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List of works by Alejandro Romero Martínez

5-Methyl--(8-(5,6,7,8-tetrahydroacridin-9-ylamino)octyl)-5-indolo[2,3-]quinolin-11-amine: a highly potent human cholinesterase inhibitor

scientific article published on 28 April 2017

A History of the Pharmacological Treatment of Bipolar Disorder

scientific article published on 23 July 2018

A review of metal-catalyzed molecular damage: protection by melatonin

scientific article published on 05 April 2014

ASS234, As a New Multi-Target Directed Propargylamine for Alzheimer's Disease Therapy.

scientific article published on 28 June 2016

Analysis of gene expression profiles of CR80, a neuroprotective 1,8-Naphthyridine

scientific article published on 21 March 2018

Both creatine and its product phosphocreatine reduce oxidative stress and afford neuroprotection in an in vitro Parkinson's model

scientific article published on 24 November 2014

Cadmium exposure differentially modifies the circadian patterns of norepinephrine at the median eminence and plasma LH, FSH and testosterone levels

scientific article

Calcium signalling mediated through α7 and non-α7 nAChR stimulation is differentially regulated in bovine chromaffin cells to induce catecholamine release

scientific article published on January 2011

Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles

scientific article published on 26 November 2010

Coronavirus Disease 2019 (COVID-19) and Its Neuroinvasive Capacity: Is It Time for Melatonin?

scientific article published on 09 August 2020

Corrigendum: Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.

scientific article published on 29 May 2017

Cytotoxicity induced by deltamethrin and its metabolites in SH-SY5Y cells can be differentially prevented by selected antioxidants.

scientific article published on 23 May 2012

Development of HuperTacrines as Non-Toxic, Cholinesterase Inhibitors for the Potential Treatment of Alzheimer’s Disease

article

Dibenzo[1,4,5]thiadiazepine: a hardly-known heterocyclic system with neuroprotective properties of potential usefulness in the treatment of neurodegenerative diseases

scientific article

Differential induction of cytochrome P450 isoforms and peroxisomal proliferation by cyfluthrin in male Wistar rats.

scientific article published on 29 April 2013

Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease

scientific article published on 29 April 2014

Effect of cadmium on 24-h variations in hypothalamic dopamine and serotonin metabolism in adult male rats

scientific article

Effect of cadmium on lymphocyte subsets distribution in thymus and spleen

scientific article published in March 2003

Effect of natamycin on cytochrome P450 enzymes in rats

scientific article published in December 2013

Effect of nitric oxide on prolactin secretion and hypothalamic biogenic amine contents.

scientific article

Effects of in utero and lactational exposure to endosulfan in prefrontal cortex of male rats

scientific article published on 25 October 2007

Enantioselective neuroprotective effects of Tacripyrine ITH122 against oxygen and glucose deprivation in rat hippocampal slices

scientific article published on 26 February 2013

Evidence for dose-additive effects of a type II pyrethroid mixture. In vitro assessment

scientific article

Fipronil sulfone induced higher cytotoxicity than fipronil in SH-SY5Y cells: Protection by antioxidants

scientific article published on 08 April 2016

Galantamine elicits neuroprotection by inhibiting iNOS, NADPH oxidase and ROS in hippocampal slices stressed with anoxia/reoxygenation.

scientific article

Guanosine protects human neuroblastoma SH-SY5Y cells against mitochondrial oxidative stress by inducing heme oxigenase-1 via PI3K/Akt/GSK-3β pathway.

scientific article published on 7 June 2012

Highlights of ASS234: a novel and promising therapeutic agent for Alzheimer's disease therapy

scientific article published on 01 January 2020

ITH12410/SC058: a new neuroprotective compound with potential in the treatment of Alzheimer's disease

scientific article published on 15 July 2014

In Vitro and In Silico ADME-Tox Profiling and Safety Significance of Multifunctional Monoamine Oxidase Inhibitors Targeting Neurodegenerative Diseases

scientific article published on 03 November 2020

In silico assessment of the metabolism and its safety significance of multitarget propargylamine ASS234

scientific article published on 28 May 2018

Ischemic brain injury: New insights on the protective role of melatonin

scientific article published on 5 January 2017

Isoxazolotacrines as non-toxic and selective butyrylcholinesterase inhibitors for Alzheimer's disease

scientific article

Melatonin Reduces NLRP3 Inflammasome Activation by Increasing α7 nAChR-Mediated Autophagic Flux

scientific article published on 18 December 2020

Melatonin and Nitrones As Potential Therapeutic Agents for Stroke.

scientific article published on 23 November 2016

Melatonin as a versatile molecule to design novel multitarget hybrids against neurodegeneration

scientific article published on 12 May 2017

Melatonin as potential candidate to prevent the toxicity induced by chemical warfare agents

scientific article published on 8 August 2013

Melatonin protects against oxygen and glucose deprivation by decreasing extracellular glutamate and Nox-derived ROS in rat hippocampal slices

scientific article published on 9 September 2016

Melatonin's efficacy in stroke patients; a matter of dose? A systematic review

scientific article published on 26 February 2020

Melatonin: A hypothesis for Kawasaki disease treatment

scientific article published on 17 July 2018

Methoxychlor modifies the ultradian secretory pattern of prolactin and affects its TRH response.

scientific article published in May 2003

Modulation of Heat Shock Response Proteins by ASS234, Targeted for Neurodegenerative Diseases Therapy

scientific article published on 27 August 2018

Modulation of serine/threonine phosphatases by melatonin: therapeutic approaches in neurodegenerative diseases

scientific article published on 19 June 2018

Modulatory Effects of Melatonin on Cadmium-Induced Changes in Biogenic Amines in Rat Hypothalamus

scientific article published on 11 January 2011

Multipotent drugs with cholinergic and neuroprotective properties for the treatment of Alzheimer and neuronal vascular diseases. I. Synthesis, biological assessment, and molecular modeling of simple and readily available 2-aminopyridine-, and 2-chlo

scientific article published on 3 July 2010

Multitarget-Directed Ligands Combining Cholinesterase and Monoamine Oxidase Inhibition with Histamine H3 R Antagonism for Neurodegenerative Diseases.

scientific article published in September 2017

Mycotoxins modify the barrier function of Caco-2 cells through differential gene expression of specific claudin isoforms: Protective effect of illite mineral clay

scientific article published on 3 May 2016

N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease

scientific article

Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease

scientific article published on 11 July 2018

Neuroinflammation Signaling Modulated by ASS234, a Multitarget Small Molecule for Alzheimer’s Disease Therapy

scientific article published on 26 July 2018

Neuroprotective effect of dimebon against ischemic neuronal damage

scientific article published on 4 March 2014

Neuroprotective effect of guanosine against glutamate-induced cell death in rat hippocampal slices is mediated by the phosphatidylinositol-3 kinase/Akt/ glycogen synthase kinase 3β pathway activation and inducible nitric oxide synthase inhibition.

scientific article

Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression

scientific article published on 16 January 2014

Neuroprotective effects of E-PodoFavalin-15999 (Atremorine®).

scientific article published on 30 March 2017

Neurotoxicity induced by dexamethasone in the human neuroblastoma SH-SY5Y cell line can be prevented by folic acid.

scientific article published on 31 May 2011

Neurotoxicity induced by okadaic acid in the human neuroblastoma SH-SY5Y line can be differentially prevented by α7 and β2* nicotinic stimulation

scientific article published on 29 June 2011

New cinnamic - N-benzylpiperidine and cinnamic - N,N-dibenzyl(N-methyl)amine hybrids as Alzheimer-directed multitarget drugs with antioxidant, cholinergic, neuroprotective and neurogenic properties

scientific article published on 25 May 2016

New flavonoid – N,N-dibenzyl(N-methyl)amine hybrids: Multi-target-directed agents for Alzheimer´s disease endowed with neurogenic properties

scientific article published on 01 December 2019

New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease

scientific article

Nontoxic and neuroprotective β-naphthotacrines for Alzheimer's disease

scientific article published on 28 May 2013

Novel multitarget ligand ITH33/IQM9.21 provides neuroprotection in in vitro and in vivo models related to brain ischemia

scientific article

Novel tacrine-grafted Ugi adducts as multipotent anti-Alzheimer drugs: a synthetic renewal in tacrine-ferulic acid hybrids

scientific article published on 23 December 2014

Oxidative stress and gene expression profiling of cell death pathways in alpha-cypermethrin-treated SH-SY5Y cells

scientific article published on 04 October 2016

PP2A ligand ITH12246 protects against memory impairment and focal cerebral ischemia in mice

scientific article published on 13 June 2013

Permethrin-induced oxidative stress and toxicity and metabolism. A review

scientific article published on 13 May 2016

Poststress treatment with PNU282987 can rescue SH-SY5Y cells undergoing apoptosis via α7 nicotinic receptors linked to a Jak2/Akt/HO-1 signaling pathway

scientific article published on 26 September 2010

Protective effect of creatine against 6-hydroxydopamine-induced cell death in human neuroblastoma SH-SY5Y cells: Involvement of intracellular signaling pathways.

scientific article published on 26 February 2013

QuinoxalineTacrine QT78, a Cholinesterase Inhibitor as a Potential Ligand for Alzheimer's Disease Therapy

scientific article published on 17 April 2019

Recent Developments on Multi-Target-Directed Tacrines for Alzheimer's Disease. I. The Pyranotacrines.

scientific article published on 12 January 2018

Relationship between blood concentrations of heavy metals and cytogenetic and endocrine parameters among subjects involved in cleaning coastal areas affected by the 'Prestige' tanker oil spill

scientific article published on 25 January 2008

Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells

scientific article published on June 2010

Synthesis and pharmacological assessment of diversely substituted pyrazolo[3,4-b]quinoline, and benzo[b]pyrazolo[4,3-g][1,8]naphthyridine derivatives

scientific article published on 07 June 2011

Synthesis, biological assessment, and molecular modeling of racemic 7-aryl-9,10,11,12-tetrahydro-7H-benzo[7,8]chromeno[2,3-b]quinolin-8-amines as potential drugs for the treatment of Alzheimer's disease.

scientific article published on 28 June 2012

Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives

scientific article published on July 2010

The Antioxidant Additive Approach for Alzheimer's Disease Therapy: New Ferulic (Lipoic) Acid Plus Melatonin Modified Tacrines as Cholinesterases Inhibitors, Direct Antioxidants, and Nuclear Factor (Erythroid-Derived 2)-Like 2 Activators

scientific article published on 13 October 2016

The emergence of melatonin in oncology: Focus on colorectal cancer

scientific article published on 04 April 2019

The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.

scientific article

Toxic effects of cadmium on GABA and taurine content in different brain areas of adult male rats

scientific article published in September 2005

Toxic effects of cadmium on the regulatory mechanism of dopamine and serotonin on prolactin secretion in adult male rats.

scientific article published in January 2005

Toxicity induced by chemical warfare agents: insights on the protective role of melatonin

scientific article published on 11 September 2013

Toxicological and pharmacological evaluation, antioxidant, ADMET and molecular modeling of selected racemic chromenotacrines {11-amino-12-aryl-8,9,10,12-tetrahydro-7H-chromeno[2,3-b]quinolin-3-ols} for the potential prevention and treatment of Alzhe

scientific article published on 8 January 2014

Toxins as Weapons: A Historical Review.

scientific article published on July 2014

Understanding the oncostatic actions displayed by melatonin in colorectal cancer therapy

scientific article published on 29 May 2020

Upregulation of Antioxidant Enzymes by ASS234, a Multitarget Directed Propargylamine for Alzheimer's Disease Therapy.

scientific article published on 6 July 2016

Wnt signaling pathway, a potential target for Alzheimer's disease treatment, is activated by a novel multitarget compound ASS234.

scientific article published on 8 April 2014

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