List of works - Harald Engler

Acute experimental endotoxemia induces visceral hypersensitivity and altered pain evaluation in healthy humans.

scientific article

Acute systemic rapamycin induces neurobehavioral alterations in rats

scientific article

Alterations in functional connectivity of resting state networks during experimental endotoxemia - An exploratory study in healthy men.

scientific article

Altered temporal variance and functional connectivity of BOLD signal is associated with state anxiety during acute systemic inflammation

scientific article published on 21 September 2018

Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress

scientific article published on 23 October 2010

B-cell dynamics during experimental endotoxemia in humans

scientific article published on 17 May 2019

Blunted Cortisol Stress Response and Depression-Induced Hypocortisolism Is Related to Inflammation in Patients With CAD.

scientific article published in March 2016

Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses

scientific article

Chemical destruction of brain noradrenergic neurons affects splenic cytokine production

scientific article published on 19 January 2010

Child sexual offenders show prenatal and epigenetic alterations of the androgen system

scientific article published on 18 January 2019

Does Human Experimental Endotoxemia Impact Negative Cognitions Related to the Self?

scientific article published on 21 August 2018

Dose-dependent effects of endotoxin on neurobehavioral functions in humans

scientific article

Effects of Neurexan ® in an experimental acute stress setting--An explorative double-blind study in healthy volunteers.

scientific article published on 06 January 2016

Effects of acute and chronic social stress on blood cellular immunity in rats

scientific article published on 01 July 1998

Effects of acute systemic inflammation on the interplay between sad mood and affective cognition

scientific article

Effects of repeated social stress on leukocyte distribution in bone marrow, peripheral blood and spleen.

scientific article

Effects of social stress on blood leukocyte distribution: the role of alpha- and beta-adrenergic mechanisms

scientific article published in November 2004

Endotoxin initiated inflammation reduces testosterone production in men of reproductive age.

scientific article published on 28 November 2017

Endotoxin-induced experimental systemic inflammation in humans: a model to disentangle immune-to-brain communication

scientific article published on 24 October 2013

Expectations and associations that heal: Immunomodulatory placebo effects and its neurobiology.

scientific article

Experimental endotoxemia as a model to study neuroimmune mechanisms in human visceral pain.

scientific article published on July 2012

Experimental human endotoxemia enhances brain activity during social cognition

scientific article

Expression of glucocorticoid resistance following social stress requires a second signal.

scientific article published on 15 July 2003

Fatigue and sleepiness responses to experimental inflammation and exploratory analysis of the effect of baseline inflammation in healthy humans

scientific article published on 01 November 2019

Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions

scientific article

Inflammation-induced hyperalgesia: effects of timing, dosage, and negative affect on somatic pain sensitivity in human experimental endotoxemia

scientific article published on 9 May 2014

Inflammation-induced pain sensitization in men and women: does sex matter in experimental endotoxemia?

scientific article published on 3 June 2015

Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice.

scientific article published on 18 January 2016

Inhibition of catecholamine degradation ameliorates while chemical sympathectomy aggravates the severity of acute Friend retrovirus infection in mice

scientific article

Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen.

scientific article

Learned immunosuppression: extinction, renewal, and the challenge of reconsolidation.

scientific article published on 13 July 2012

Lipopolysaccharide-induced experimental immune activation does not impair memory functions in humans

scientific article published on 27 September 2010

Memory-updating abrogates extinction of learned immunosuppression

scientific article published on 16 September 2015

Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms.

scientific article published on 17 August 2015

Mood disturbance during experimental endotoxemia: Predictors of state anxiety as a psychological component of sickness behavior

scientific article published on 11 January 2016

Neural circuitry mediating inflammation-induced central pain amplification in human experimental endotoxemia

scientific article published on 14 April 2015

Neural circuitry of abdominal pain-related fear learning and reinstatement in irritable bowel syndrome

scientific article

Neural response to emotional stimuli during experimental human endotoxemia

scientific article published on 28 March 2012

Neuro-Immune Associative Learning

Neurobehavioral consequences of small molecule-drug immunosuppression

scientific article published on 19 December 2014

No PTSD-related differences in diurnal cortisol profiles of genocide survivors

scientific article published on 2 December 2008

No retrieval-induced forgetting under stress

scientific article published on 8 October 2009

Physical defeat reduces the sensitivity of murine splenocytes to the suppressive effects of corticosterone.

scientific article

Placebo analgesia in patients with functional and organic abdominal pain: a fMRI study in IBS, UC and healthy volunteers.

scientific article published on 15 May 2014

Placebo effects on the immune response in humans: the role of learning and expectation

scientific article

Plasma cortisol response cannot be classically conditioned in a taste-endocrine paradigm in humans.

scientific article published on 13 August 2017

Plasma noradrenaline and state anxiety levels predict placebo response in learned immunosuppression

scientific article

Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells

scientific article

Pre-exposure to the unconditioned or conditioned stimulus does not affect learned immunosuppression in rats.

scientific article published on 10 September 2015

Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies.

scientific article published on 23 September 2015

Preserving learned immunosuppressive placebo response: perspectives for clinical application

scientific article published on 3 April 2014

Pro-Inflammatory Th1 and Th17 Cells Are Suppressed During Human Experimental Endotoxemia Whereas Anti-Inflammatory IL-10 Producing T-Cells Are Unaffected.

scientific article

Randomised clinical trial: yoga vs written self-care advice for ulcerative colitis

scientific article published on 05 April 2017

Rats taste-aversive learning with cyclosporine a is not affected by contextual changes.

scientific article published on 14 June 2016

Reduced peripheral expression of the glucocorticoid receptor α isoform in individuals with posttraumatic stress disorder: a cumulative effect of trauma burden

scientific article published on 21 January 2014

Relationship between pharmacokinetics and pharmacodynamics of calcineurin inhibitors in renal transplant patients

scientific article published on 27 March 2015

Repeated recall of learned immunosuppression: evidence from rats and men.

scientific article published on 27 May 2011

Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway

article

Retrieval-induced forgetting under psychosocial stress: no reduction by delayed stress and beta-adrenergic blockade

scientific article published on 29 January 2014

Salivary alpha-amylase and noradrenaline responses to corticotropin-releasing hormone administration in humans.

scientific article

Salivary α-amylase response to endotoxin administration in humans

scientific article published on 8 February 2013

Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms.

scientific article

Sex differences in the pro-inflammatory cytokine response to endotoxin unfold in vivo but not ex vivo in healthy humans

scientific article published on January 2017

Short-term treatment with the calcineurin inhibitor cyclosporine A decreases HPA axis activity and plasma noradrenaline levels in healthy male volunteers.

scientific article published on 16 September 2014

Single-trial conditioning in a human taste-endotoxin paradigm induces conditioned odor aversion but not cytokine responses

scientific article published on 8 September 2011

Social stress and T cell maturation in male rats: transient and persistent alterations in thymic function

scientific article published in November 2003

Social stress, dominance and blood cellular immunity

scientific article published on 01 February 1999

Stimulation of β₂-adrenergic receptors inhibits calcineurin activity in CD4(+) T cells via PKA-AKAP interaction

scientific article

Stress and the brain-gut axis in functional and chronic-inflammatory gastrointestinal diseases: A transdisciplinary challenge

scientific article published on 02 November 2019

Stress burden and neuroendocrine regulation of cytokine production in patients with ulcerative colitis in remission

scientific article published on 07 August 2018

Stress eliminates retrieval-induced forgetting--does the oral application of cortisol?

scientific article published on 9 June 2012

Stress enhances the consolidation of extinction memory in a predictive learning task

scientific article published on 22 August 2013

Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice

scientific article

Stress induces the translocation of cutaneous and gastrointestinal microflora to secondary lymphoid organs of C57BL/6 mice

scientific article published on 25 October 2005

Stress-induced modulation of NK activity during influenza viral infection: role of glucocorticoids and opioids

scientific article published in March 2005

Substantial reduction of naïve and regulatory T cells following traumatic stress

scientific article

The hypothalamic-pituitary-adrenal axis and viral infection.

scientific article

The sympathetic nervous system modulates CD4+Foxp3+ regulatory T cells via noradrenaline-dependent apoptosis in a murine model of lymphoproliferative disease

scientific article published on 15 January 2014

Time-dependent alterations of peripheral immune parameters after nigrostriatal dopamine depletion in a rat model of Parkinson's disease.

scientific article published on 7 February 2009

Tissue-specific alterations in the glucocorticoid sensitivity of immune cells following repeated social defeat in mice

scientific article published on 20 April 2005

Towards understanding sex differences in visceral pain: enhanced reactivation of classically-conditioned fear in healthy women

scientific article published on 4 January 2014

Transient inhibition of protein synthesis in the rat insular cortex delays extinction of conditioned taste aversion with cyclosporine A.

scientific article published on 13 June 2016

Vestibular stimulation on a motion-simulator impacts on mood States

scientific article

Victims of rape show increased cortisol responses to trauma reminders: a study in individuals with war- and torture-related PTSD.

scientific article

What Makes You Feel Sick After Inflammation? Predictors of Acute and Persisting Physical Sickness Symptoms Induced by Experimental Endotoxemia

scientific article published on 11 January 2017

List of works by Harald Engler

Acute experimental endotoxemia induces visceral hypersensitivity and altered pain evaluation in healthy humans.

Acute systemic rapamycin induces neurobehavioral alterations in rats

Alterations in functional connectivity of resting state networks during experimental endotoxemia - An exploratory study in healthy men.

Altered temporal variance and functional connectivity of BOLD signal is associated with state anxiety during acute systemic inflammation

Attenuation of the cytotoxic T lymphocyte response to lymphocytic choriomeningitis virus in mice subjected to chronic social stress

B-cell dynamics during experimental endotoxemia in humans

Blunted Cortisol Stress Response and Depression-Induced Hypocortisolism Is Related to Inflammation in Patients With CAD.

Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses

Chemical destruction of brain noradrenergic neurons affects splenic cytokine production

Child sexual offenders show prenatal and epigenetic alterations of the androgen system

Does Human Experimental Endotoxemia Impact Negative Cognitions Related to the Self?

Dose-dependent effects of endotoxin on neurobehavioral functions in humans

Effects of Neurexan ® in an experimental acute stress setting--An explorative double-blind study in healthy volunteers.

Effects of acute and chronic social stress on blood cellular immunity in rats

Effects of acute systemic inflammation on the interplay between sad mood and affective cognition

Effects of repeated social stress on leukocyte distribution in bone marrow, peripheral blood and spleen.

Effects of social stress on blood leukocyte distribution: the role of alpha- and beta-adrenergic mechanisms

Endotoxin initiated inflammation reduces testosterone production in men of reproductive age.

Endotoxin-induced experimental systemic inflammation in humans: a model to disentangle immune-to-brain communication

Expectations and associations that heal: Immunomodulatory placebo effects and its neurobiology.

Experimental endotoxemia as a model to study neuroimmune mechanisms in human visceral pain.

Experimental human endotoxemia enhances brain activity during social cognition

Expression of glucocorticoid resistance following social stress requires a second signal.

Fatigue and sleepiness responses to experimental inflammation and exploratory analysis of the effect of baseline inflammation in healthy humans

Functional capacities of human IgM memory B cells in early inflammatory responses and secondary germinal center reactions

Inflammation-induced hyperalgesia: effects of timing, dosage, and negative affect on somatic pain sensitivity in human experimental endotoxemia

Inflammation-induced pain sensitization in men and women: does sex matter in experimental endotoxemia?

Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice.

Inhibition of catecholamine degradation ameliorates while chemical sympathectomy aggravates the severity of acute Friend retrovirus infection in mice

Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen.

Learned immunosuppression: extinction, renewal, and the challenge of reconsolidation.

Lipopolysaccharide-induced experimental immune activation does not impair memory functions in humans

Memory-updating abrogates extinction of learned immunosuppression

Men and women differ in inflammatory and neuroendocrine responses to endotoxin but not in the severity of sickness symptoms.

Mood disturbance during experimental endotoxemia: Predictors of state anxiety as a psychological component of sickness behavior

Neural circuitry mediating inflammation-induced central pain amplification in human experimental endotoxemia

Neural circuitry of abdominal pain-related fear learning and reinstatement in irritable bowel syndrome

Neural response to emotional stimuli during experimental human endotoxemia

Neuro-Immune Associative Learning

Neurobehavioral consequences of small molecule-drug immunosuppression

No PTSD-related differences in diurnal cortisol profiles of genocide survivors

No retrieval-induced forgetting under stress

Physical defeat reduces the sensitivity of murine splenocytes to the suppressive effects of corticosterone.

Placebo analgesia in patients with functional and organic abdominal pain: a fMRI study in IBS, UC and healthy volunteers.

Placebo effects on the immune response in humans: the role of learning and expectation

Plasma cortisol response cannot be classically conditioned in a taste-endocrine paradigm in humans.

Plasma noradrenaline and state anxiety levels predict placebo response in learned immunosuppression

Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood mononuclear cells

Pre-exposure to the unconditioned or conditioned stimulus does not affect learned immunosuppression in rats.

Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies.

Preserving learned immunosuppressive placebo response: perspectives for clinical application

Pro-Inflammatory Th1 and Th17 Cells Are Suppressed During Human Experimental Endotoxemia Whereas Anti-Inflammatory IL-10 Producing T-Cells Are Unaffected.

Randomised clinical trial: yoga vs written self-care advice for ulcerative colitis

Rats taste-aversive learning with cyclosporine a is not affected by contextual changes.

Reduced peripheral expression of the glucocorticoid receptor α isoform in individuals with posttraumatic stress disorder: a cumulative effect of trauma burden

Relationship between pharmacokinetics and pharmacodynamics of calcineurin inhibitors in renal transplant patients

Repeated recall of learned immunosuppression: evidence from rats and men.

Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway

Retrieval-induced forgetting under psychosocial stress: no reduction by delayed stress and beta-adrenergic blockade

Salivary alpha-amylase and noradrenaline responses to corticotropin-releasing hormone administration in humans.

Salivary α-amylase response to endotoxin administration in humans

Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms.

Sex differences in the pro-inflammatory cytokine response to endotoxin unfold in vivo but not ex vivo in healthy humans

Short-term treatment with the calcineurin inhibitor cyclosporine A decreases HPA axis activity and plasma noradrenaline levels in healthy male volunteers.

Single-trial conditioning in a human taste-endotoxin paradigm induces conditioned odor aversion but not cytokine responses

Social stress and T cell maturation in male rats: transient and persistent alterations in thymic function

Social stress, dominance and blood cellular immunity

Stimulation of β₂-adrenergic receptors inhibits calcineurin activity in CD4(+) T cells via PKA-AKAP interaction

Stress and the brain-gut axis in functional and chronic-inflammatory gastrointestinal diseases: A transdisciplinary challenge

Stress burden and neuroendocrine regulation of cytokine production in patients with ulcerative colitis in remission

Stress eliminates retrieval-induced forgetting--does the oral application of cortisol?

Stress enhances the consolidation of extinction memory in a predictive learning task

Stress in puberty unmasks latent neuropathological consequences of prenatal immune activation in mice

Stress induces the translocation of cutaneous and gastrointestinal microflora to secondary lymphoid organs of C57BL/6 mice

Stress-induced modulation of NK activity during influenza viral infection: role of glucocorticoids and opioids

Substantial reduction of naïve and regulatory T cells following traumatic stress

The hypothalamic-pituitary-adrenal axis and viral infection.

The sympathetic nervous system modulates CD4+Foxp3+ regulatory T cells via noradrenaline-dependent apoptosis in a murine model of lymphoproliferative disease

Time-dependent alterations of peripheral immune parameters after nigrostriatal dopamine depletion in a rat model of Parkinson's disease.