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List of works by Naoto Ishii

A genome-wide association study identifies RNF213 as the first Moyamoya disease gene.

scientific article

A small molecule inhibitor to plasminogen activator inhibitor 1 inhibits macrophage migration.

scientific article published on 7 March 2013

A transgenic mouse model for non-immune hydrops fetalis induced by the NS1 gene of human parvovirus B19.

scientific article published in February 2002

ATP drives lamina propria T(H)17 cell differentiation

scientific article

Activation of Notch1 promotes development of human CD8(+) single positive T cells in humanized mice.

scientific article published on 13 April 2014

Adenovirus vector-mediated in vivo gene transfer of OX40 ligand to tumor cells enhances antitumor immunity of tumor-bearing hosts

scientific article published on May 2004

Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 (Ape1/Ref-1) Modulates Antigen Presenting Cell-mediated T Helper Cell Type 1 Responses

scientific article published on 16 September 2016

CD103+ CD11b- salivary gland dendritic cells have antigen cross-presenting capacity

scientific article published on 11 November 2016

CD40/CD40L expression correlates with the survival of patients with glioblastomas and an augmentation in CD40 signaling enhances the efficacy of vaccinations against glioma models.

scientific article

Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines.

scientific article published on 12 August 2010

Co-inhibitory roles for glucocorticoid-induced TNF receptor in CD1d-dependent natural killer T cells

scientific article published on 01 August 2008

Cohort Profile: Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study (TMM BirThree Cohort Study): rationale, progress and perspective

scientific article published on 01 February 2020

Consequences of OX40-OX40 ligand interactions in langerhans cell function: enhanced contact hypersensitivity responses in OX40L-transgenic mice

scientific article published on 01 November 2002

Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma

scientific article published on 01 April 2003

Decreased expression of c-myc family genes in thymuses from myasthenia gravis patients

scientific article published on 01 April 2001

Development of a multi-step leukemogenesis model of MLL-rearranged leukemia using humanized mice

scientific article

Differences in the interleukin-2 (IL-2) receptor system in human and mouse: alpha chain is required for formation of the functional mouse IL-2 receptor

scientific article published on November 1995

Differential requirements for OX40 signals on generation of effector and central memory CD4+ T cells.

scientific article

ER Stress Protein CHOP Mediates Insulin Resistance by Modulating Adipose Tissue Macrophage Polarity

scientific article published in February 2017

Early production of tumor necrosis factor-alpha by Gr-1 cells and its role in the host defense to pneumococcal infection in lungs

scientific article published on 10 November 2009

Effects of deficiencies of STAMs and Hrs, mammalian class E Vps proteins, on receptor downregulation.

scientific article

Essential role of OX40L on B cells in persistent alloantibody production following repeated alloimmunizations

scientific article

Establishment of a new sensitive assay for anti-human aquaporin-4 antibody in neuromyelitis optica

scientific article published in December 2006

Expansion of dysfunctional Tim-3-expressing effector memory CD8+ T cells during simian immunodeficiency virus infection in rhesus macaques

scientific article

Expression of OX40 and OX40 ligand (gp34) in the normal and myasthenic thymus.

scientific article published in October 2000

Expression of OX40 in muscles of polymyositis and granulomatous myopathy

scientific article published on 01 February 2002

Expression of gp34 (OX40 ligand) and OX40 on human T cell clones

scientific article published on April 2001

Expression of the IL-2 receptor gamma chain on various populations in human peripheral blood

scientific article published on 01 August 1994

Fluorescently activated cell sorting followed by microarray profiling of helper T cell subtypes from human peripheral blood

scientific article

Functional analysis of the human interleukin 2 receptor gamma chain gene promoter

scientific article

Functional expression on human trophoblasts of interleukin 4 and interleukin 7 receptor complexes with a common gamma chain.

scientific article published on February 1997

GITR co-signal in ILC2 controls allergic lung inflammation

scientific article published on 7 February 2018

Gene therapy model of X-linked severe combined immunodeficiency using a modified foamy virus vector

scientific article

Hepatocyte growth factor regulated tyrosine kinase substrate in the peripheral development and function of B-cells.

scientific article published on 15 November 2013

Homeostatic proliferation of naive CD4+ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells.

scientific article published on 22 April 2013

Human CD4+ central and effector memory T cells produce IL-21: effect on cytokine-driven proliferation of CD4+ T cell subsets.

scientific article published on 13 August 2007

Ibudilast, a nonselective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in multiple sclerosis

Identification of AMSH-LP containing a Jab1/MPN domain metalloenzyme motif

scientific article

Important role of endogenous erythropoietin system in recruitment of endothelial progenitor cells in hypoxia-induced pulmonary hypertension in mice

scientific article published on 13 March 2006

Important role of erythropoietin receptor to promote VEGF expression and angiogenesis in peripheral ischemia in mice

scientific article published on 09 February 2007

In vivo assay of human NK-dependent ADCC using NOD/SCID/gammac(null) (NOG) mice

scientific article published on 7 August 2010

Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γcnull mouse

scientific article published on 7 March 2012

Inhibition of tumor growth and metastasis by depletion of vesicular sorting protein Hrs: its regulatory role on E-cadherin and beta-catenin.

scientific article published in June 2007

Interleukin 2-induced activation of JAK3: possible involvement in signal transduction for c-myc induction and cell proliferation

scientific article published on September 1994

Involvement of osteopontin and its signaling molecule CD44 in clinicopathological features of adult T cell leukemia.

scientific article published on 6 June 2011

Kinetic study of interleukin-2 binding on the reconstituted interleukin-2 receptor complexes including the human gamma chain

scientific article published on October 1993

Local convection-enhanced delivery of an anti-CD40 agonistic monoclonal antibody induces antitumor effects in mouse glioma models

scientific article published on 24 February 2016

Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice

scientific article published on 17 February 2016

OX40 (CD134) and OX40 ligand interaction plays an adjuvant role during in vivo Th2 responses.

scientific article

OX40 Costimulation Inhibits Foxp3 Expression and Treg Induction via BATF3-Dependent and Independent Mechanisms.

scientific article published in July 2018

OX40 and IL-7 play synergistic roles in the homeostatic proliferation of effector memory CD4⁺ T cells

scientific article published on 18 September 2014

OX40 costimulation turns off Foxp3+ Tregs.

scientific article

OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: a clue for successful immunotherapy

scientific article

OX40 ligand newly expressed on bronchiolar progenitors mediates influenza infection and further exacerbates pneumonia.

scientific article published on 14 March 2016

OX40 ligand regulates splenic CD8⁻ dendritic cell-induced Th2 responses in vivo

scientific article published on 22 January 2014

OX40-OX40 ligand interaction in T-cell-mediated immunity and immunopathology.

scientific article published on January 2010

Oral CD103-CD11b+ classical dendritic cells present sublingual antigen and induce Foxp3+ regulatory T cells in draining lymph nodes

scientific article published on 11 May 2016

Phenotypic heterogeneity in individuals with <i>MECOM</i> variants in 2 families

scientific article published in 2022

Physical association of JAK1 and JAK2 tyrosine kinases with the interleukin 2 receptor beta and gamma chains.

scientific article published on July 1994

Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibility

scientific article

Prolongation of allograft survival by administration of mAb specific for the three subunits of IL-2 receptor

scientific article published in May 1998

Regulation of Interleukin-6 Receptor Signaling by TNF Receptor-Associated Factor 2 and 5 During Differentiation of Inflammatory CD4+ T Cells.

scientific article published on 30 August 2018

Regulatory T cell-like activity of Foxp3+ adult T cell leukemia cells.

scientific article published on 16 December 2005

Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice

scientific article published on 2 May 2010

Roles of DNA-dependent protein kinase and ATM in cell-cycle-dependent radiation sensitivity in human cells

scientific article

Runx1 deficiency in CD4+ T cells causes fatal autoimmune inflammatory lung disease due to spontaneous hyperactivation of cells.

scientific article published on 2 May 2012

Serial OX40 engagement on CD4+ T cells and natural killer T cells causes allergic airway inflammation

scientific article published on 17 December 2009

Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex

scientific article

Signal-transducing adaptor molecules STAM1 and STAM2 are required for T-cell development and survival

scientific article

Statin ameliorates hypoxia-induced pulmonary hypertension associated with down-regulated stromal cell-derived factor-1.

scientific article

Study profile of The Tohoku Medical Megabank Community-Based Cohort Study

scientific article published on 11 January 2020

T-cell-depleted CD34+ cell transplantation from an HLA-mismatched donor in a low-birthweight infant with X-linked severe combined immunodeficiency

scientific article published on 01 February 2005

TIGIT Marks Exhausted T Cells, Correlates with Disease Progression, and Serves as a Target for Immune Restoration in HIV and SIV Infection

scientific article (publication date: 2016)

TNF Receptor-Associated Factor (TRAF) Signaling Network in CD4(+) T-Lymphocytes

scientific article

TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation

scientific article published on 02 April 2018

TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury.

scientific article published on 24 April 2017

TNF-α is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist–deficient mice

TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development.

scientific article published on 13 April 2016

TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction

scientific article published on 01 June 2018

The Tohoku Medical Megabank Project: Design and Mission

scientific article published on 02 July 2016

The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6.

scientific article

The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice)

scientific article published on 10 June 2009

The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID

scientific article

The role of common gamma chain in human monocytes in vivo; evaluation from the studies of X-linked severe combined immunodeficiency (X-SCID) carriers and X-SCID patients who underwent cord blood stem cell transplantation

scientific article published in September 2002

The role of fatty acid binding protein 7 in spinal cord astrocytes in a mouse model of experimental autoimmune encephalomyelitis

scientific article published on 30 April 2019

Three novel mutations in the interleukin-2 receptor gamma chain gene in four Japanese patients with X-linked severe combined immunodeficiency

scientific article published on 01 December 1995

Y chromosome-linked B and NK cell deficiency in mice

scientific article published on 20 May 2013

c-Cbl-dependent monoubiquitination and lysosomal degradation of gp130

scientific article

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