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List of works by Cyril Goudet

A critical pocket close to the glutamate binding site of mGlu receptors opens new possibilities for agonist design

scientific article published on 16 July 2010

A novel selective metabotropic glutamate receptor 4 agonist reveals new possibilities for developing subtype selective ligands with therapeutic potential ⬇️

scientific article published on January 5, 2012

A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists

scientific article published on April 2010

Agonists and allosteric modulators promote signaling from different metabotropic glutamate receptor 5 conformations

scientific article published on 01 August 2021

Alleviating pain hypersensitivity through activation of type 4 metabotropic glutamate receptor.

scientific article published in November 2013

Allosteric control of an asymmetric transduction in a G protein-coupled receptor heterodimer.

scientific article

Allosteric functioning of dimeric class C G-protein-coupled receptors.

scientific article

Allosteric modulation of metabotropic glutamate receptors by chloride ions

scientific article

An allosteric modulator to control endogenous G protein-coupled receptors with light.

scientific article published on 31 August 2014

Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.

scientific article

Chloride ions stabilize the glutamate-induced active state of the metabotropic glutamate receptor 3

scientific article published on 11 August 2018

Cinnabarinic Acid, an Endogenous Metabolite of the Kynurenine Pathway, Activates Type 4 Metabotropic Glutamate Receptors ⬇️

scientific article published on February 6, 2012

Correction: Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

scientific article

D-myo-inositol 1-phosphate as a surrogate of D-myo-inositol 1,4,5-tris phosphate to monitor G protein-coupled receptor activation

scientific article published on 30 August 2006

Determination of the absolute configuration of phosphinic analogues of glutamate

scientific article published on 24 November 2014

Development and validation of a mass spectrometry binding assay for mGlu5 receptor

scientific article published on 20 June 2020

Dimers and beyond: The functional puzzles of class C GPCRs.

scientific article published on 20 January 2011

Dynamic modulation of inflammatory pain-related affective and sensory symptoms by optical control of amygdala metabotropic glutamate receptor 4.

scientific article published on 20 December 2016

Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism.

scientific article

Electrophysiological characterization of BmK M1, an alpha-like toxin from Buthus martensi Karsch venom

scientific article published in April 2001

Electrophysiological properties of the hypokalaemic periodic paralysis mutation (R528H) of the skeletal muscle alpha 1s subunit as expressed in mouse L cells.

scientific article

Emerging Trends in Pain Modulation by Metabotropic Glutamate Receptors

scientific article published on 01 January 2018

Exploring the Active Conformation of Cyclohexane Carboxylate Positive Allosteric Modulators of the Type 4 Metabotropic Glutamate Receptor

scientific article published on 05 September 2014

Group III and subtype 4 metabotropic glutamate receptor agonists: Discovery and pathophysiological applications in Parkinson's disease ⬇️

scientific article published on June 1, 2012

Group III metabotropic glutamate receptors inhibit hyperalgesia in animal models of inflammation and neuropathic pain.

scientific article

Illuminating Phenylazopyridines To Photoswitch Metabotropic Glutamate Receptors: From the Flask to the Animals

scientific article published on 19 December 2016

Importance of the conserved aromatic residues in the scorpion alpha-like toxin BmK M1: the hydrophobic surface region revisited.

scientific article published on 13 April 2003

Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.

scientific article published on 4 February 2018

Integrated synthetic, pharmacological, and computational investigation of cis-2-(3,5-dichlorophenylcarbamoyl)cyclohexanecarboxylic acid enantiomers as positive allosteric modulators of metabotropic glutamate receptor subtype 4.

scientific article published on January 2011

Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses.

scientific article published on 15 February 2007

L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.

scientific article published on 28 August 2007

Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.

scientific article published on January 2004

Magnesium ions promote assembly of channel-like structures from beticolin 0, a non-peptide fungal toxin purified from Cercospora beticola.

scientific article published in May 1998

Metabotropic receptors for glutamate and GABA in pain.

scientific article published on 25 December 2008

Molecular mechanisms of GABA(B) receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator.

scientific article published in November 2004

New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.

scientific article

Optical control of pain in vivo with a photoactive mGlu5 receptor negative allosteric modulator

scientific article published on 11 April 2017

OptoGluNAM4.1, a Photoswitchable Allosteric Antagonist for Real-Time Control of mGlu4 Receptor Activity.

scientific article published on 27 July 2016

Overlapping binding sites drive allosteric agonism and positive cooperativity in type 4 metabotropic glutamate receptors

scientific article published on 23 October 2014

Positional isomers of bispyridine benzene derivatives induce efficacy changes on mGlu5 negative allosteric modulation.

scientific article published on 12 January 2017

Roles of disulfide bridges in scorpion toxin BmK M1 analyzed by mutagenesis

scientific article published in November 2002

Shedding light on metabotropic glutamate receptors using optogenetics and photopharmacology

scientific article published on 15 February 2018

Shining Light on an mGlu5 Photoswitchable NAM: A Theoretical Perspective

scientific article published on 7 April 2015

Synthesis and biological evaluation of 1-amino-2-phosphonomethylcyclopropanecarboxylic acids, new group III metabotropic glutamate receptor agonists

scientific article

Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.

scientific article published on 22 April 2015

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein‐coupled receptors ⬇️

journal article from 'British Journal of Pharmacology' published in 2021

Therapeutic potential of group III metabotropic glutamate receptor ligands in pain.

scientific article

α-Amino-β-fluorocyclopropanecarboxylic acids as a new tool for drug development: Synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4

article

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