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List of works by David H. Phillips

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scientific article published on 01 July 1996

3-Nitrobenzanthrone and 3-aminobenzanthrone induce DNA damage and cell signalling in Hepa1c1c7 cells.

scientific article

3-aminobenzanthrone, a human metabolite of the carcinogenic environmental pollutant 3-nitrobenzanthrone, induces biotransformation enzymes in rat kidney and lung.

scientific article published on 3 May 2009

3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone, forms DNA adducts after metabolic activation by human and rat liver microsomes: evidence for activation by cytochrome P450 1A1 and P450 1A2.

scientific article published on August 2004

32P-Post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. II. Newborn male B6C3F1 mice

scientific article published on 01 December 1984

32P-Postlabelling analysis of DNA adducts in the skin of mice treated with petrol and diesel engine lubricating oils and exhaust condensates

scientific article published on 01 August 1989

32P-Postlabelling analysis of DNA adducts of benzo[a]pyrene formed in complex metabolic activation systems in vitro

scientific article published on 01 November 1989

32P-Postlabelling detection of aromatic DNA adducts in peripheral blood lymphocytes from aluminium production plant workers

article

32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice

scientific article published in December 1984

32P-postlabelling analysis of the covalent binding of benzo[ghi]perylene to DNA in vivo and in vitro

scientific article published in January 1993

4-Hydroxytamoxifen gives DNA adducts by chemical activation, but not in rat liver cells

scientific article published in February 1999

A biomarker model of sublethal genotoxicity (DNA single-strand breaks and adducts) using the sentinel organism Aporrectodea longa in spiked soil

scientific article published in November 2005

A comparison of 32P-postlabelling and immunological methods to examine human lung DNA for benzo[a]pyrene adducts

scientific article published on 01 January 1988

A novel method for source-specific hemoglobin adducts of nitro-polycyclic aromatic hydrocarbons.

scientific article published on 21 March 2018

A quantitative determination of the covalent binding of a series of polycylic hydrocarbons to DNA in mouse skin

scientific article published in February 1979

ACB-PCR measurement of H-ras codon 61 CAA→CTA mutation provides an early indication of aristolochic acid I carcinogenic effect in tumor target tissues.

scientific article published on 25 June 2012

AHR- and DNA-damage-mediated gene expression responses induced by benzo(a)pyrene in human cell lines.

scientific article published on 19 October 2007

Aberrant activation of benzo(a)pyrene in cultured rat mammary cells in vitro and following direct application to rat mammary glands in vivo

scientific article published on 01 September 1985

Activating mutations in human c-Ha-ras-1 gene induced by reactive derivatives of safrole and the glutamic pyrolysis product, Glu-P-3.

scientific article published on September 1988

Activating mutations in human c-Ha-ras-1 protooncogene induced by stereoisomeric fjord-region benzo[c]chrysene diol-epoxides

scientific article published on November 1995

Activation of 3-nitrobenzanthrone and its metabolites to DNA-damaging species in human B lymphoblastoid MCL-5 cells

scientific article published on March 2004

Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide

scientific article published on August 1984

Activation of genotoxins to DNA-damaging species in exfoliated breast milk cells

scientific article published in October 2000

Activation of tamoxifen and its metabolite α-hydroxytamoxifen to DNA-binding products: comparisons between human, rat and mouse hepatocytes

scientific article published on 01 January 1996

Age-dependent change of metabolic capacity and genotoxic injury in rat intestine

scientific article published on May 1998

Alkali-sensitive sites in DNA from human cells treated with ultraviolet light, 1'-acetoxysafrole or 1'-acetoxyestragole.

scientific article published on January 1982

An ECVAG inter-laboratory validation study of the comet assay: inter-laboratory and intra-laboratory variations of DNA strand breaks and FPG-sensitive sites in human mononuclear cells

scientific article published on 27 February 2013

An ECVAG trial on assessment of oxidative damage to DNA measured by the comet assay

scientific article published on 30 November 2009

Analysis of tamoxifen-DNA adducts in endometrial explants by MS and 32P-postlabeling.

scientific article

Analysis of the polycyclic aromatic hydrocarbon content of petrol and diesel engine lubricating oils and determination of DNA adducts in topically treated mice by 32P-postlabelling

scientific article

Aristolochic acid mutagenesis: molecular clues to the aetiology of Balkan endemic nephropathy-associated urothelial cancer.

scientific article published on 13 April 2007

Aristolochic acid nephropathy and the peritoneum: Functional, structural, and molecular studies

scientific article published in November 2003

Aromatic DNA adducts in human bone marrow and peripheral blood leukocytes

scientific article published in December 1986

Aromatic DNA adducts in white blood cells of coke workers

scientific article published on 01 January 1990

Aromatic deoxyribonucleic acid adducts in white blood cells of foundry and coke oven workers

scientific article published on January 1, 1988

Association between carcinogen-DNA adducts in white blood cells and lung cancer risk in the physicians health study

article

Associations between carcinogen-DNA damage, glutathione S-transferase genotypes, and risk of lung cancer in the prospective Physicians' Health Cohort Study

scientific article published in October 2002

Benzo pyrene-induced DNA adducts and gene expression profiles in target and non-target organs for carcinogenesis in mice

scientific article

Bioactivation of 3-aminobenzanthrone, a human metabolite of the environmental pollutant 3-nitrobenzanthrone: evidence for DNA adduct formation mediated by cytochrome P450 enzymes and peroxidases

scientific article published in March 2006

Bioactivation versus detoxication of the urothelial carcinogen aristolochic acid I by human cytochrome P450 1A1 and 1A2.

scientific article published on 15 November 2011

Biologically-active and chemically-reactive polycyclic hydrocarbon metabolites

scientific article

Biotransformation of benzo[a]pyrene in Ahr knockout mice is dependent on time and route of exposure

scientific article published in March 2009

Boronic acids-a novel class of bacterial mutagen

scientific article published on 26 May 2011

Bulky DNA adducts in white blood cells: a pooled analysis of 3,600 subjects

scientific article published on 04 October 2010

Bulky DNA adducts, microRNA profiles, and lipid biomarkers in Norwegian tunnel finishing workers occupationally exposed to diesel exhaust

scientific article published on 13 November 2018

Carcinogen-DNA adducts in human breast tissue

scientific article published on 01 April 1995

Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism.

scientific article published on 15 November 2014

Co-chromatography of a tamoxifen epoxide-deoxyguanylic acid adduct with a major DNA adduct formed in the livers of tamoxifen-treated rats

scientific article

Comparison of the formation of 8-hydroxy-2'-deoxyguanosine and single- and double-strand breaks in DNA mediated by fenton reactions.

scientific article published in May 1998

Comparison of the metabolic activation of environmental carcinogens in mouse embryonic stem cells and mouse embryonic fibroblasts

scientific article published on 16 September 2014

Comparison of total DNA adduct levels induced in mouse tissues and human skin by mainstream and sidestream cigarette smoke condensates

scientific article published on 01 January 1993

Constitutive expression of bioactivating enzymes in normal human prostate suggests a capability to activate pro-carcinogens to DNA-damaging metabolites.

scientific article published on October 2010

Correlation of DNA adduct levels in human lung with cigarette smoking

scientific article published in Nature

Correlative changes in metabolism and DNA damage in turbot (Scophthalmus maximus) exposed to benzo[a]pyrene

scientific article published in September 2002

Corrigendum to “STrengthening the Reporting of OBservational studies in Epidemiology — Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement” [Prev. Med. 53 (2011) 377–387]

scholarly article by Valentina Gallo et al published May 2012 in Preventive Medicine

Covalent DNA adducts formed by benzo[c]chrysene in mouse epidermis and by benzo[c]chrysene fjord-region diol epoxides reacted with DNA and polynucleotides

scientific article published in November 1997

Covalent DNA adducts formed in mouse epidermis by benzo[g]chrysene

scientific article

Covalent binding of components of coal-tar, creosote and bitumen to the DNA of the skin and lungs of mice following topical application

scientific article published in July 1988

Covalent binding of dibenzpyrenes and benzo[a]Pyrene to DNA: evidence for synergistic and inhibitory interactions when applied in combination to mouse skin

article

Covalent binding of polycyclic aromatic hydrocarbon components of coal tar to DNA in mouse skin

scientific article published in January 1993

Cytochrome b 5 impacts on cytochrome P450-mediated metabolism of benzo[a]pyrene and its DNA adduct formation: studies in hepatic cytochrome b 5 /P450 reductase null (HBRN) mice

scientific article published on 24 January 2018

Cytochrome b5 and epoxide hydrolase contribute to benzo[a]pyrene-DNA adduct formation catalyzed by cytochrome P450 1A1 under low NADPH:P450 oxidoreductase conditions.

scientific article published on 14 February 2014

DNA adduct assay in cervical epithelium

scientific article published on 01 January 1994

DNA adduct formation and mutation induction by aristolochic acid in rat kidney and liver.

scientific article published on 28 September 2006

DNA adduct formation by 7-methoxy-2-nitro-naphtho[2,1-b]furan (R7000), an extremely potent mutagen

scientific article published on 01 July 1989

DNA adduct formation by the environmental contaminant 3-nitrobenzanthrone after intratracheal instillation in rats

scientific article published in October 2005

DNA adduct formation by the ubiquitous environmental pollutant 3-nitrobenzanthrone and its metabolites in rats

scientific article published in January 2003

DNA adduct formation in human hepatoma cells treated with 3-nitrobenzanthrone: analysis by the (32)P-postlabeling method

scientific article published on 10 July 2007

DNA adduct formation in mice following treatment with used engine oil and identification of some of the major adducts by 32P-postlabelling

scientific article published on 01 June 1992

DNA adducts and cancer risk in prospective studies: a pooled analysis and a meta-analysis

article

DNA adducts and mutagenic specificity of the ubiquitous environmental pollutant 3-nitrobenzanthrone in Muta Mouse

scientific article published in January 2004

DNA adducts as markers of exposure and risk.

scientific article

DNA adducts derived from safrole, estragole and related compounds, and from benzene and its metabolites.

scientific article published on January 1994

DNA adducts from chemotherapeutic agents

scientific article published on August 1996

DNA adducts in cervical tissue of smokers and non-smokers

scientific article published on October 1994

DNA adducts in human and mouse skin maintained in short-term culture and treated with petrol and diesel engine lubricating oils

scientific article published in May 1991

DNA adducts in human breast tissue: association with N-acetyltransferase-2 (NAT2) and NAT1 genotypes

scientific article published on 01 November 1998

DNA adducts in human environmentally exposed to aromatic compounds in an industrial area of Poland

scientific article published on July 1990

DNA adducts in human tissues: biomarkers of exposure to carcinogens in tobacco smoke.

scientific article

DNA adducts in human urinary bladder and other tissues.

scientific article

DNA adducts in peripheral blood lymphocytes from aluminum production plant workers determined by 32P-postlabeling and enzyme-linked immunosorbent assay

scientific article

DNA adducts: mass spectrometry methods and future prospects.

scientific article

DNA and protein adducts in human tissues resulting from exposure to tobacco smoke ⬇️

scientific article published on October 5, 2012

DNA damage and DNA damage response in human bronchial epithelial BEAS-2B cells following exposure to 2-nitrobenzanthrone and 3-nitrobenzanthrone: role in apoptosis.

scientific article published on 29 June 2011

DNA damage in breast epithelial cells: detection by the single-cell gel (comet) assay and induction by human mammary lipid extracts

scientific article published on 01 December 1997

DNA damage in human breast milk cells and its induction by 'early' and 'late' milk extracts

scientific article published in April 2000

DNA-repair measurements by use of the modified comet assay: an inter-laboratory comparison within the European Comet Assay Validation Group (ECVAG).

scientific article published on 2 July 2013

Damage to DNA in cervical epithelium related to smoking tobacco

scientific article

Deletion of cytochrome P450 oxidoreductase enhances metabolism and DNA adduct formation of benzo[a]pyrene in Hepa1c1c7 cells

scientific article published on 14 October 2019

Detection and characterization by 32P-postlabelling of DNA adducts induced by a Fenton-type oxygen radical-generating system

scientific article published on July 1992

Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry.

scientific article

Detection of DNA modifications by the 32P-postlabelling assay ⬇️

scientific article published on August 1, 1997

Detection of Herba Aristolochia Mollissemae in a patient with unexplained nephropathy

scientific article

Detection of bulky DNA lesions in the liver of patients with Wilson's disease and primary haemochromatosis

scientific article published on 01 February 1995

Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells from coke oven workers: correlation with job categories ⬇️

article by S Ovrebø et al published 15 March 1992 in Cancer Research

Determination of benzidine--DNA adduct formation in CHO, HeLa, L5178Y, TK6 and V79 cells

scientific article published on January 1990

Determination of target nucleotides involved in 7-methoxy-2-nitro-naphtho[2,1-b]furan (R7000)-DNA adduct formation.

scientific article

Determination of the enzymes responsible for activation of the heterocyclic amine 2-amino-3-methylimidazo[4,5-f]quinoline in the human breast

scientific article published on 01 December 1998

Different susceptibility to smoking-induced DNA damage among male and female lung cancer patients

scientific article published on 01 November 1994

Differential effects of nitro-PAHs and amino-PAHs on cytokine and chemokine responses in human bronchial epithelial BEAS-2B cells

scientific article published on 29 October 2009

Differentiation-associated urothelial cytochrome P450 oxidoreductase predicates the xenobiotic-metabolizing activity of "luminal" muscle-invasive bladder cancers.

scientific article

Diversity of TMPRSS2-ERG fusion transcripts in the human prostate

scientific article published on 16 October 2006

Early proximal tubule injury in experimental aristolochic acid nephropathy: functional and histological studies

scientific article published on 2 August 2005

Effect of hepatic cytochrome P450 (P450) oxidoreductase deficiency on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-DNA adduct formation in P450 reductase conditional null mice

scientific article published on 22 September 2011

Effect of tissue fixation on recovery of DNA adducts in the 32P-postlabelling assay

scientific article published on 01 January 1993

Effects of dexfenfluramine on aristolochic acid nephrotoxicity in a rat model for Chinese-herb nephropathy

scientific article published on 20 February 2003

Effects of mixing metal ions on oxidative DNA damage mediated by a Fenton-type reduction

scientific article published on 10 August 2007

Electrospray ionization-tandem mass spectrometry and 32P-postlabeling analyses of tamoxifen-DNA adducts in humans

scientific article

Enzyme-mediated phosphorylation of polycyclic hydrocarbon metabolites: detection of non-adduct compounds in the 32P-postlabelling assay

scientific article published in August 1989

Erratum to: STrengthening the reporting of OBservational studies in Epidemiology—Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement

scholarly article by Valentina Gallo et al published February 2012 in European Journal of Epidemiology

Estragole: a weak direct-acting food-borne genotoxin and potential carcinogen.

scientific article published on 3 May 2012

Estrogen receptor expression and gene promoter methylation in non-small cell lung cancer - a short report

scientific article published on 29 August 2016

Evaluation of DNA-binding activity of hydroxyanthraquinones occurring in Rubia tinctorum L

scientific article published on 01 July 1991

Evidence for DNA and protein binding by styrene and styrene oxide

scientific article published on January 1994

Evidence for N-(deoxyguanosin-8-yl)-1-aminopyrene as a major DNA adduct in female rats treated with 1-nitropyrene

scientific article published on April 1985

Evidence for the involvement of a bis-diol-epoxide in the metabolic activation of dibenz[a,h]anthracene to DNA-binding species in mouse skin

scientific article published on 01 March 1993

Evidence of exposure to aristolochic acid in patients with urothelial cancer from a Balkan endemic nephropathy region of Romania

scientific article published on 17 September 2012

Evidence of involvement of multiple sites of metabolism in the in vivo covalent binding of dibenzo[a,h]pyrene to DNA

scientific article published on November 1, 1992

Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy

article

Exposure to Polycyclic Aromatic Hydrocarbons Among Never Smokers in Golestan Province, Iran, an Area of High Incidence of Esophageal Cancer - a Cross-Sectional Study with Repeated Measurement of Urinary 1-OHPG in Two Seasons

scientific article

Exposure to benzo[a]pyrene of Hepatic Cytochrome P450 Reductase Null (HRN) and P450 Reductase Conditional Null (RCN) mice: Detection of benzo[a]pyrene diol epoxide-DNA adducts by immunohistochemistry and 32P-postlabelling.

scientific article

Fifty years of benzo(a)pyrene ⬇️

scientific article published on June 9, 1983

Formation and persistence of DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in target and non-target organs after intratracheal instillation in rats

scientific article published on 17 November 2006

Formation and persistence of benzo[a]pyrene-DNA adducts in mouse epidermis in vivo: importance of adduct conformation ⬇️

scientific article published on October 1, 1995

Formation of DNA adducts from 1-hydroxymethylpyrene in liver cells in vivo and in vitro

scientific article published on 01 January 1993

Formation of DNA adducts in human skin maintained in short-term organ culture and treated with coal-tar, creosote or bitumen

scientific article published in October 1988

Formation of DNA adducts in mouse skin treated with metabolites of chrysene

scientific article published on May 1987

Formation of DNA adducts in rat lung following chronic inhalation of diesel emissions, carbon black and titanium dioxide particles

scientific article

Formation of DNA adducts in the skin of psoriasis patients, in human skin in organ culture, and in mouse skin and lung following topical application of coal-tar and juniper tar.

scientific article published in February 1990

From the exposome to mechanistic understanding of chemical-induced adverse effects

scientific article

Further evidence that eugenol does not bind to DNA in vivo

article

Further metabolism of diol-epoxides of chrysene and dibenz[a,c]anthracene to DNA binding species as evidenced by 32P-postlabelling analysis

scientific article

GSTM1, GSTP1, CYP1A1 and CYP2D6 polymorphisms in lung cancer patients from an environmentally polluted region of Poland: correlation with lung DNA adduct levels

article

Gender-related differences in response to mutagens and carcinogens

scientific article published on 01 March 2010

Gene expression profiles modulated by the human carcinogen aristolochic acid I in human cancer cells and their dependence on TP53.

scientific article published on 25 June 2008

Generation of Putative Intrastrand Cross-Links and Strand Breaks in DNA by Transition Metal Ion-Mediated Oxygen Radical Attack

scientific article published on 01 April 1997

Genotoxic potential of tamoxifen and analogues in female Fischer F344/n rats, DBA/2 and C57BL/6 mice and in human MCL-5 cells

scientific article published on December 1992

Genotoxicity characteristics of reverse diol-epoxides of chrysene

scientific article published in January 1993

Genotoxicity of 3-nitrobenzanthrone and 3-aminobenzanthrone in MutaMouse and lung epithelial cells derived from MutaMouse

scientific article

Genotoxicity of fine and coarse fraction ambient particulate matter in immortalised normal (TT1) and cancer-derived (A549) alveolar epithelial cells

scientific article

Genotoxicity of human breast milk from different countries

scientific article published in September 2001

Genotoxicity of human mammary lipid

scientific article published on December 1996

Genotypes of glutathione transferase M1 and P1 and their significance for lung DNA adduct levels and cancer risk

scientific article published in July 1997

Growth kinetics in MCF-7 cells modulate benzo[a]pyrene-induced CYP1A1 up-regulation.

scientific article published on 20 January 2007

HPLC separation of 32P-postlabelled DNA adducts formed from dibenz[a,h]anthracene in skin

scientific article published in December 1992

HPLC separation of 32P-postlabelled benzo[b]fluoranthene-DNA adducts

scientific article published on 01 August 1992

Hepatic DNA adduct dosimetry in rats fed tamoxifen: a comparison of methods.

scientific article

Hepatic DNA damage in harbour porpoises (Phocoena phocoena) stranded along the English and Welsh coastlines

scientific article published on 03 July 2018

Hepatic genotoxicity and toxicogenomic responses in Muta™Mouse males treated with dibenz[a,h]anthracene

scientific article

Heterocyclic aromatic amines induce DNA strand breaks and cell transformation

scientific article published on April 1999

Heterogeneous DNA damage and repair in the mammalian genome

scientific article published on December 1987

Human enzymes involved in the metabolic activation of the environmental contaminant 3-nitrobenzanthrone: evidence for reductive activation by human NADPH:cytochrome p450 reductase.

scientific article

Identification of the major tamoxifen-deoxyguanosine adduct formed in the liver DNA of rats treated with tamoxifen

scientific article published on 01 January 1996

Identification of three major DNA adducts formed by the carcinogenic air pollutant 3-nitrobenzanthrone in rat lung at the C8 and N2 position of guanine and at the N6 position of adenine

scientific article

Identification through microarray gene expression analysis of cellular responses to benzo(a)pyrene and its diol-epoxide that are dependent or independent of p53.

scientific article

Idoxifene derivatives are less reactive to DNA than tamoxifen derivatives, both chemically and in human and rat liver cells

scientific article published in February 1999

Impact of genetic modulation of SULT1A enzymes on DNA adduct formation by aristolochic acids and 3-nitrobenzanthrone.

scientific article

Impact of p53 function on the sulfotransferase-mediated bioactivation of the alkylated polycyclic aromatic hydrocarbon 1-hydroxymethylpyrene in vitro

scientific article published on 04 June 2019

In Vitro Reaction with DNA of the Fjord-Region Diol Epoxides of Benzo[g]chrysene and Benzo[c]phenanthrene As Studied by 32P-Postlabeling

scientific article published on 01 June 1995

In vitro mechanistic differences in benzo[a]pyrene-DNA adduct formation using fish liver and mussel digestive gland microsomal activating systems

scientific article published in September 2002

Induction of activating mutations in the human c-Ha-ras-1 proto-oncogene by oxygen free radicals

scientific article published on November 1994

Influence of cigarette smoking on the levels of DNA adducts in human bronchial epithelium and white blood cells

scientific article published on 01 October 1990

Influence of dietary fat on DNA binding by 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) in the mouse liver

scientific article published in July 1993

Influence of the alkyl substituent on mutagenicity and covalent DNA binding of bay region diol-epoxides of 7-methyl- and 7-ethylbenz(a)anthracene in Salmonella and V79 Chinese hamster cells.

scientific article published on April 1989

Inhibition by an extract of Ocimum sanctum of DNA-binding activity of 7,12-dimethylbenz[a]anthracene in rat hepatocytes in vitro

scientific article published in June 1998

Inter-individual differences in the ability of human milk-fat extracts to enhance the genotoxic potential of the procarcinogen benzo[a]pyrene in MCF-7 breast cells

scientific article

Inter-laboratory variation in DNA damage using a standard comet assay protocol.

scientific article published on 27 July 2012

Interaction of omeprazole with DNA in rat tissues

scientific article published on 01 July 1992

Interindividual variation in the metabolic activation of heterocyclic amines and their N-hydroxy derivatives in primary cultures of human mammary epithelial cells

scientific article published in May 1998

Interlaboratory and interplatform comparison of microarray gene expression analysis of HepG2 cells exposed to benzo(a)pyrene

scientific article

Interlaboratory comparison of the 32P-postlabelling assay for aromatic DNA adducts in white blood cells of iron foundry workers

scientific article published on 01 December 1989

Interleukin 1 receptor antagonist gene polymorphism and risk of lung cancer: a possible interaction with polymorphisms in the interleukin 1 beta gene

scientific article

Lack of evidence for tamoxifen- and toremifene-DNA adducts in lymphocytes of treated patients

scientific article published in April 2000

Lack of evidence from HPLC 32P-post-labelling for tamoxifenDNA adducts in the human endometrium

article

Lack of genotoxicity of tamoxifen in human endometrium

scientific article published on 01 April 1996

Lagos lagoon sediment organic extracts and polycyclic aromatic hydrocarbons induce embryotoxic, teratogenic and genotoxic effects in Danio rerio (zebrafish) embryos

scientific article published on 11 April 2016

Linking environmental carcinogen exposure to TP53 mutations in human tumours using the human TP53 knock-in (Hupki) mouse model.

scientific article published on June 2010

Lipid peroxidation-induced etheno-DNA adducts in the liver of patients with the genetic metal storage disorders Wilson's disease and primary hemochromatosis.

scientific article published in May 1998

MGMT promoter hypermethylation and K-RAS, PTEN and TP53 mutations in tamoxifen-exposed and non-exposed endometrial cancer cases

scientific article

Mammary expression of xenobiotic metabolizing enzymes and their potential role in breast cancer.

scientific article

Mechanisms of the different DNA adduct forming potentials of the urban air pollutants 2-nitrobenzanthrone and carcinogenic 3-nitrobenzanthrone

scientific article published on July 2010

Metabolic activation and DNA binding of food mutagens and other environmental carcinogens in human mammary epithelial cells

scientific article

Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) mice

scientific article published on 3 September 2015

Metabolic activation of 7,12-dimethylbenz[a]anthracene in rat mammary tissue: Fluorescence spectral characteristics of hydrocarbon-DNA adducts

scientific article published on 01 February 1985

Metabolic activation of 7-ethyl- and 7-methylbenz[a]anthracene in mouse skin

scientific article published on January 1988

Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice.

scientific article

Metabolic activation of carcinogens and expression of various cytochromes P450 in human prostate tissue

scientific article

Metabolic activation of the environmental contaminant 3-nitrobenzanthrone by human acetyltransferases and sulfotransferase

scientific article published on November 2002

Metabolic activation of the food mutagens 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) to DNA binding species in human mammary epithelial cells

scientific article published in May 1992

Metabolic competence and susceptibility of intestinal epithelium to genotoxic injury during regeneration

scientific article published on November 1997

Metabolic proficiency and benzo[a]pyrene DNA adduct formation in APCMin mouse adenomas and uninvolved mucosa

scientific article published in June 1999

Methods of DNA adduct determination and their application to testing compounds for genotoxicity

scientific article published on 01 January 2000

Microsomal metabolism of dibenz[a,c]anthracene, dibenz[a,h]anthracene and dibenz[a,j]anthracene to bis-dihydrodiols and polyhydroxylated products

scientific article published on 01 January 1991

Microsome-mediated reactions of phenols of polycyclic hydrocarbons with DNA.

scientific article

Minor products of reaction of DNA with alpha-acetoxytamoxifen

scientific article published in March 1997

Modulation of N-methyl-N-nitrosourea-induced crypt restricted metallothionein immunopositivity in mouse colon by a non-genotoxic diet-related chemical

scientific article

Molecular and metabolic consequences following E6 transfection in an isogenic ovarian cell line (A2780) pair

scientific article published on January 2013

Molecular evidence for an involvement of organic anion transporters (OATs) in aristolochic acid nephropathy.

scientific article published on 28 July 2009

Monitoring occupational exposure to carcinogens: detection by 32P-postlabelling of aromatic DNA adducts in white blood cells from iron foundry workers

scientific article

Morphological transformation of C3H/M2 mouse fibroblasts by extracts of human mammary lipid

scientific article published on October 1998

Morphological transformation of C3H/M2 mouse fibroblasts by, and genotoxicity of, extracts of human milk

scientific article published in November 2001

Msh2 deficiency increases susceptibility to benzo[a]pyrene-induced lymphomagenesis.

scientific article published in June 2006

Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung

scientific article published in September 2001

Mutagenic fingerprint of ozone in human cells.

scientific article published on May 2002

Mutagenic potential of DNA adducts formed by diol-epoxides, triol-epoxides and the K-region epoxide of chrysene in mammalian cells

scientific article published on October 1986

Mutagenic potential of nitrenium ions of nitrobenzanthrones: correlation between theory and experiment

scientific article published in October 2008

Mutagenicity and DNA adduct formation by the urban air pollutant 2-nitrobenzanthrone

scientific article published on 4 May 2007

Mutagenicity testing for chemical risk assessment: update of the WHO/IPCS Harmonized Scheme

scientific article

Mutagens in human breast lipid and milk: the search for environmental agents that initiate breast cancer.

scientific article

Mutational signatures associated with tobacco smoking in human cancer

scientific article (publication date: 3 November 2016)

Mutational spectra and mutational signatures: Insights into cancer aetiology and mechanisms of DNA damage and repair

scholarly article by David H. Phillips published in August 2018

Mutations activating human c-Ha-ras1 protooncogene (HRAS1) induced by chemical carcinogens and depurination.

scientific article published on March 1986

N-Acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation

scientific article published on 01 June 2006

N-Acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast.

scientific article published in July 2001

N-Demethylation accompanies α-hydroxylation in the metabolic activation of tamoxifen in rat liver cells

scientific article published on 01 October 1999

NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.

scientific article

NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.

scientific article published on 12 July 2016

Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine

scientific article

Nutlin-3a selects for cells harbouring TP53 mutations

scientific article published on 4 November 2016

On the origins and development of the (32)P-postlabelling assay for carcinogen-DNA adducts.

scientific article

Organ specificity of DNA adduct formation by tamoxifen and alpha-hydroxytamoxifen in the rat: implications for understanding the mechanism(s) of tamoxifen carcinogenicity and for human risk assessment

scientific article published on 31 May 2005

Pathways of heterocyclic amine activation in the breast: DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) formed by peroxidases and in human mammary epithelial cells and fibroblasts

scientific article published on 01 March 2000

Philip D. Lawley (1927-2011)

scientific article published on 21 March 2012

Philip D. Lawley (1927–2011).

scientific article published in April 2012

Polycyclic aromatic hydrocarbon (PAH) exposure and DNA adduct semi-quantitation in archived human tissues

scientific article

Polycyclic aromatic hydrocarbon-DNA adducts in coke-oven workers

scientific article published in January 1990

Polycyclic aromatic hydrocarbons in the diet.

scientific article

Polycyclic aromatic hydrocarbons-aromatic DNA adducts in cord blood and behavior scores in New York city children

scientific article (publication date: August 2011)

Polycyclic hydrocarbon activation: bay regions and beyond

scientific article published on January 1994

Polymorphisms of DNA repair genes and risk of non-small cell lung cancer.

scientific article

Polymorphisms of the GSTP1 and GSTM1 genes and PAH-DNA adducts in human mononuclear white blood cells

scientific article published in January 2000

Postlabeling and immunoassay analysis of polycyclic aromatic hydrocarbons--adducts of deoxyribonucleic acid in white blood cells of foundry workers

scientific article

Preparation of a Methylated DNA Standard, and Its Stability on Storage

scientific article published on 01 April 2000

Primary cultures of prostate cells and their ability to activate carcinogens

scientific article

Protective action of n-3 fatty acids on benzo[a]pyrene-induced apoptosis through the plasma membrane remodeling-dependent NHE1 pathway.

scientific article published on 15 November 2013

Protein Adductomics: Analytical Developments and Applications in Human Biomonitoring

scientific article published on 25 May 2019

Pulmonary Inflammation Impacts on CYP1A1-Mediated Respiratory Tract DNA Damage Induced by the Carcinogenic Air Pollutant Benzo[a]pyrene

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Quantifiable mRNA transcripts for tamoxifen-metabolising enzymes in human endometrium

scientific article published on 22 April 2008

Quantification of 3-nitrobenzanthrone-DNA adducts using online column-switching HPLC-electrospray tandem mass spectrometry

scientific article published in November 2009

Quantification of a peptide standard using the intrinsic fluorescence of tyrosine

scientific article

Quantification of phase I/II metabolizing enzyme gene expression and polycyclic aromatic hydrocarbon-DNA adduct levels in human prostate

scientific article (publication date: April 2009)

Quantitative relationships between lacZ mutant frequency and DNA adduct frequency in Muta™Mouse tissues and cultured cells exposed to 3-nitrobenzanthrone

scientific article published on 16 January 2017

Rat, but not human, sulfotransferase activates a tamoxifen metabolite to produce DNA adducts and gene mutations in bacteria and mammalian cells in culture

scientific article published on October 1998

Reduced genotoxicity of [D5-ethyl]-tamoxifen implicates alpha-hydroxylation of the ethyl group as a major pathway of tamoxifen activation to a liver carcinogen

scientific article published in August 1994

Refinement of a Methodology for Untargeted Detection of Serum Albumin Adducts in Human Populations.

scientific article published in November 2017

Relationship between mutagenicity and DNA adduct formation in mammalian cells for fjord- and bay-region diol-epoxides of polycyclic aromatic hydrocarbons

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Repair replication characteristics of human cells exposed to 1'-acetoxysafrole or 1'-acetoxyestragole

scientific article published in January 1982

Resolution of alpha-hydroxytamoxifen; R-isomer forms more DNA adducts in rat liver cells

scientific article published in July 2001

Results of an interlaboratory trial of 32P-postlabelling

scientific article published on 01 January 1993

Resveratrol inhibits benzo[a]pyrene-DNA adduct formation in human bronchial epithelial cells

scientific article published on July 2004

Role of P450 1A1 and P450 1A2 in bioactivation versus detoxication of the renal carcinogen aristolochic acid I: studies in Cyp1a1-/-, Cyp1a2-/-, and Cyp1a1/1a2-/- mice.

scientific article published on 29 September 2011

Role of cytochromes P450 1A1/2 in detoxication and activation of carcinogenic aristolochic acid I: studies with the hepatic NADPH:cytochrome P450 reductase null (HRN) mouse model.

scientific article

Role of estrogen receptor in regulation of polycyclic aromatic hydrocarbon metabolic activation in lung

scientific article published on September 2004

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: studies with the hepatic NADPH:cytochrome P450 reductase null mouse.

scientific article published on 26 September 2007

STrengthening the Reporting of OBservational studies in Epidemiology - Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement

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STrengthening the Reporting of OBservational studies in Epidemiology – Molecular Epidemiology STROBE-ME: an extension of the STROBE statement

scientific article published in December 2011

STrengthening the Reporting of OBservational studies in Epidemiology — Molecular Epidemiology (STROBE-ME): An extension of the STROBE statement

scientific article published in December 2011

STrengthening the Reporting of OBservational studies in Epidemiology — Molecular Epidemiology STROBE-ME: an extension of the STROBE statement [J Clin Epidemiol 2011;64(12):1350–1363]

scholarly article by Valentina Gallo et al published July 2012 in Journal of Clinical Epidemiology

STrengthening the Reporting of OBservational studies in Epidemiology--Molecular Epidemiology (STROBE-ME): an extension of the STROBE Statement

scientific article

STrengthening the Reporting of OBservational studies in Epidemiology: Molecular Epidemiology STROBE-ME. An extension of the STROBE statement

scientific article

STrengthening the reporting of OBservational studies in Epidemiology—Molecular Epidemiology (STROBE-ME): an extension of the STROBE statement

scholarly article by Valentina Gallo et al published October 2011 in European Journal of Epidemiology

Safety of prophylactic tamoxifen

scientific article published in The Lancet

Sex differences in risk of lung cancer: Expression of genes in the PAH bioactivation pathway in relation to smoking and bulky DNA adducts

scientific article published in August 2006

Sex differences in susceptibility to PAHs is an intrinsic property of human lung adenocarcinoma cells

scientific article published on 15 October 2010

Sex differences in the activation of tamoxifen to DNA binding species in rat liver in vivo and in rat hepatocytes in vitro: role of sulfotransferase induction

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Simultaneous measurement of benzo[a]pyrene-induced Pig-a and lacZ mutations, micronuclei and DNA adducts in Muta™ Mouse

scientific article published on 4 October 2011

Smoking and Breast Cancer: Is There Really a Link?

scientific article published on 09 January 2008

Smoking and DNA damage in cervical cells

scientific article published in The Lancet

Smoking-associated bulky DNA adducts in bronchial tissue related to CYP1A1 MspI and GSTM1 genotypes in lung patients

scientific article published in May 1998

Smoking-related DNA adducts in anal epithelium

scientific article published on 01 June 2004

Smoking-related DNA adducts in human cervical biopsies

scientific article published on 01 January 1993

Smoking-related DNA and protein adducts in human tissues.

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Some properties of vicinal diol-epoxides derived from benz(a)anthracene and benzo(a)pyrene

scientific article published on 01 January 1978

Standardization and validation of DNA adduct postlabelling methods: report of interlaboratory trials and production of recommended protocols

scientific article published on May 1999

Stereoselective metabolic activation of alpha-hydroxy-N-desmethyltamoxifen: the R-isomer forms more DNA adducts in rat liver cells

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Strategies in case of positive in vivo results in genotoxicity testing

scientific article published on 17 September 2010

Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole.

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Subchronic oral exposure to benzo(a)pyrene leads to distinct transcriptomic changes in the lungs that are related to carcinogenesis

scientific article published on 18 May 2012

Sulfotransferase-mediated activation of mutagens studied using heterologous expression systems

scientific article published in February 1998

Synthesis and DNA Reactivity of α-Hydroxylated Metabolites of Nonsteroidal Antiestrogens

scientific article published on 01 April 1998

Synthesis, characterization, and 32p-postlabeling analysis of DNA adducts derived from the environmental contaminant 3-nitrobenzanthrone

scientific article published in June 2005

THE ENVIRONMENTAL POLLUTANT AND CARCINOGEN 3-NITROBENZANTHRONE AND ITS HUMAN METABOLITE 3-AMINOBENZANTHRONE ARE POTENT INDUCERS OF RAT HEPATIC CYTOCHROMES P450 1A1 AND -1A2 AND NAD(P)H:QUINONE OXIDOREDUCTASE

scientific article published on 19 May 2006

TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts

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TP53 mutation signature supports involvement of aristolochic acid in the aetiology of endemic nephropathy-associated tumours

scientific article published in February 2009

TP53 mutations induced by BPDE in Xpa-WT and Xpa-Null human TP53 knock-in (Hupki) mouse embryo fibroblasts

scientific article published on 30 January 2015

Tamoxifen does not form detectable DNA adducts in white blood cells of breast cancer patients

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Tamoxifen-DNA adduct formation in human endometrium.

scientific article published in October 2005

Tamoxifen-DNA adduct formation in rat liver determined by immunoassay and 32P-postlabeling.

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The 32P-postlabeling assay for DNA adducts

scientific article published on 01 January 2007

The DNA repair inhibitors hydroxyurea and cytosine arabinoside enhance the sensitivity of the alkaline single-cell gel electrophoresis ('comet') assay in metabolically-competent MCL-5 cells

scientific article published on September 1999

The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes.

scientific article published on 29 September 2013

The Genome Stability Network

scientific article published on 01 May 2005

The Impact of p53 on Aristolochic Acid I-Induced Gene Expression In Vivo ⬇️

scientific article published on 06 December 2019

The TERT-CLPTM1L lung cancer susceptibility variant associates with higher DNA adduct formation in the lung

scientific article published on 22 May 2009

The application of the comet assay to assess the genotoxicity of environmental pollutants in the nematode Caenorhabditis elegans

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The covalent binding of polycyclic hydrocarbons to DNA in the skin of mice of different strains ⬇️

scientific article published on October 15, 1978

The environmental pollutant and carcinogen 3-nitrobenzanthrone induces cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase in rat lung and kidney, thereby enhancing its own genotoxicity

scientific article published on 6 February 2008

The epidemiology, diagnosis, and management of aristolochic acid nephropathy: a narrative review

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The exposome in practice: Design of the EXPOsOMICS project.

scientific article published on 19 August 2016

The expression of xenobiotic-metabolizing enzymes in human prostate and in prostate epithelial cells (PECs) derived from primary cultures

scientific article published in June 2006

The genome as a record of environmental exposure

scientific article published on 6 October 2015

The genotoxic air pollutant 3-nitrobenzanthrone and its reactive metabolite N-hydroxy-3-aminobenzanthrone lack initiating and complete carcinogenic activity in NMRI mouse skin.

scientific article published on 12 May 2009

The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its metabolites 3-aminobenzanthrone and N-hydroxy-3-aminobenzanthrone in human cells

scientific article published on 01 October 2018

The impact of p53 on DNA damage and metabolic activation of the environmental carcinogen benzo[a]pyrene: effects in Trp53(+/+), Trp53(+/-) and Trp53(-/-) mice

scientific article published on 21 May 2015

The in vitro metabolic activation of dibenz[a,h]anthracene, catalyzed by rat liver microsomes and examined by 32P-postlabelling

scientific article published on 01 May 1991

The in vivo formation and repair of DNA adducts from 1'-hydroxysafrole

scientific article published in January 1981

The influence of dietary and environmental factors on prostate cancer risk

scientific article published in December 2000

The interaction of core histones with DNA: equilibrium binding studies

scientific article published on October 1978

The metabolic activation of dibenz[a,h]anthracene in mouse skin examined by 32P-postlabelling: minor contribution of the 3,4-diol 1,2-oxides to DNA binding

scientific article published in June 1991

The metabolic activation of tamoxifen and alpha-hydroxytamoxifen to DNA- binding species in rat hepatocytes proceeds via sulphation

scientific article published on 01 May 1998

The metabolism of 7,12-dimethylbenz[a]anthracene and 7-hydroxymethyl-12-methylbenz[a]anthracene by rat liver and adrenal homogenates and by rat adrenocortical cells

scientific article published on December 1983

The potential of omics approaches to elucidate mechanisms of biodiesel-induced pulmonary toxicity

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The pros and cons of publishing genetic toxicology studies in which the identities of the compounds are withheld

scientific article published on 01 January 2004

The proteolytic release of genotoxins from cooked beef

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The role of cytochrome P450 enzymes in carcinogen activation and detoxication: an in vivo-in vitro paradox

scientific article published on 01 July 2018

The role of the N-(hydroxymethyl)melamines as antitumour agents: mechanism of action studies

scientific article published on May 1995

Theoretical investigations on the formation of nitrobenzanthrone-DNA Adducts

scientific article published on 20 July 2011

Time- and concentration-dependent changes in gene expression induced by benzo(a)pyrene in two human cell lines, MCF-7 and HepG2.

scientific article published on 16 October 2006

Tissue distribution of DNA adducts in CDF1 mice fed 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ).

scientific article

Transcriptional Profiling of Dibenzo[def,p]chrysene-induced Spleen Atrophy Provides Mechanistic Insights into its Immunotoxicity in MutaMouse.

scientific article published on 24 October 2015

Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene.

scientific article published on 19 May 2016

Tumour necrosis factor-alpha mediates tumour promotion via a PKC alpha- and AP-1-dependent pathway

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Understanding the genotoxicity of tamoxifen?

scientific article published in June 2001

Use of 32P-postlabelling to distinguish between genotoxic and nongenotoxic carcinogens

scientific article published on January 1, 1992

Validation of biomarkers for the study of environmental carcinogens: a review

scientific article published on August 2008

Variation in PAH-related DNA adduct levels among non-smokers: the role of multiple genetic polymorphisms and nucleotide excision repair phenotype

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Variation in the measurement of DNA damage by comet assay measured by the ECVAG inter-laboratory validation trial.

scientific article published on 12 November 2009

Variation of DNA damage levels in peripheral blood mononuclear cells isolated in different laboratories

scientific article published on 15 April 2014

Whole body exposure of mice to secondhand smoke induces dose-dependent and persistent promutagenic DNA adducts in the lung.

scientific article

alpha-Hydroxytamoxifen, a metabolite of tamoxifen with exceptionally high DNA-binding activity in rat hepatocytes

scientific article published in November 1994

p53 mutations in lung tumours: relationship to gender and lung DNA adduct levels

scientific article published in October 1996

p53 tumour suppressor gene and the tobacco industry

scientific article published in March 2005

p53-dependent global nucleotide excision repair of cisplatin-induced intrastrand cross links in human cells

scientific article published on 10 February 2008

³²P-postlabeling analysis of DNA adducts

scientific article published in January 2014

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