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List of works by Michael F. Olson

A Cell-Permeable Biscyclooctyne As a Novel Probe for the Identification of Protein Sulfenic Acids

scientific article published on 28 October 2016

A novel small molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma

scientific article published on 02 October 2018

A novel small-molecule MRCK inhibitor blocks cancer cell invasion

scientific article

A one-step procedure to probe the viscoelastic properties of cells by Atomic Force Microscopy

scientific article published in Scientific Reports

AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins

scientific article

Actin-myosin-based contraction is responsible for apoptotic nuclear disintegration

scientific article

Activating ROCK1 somatic mutations in human cancer

scientific article published on 8 February 2010

Actomyosin contractililty: Force power drives tumor growth ⬇️

scientific article published on October 15, 2011

Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth

scientific article

Agonist-induced desensitization of adenylyl cyclase in Y1 adrenocortical tumor cells

scientific article published in January 1991

Alan Hall 1952-2015.

scientific article published on 25 May 2015

Alpha(E)-Catenin induces SRF-dependent transcriptional activity through its C-terminal region and is partly RhoA/ROCK-dependent

scientific article published on 17 December 2007

An Essential Role for Rho, Rac, and Cdc42 GTPases in Cell Cycle Progression Through G 1 ⬇️

scientific article (publication date: September 1995)

An apical MRCK-driven morphogenetic pathway controls epithelial polarity.

scientific article published on 21 August 2017

Analysis of the human cofilin 1 structure reveals conformational changes required for actin binding

scientific article

Apoptotic membrane dynamics in health and disease

article

Applications for ROCK kinase inhibition

scientific article published on 20 February 2008

Blebs produced by actin-myosin contraction during apoptosis release damage-associated molecular pattern proteins before secondary necrosis occurs

scientific article

Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion

scientific article

Collective migration: spatial tension relief

scientific article

Conditional ROCK activation in vivo induces tumor cell dissemination and angiogenesis

scientific article

Conditional regulation of a ROCK-estrogen receptor fusion protein

scientific article published on January 2006

Constitutively active RhoA inhibits proliferation by retarding G(1) to S phase cell cycle progression and impairing cytokinesis

scientific article published on 09 June 2009

Contraction reaction: mechanical regulation of Rho GTPase

scientific article published on March 2004

Coping with Loss: Cell Adaptation to Cytoskeleton Disruption

scientific article published in October 2016

Cross-talk between Ras and Rho signalling pathways in transformation favours proliferation and increased motility

scientific article published on February 2001

Cucurbitacin covalent bonding to cysteine thiols: the filamentous-actin severing protein Cofilin1 as an exemplary target

scientific article published on 14 August 2013

Development of a high-throughput screening method for LIM kinase 1 using a luciferase-based assay of ATP consumption

scientific article

Differing contributions of LIMK and ROCK to TGFβ-induced transcription, motility and invasion

scientific article published on 11 November 2010

Direct involvement of the small GTP-binding protein Rho in lbc oncogene function

scientific article published on April 1995

Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties

scientific article

Distinct roles for DH and PH domains in the Lbc oncogene

scientific article published on December 1997

Dying Alone: A Tale of Rho

scientific article published on 01 August 2010

Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation

scientific article

Extracellular ATP causes ROCK I-dependent bleb formation in P2X7-transfected HEK293 cells

scientific journal article

Faculty of 1000 evaluation for A Rac/Cdc42 exchange factor complex promotes formation of lateral filopodia and blood vessel lumen morphogenesis

Finding the shape-shifter genes ⬇️

scientific article published on July 1, 2013

Follow the leader: LIM kinases pave the way for collective tumor cell invasion ⬇️

article by Michael F Olson et al published 15 November 2010 in Cell Cycle

GTPase Signalling: New Functions for Diaphanous-Related Formins ⬇️

scientific article published on April 29, 2003

Gem GTPase: between a ROCK and a hard place

scientific article

Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease?

scientific article published on October 1996

How apoptotic cells aid in the removal of their own cold dead bodies

scientific article

Inhibition of CXCR2 profoundly suppresses inflammation-driven and spontaneous tumorigenesis

scientific article

K-Ras mediated murine epidermal tumorigenesis is dependent upon and associated with elevated Rac1 activity

scientific article

Keratinocyte differentiation is regulated by the Rho and ROCK signaling pathway

scientific article published on December 2003

LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation

scientific article published on 3 November 2015

LIM kinases are required for invasive path generation by tumor and tumor-associated stromal cells

scientific article

LIM kinases: function, regulation and association with human disease

scientific article

MST kinases monitor actin cytoskeletal integrity and signal via c-Jun N-terminal kinase stress-activated kinase to regulate p21Waf1/Cip1 stability

scientific article published on 12 October 2009

Mammary stem cells have myoepithelial cell properties

scientific article

Mechanisms of tumour cell invasion and metastasis

scientific article published on 03 April 2007

Mechanotransduction pathways promoting tumor progression are activated in invasive human squamous cell carcinoma

scientific article published on 2 July 2013

Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I.

scientific article

Microtrack migration: insights into 3D cell motility. Focus on “Comparative mechanisms of cancer cell migration through 3D matrix and physiological microtracks”

scientific article published on 21 January 2015

Migration through physical constraints is enabled by MAPK-induced cell softening via actin cytoskeleton re-organization

scientific article published on 31 May 2019

Modeling Human Cancer: Report on the Eighth Beatson International Cancer Conference

scientific article published on 01 December 2005

Modeling and imaging 3-dimensional collective cell invasion

scientific article

Molecular basis for the 3',5'-cyclic adenosine monophosphate resistance of Kin mutant Y1 adrenocortical tumor cells

scientific article published on April 1993

Mouse embryo fibroblasts: a genetic model system for studying Rho- and Ras-dependent cell cycle progression

scientific article published on January 2000

Polarized cell motility induces hydrogen peroxide to inhibit cofilin via cysteine oxidation

scientific article published on 14 May 2015

Purification of TAT-C3 exoenzyme

scientific article published on January 2006

RAS and RHO GTPases in G1-phase cell-cycle regulation

scientific article published on May 2004

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

scientific article published on 28 December 2016

ROCK signalling induced gene expression changes in mouse pancreatic ductal adenocarcinoma cells

scientific article

ROCK2/rasHa co-operation induces malignant conversion via p53 loss, elevated NF-κB and tenascin C-associated rigidity, but p21 inhibits ROCK2/NF-κB-mediated progression

scientific article published on 19 December 2016

Ras promotes p21(Waf1/Cip1) protein stability via a cyclin D1-imposed block in proteasome-mediated degradation

scientific article

Ras signalling is required for inactivation of the tumour suppressor pRb cell-cycle control protein

scientific article published in March 1997

Reactive oxygen species and hydrogen peroxide generation in cell migration

scientific article

Receptor-G-protein coupling in desensitization-resistant mutant adrenal cells

scientific article published on January 1994

Reduced LIMK2 expression in colorectal cancer reflects its role in limiting stem cell proliferation.

scientific article published on 12 April 2013

Regulating the Conversion between Rounded and Elongated Modes of Cancer Cell Movement

scientific article published on 01 November 2008

Regulation of adenylyl cyclase activity by beta-adrenergic agonists in a desensitization-resistant mutant cell line

scientific article published on January 1991

Regulation of autophagosome formation by Rho kinase

scientific article published on 10 September 2012

Regulation of pancreatic cancer aggressiveness by stromal stiffening

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

scientific article published in Science

Rho GTPase signalling pathways in the morphological changes associated with apoptosis.

scientific article

Rho GTPases, their post-translational modifications, disease-associated mutations and pharmacological inhibitors

scientific article

Rho-associated coiled-coil containing kinases (ROCK): structure, regulation, and functions

scientific article

Rho‐associated kinases in tumorigenesis: re‐considering ROCK inhibition for cancer therapy ⬇️

scientific article published on September 11, 2012

Rock1

SPRY2 is an inhibitor of the ras/extracellular signal-regulated kinase pathway in melanocytes and melanoma cells with wild-type BRAF but not with the V599E mutant

scientific article

Signals from Ras and Rho GTPases interact to regulate expression of p21Waf1/Cip1.

scientific article published on July 1998

Spatial regulation of RhoA activity during pancreatic cancer cell invasion driven by mutant p53

scientific article

Sprouty2 association with B-Raf is regulated by phosphorylation and kinase conformation

scientific article published on 18 August 2009

Stability of p21Waf1/Cip1 CDK inhibitor protein is responsive to RhoA-mediated regulation of the actin cytoskeleton.

scientific article published on May 2006

Targeting ROCK activity to disrupt and prime pancreatic cancer for chemotherapy.

scientific article published on 3 October 2017

Targeting Ras and Rho GTPases as opportunities for cancer therapeutics

scientific article

Targeting Rho GTPase signaling for cancer therapy

scientific article published on February 2012

The CDC42 effector protein MRCKβ autophosphorylates on Threonine 1108

scientific article published on 22 January 2019

The Rho GTPase effector ROCK regulates cyclin A, cyclin D1, and p27Kip1 levels by distinct mechanisms

scientific article published on June 2006

The Rho-Regulated ROCK Kinases in Cancer

The actin cytoskeleton in cancer cell motility

scientific article published on 23 May 2008

The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer

scientific article published on 20 February 2014

The development of a rat in vitro model of spinal cord injury demonstrating the additive effects of Rho and ROCK inhibitors on neurite outgrowth and myelination.

scientific article

The ras signalling pathway as a target in cancer therapy.

scientific article published on January 2007

Tissue selective expression of conditionally-regulated ROCK by gene targeting to a defined locus.

scientific article published in July 2009

Tissue-selective expression of a conditionally-active ROCK2-estrogen receptor fusion protein.

scientific article published on 24 October 2016

Trailblazing LIM kinases take the lead in collective tumor cell invasion

scientific article published on January 2011

Transcriptional regulation of Rho GTPase signaling

scientific article published on September 2011

Transcriptomic profiling of human breast and melanoma cells selected by migration through narrow constraints

scientific article published on 14 November 2017

Yeast two-hybrid system to detect protein-protein interactions with Rho GTPases.

scientific article

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

scientific article published on 16 November 2010

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