List of works - George Hajishengallis

The keystone-pathogen hypothesis.

scientific article

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

scientific article published in January 2018

Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement

scientific article

Periodontitis: from microbial immune subversion to systemic inflammation

scientific article published on January 1, 2015

Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology.

scientific article

Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response

scientific article (publication date: 2014)

TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.

scientific article

Porphyromonas gingivalis as a potential community activist for disease

scientific article

Polymicrobial synergy and dysbiosis in inflammatory disease

scientific article

Microbial manipulation of receptor crosstalk in innate immunity

scientific article published on March 1, 2011

A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17.

scientific article published on September 2008

Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis

scientific article

Breaking bad: manipulation of the host response by Porphyromonas gingivalis.

scientific article published on February 2014

Crosstalk pathways between Toll-like receptors and the complement system

scientific article published on 10 February 2010

The inflammophilic character of the periodontitis-associated microbiota

scientific article

Microbial hijacking of complement-toll-like receptor crosstalk

scientific article published on 16 February 2010

Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss

scientific article

Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus

scientific article published on October 2006

Optimization of the ligature-induced periodontitis model in mice

scientific article published on May 12, 2013

The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss

scientific article

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

scientific article

Novel mechanisms and functions of complement.

scientific article published in November 2017

Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase

scientific article published in April 2005

Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist

scientific article

Dancing with the Stars: How Choreographed Bacterial Interactions Dictate Nososymbiocity and Give Rise to Keystone Pathogens, Accessory Pathogens, and Pathobionts

scientific article published on 8 March 2016

The oral microbiota: dynamic communities and host interactions

article

Affinity and specificity of the interactions between Streptococcus mutans antigen I/II and salivary components.

scientific article published on September 1994

Too old to fight? Aging and its toll on innate immunity

scientific article published on February 1, 2010

Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages

scientific article

Immune evasion strategies of Porphyromonas gingivalis.

scientific article published on January 2011

Endogenous modulators of inflammatory cell recruitment

scientific article published on August 30, 2012

Basic biology and role of interleukin-17 in immunity and inflammation

scientific article

Complement and periodontitis.

scientific article published on 23 June 2010

Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors

scientific article published on 29 August 2005

Commensal bacteria-dependent select expression of CXCL2 contributes to periodontal tissue homeostasis

scientific article published on 22 March 2013

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity

scientific article published on 17 April 2017

Porphyromonas gingivalis virulence factors involved in subversion of leukocytes and microbial dysbiosis

scientific article

Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis

scientific article

Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host

scientific article published on February 2010

Complement and dysbiosis in periodontal disease

scientific article published on November 1, 2012

Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA.

scientific article published on 29 October 2007

Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction.

scientific article

Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway

scientific article

Lipid raft-dependent uptake, signalling and intracellular fate of Porphyromonas gingivalis in mouse macrophages

scientific article

Counteracting interactions between lipopolysaccharide molecules with differential activation of toll-like receptors

scientific article published on December 2002

Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro.

scientific article published on 25 June 2009

Human variability in innate immunity.

scientific article published on January 2007

A dysbiotic microbiome triggers T17 cells to mediate oral mucosal immunopathology in mice and humans

scientific article published on 01 October 2018

Aging and its Impact on Innate Immunity and Inflammation: Implications for Periodontitis.

scientific article published on February 2014

The Type II heat-labile enterotoxins LT-IIa and LT-IIb and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cells.

scientific article published on November 2004

List of works by George Hajishengallis

The keystone-pathogen hypothesis.

Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity

Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement

Periodontitis: from microbial immune subversion to systemic inflammation

Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology.

Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response

TLR-signaling networks: an integration of adaptor molecules, kinases, and cross-talk.

Porphyromonas gingivalis as a potential community activist for disease

Polymicrobial synergy and dysbiosis in inflammatory disease

Microbial manipulation of receptor crosstalk in innate immunity

A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17.

Porphyromonas gingivalis manipulates complement and TLR signaling to uncouple bacterial clearance from inflammation and promote dysbiosis

Breaking bad: manipulation of the host response by Porphyromonas gingivalis.

Crosstalk pathways between Toll-like receptors and the complement system

The inflammophilic character of the periodontitis-associated microbiota

Microbial hijacking of complement-toll-like receptor crosstalk

Defective neutrophil recruitment in leukocyte adhesion deficiency type I disease causes local IL-17-driven inflammatory bone loss

Differential interactions of fimbriae and lipopolysaccharide from Porphyromonas gingivalis with the Toll-like receptor 2-centred pattern recognition apparatus

Optimization of the ligature-induced periodontitis model in mice

The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss

Compstatin: a C3-targeted complement inhibitor reaching its prime for bedside intervention

Novel mechanisms and functions of complement.

Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinase

Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist

Dancing with the Stars: How Choreographed Bacterial Interactions Dictate Nososymbiocity and Give Rise to Keystone Pathogens, Accessory Pathogens, and Pathobionts

The oral microbiota: dynamic communities and host interactions

Affinity and specificity of the interactions between Streptococcus mutans antigen I/II and salivary components.

Too old to fight? Aging and its toll on innate immunity

Porphyromonas gingivalis fimbriae proactively modulate beta2 integrin adhesive activity and promote binding to and internalization by macrophages

Immune evasion strategies of Porphyromonas gingivalis.

Endogenous modulators of inflammatory cell recruitment

Basic biology and role of interleukin-17 in immunity and inflammation

Complement and periodontitis.

Peptide mapping of bacterial fimbrial epitopes interacting with pattern recognition receptors

Commensal bacteria-dependent select expression of CXCL2 contributes to periodontal tissue homeostasis

A self-sustained loop of inflammation-driven inhibition of beige adipogenesis in obesity

Porphyromonas gingivalis virulence factors involved in subversion of leukocytes and microbial dysbiosis

Genetic and intervention studies implicating complement C3 as a major target for the treatment of periodontitis

Complementary Tolls in the periodontium: how periodontal bacteria modify complement and Toll-like receptor responses to prevail in the host

Complement and dysbiosis in periodontal disease

Toll-like receptor 2-mediated interleukin-8 expression in gingival epithelial cells by the Tannerella forsythia leucine-rich repeat protein BspA.

Dependence of bacterial protein adhesins on toll-like receptors for proinflammatory cytokine induction.

Antagonistic effects of IL-17 and D-resolvins on endothelial Del-1 expression through a GSK-3β-C/EBPβ pathway

Lipid raft-dependent uptake, signalling and intracellular fate of Porphyromonas gingivalis in mouse macrophages

Counteracting interactions between lipopolysaccharide molecules with differential activation of toll-like receptors

Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro.

Human variability in innate immunity.

A dysbiotic microbiome triggers T17 cells to mediate oral mucosal immunopathology in mice and humans

Aging and its Impact on Innate Immunity and Inflammation: Implications for Periodontitis.

The Type II heat-labile enterotoxins LT-IIa and LT-IIb and their respective B pentamers differentially induce and regulate cytokine production in human monocytic cells.