 19 June 2019

β-Lactams and β-Lactamase Inhibitors: An Overview

scientific article published on 21 June 2016

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