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List of works by David E. Levy

A Kaposi's sarcoma-associated herpesviral protein inhibits virus-mediated induction of type I interferon by blocking IRF-7 phosphorylation and nuclear accumulation.

scientific article

A STAT3-mediated metabolic switch is involved in tumour transformation and STAT3 addiction.

scientific article

A Synthetic Lethal Interaction between Glutathione Synthesis and Mitochondrial Reactive Oxygen Species Provides a Tumor-Specific Vulnerability Dependent on STAT3.

scientific article published on 17 August 2015

A cryptic sensor for HIV-1 activates antiviral innate immunity in dendritic cells

scientific article

A novel interferon-alpha-regulated, DNA-binding protein participates in the regulation of the IFP53/tryptophanyl-tRNA synthetase gene

scientific article published in Journal of Biological Chemistry

Activation of Stat3 in renal tumors.

scientific article published on 28 February 2009

Activation of acute phase response factor (APRF)/Stat3 transcription factor by growth hormone.

scientific article published on February 1995

Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons

scientific article published on 11 January 2005

Activation of the signal transducer and transcription (STAT) signaling pathway in a primary T cell response. Critical role for IL-6 ⬇️

scientific article published on November 15, 1995

Acute phase response factor and additional members of the interferon-stimulated gene factor 3 family integrate diverse signals from cytokines, interferons, and growth factors.

scientific article published on September 1994

An essential role of Th1 responses and interferon gamma in infection-mediated suppression of neoplastic growth

scientific article published on November 2003

Analysis of Interferon-Regulated Proteins Binding the Interferon-α-Stimulated Response Element ⬇️

scientific article published on July 1, 1998

Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors

scientific article published on December 2009

Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death

scientific article (publication date: 7 February 2002)

Ancrod for Acute Ischemic Stroke: A New Dosing Regimen Derived from Analysis of Prior Ancrod Stroke Studies

article

C. elegans STAT cooperates with DAF-7/TGF-beta signaling to repress dauer formation

scientific article published in January 2006

C. elegans STAT: evolution of a regulatory switch

scientific article published in August 2006

Cell signaling. Stat acetylation--a key facet of cytokine signaling?

scientific article published in January 2005

Cells resistant to interferon are defective in activation of a promoter-binding factor.

scientific article

Central role for type I interferons and Tyk2 in lipopolysaccharide-induced endotoxin shock

scientific article

Chemokine gene silencing in decidual stromal cells limits T cell access to the maternal-fetal interface

scientific article published on June 2012

Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses.

scientific article

Comparative evolutionary genomics of the STAT family of transcription factors

scientific article

Constitutive type I interferon modulates homeostatic balance through tonic signaling

scientific article

Contribution of a TANK-binding kinase 1-interferon (IFN) regulatory factor 7 pathway to IFN-γ-induced gene expression

scientific article published on 17 January 2012

Cooperation between STAT3 and c-jun suppresses Fas transcription.

scientific article published in March 2001

Cost-effectiveness of ancrod treatment of acute ischaemic stroke: results from the Stroke Treatment with Ancrod Trial (STAT).

scientific article

Cytokines and growth factors signal through tyrosine phosphorylation of a family of related transcription factors

scientific article published on September 1994

Cytoplasmic, full length and novel cleaved variant, TBLR1 reduces apoptosis in prostate cancer under androgen deprivation.

scientific article published on 26 April 2016

Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli.

scientific article published in September 2002

Differences in cerebral blood flow and glucose utilization in vegetative versus locked-in patients

scientific article

Differential regulation of TSG-14 expression in murine fibroblasts and peritoneal macrophages

scientific article published on March 2000

Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7

scientific article

Differentiation of monocytes to macrophages switches the Mycobacterium tuberculosis effect on HIV-1 replication from stimulation to inhibition: modulation of interferon response and CCAAT/enhancer binding protein beta expression

scientific article published on August 2000

Disruption of the gamma-interferon signaling pathway at the level of signal transducer and activator of transcription-1 prevents immune destruction of beta-cells

scientific article published in August 2005

Distinct inflammatory signals have physiologically divergent effects on epigenetic regulation of Foxp3 expression and Treg function.

scientific article

Distinct requirements for IFNs and STAT1 in NK cell function

scientific article

Erratum: STAT3 regulated ARF expression suppresses prostate cancer metastasis

scientific article published in Nature Communications

Expression of many immunologically important genes in Mycobacterium tuberculosis-infected macrophages is independent of both TLR2 and TLR4 but dependent on IFN-alphabeta receptor and STAT1.

scientific article published in September 2005

FGF signaling inhibits chondrocyte proliferation and regulates bone development through the STAT-1 pathway

scientific article

Functional crosstalk between type I and II interferon through the regulated expression of STAT1.

scientific article

Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host

article

HDAC stimulates gene expression through BRD4 availability in response to IFN and in interferonopathies

scientific article published on 21 November 2018

ID: 263

scholarly article by Jan Pencik published in November 2015

IFN-Stimulated transcription through a TBP-free acetyltransferase complex escapes viral shutoff

scientific article published on February 2002

IFNgamma signaling-does it mean JAK-STAT?

scientific article published on 16 October 2008

IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

scientific article (publication date: September 2007)

IL-6 signaling via the STAT3/SOCS3 pathway: functional analysis of the conserved STAT3 N-domain

scientific article published on 23 May 2006

ISGF3 gamma p48, a specificity switch for interferon activated transcription factors

scientific article published on June 1996

Identification of a PTEN-regulated STAT3 brain tumor suppressor pathway

scientific article

Identification of a Stat3-dependent transcription regulatory network involved in metastatic progression.

scientific article

Induction and function of type I and III interferon in response to viral infection

scientific article

Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi's sarcoma-associated herpesvirus viral IRF homolog vIRF3.

scientific article published on 23 May 2007

Inhibition of nonsense-mediated RNA decay by the tumor microenvironment promotes tumorigenesis

scientific article

Inhibition of pyrimidine synthesis reverses viral virulence factor-mediated block of mRNA nuclear export

scientific article published on February 2012

Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation.

scientific article published on 16 February 2016

Interactions of alpha- and gamma-interferon in the transcriptional regulation of the gene encoding a guanylate-binding protein

scientific article published on July 1989

Interferon-dependent transcriptional activation: signal transduction without second messenger involvement?

scientific article published on October 1, 1990

Interferon-gamma-induced inhibition of neuronal vesicular stomatitis virus infection is STAT1 dependent.

scientific article published on February 2004

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control

scientific article published on 01 April 1988

Interferon-induced nuclear signalling by Jak protein tyrosine kinases

scientific article published on December 1993

Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element

scientific article

Interleukin-10 induces inhibitory C/EBPbeta through STAT-3 and represses HIV-1 transcription in macrophages

scientific article published on 13 July 2005

Knockdown of Stat3 activity in vivo prevents diabetic glomerulopathy

scientific article published on 8 April 2009

Mechanism of STAT3 activation by insulin-like growth factor I receptor

scientific article

Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.

scientific article published on June 2009

Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

scientific article published on 5 June 2017

Molecular interactions between interferon consensus sequence binding protein and members of the interferon regulatory factor family.

scientific article

NF-kappaB-ISGF3 transcription factor cooperation: coincidence detector or memory chip?

scientific article published in July 2010

Nongenomic STAT5-dependent effects on Golgi apparatus and endoplasmic reticulum structure and function

scientific article published on 7 December 2011

Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation

scientific article published in February 2005

Nuclear and cytoplasmic mRNA quantification by SYBR green based real-time RT-PCR.

scientific article published in August 2006

Nuclear receptor coregulator (NRC): mapping of the dimerization domain, activation of p53 and STAT-2, and identification of the activation domain AD2 necessary for nuclear receptor signaling

scientific journal article

Nucleoporin levels regulate cell cycle progression and phase-specific gene expression

scientific article

Outcome from severe neurological illness; should it influence medical decisions?

scientific article

PKR Transduces MDA5-Dependent Signals for Type I IFN Induction

scientific article

Prolactin, growth hormone, erythropoietin and granulocyte-macrophage colony stimulating factor induce MGF-Stat5 DNA binding activity

scientific article published on May 1995

Protein kinase activity required for an early step in interferon-alpha signaling

scientific article published in Journal of Biological Chemistry

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation

scientific journal article

Rapid activation of proteins that interact with the interferon gamma activation site in response to multiple cytokines

article

Ras-independent growth factor signaling by transcription factor tyrosine phosphorylation

scientific article published on September 1993

Reduced STAT3 activity in mice mimics clinical disease syndromes

scientific article published in April 2005

Regulation of Interferon-α Responsiveness by the Duration of Janus Kinase Activity ⬇️

scientific article published in Journal of Biological Chemistry

Regulation of Stat3 transcriptional activity by the conserved LPMSP motif for OSM and IL-6 signaling

scientific article published on 02 October 2006

Regulatory serine residues mediate phosphorylation-dependent and phosphorylation-independent activation of interferon regulatory factor 7

scientific article

Restricted tissue tropism and acquired resistance to Sindbis viral vector expression in the absence of innate and adaptive immunity

scientific article published on 17 May 2007

Retinoic acid induces signal transducer and activator of transcription (STAT) 1, STAT2, and p48 expression in myeloid leukemia cells and enhances their responsiveness to interferons

scientific article published on 01 June 1997

Ringing the interferon alarm: differential regulation of gene expression at the interface between innate and adaptive immunity.

scientific article

Role of nucleoporin induction in releasing an mRNA nuclear export block

scientific article published on 24 January 2002

Role of p38alpha Map kinase in Type I interferon signaling

scientific article published on 24 October 2003

STAT1 acts as a tumor promoter for leukemia development

scientific article published on July 2006

STAT1 mediates the increased apoptosis and reduced chondrocyte proliferation in mice overexpressing FGF2

scientific article published on 01 June 2001

STAT3 negatively regulates type I IFN-mediated antiviral response.

scientific article

STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

scientific article published on 17 May 2011

STAT3 positively regulates an early step in B-cell development.

scientific article published on 6 July 2006

STAT3 regulated ARF expression suppresses prostate cancer metastasis

scientific article published on 22 July 2015

STAT3 signaling and the hyper-IgE syndrome

scientific article

STAT3 supports experimental K-RasG12D-induced murine myeloproliferative neoplasms dependent on serine phosphorylation.

scientific article

STAT3-dependent IL-21 production from T helper cells regulates hematopoietic progenitor cell homeostasis

scientific article published on 19 April 2011

STATus Report on Tetramers

scientific article published on 01 April 2012

Signal transducer and activator of transcription 4 limits the development of adaptive regulatory T cells

article

Spatiotemporal trafficking of HIV in human plasmacytoid dendritic cells defines a persistently IFN-α-producing and partially matured phenotype

scientific article

Stat protein transactivation domains recruit p300/CBP through widely divergent sequences

scientific article (publication date: 3 September 1999)

Stat3 and Stat4 direct development of IL-17-secreting Th cells.

scientific article

Stat5 is essential for the myelo- and lymphoproliferative disease induced by TEL/JAK2

scientific article published on 01 September 2000

Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins ⬇️

scientific article published on August 1, 1992

Superantigen-activated T cells redirected by a bispecific antibody inhibit vesicular stomatitis virus replication in vitro and in vivo.

scientific article published in February 1998

Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3

scientific article published on April 1990

TLR4 engagement during TLR3-induced proinflammatory signaling in dendritic cells promotes IL-10-mediated suppression of antitumor immunity

scientific article published on 5 July 2011

Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease

scientific article (publication date: 9 February 1996)

The MEK-ERK pathway is necessary for serine phosphorylation of mitochondrial STAT3 and Ras-mediated transformation

scientific article

The Nucleoporin Nup96 Is Required for Proper Expression of Interferon-Regulated Proteins and Functions

scientific article published on 01 March 2006

The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex

scientific article (publication date: 15 September 2003)

The house that Jak/Stat built.

scientific article

The human RVB complex is required for efficient transcription of type I interferon-stimulated genes.

scientific article

The interferon-stimulable response elements of two human genes detect overlapping sets of transcription factors

article

The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity.

scientific article published on 29 March 2017

The proximal tyrosines of the cytoplasmic domain of the beta chain of the type I interferon receptor are essential for signal transducer and activator of transcription (Stat) 2 activation. Evidence that two Stat2 sites are required to reach a thresh

scientific article published on February 1999

The transcription factor STAT3 is required for T helper 2 cell development

scientific article published on 6 January 2011

Three distinct loci on human chromosome 21 contribute to interferon-alpha/beta responsiveness.

scientific article

Transcription of interferon-stimulated genes is induced by adenovirus particles but is suppressed by E1A gene products

scientific article published on January 1988

Transcriptional regulation of interferon-stimulated genes: a DNA response element and induced proteins that recognize it

article

Type I IFN modulates innate and specific antiviral immunity.

scientific article published in April 2000

Virus infection and interferon can activate gene expression through a single synthetic element, but endogenous genes show distinct regulation.

scientific article published in October 1989

What does Stat3 do?

scientific article

Whence interferon? Variety in the production of interferon in response to viral infection.

scientific article

c-Maf regulates IL-10 expression during Th17 polarization

scientific article

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