List of works - Francisco Estévez

3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells

scientific article published on 3 October 2017

3'-Hydroxy-3,4'-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK.

scientific article published on 6 April 2018

5,7,3'-Trihydroxy-3,4'-dimethoxyflavone inhibits the tubulin polymerization and activates the sphingomyelin pathway

scientific article published on 10 December 2010

5,7,3'-trihydroxy-3,4'-dimethoxyflavone-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway

scientific article

6'-Benzyloxy-4-bromo-2'-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8- and reactive oxygen species-dependent apoptosis

scientific article published on 19 December 2018

A Novel Naphthoquinone-Coumarin Hybrid That Inhibits BCR-ABL1-STAT5 Oncogenic Pathway and Reduces Survival in Imatinib-Resistant Chronic Myelogenous Leukemia Cells

scientific article published on 01 January 2018

A homo-isoflavonoid and a cytotoxic saponin from Dracaena draco

scientific article published on January 2006

A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells

scientific article

Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK.

scientific article published on 4 June 2007

Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction.

scientific article published on 11 May 2018

Antiproliferative activity and apoptosis induction by 3',4'-dibenzyloxyflavonol on human leukemia cells

scientific article published on 21 February 2017

Antiproliferative activity of abietane diterpenoids against human tumor cells

scientific article published on 18 July 2013

Astragalin heptaacetate-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway

scientific article published on 11 June 2011

Betuletol 3-methyl ether induces G(2)-M phase arrest and activates the sphingomyelin and MAPK pathways in human leukemia cells

scientific article

Ceramide mediates tumor necrosis factor effects on P450-aromatase activity in cultured granulosa cells

scientific article published on 01 May 1995

Chemical constituents of Tolpis species

scientific article

Chemotaxonomy of Gonospermum and related genera

scientific article published on 22 January 2010

Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells

scientific article published on 21 December 2020

Cladocalol, a pentacyclic 28-nor-triterpene from Eucalyptus cladocalyx with cytotoxic activity

scientific article

Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana

scientific article

Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds

scientific article published on 25 June 2015

Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and alpha-bromoacryloyl moieties.

scientific article published on December 2005

Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and polypyrrole minor groove binders

scientific article published on May 2004

Diacylglycerol rather than Ca2+ mediates GnRH inhibition of FSH induced steroidogenesis in ovarian granulosa cells

scientific article published on October 1992

Does oligosaccharide-phosphatidylinositol (glycosyl-phosphatidylinositol) hydrolysis mediate prolactin signal transduction in granulosa cells?

scientific article published on 01 September 1993

Effect of the protein phosphatase inhibitor okadaic acid on FSH-induced granulosa cell steroidogenesis

scientific article published on 01 January 1997

Enantioselective synthesis and biological activity of (3S,4R)- and (3S,4S)-3-hydroxy-4-hydroxymethyl- 4-butanolides in relation to PGE2.

scientific article

Eupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway

scientific article

Follicle-stimulating hormone and human chorionic gonadotropin induced changes in granulosa cell glycosyl-phosphatidylinositol concentration

scientific article published on 01 May 1993

Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species.

scientific article published on 13 July 2016

Hybrid molecules containing benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazole and alpha-bromoacryloyl moieties as potent apoptosis inducers on human myeloid leukaemia cells

scientific article published on 25 February 2007

Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco

scientific article published on August 2004

Identification and quantitation of allelochemicals from the lichen Lethariella canariensis: phytotoxicity and antioxidative activity

scientific article published in September 2003

Induction of G2-M phase arrest and apoptosis by alpha-methylene-gamma-butyrolactones in human leukemia cells.

scientific article published on 2 June 2008

Induction of G2/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells

scientific article published on 13 June 2013

Inhibition of proliferation and induction of apoptosis by melatonin in human myeloid HL-60 cells

scientific article published on 01 March 2007

Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis

scientific article published on 01 June 1996

Isolation from Eucalyptus occidentalis and identification of a new kaempferol derivative that induces apoptosis in human myeloid leukemia cells

scientific article

Isolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells

scientific article published on September 2006

Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells

scientific article published in December 2004

Melatonin Induces Melanogenesis in Human SK-MEL-1 Melanoma Cells Involving Glycogen Synthase Kinase-3 and Reactive Oxygen Species

scientific article published on 14 July 2020

Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells

scientific article published on 29 April 2010

Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells

scientific article

Melatonin prevents apoptosis and enhances HSP27 mRNA expression induced by heat shock in HL-60 cells: possible involvement of the MT2 receptor

scientific article published in November 2003

Naturally occurring asteriscunolide A induces apoptosis and activation of mitogen-activated protein kinase pathway in human tumor cell lines.

scientific article published on May 2010

New lanostanoids from the fungus Ganoderma concinna.

scientific article published in March 2002

Phenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agents

scientific article published on 22 July 2006

Potent induction of apoptosis by germacranolide sesquiterpene lactones on human myeloid leukemia cells.

scientific article

Pregnane steroidal glycosides and their cytostatic activities

scientific article published on 8 December 2010

Recent Advances on Cytotoxic Sesquiterpene Lactones

scientific article published on 01 January 2018

Secondary metabolites from two species of Pulicaria and their cytotoxic activity.

scientific article published in November 2011

Secondary metabolites from two species of Tolpis and their biological activities.

scientific article published in November 2012

Sesquiterpene lactones and other constituents from Matricaria chamomilla L

scientific article

Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities

scientific article

Sesquiterpenoid derivatives from Gonospermum elegans and their cytotoxic activity for HL-60 human promyelocytic cells.

scientific article published in July 2003

Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance

scientific article published on 4 May 2016

Sesquiterpenoids from Pulicaria canariensis and their cytotoxic activities.

scientific article

Steroidal saponins from the bark of Dracaena draco and their cytotoxic activities

scientific article

Synthesis and antiproliferative activity of a new compound containing an alpha-methylene-gamma-lactone group.

scientific article

Synthesis and antitumor molecular mechanism of agents based on amino 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan: inhibition of tubulin and induction of apoptosis

scientific article

Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells.

scientific article published in December 2018

Synthesis of novel spirostanic saponins and their cytotoxic activity

scientific article published on 4 November 2007

Testicular 3 beta-hydroxysteroid dehydrogenase/delta 5-4 isomerase in the hypophysectomized rat: effect of treatment with 5 alpha-dihydrotestosterone

scientific article published on 01 May 1992

The abietane diterpenoid parvifloron D from Plectranthus ecklonii is a potent apoptotic inducer in human leukemia cells

scientific article published on 10 July 2015

The eudesmanolide tanapsin from Tanacetum oshanahanii and its acetate induce cell death in human tumor cells through a mechanism dependent on reactive oxygen species

scientific article

Trifolin acetate-induced cell death in human leukemia cells is dependent on caspase-6 and activates the MAPK pathway

scientific article published in May 2008

alpha-Bromoacrylamido N-substituted isatin derivatives as potent inducers of apoptosis in human myeloid leukemia cells

scientific article published in October 2009

List of works by Francisco Estévez

3'-Hydroxy-3,4'-dimethoxyflavone blocks tubulin polymerization and is a potent apoptotic inducer in human SK-MEL-1 melanoma cells

3'-Hydroxy-3,4'-dimethoxyflavone-induced cell death in human leukaemia cells is dependent on caspases and reactive oxygen species and attenuated by the inhibition of JNK/SAPK.

5,7,3'-Trihydroxy-3,4'-dimethoxyflavone inhibits the tubulin polymerization and activates the sphingomyelin pathway

5,7,3'-trihydroxy-3,4'-dimethoxyflavone-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway

6'-Benzyloxy-4-bromo-2'-hydroxychalcone is cytotoxic against human leukaemia cells and induces caspase-8- and reactive oxygen species-dependent apoptosis

A Novel Naphthoquinone-Coumarin Hybrid That Inhibits BCR-ABL1-STAT5 Oncogenic Pathway and Reduces Survival in Imatinib-Resistant Chronic Myelogenous Leukemia Cells

A homo-isoflavonoid and a cytotoxic saponin from Dracaena draco

A new ceramide from Suillus luteus and its cytotoxic activity against human melanoma cells

Acetyl derivative of quercetin 3-methyl ether-induced cell death in human leukemia cells is amplified by the inhibition of ERK.

Anticancer properties of the abietane diterpene 6,7-dehydroroyleanone obtained by optimized extraction.

Antiproliferative activity and apoptosis induction by 3',4'-dibenzyloxyflavonol on human leukemia cells

Antiproliferative activity of abietane diterpenoids against human tumor cells

Astragalin heptaacetate-induced cell death in human leukemia cells is dependent on caspases and activates the MAPK pathway

Betuletol 3-methyl ether induces G(2)-M phase arrest and activates the sphingomyelin and MAPK pathways in human leukemia cells

Ceramide mediates tumor necrosis factor effects on P450-aromatase activity in cultured granulosa cells

Chemical constituents of Tolpis species

Chemotaxonomy of Gonospermum and related genera

Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells

Cladocalol, a pentacyclic 28-nor-triterpene from Eucalyptus cladocalyx with cytotoxic activity

Cytotoxic activities of flavonoid glycoside acetates from Consolida oliveriana

Design, synthesis and antiproliferative activity of novel heterobivalent hybrids based on imidazo[2,1-b][1,3,4]thiadiazole and imidazo[2,1-b][1,3]thiazole scaffolds

Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and alpha-bromoacryloyl moieties.

Design, synthesis, and biological evaluation of hybrid molecules containing alpha-methylene-gamma-butyrolactones and polypyrrole minor groove binders

Diacylglycerol rather than Ca2+ mediates GnRH inhibition of FSH induced steroidogenesis in ovarian granulosa cells

Does oligosaccharide-phosphatidylinositol (glycosyl-phosphatidylinositol) hydrolysis mediate prolactin signal transduction in granulosa cells?

Effect of the protein phosphatase inhibitor okadaic acid on FSH-induced granulosa cell steroidogenesis

Enantioselective synthesis and biological activity of (3S,4R)- and (3S,4S)-3-hydroxy-4-hydroxymethyl- 4-butanolides in relation to PGE2.

Eupatorin-induced cell death in human leukemia cells is dependent on caspases and activates the mitogen-activated protein kinase pathway

Follicle-stimulating hormone and human chorionic gonadotropin induced changes in granulosa cell glycosyl-phosphatidylinositol concentration

Gardenin B-induced cell death in human leukemia cells involves multiple caspases but is independent of the generation of reactive oxygen species.

Hybrid molecules containing benzo[4,5]imidazo[1,2-d][1,2,4]thiadiazole and alpha-bromoacryloyl moieties as potent apoptosis inducers on human myeloid leukaemia cells

Icogenin, a new cytotoxic steroidal saponin isolated from Dracaena draco

Identification and quantitation of allelochemicals from the lichen Lethariella canariensis: phytotoxicity and antioxidative activity

Induction of G2-M phase arrest and apoptosis by alpha-methylene-gamma-butyrolactones in human leukemia cells.

Induction of G2/M phase arrest and apoptosis by the flavonoid tamarixetin on human leukemia cells

Inhibition of proliferation and induction of apoptosis by melatonin in human myeloid HL-60 cells

Interleukin-1 beta stimulates sphingomyelin hydrolysis in cultured granulosa cells: evidence for a regulatory role of ceramide on progesterone and prostaglandin biosynthesis

Isolation from Eucalyptus occidentalis and identification of a new kaempferol derivative that induces apoptosis in human myeloid leukemia cells

Isolation, structure elucidation, total synthesis, and evaluation of new natural and synthetic ceramides on human SK-MEL-1 melanoma cells

Lanostanoid triterpenes from Laetiporus sulphureus and apoptosis induction on HL-60 human myeloid leukemia cells

Melatonin Induces Melanogenesis in Human SK-MEL-1 Melanoma Cells Involving Glycogen Synthase Kinase-3 and Reactive Oxygen Species

Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells

Melatonin enhances hyperthermia-induced apoptotic cell death in human leukemia cells

Melatonin prevents apoptosis and enhances HSP27 mRNA expression induced by heat shock in HL-60 cells: possible involvement of the MT2 receptor

Naturally occurring asteriscunolide A induces apoptosis and activation of mitogen-activated protein kinase pathway in human tumor cell lines.

New lanostanoids from the fungus Ganoderma concinna.

Phenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agents

Potent induction of apoptosis by germacranolide sesquiterpene lactones on human myeloid leukemia cells.

Pregnane steroidal glycosides and their cytostatic activities

Recent Advances on Cytotoxic Sesquiterpene Lactones

Secondary metabolites from two species of Pulicaria and their cytotoxic activity.

Secondary metabolites from two species of Tolpis and their biological activities.

Sesquiterpene lactones and other constituents from Matricaria chamomilla L

Sesquiterpene lactones from Gonospermum gomerae and G. fruticosum and their cytotoxic activities

Sesquiterpenoid derivatives from Gonospermum elegans and their cytotoxic activity for HL-60 human promyelocytic cells.

Sesquiterpenoids Isolated from Two Species of the Asteriscus Alliance

Sesquiterpenoids from Pulicaria canariensis and their cytotoxic activities.

Steroidal saponins from the bark of Dracaena draco and their cytotoxic activities

Synthesis and antiproliferative activity of a new compound containing an alpha-methylene-gamma-lactone group.

Synthesis and antitumor molecular mechanism of agents based on amino 2-(3',4',5'-trimethoxybenzoyl)benzo[b]furan: inhibition of tubulin and induction of apoptosis

Synthesis and biological evaluation of alpha-bromoacryloylamido indolyl pyridinyl propenones as potent apoptotic inducers in human leukaemia cells.

Synthesis of novel spirostanic saponins and their cytotoxic activity

Testicular 3 beta-hydroxysteroid dehydrogenase/delta 5-4 isomerase in the hypophysectomized rat: effect of treatment with 5 alpha-dihydrotestosterone

The abietane diterpenoid parvifloron D from Plectranthus ecklonii is a potent apoptotic inducer in human leukemia cells

The eudesmanolide tanapsin from Tanacetum oshanahanii and its acetate induce cell death in human tumor cells through a mechanism dependent on reactive oxygen species

Trifolin acetate-induced cell death in human leukemia cells is dependent on caspase-6 and activates the MAPK pathway

alpha-Bromoacrylamido N-substituted isatin derivatives as potent inducers of apoptosis in human myeloid leukemia cells