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List of works by Sharon L McKenna

Activation of SAPK/JNK by camptothecin sensitizes androgen-independent prostate cancer cells to Fas-induced apoptosis.

scientific article published in June 2000

Alterations of the retinoic acid receptor alpha (RAR alpha) gene in myeloid and lymphoid malignancies.

scientific article published in March 1999

Analysis of a myosin-like protein and the role of calcium in the E. coli cell cycle.

scientific article published on February 1991

Antibody-Targeted Cyclodextrin-Based Nanoparticles for siRNA Delivery in the Treatment of Acute Myeloid Leukemia: Physicochemical Characteristics, in Vitro Mechanistic Studies, and ex Vivo Patient Derived Therapeutic Efficacy

scientific article published on February 2017

Autocrine secretion of osteopontin results in degradation of I kappa B in Bcr-Abl-expressing cells.

scientific article published on March 2005

Autophagy induction by Bcr-Abl-expressing cells facilitates their recovery from a targeted or nontargeted treatment

scientific article published on January 2011

Bcr-Abl reduces endoplasmic reticulum releasable calcium levels by a Bcl-2-independent mechanism and inhibits calcium-dependent apoptotic signaling

scientific article published on 09 February 2006

Bcr‐Abl upregulates cytosolic p21WAF‐1/CIP‐1 by a phosphoinositide‐3‐kinase (PI3K)‐independent pathway ⬇️

scientific article published on October 1, 2003

Beta-catenin transcriptional activity is inhibited downstream of nuclear localisation and is not influenced by IGF signalling in oesophageal cancer cells

scientific article

Biomimetic nanoparticles for siRNA delivery in the treatment of leukaemia

scientific article published on 16 September 2014

Curcumin Affects Components of the Chromosomal Passenger Complex and Induces Mitotic Catastrophe in Apoptosis-Resistant Bcr-Abl-Expressing Cells

scientific article published on 01 July 2006

Curcumin induces apoptosis-independent death in oesophageal cancer cells.

scientific article published on 6 October 2009

Cyclooxygenase-2 inhibitors demonstrate anti-proliferative effects in oesophageal cancer cells by prostaglandin E(2)-independent mechanisms

scientific article published on 17 August 2007

Detection of Molecular Events During Apoptosis by Flow Cytometry

scientific article published on 01 January 2000

Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype

scientific article

Evaluation of cellular uptake and gene transfer efficiency of pegylated poly-L-lysine compacted DNA: implications for cancer gene therapy

scientific article published on November 2006

Expression of oncogenic kinase Bcr-Abl impairs mitotic checkpoint and promotes aberrant divisions and resistance to microtubule-targeting agents

scientific article published on 4 May 2010

Flow cytometric apoptosis assays indicate different types of endonuclease activity in haematopoietic cells and suggest a cautionary approach to their quantitative use

scientific article published on 01 February 1998

Functional aspects of apoptosis in hematopoiesis and consequences of failure

scientific article

Glycolysis inhibition as a cancer treatment and its role in an anti-tumour immune response

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion

scientific article published in September 2002

Increased acetylation of lysine 317/320 of p53 caused by BCR-ABL protects from cytoplasmic translocation of p53 and mitochondria-dependent apoptosis in response to DNA damage

scientific article

Induction of autophagy by Imatinib sequesters Bcr-Abl in autophagosomes and down-regulates Bcr-Abl protein

scientific article published on 2 April 2013

Induction of autophagy by drug-resistant esophageal cancer cells promotes their survival and recovery following treatment with chemotherapeutics

scientific article published on May 2011

Induction of autophagy is a key component of all-trans-retinoic acid-induced differentiation in leukemia cells and a potential target for pharmacologic modulation

scientific article published on 15 May 2015

Inhibition of PI3-kinase sensitises HL60 human leukaemia cells to both chemotherapeutic drug- and Fas-induced apoptosis by a JNK independent pathway.

scientific article

Inhibition of caspase activity delays apoptosis in a transfected NS/0 myeloma cell line

scientific article

LC3B globular structures correlate with survival in esophageal adenocarcinoma

scientific article published on 12 August 2015

Lithium Modulates Autophagy in Esophageal and Colorectal Cancer Cells and Enhances the Efficacy of Therapeutic Agents In Vitro and In Vivo

scientific article published on 6 August 2015

Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors

scientific article published on 28 July 2006

MULTIDRUG RESISTANCE IN LEUKAEMIA

scientific article published on 01 March 1997

MiR-193b promotes autophagy and non-apoptotic cell death in oesophageal cancer cells

scientific article published on 15 February 2016

Molecular mechanisms of programmed cell death

article

Pharmacological agents with inherent anti-autophagic activity improve the cytotoxicity of imatinib

scientific article published on 3 April 2013

RNA interference for multiple myeloma therapy: targeting signal transduction pathways

scientific article published on 20 July 2015

Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy

scientific article published on 19 March 2021

Retinoid receptor signaling and autophagy in acute promyelocytic leukemia

scientific article published on 30 March 2014

Role of the VHL (von Hippel-Lindau) gene in renal cancer: a multifunctional tumour suppressor

scientific article published on June 2008

Sensitisation of HL60 human leukaemic cells to cytotoxic drug-induced apoptosis by inhibition of PI3-kinase survival signals.

scientific article

The BH3 mimetic HA14-1 enhances 5-fluorouracil-induced autophagy and type II cell death in oesophageal cancer cells ⬇️

scientific article published on January 12, 2012

The potential for clinical translation of antibody-targeted nanoparticles in the treatment of acute myeloid leukaemia

scientific article published on 29 July 2018

Topoisomerase II alpha expression in acute myeloid leukaemia and its relationship to clinical outcome

scientific article published on September 1994

Topoisomerase II expression in normal haemopoietic cells and chronic lymphocytic leukaemia: drug sensitivity or resistance?

scientific article

UBE2L6/UBCH8 and ISG15 attenuate autophagy in esophageal cancer cells

scientific article

VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin.

scientific article published on 6 May 2011

VHL genetic alteration in CCRCC does not determine de-regulation of HIF, CAIX, hnRNP A2/B1 and osteopontin.

scientific article published in January 2010

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