List of works - Dario Ghigo

A LDL-masked liposomal-doxorubicin reverses drug resistance in human cancer cells

scientific article

Absence of soluble CD14 in saliva of young patients with dental caries

scientific article published on 01 April 2007

Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells

scientific article published on 7 May 2008

Altered nitric oxide/cGMP platelet signaling pathway in platelets from patients with acute coronary syndromes

scientific article published on 14 May 2010

Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.

scientific article published on 09 March 2009

Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation

scientific article published on September 2003

Asbestos induces doxorubicin resistance in MM98 mesothelioma cells via HIF-1alpha.

scientific article

Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition

scientific article published on 22 February 2007

Association among oral health, apical periodontitis, CD14 polymorphisms, and coronary heart disease in middle-aged adults

scientific article

Carbon in intimate contact with quartz reduces the biological activity of crystalline silica dusts.

scientific article

Characterization of a new compound, S35b, as a guanylate cyclase activator in human platelets

scientific article published on 01 March 1992

Classical inhibitors of NOX NAD(P)H oxidases are not specific.

scientific article published on October 2008

Correlation between nitric oxide synthase activity and reduced glutathione level in human and murine endothelial cells

scientific article published on 01 September 1996

Crocidolite asbestos inhibits pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human lung epithelial cells.

scientific article published in May 2002

Cycling of NADPH by glucose 6-phosphate dehydrogenase optimizes the spectrophotometric assay of nitric oxide synthase activity in cell lysates

scientific article published on 17 February 2006

Cytotoxicity of zinc-containing bioactive glasses in contact with human osteoblasts

scientific article published on 12 March 2007

Different cellular responses evoked by natural and stoichiometric synthetic chrysotile asbestos

scientific article

Digoxin and ouabain increase the synthesis of cholesterol in human liver cells.

scientific article published in May 2009

Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells.

scientific article published on 30 July 2009

Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes.

scientific article

Diphenyleneiodonium inhibits the cell redox metabolism and induces oxidative stress

scientific article published on 9 September 2004

Does vitreous silica contradict the toxicity of the crystalline silica paradigm?

scientific article

Doxorubicin induces an increase of nitric oxide synthesis in rat cardiac cells that is inhibited by iron supplementation.

scientific article published on December 2002

Effects of TiO2-containing phosphate glasses on solubility and in vitro biocompatibility.

scientific article

Fluoride effects: the two faces of janus.

scientific article published on January 2010

Fluoride-containing bioactive glasses inhibit pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human osteoblasts.

scientific article published on 27 November 2009

Follicular fluid proteins stimulate nitric oxide (NO) synthesis in human sperm: a possible role for NO in acrosomal reaction.

scientific article published in January 1999

Formation of a vitreous phase at the surface of some commercial diatomaceous earth prevents the onset of oxidative stress effects

scientific article

Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways

scientific article

Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis

scientific article

Gold-containing bioactive glasses: a solid-state synthesis to produce alternative biomaterials for bone implantations

scientific article published on 20 February 2013

Guanylate cyclase activity and sperm function.

scientific article

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast.

scientific article

Hematite nanoparticles larger than 90 nm show no sign of toxicity in terms of lactate dehydrogenase release, nitric oxide generation, apoptosis, and comet assay in murine alveolar macrophages and human lung epithelial cells

scientific article published on 29 February 2012

High aspect ratio materials: role of surface chemistry vs. length in the historical "long and short amosite asbestos fibers".

scientific article published on October 2010

Human vascular smooth muscle cells express a constitutive nitric oxide synthase that insulin rapidly activates, thus increasing guanosine 3':5'-cyclic monophosphate and adenosine 3':5'-cyclic monophosphate concentrations

scientific article published on 01 July 1999

In vitro and in vivo vasodilating activity of nitroso derivatives gem -substituted with electron-withdrawing groups

scientific article

Iron inhibits the nitric oxide synthesis elicited by asbestos in murine macrophages

scientific article

Iron-loaded synthetic chrysotile: a new model solid for studying the role of iron in asbestos toxicity

scientific article published on 22 February 2007

Liposome-encapsulated doxorubicin reverses drug resistance by inhibiting P-glycoprotein in human cancer cells.

scientific article published on 5 May 2011

Long and short fiber amosite asbestos alters at a different extent the redox metabolism in human lung epithelial cells

scientific article published in November 2003

Middle T antigen-transformed endothelial cells exhibit an increased activity of nitric oxide synthase.

scientific article

Mitochondrial-targeting nitrooxy-doxorubicin: a new approach to overcome drug resistance

scientific article published on 7 December 2012

Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity

scientific article published on October 2011

Modulation of guinea-pig cardiac L-type calcium current by nitric oxide synthase inhibitors

scientific article published on February 1998

NO donor and biological properties of different benzofuroxans

scientific article published in June 1999

Na+/H+ exchanger activity is increased in doxorubicin-resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin

scientific article

Nitric oxide and P-glycoprotein modulate the phagocytosis of colon cancer cells.

scientific article published on July 2011

Nitric oxide stimulates human sperm motility via activation of the cyclic GMP/protein kinase G signaling pathway.

scientific article

Nitric oxide synthesis in human nonpregnant myometrium and uterine myomas

scientific article published on March 2003

Nitroarginine methyl ester and canavanine lower intracellular reduced glutathione.

scientific article

Nitrovasodilators inhibit thrombin-induced platelet-activating factor synthesis in human endothelial cells

scientific article published on 01 July 1992

Novel bio-conjugate materials: soybean peroxidase immobilized on bioactive glasses containing Au nanoparticles

Physicochemical determinants in the cellular responses to nanostructured amorphous silicas

scientific article published on 05 April 2012

Pleiotropic effects of cardioactive glycosides.

scientific article

Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 1: Identification and characterization.

scientific article published on January 2005

Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 2: Oxidant activity of the fibers.

scientific article published on January 2005

Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 3: Depletion of antioxidant defenses.

scientific article published on January 2005

Quartz inhibits glucose 6-phosphate dehydrogenase in murine alveolar macrophages

scientific article

Retracted: Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells

retracted article

Reversal of doxorubicin resistance by the amiloride analogue EIPA in multidrug resistant human colon carcinoma cells

scientific article published on March 1996

Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells

scientific article published on 9 September 2015

Simian virus 40 infection down-regulates the expression of nitric oxide synthase in human mesothelial cells

scientific article published in June 2004

Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma.

scientific article published on July 2006

Stimulation of the nitric oxide/cyclic guanosine monophosphate signaling pathway elicits human sperm chemotaxis in vitro

scientific article published on 5 February 2007

Surface reactivity and cell responses to chrysotile asbestos nanofibers.

scientific article

The NADPH oxidase inhibitor apocynin (acetovanillone) induces oxidative stress

scientific article published on 24 August 2005

The NADPH oxidase inhibitor apocynin induces nitric oxide synthesis via oxidative stress

scientific article published on 23 December 2007

The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells.

scientific article

The concentration of nitrite in seminal plasma does not correlate with sperm concentration, sperm motility, leukocytospermia, or sperm culture

scientific article published on 01 September 2001

The pentose phosphate pathway plays an essential role in supporting human sperm capacitation.

scientific article published on 12 October 2009

The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate ⬇️

scientific article published on May 11, 2012

The surface reactivity and implied toxicity of ash produced from sugarcane burning.

scientific article

The toxic effect of fluoride on MG-63 osteoblast cells is also dependent on the production of nitric oxide.

scientific article published on 15 February 2011

Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors

scientific article published on 09 March 2016

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells.

scientific article

List of works by Dario Ghigo

A LDL-masked liposomal-doxorubicin reverses drug resistance in human cancer cells

Absence of soluble CD14 in saliva of young patients with dental caries

Activation of nuclear factor-kappa B pathway by simvastatin and RhoA silencing increases doxorubicin cytotoxicity in human colon cancer HT29 cells

Altered nitric oxide/cGMP platelet signaling pathway in platelets from patients with acute coronary syndromes

Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1alpha and P-glycoprotein overexpression.

Artemisinin inhibits inducible nitric oxide synthase and nuclear factor NF-kB activation

Asbestos induces doxorubicin resistance in MM98 mesothelioma cells via HIF-1alpha.

Asbestos induces nitric oxide synthesis in mesothelioma cells via Rho signaling inhibition

Association among oral health, apical periodontitis, CD14 polymorphisms, and coronary heart disease in middle-aged adults

Carbon in intimate contact with quartz reduces the biological activity of crystalline silica dusts.

Characterization of a new compound, S35b, as a guanylate cyclase activator in human platelets

Classical inhibitors of NOX NAD(P)H oxidases are not specific.

Correlation between nitric oxide synthase activity and reduced glutathione level in human and murine endothelial cells

Crocidolite asbestos inhibits pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human lung epithelial cells.

Cycling of NADPH by glucose 6-phosphate dehydrogenase optimizes the spectrophotometric assay of nitric oxide synthase activity in cell lysates

Cytotoxicity of zinc-containing bioactive glasses in contact with human osteoblasts

Different cellular responses evoked by natural and stoichiometric synthetic chrysotile asbestos

Digoxin and ouabain increase the synthesis of cholesterol in human liver cells.

Digoxin and ouabain induce P-glycoprotein by activating calmodulin kinase II and hypoxia-inducible factor-1alpha in human colon cancer cells.

Digoxin and ouabain induce the efflux of cholesterol via liver X receptor signalling and the synthesis of ATP in cardiomyocytes.

Diphenyleneiodonium inhibits the cell redox metabolism and induces oxidative stress

Does vitreous silica contradict the toxicity of the crystalline silica paradigm?

Doxorubicin induces an increase of nitric oxide synthesis in rat cardiac cells that is inhibited by iron supplementation.

Effects of TiO2-containing phosphate glasses on solubility and in vitro biocompatibility.

Fluoride effects: the two faces of janus.

Fluoride-containing bioactive glasses inhibit pentose phosphate oxidative pathway and glucose 6-phosphate dehydrogenase activity in human osteoblasts.

Follicular fluid proteins stimulate nitric oxide (NO) synthesis in human sperm: a possible role for NO in acrosomal reaction.

Formation of a vitreous phase at the surface of some commercial diatomaceous earth prevents the onset of oxidative stress effects

Genome-wide expression profiling and functional characterization of SCA28 lymphoblastoid cell lines reveal impairment in cell growth and activation of apoptotic pathways

Geranylgeraniol prevents the cytotoxic effects of mevastatin in THP-1 cells, without decreasing the beneficial effects on cholesterol synthesis

Gold-containing bioactive glasses: a solid-state synthesis to produce alternative biomaterials for bone implantations

Guanylate cyclase activity and sperm function.

HIF-1 activation induces doxorubicin resistance in MCF7 3-D spheroids via P-glycoprotein expression: a potential model of the chemo-resistance of invasive micropapillary carcinoma of the breast.

Hematite nanoparticles larger than 90 nm show no sign of toxicity in terms of lactate dehydrogenase release, nitric oxide generation, apoptosis, and comet assay in murine alveolar macrophages and human lung epithelial cells

High aspect ratio materials: role of surface chemistry vs. length in the historical "long and short amosite asbestos fibers".

Human vascular smooth muscle cells express a constitutive nitric oxide synthase that insulin rapidly activates, thus increasing guanosine 3':5'-cyclic monophosphate and adenosine 3':5'-cyclic monophosphate concentrations

In vitro and in vivo vasodilating activity of nitroso derivatives gem -substituted with electron-withdrawing groups

Iron inhibits the nitric oxide synthesis elicited by asbestos in murine macrophages

Iron-loaded synthetic chrysotile: a new model solid for studying the role of iron in asbestos toxicity

Liposome-encapsulated doxorubicin reverses drug resistance by inhibiting P-glycoprotein in human cancer cells.

Long and short fiber amosite asbestos alters at a different extent the redox metabolism in human lung epithelial cells

Middle T antigen-transformed endothelial cells exhibit an increased activity of nitric oxide synthase.

Mitochondrial-targeting nitrooxy-doxorubicin: a new approach to overcome drug resistance

Modulation of doxorubicin resistance by the glucose-6-phosphate dehydrogenase activity

Modulation of guinea-pig cardiac L-type calcium current by nitric oxide synthase inhibitors

NO donor and biological properties of different benzofuroxans

Na+/H+ exchanger activity is increased in doxorubicin-resistant human colon cancer cells and its modulation modifies the sensitivity of the cells to doxorubicin

Nitric oxide and P-glycoprotein modulate the phagocytosis of colon cancer cells.

Nitric oxide stimulates human sperm motility via activation of the cyclic GMP/protein kinase G signaling pathway.

Nitric oxide synthesis in human nonpregnant myometrium and uterine myomas

Nitroarginine methyl ester and canavanine lower intracellular reduced glutathione.

Nitrovasodilators inhibit thrombin-induced platelet-activating factor synthesis in human endothelial cells

Novel bio-conjugate materials: soybean peroxidase immobilized on bioactive glasses containing Au nanoparticles

Physicochemical determinants in the cellular responses to nanostructured amorphous silicas

Pleiotropic effects of cardioactive glycosides.

Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 1: Identification and characterization.

Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 2: Oxidant activity of the fibers.

Potential toxicity of nonregulated asbestiform minerals: balangeroite from the western Alps. Part 3: Depletion of antioxidant defenses.

Quartz inhibits glucose 6-phosphate dehydrogenase in murine alveolar macrophages

Retracted: Zoledronic Acid Restores Doxorubicin Chemosensitivity and Immunogenic Cell Death in Multidrug-Resistant Human Cancer Cells

Reversal of doxorubicin resistance by the amiloride analogue EIPA in multidrug resistant human colon carcinoma cells

Self-assembling nanoparticles encapsulating zoledronic acid revert multidrug resistance in cancer cells

Simian virus 40 infection down-regulates the expression of nitric oxide synthase in human mesothelial cells

Statins revert doxorubicin resistance via nitric oxide in malignant mesothelioma.

Stimulation of the nitric oxide/cyclic guanosine monophosphate signaling pathway elicits human sperm chemotaxis in vitro

Surface reactivity and cell responses to chrysotile asbestos nanofibers.

The NADPH oxidase inhibitor apocynin (acetovanillone) induces oxidative stress

The NADPH oxidase inhibitor apocynin induces nitric oxide synthesis via oxidative stress

The association of statins plus LDL receptor-targeted liposome-encapsulated doxorubicin increases in vitro drug delivery across blood-brain barrier cells.

The concentration of nitrite in seminal plasma does not correlate with sperm concentration, sperm motility, leukocytospermia, or sperm culture

The pentose phosphate pathway plays an essential role in supporting human sperm capacitation.

The pentose phosphate pathway: An antioxidant defense and a crossroad in tumor cell fate ⬇️

The surface reactivity and implied toxicity of ash produced from sugarcane burning.

The toxic effect of fluoride on MG-63 osteoblast cells is also dependent on the production of nitric oxide.

Zoledronic acid-encapsulating self-assembling nanoparticles and doxorubicin: a combinatorial approach to overcome simultaneously chemoresistance and immunoresistance in breast tumors

iNOS activity is necessary for the cytotoxic and immunogenic effects of doxorubicin in human colon cancer cells.