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List of works by George Hajishengallis

'Stealth' corporate innovation: an emerging threat for therapeutic drug development

scientific article published on 01 November 2019

A dysbiotic microbiome triggers T17 cells to mediate oral mucosal immunopathology in mice and humans

scientific article published on 01 October 2018

A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17.

scientific article published on September 2008

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity

scientific article published on 17 April 2017

Aegean reflections on innate immunity

scientific article published in October 2013

Affinity and specificity of the interactions between Streptococcus mutans antigen I/II and salivary components.

scientific article published on September 1994

Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro.

scientific article published on 25 June 2009

Aging and its Impact on Innate Immunity and Inflammation: Implications for Periodontitis.

scientific article published on February 2014

Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway

scientific article

Author Correction: 'Stealth' corporate innovation: an emerging threat for therapeutic drug development

scientific article published on 01 November 2019

Basic biology and role of interleukin-17 in immunity and inflammation

scientific article

Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology.

scientific article

Breaking bad: manipulation of the host response by Porphyromonas gingivalis.

scientific article published on February 2014

Cell clustering and delay/arrest in T-cell division implicate a novel mechanism of immune modulation by E. coli heat-labile enterotoxin B-subunits.

scientific article published on 5 March 2015

Cholera toxin B subunit as an immunomodulator for mucosal vaccine delivery.

scientific article published in January 1999

Commensal bacteria-dependent select expression of CXCL2 contributes to periodontal tissue homeostasis

scientific article published on 22 March 2013

Complement and dysbiosis in periodontal disease ⬇️

scientific article published on November 1, 2012

Complement and periodontitis.

scientific article published on 23 June 2010

Complement-targeted therapeutics in periodontitis

scientific article

Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host

scientific article published on February 2010

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

scientific article

Construction and characterization of a Salmonella enterica serovar typhimurium clone expressing a salivary adhesin of Streptococcus mutans under control of the anaerobically inducible nirB promoter

scientific article

Construction and oral immunogenicity of a Salmonella typhimurium strain expressing a streptococcal adhesin linked to the A2/B subunits of cholera toxin.

scientific article published in November 1996

Counteracting interactions between lipopolysaccharide molecules with differential activation of toll-like receptors

scientific article published on December 2002

Crosstalk pathways between Toll-like receptors and the complement system

scientific article published on 10 February 2010

DEL-1 promotes macrophage efferocytosis and clearance of inflammation

scientific article published on 19 November 2018

DEL-1-Regulated Immune Plasticity and Inflammatory Disorders

scientific article published on 15 March 2019

Dancing with the Stars: How Choreographed Bacterial Interactions Dictate Nososymbiocity and Give Rise to Keystone Pathogens, Accessory Pathogens, and Pathobionts

scientific article published on 8 March 2016

Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss

scientific article

Dendritic Cell-Mediated Mechanisms Triggered by LT-IIa-B5, a Mucosal Adjuvant Derived from a Type II Heat-Labile Enterotoxin of Escherichia coli.

scientific article

Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction.

scientific article

Developmental endothelial locus-1 attenuates complement-dependent phagocytosis through inhibition of Mac-1-integrin

scientific article

Developmental endothelial locus-1 is a homeostatic factor in the central nervous system limiting neuroinflammation and demyelination.

scientific article

Developmental endothelial locus-1 modulates platelet-monocyte interactions and instant blood-mediated inflammatory reaction in islet transplantation

scientific article published on 17 December 2015

Diagnostic accuracy of different immunological methods for the detection of antineuronal antibodies in paraneoplastic neurological syndromes

scientific article published in January 2010

Differential Expression and Roles of Secreted Frizzled-Related Protein 5 and the Wingless Homolog Wnt5a in Periodontitis

scientific article published on January 2017

Differential activation of human gingival epithelial cells and monocytes by Porphyromonas gingivalis fimbriae

scientific article

Differential capacity for complement receptor-mediated immune evasion by Porphyromonas gingivalis depending on the type of innate leukocyte

scientific article

Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus

scientific article published on October 2006

Differential virulence and innate immune interactions of Type I and II fimbrial genotypes of Porphyromonas gingivalis

scientific article published on December 2009

Downregulation of the DNA-binding activity of nuclear factor-kappaB p65 subunit in Porphyromonas gingivalis fimbria-induced tolerance.

scientific article

Editorial: A Toll gate to escape T cells ⬇️

scientific article published on 01 January 2013

Endogenous developmental endothelial locus-1 limits ischaemia-related angiogenesis by blocking inflammation.

scientific article published on 27 April 2017

Endogenous modulators of inflammatory cell recruitment ⬇️

scientific article published on August 30, 2012

Endothelial Cell-Specific Overexpression of Del-1 Drives Expansion of Haematopoietic Progenitor Cells in the Bone Marrow

scientific article published on 7 February 2018

Endothelial cell-specific overexpression of developmental endothelial locus-1 does not influence atherosclerosis development in ApoE-/- mice

scientific article published on 10 August 2017

Erratum to: Endogenous developmental endothelial locus-1 limits ischaemia-related angiogenesis by blocking inflammation

scientific article published on 01 June 2017

Etiology of leukocyte adhesion deficiency-associated periodontitis revisited: not a raging infection but a raging inflammatory response.

scientific article

Expression and function of the homeostatic molecule Del-1 in endothelial cells and the periodontal tissue

scientific article published on 12 December 2013

From leukocyte recruitment to resolution of inflammation: the cardinal role of integrins

scientific article published on 14 March 2017

From orphan drugs to adopted therapies: Advancing C3-targeted intervention to the clinical stage.

scientific article published on 16 June 2016

Frontline Science: Activation of metabolic nuclear receptors restores periodontal tissue homeostasis in mice with leukocyte adhesion deficiency-1

scientific article published on 18 May 2020

Ganglioside GD1a is an essential coreceptor for Toll-like receptor 2 signaling in response to the B subunit of type IIb enterotoxin

scientific article published on 16 January 2007

Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis

scientific article

Gingival Exudatome Dynamics Implicate Inhibition of the Alternative Complement Pathway in the Protective Action of the C3 Inhibitor Cp40 in Nonhuman Primate Periodontitis

scientific article published on 29 August 2018

Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation

scientific article published on 18 June 2019

Host adhesive activities and virulence of novel fimbrial proteins of Porphyromonas gingivalis

scientific article

Human variability in innate immunity.

scientific article published on January 2007

Identification and characterization of a nonimmunoglobulin factor in human saliva that inhibits Streptococcus mutans glucosyltransferase.

scientific article

Illuminating the latest advances in innate immunity on the island of the sun god ⬇️

scientific article published on 01 November 2010

Immune evasion strategies of Porphyromonas gingivalis.

scientific article published on January 2011

Immunogenicity of Salmonella vector vaccines expressing SBR of Streptococcus mutans under the control of a T7-nirB (dual) promoter system

scientific article published on 31 March 2006

Immunometabolic Crosstalk: An Ancestral Principle of Trained Immunity?

scientific article published on 29 November 2018

Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response

scientific article (publication date: 2014)

In vivo and in vitro adjuvant activities of the B subunit of Type IIb heat-labile enterotoxin (LT-IIb-B5) from Escherichia coli.

scientific article published on 29 May 2009

Inborn errors in immunity: unique natural models to dissect oral immunity

scientific article published on 21 April 2015

Induction of protective immunity against Streptococcus mutans colonization after mucosal immunization with attenuated Salmonella enterica serovar typhimurium expressing an S. mutans adhesin under the control of in vivo-inducible nirB promoter.

scientific article

Inhibition of Porphyromonas gingivalis-induced periodontal bone loss by CXCR4 antagonist treatment.

scientific article

Inhibition of proinflammatory activities of major periodontal pathogens by aqueous extracts from elder flower (Sambucus nigra).

scientific article published in February 2006

Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase

scientific article published in April 2005

Interleukin-12 and Interleukin-23 Blockade in Leukocyte Adhesion Deficiency Type 1.

scientific article published on March 2017

Intradermal administration of the Type II heat-labile enterotoxins LT-IIb and LT-IIc of enterotoxigenic Escherichia coli enhances humoral and CD8+ T cell immunity to a co-administered antigen

scientific article

LT-IIc, a new member of the type II heat-labile enterotoxin family, exhibits potent immunomodulatory properties that are different from those induced by LT-IIa or LT-IIb.

scientific article

Lipid raft-dependent uptake, signalling and intracellular fate of Porphyromonas gingivalis in mouse macrophages

scientific article

Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities

scientific article published in 2021

Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist

scientific article

Local destruction from distant action

scientific article published on 17 August 2020

Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement

scientific article

Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis

scientific article published on 01 February 2019

Major neutrophil functions subverted by Porphyromonas gingivalis

scientific article published on 17 March 2016

Maladaptive innate immune training of myelopoiesis links inflammatory comorbidities

scientific article published in 2022

Mapping of a microbial protein domain involved in binding and activation of the TLR2/TLR1 heterodimer

scientific article

Mechanism and implications of CXCR4‐mediated integrin activation by Porphyromonas gingivalis ⬇️

scientific article published on January 21, 2013

Mechanisms and Therapeutic Modulation of Neutrophil-Mediated Inflammation

scientific article published in 2022

Meeting report: The 12th European oral microbiology workshop (EOMW) in Stockholm, Sweden

scientific article published on 7 September 2017

Metabolic nuclear receptors in periodontal host-microbe interactions and inflammation.

scientific article published on 5 October 2017

Microbial hijacking of complement-toll-like receptor crosstalk

scientific article published on 16 February 2010

Microbial manipulation of receptor crosstalk in innate immunity ⬇️

scientific article published on March 1, 2011

Milk fat globule epidermal growth factor 8 inhibits periodontitis in non-human primates and its gingival crevicular fluid levels can differentiate periodontal health from disease in humans.

scientific article published on 16 February 2017

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

scientific article published in January 2018

More than complementing Tolls: complement-Toll-like receptor synergy and crosstalk in innate immunity and inflammation

scientific article

Myelopoiesis in the Context of Innate Immunity

scientific article published on 06 June 2018

New insights into the immune functions of complement

scientific article published on 01 August 2019

Novel inflammatory pathways in periodontitis.

scientific article published on May 2014

Novel mechanisms and functions of complement.

scientific article published in November 2017

Optimization of the ligature-induced periodontitis model in mice ⬇️

scientific article published on May 12, 2013

Oral bacteria and leaky endothelial junctions in remote extraoral sites

scientific article published on 25 August 2020

Pathogenic microbes and community service through manipulation of innate immunity

scientific article published on January 2012

Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors

scientific article published on 29 August 2005

Periodontal inflammation and bone loss in aged mice.

scientific article

Periodontitis: from microbial immune subversion to systemic inflammation

scientific article

Polymicrobial infections, biofilms, and beyond

scientific article published on 01 May 2009

Polymicrobial synergy and dysbiosis in inflammatory disease

scientific article

Porphyromonas gingivalis Stimulates TLR2-PI3K Signaling to Escape Immune Clearance and Induce Bone Resorption Independently of MyD88.

scientific article

Porphyromonas gingivalis as a potential community activist for disease

scientific article

Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages

scientific article

Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis

scientific article

Porphyromonas gingivalis virulence factors involved in subversion of leukocytes and microbial dysbiosis

scientific article

Regulation of osteoclast homeostasis and inflammatory bone loss by MFG-E8.

scientific article

Regulation of tissue infiltration by neutrophils: role of integrin α3β1 and other factors

scientific article

Response to Comment on "The B Cell-Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell-Dependent Bone Loss in Experimental Murine Periodontitis".

scientific article

Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later.

scientific article published in October 2017

Role of bacteria in leukocyte adhesion deficiency-associated periodontitis

scientific article published on 13 September 2015

Role of complement in host-microbe homeostasis of the periodontium

scientific article

Safety profile after prolonged C3 inhibition

scientific article published on 10 October 2018

Secreted protein Del-1 regulates myelopoiesis in the hematopoietic stem cell niche.

scientific article

Secretory immunity in defense against cariogenic mutans streptococci

scientific article published on 01 January 1999

Sex dimorphism in periodontitis in animal models

scientific article

Smad6 Methylation Represses NFκB Activation and Periodontal Inflammation.

scientific article published in February 2018

Structure–activity correlations of variant forms of the B pentamer ofEscherichia colitype II heat-labile enterotoxin LT-IIb with Toll-like receptor 2 binding

scientific article

TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.

scientific article

TLR2-dependent modulation of dendritic cells by LT-IIa-B5, a novel mucosal adjuvant derived from a type II heat-labile enterotoxin.

scientific article published on 26 July 2011

TREM-1 Is Upregulated in Experimental Periodontitis, and Its Blockade Inhibits IL-17A and RANKL Expression and Suppresses Bone loss

scientific article published on 01 October 2019

The B Cell-Stimulatory Cytokines BLyS and APRIL Are Elevated in Human Periodontitis and Are Required for B Cell-Dependent Bone Loss in Experimental Murine Periodontitis

scientific article

The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss

scientific article

The Type II heat-labile enterotoxins LT-IIa and LT-IIb and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cells.

scientific article published on November 2004

The XXIV International Complement Workshop (ICW) on October 10-15, 2012. Preface

scientific article published in November 2012

The enduring importance of animal models in understanding periodontal disease

scientific article

The inflammophilic character of the periodontitis-associated microbiota

scientific article

The keystone-pathogen hypothesis.

scientific article

The oral microbiota: dynamic communities and host interactions

article

The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis

scientific article published on 01 September 2018

The secreted protein DEL-1 activates a β3 integrin-FAK-ERK1/2-RUNX2 pathway and promotes osteogenic differentiation and bone regeneration

scientific article published on 12 April 2020

Toll-Like Receptor 9-Mediated Inflammation Triggers Alveolar Bone Loss in Experimental Murine Periodontitis

scientific article published on 11 May 2015

Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA.

scientific article published on 29 October 2007

Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss.

scientific article

Type II heat-labile enterotoxins: Structure, function, and immunomodulatory properties ⬇️

scientific article published on September 26, 2012

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