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List of works by Steven D Shnyder

A Proteomic Investigation to Discover Candidate Proteins Involved in Novel Mechanisms of 5-Fluorouracil Resistance in Colorectal Cancer

scientific article published in 2024

Adenovirus-mediated hypoxia-targeted gene therapy using HSV thymidine kinase and bacterial nitroreductase prodrug-activating genes in vitro and in vivo.

scientific article

An agarose spot chemotaxis assay for chemokine receptor antagonists.

scientific article published on February 2011

Antitumor activity of a duocarmycin analogue rationalized to be metabolically activated by cytochrome P450 1A1 in human transitional cell carcinoma of the bladder.

scientific article

Auristatin PYE, a novel synthetic derivative of dolastatin 10, is highly effective in human colon tumour models.

scientific article

Colon cancer-specific cytochrome P450 2W1 converts duocarmycin analogues into potent tumor cytotoxins

scientific article published on 15 April 2013

Combretastatin A-1 phosphate a novel tubulin-binding agent with in vivo anti vascular effects in experimental tumours

scientific article

Combretastatin A-1 phosphate potentiates the antitumour activity of cisplatin in a murine adenocarcinoma model.

scientific article

Comparative preclinical pharmacokinetic and metabolic studies of the combretastatin prodrugs combretastatin A4 phosphate and A1 phosphate

scientific article published on February 2004

Design, synthesis, and biophysical and biological evaluation of a series of pyrrolobenzodiazepine-poly(N-methylpyrrole) conjugates

scientific article published on September 2006

Development of a Novel Tumor-Targeted Vascular Disrupting Agent Activated by Membrane-Type Matrix Metalloproteinases ⬇️

scientific article published on July 27, 2010

Development of a modified hollow fibre assay for studying agents targeting the tumour neovasculature.

scientific article published on May 2005

ERp29 is a ubiquitous resident of the endoplasmic reticulum with a distinct role in secretory protein production

scientific article

Guaianolide sesquiterpenes from Pulicaria crispa (Forssk.) Oliv.

scientific article

Heparin octasaccharides inhibit angiogenesis in vivo.

scientific article published on November 2005

In vitro and in vivo activity of LS 4477 and LS 4559, novel analogues of the tubulin binder estramustine.

scientific article published in January 2002

In vivo activation of the hypoxia-targeted cytotoxin AQ4N in human tumor xenografts.

scientific article

Modification of the duocarmycin pharmacophore enables CYP1A1 targeting for biological activity.

scientific article published on 14 October 2011

NCAM polysialylation during adherence transitions: live cell monitoring using an antibody-mimetic EGFP-endosialidase and the viability dye DRAQ7.

scientific article published on 28 May 2013

Non-invasive molecular imaging for preclinical cancer therapeutic development.

scientific article published on June 2013

Organometallic osmium arene complexes with potent cancer cell cytotoxicity

scientific article published on 26 October 2010

P-glycoprotein and metallothionein expression and resistance to chemotherapy in osteosarcoma

scientific article

Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs

scientific article published in December 2004

Pharmacological inhibition of polysialyltransferase ST8SiaII modulates tumour cell migration

scientific article (publication date: 2013)

Potent organometallic osmium compounds induce mitochondria-mediated apoptosis and S-phase cell cycle arrest in A549 non-small cell lung cancer cells.

scientific article published on May 2014

Potentiation of the activity of cisplatin in a human colon tumour xenograft model by auristatin PYE, a structural modification of dolastatin 10.

scientific article published in March 2010

Preliminary pharmacokinetic and bioanalytical studies of SJG-136 (NSC 694501), a sequence-selective pyrrolobenzodiazepine dimer DNA-cross-linking agent.

scientific article published on August 2004

Quantitative angiogenesis assays in vivo--a review.

scientific article published in January 2004

RGD-Binding Integrins in Prostate Cancer: Expression Patterns and Therapeutic Prospects against Bone Metastasis.

scientific article published on 26 October 2012

Re-engineering of the duocarmycin structural architecture enables bioprecursor development targeting CYP1A1 and CYP2W1 for biological activity.

scientific article published on 26 July 2013

Reducing the cost of screening novel agents using the hollow fibre assay.

scientific article published on May 2006

Retargeted adenoviral cancer gene therapy for tumour cells overexpressing epidermal growth factor receptor or urokinase-type plasminogen activator receptor

scientific article published on 22 April 2010

Secretory phospholipase A2 as a tumor-specific trigger for targeted delivery of a novel class of liposomal prodrug anticancer etherlipids

scientific article

Single-chain TNF, a TNF derivative with enhanced stability and antitumoral activity

scientific article

Small molecule FGF receptor inhibitors block FGFR-dependent urothelial carcinoma growth in vitro and in vivo. ⬇️

scientific article

Sodium pancratistatin 3,4-o-cyclic phosphate, a water-soluble synthetic derivative of pancratistatin, is highly effective in a human colon tumor model.

scientific article published on 22 December 2007

Study of the Chemotactic Response of Multicellular Spheroids in a Microfluidic Device

scientific article

Synthesis and biological evaluation of colchicine B-ring analogues tethered with halogenated benzyl moieties

scientific article

Synthesis and biological evaluation of colchicine C-ring analogues tethered with aliphatic linkers suitable for prodrug derivatisation.

scientific article

Synthesis of DNA-directed pyrrolidinyl and piperidinyl confined alkylating chloroalkylaminoanthraquinones: potential for development of tumor-selective N-oxides

scientific article published on November 2006

Synthesis of cryptolepine analogues as potential bioreducible anticancer agents.

scientific article

The Effect of Polysialic Acid Expression on Glioma Cell Nano-mechanics

scientific article published on 25 January 2016

The hollow fibre model--facilitating anti-cancer pre-clinical pharmacodynamics and improving animal welfare.

scientific article published on December 2006

Thin-layer chromatography/matrix-assisted laser desorption/ionisation mass spectrometry and matrix-assisted laser desorption/ionisation mass spectrometry imaging for the analysis of phospholipids in LS174T colorectal adenocarcinoma xenografts treate

scientific article published on July 2015

Triplex profiling of functionally distinct chaperones (ERp29/PDI/BiP) reveals marked heterogeneity of the endoplasmic reticulum proteome in cancer

scientific article

Tumor-targeted prodrug ICT2588 demonstrates therapeutic activity against solid tumors and reduced potential for cardiovascular toxicity.

scientific article published on 27 March 2014

Use of the hollow fiber assay for the evaluation of DNA damaging agents.

scientific article published on 30 April 2011

Use of the hollow fibre assay for studies of tumor neovasculature

scientific article published on January 2009

Vinflunine potentiates the activity of cisplatin but not 5-fluorouracil in a transplantable murine adenocarcinoma model

scientific article published in November 2003

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