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List of works by Richard Humphries

5-Azacytidine Selectively Increases γ-Globin Synthesis in a Patient with β+Thalassemia ⬇️

scientific article published on 01 December 1982

A human parvovirus-like virus inhibits haematopoietic colony formation in vitro

scientific article

A regulatory network controls nephrocan expression and midgut patterning

scientific journal article

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis

article

Activation of stem-cell specific genes by HOXA9 and HOXA10 homeodomain proteins in CD34+ human cord blood cells

scientific article published in May 2005

Acute myeloid leukemia and the Wnt pathway

scientific article published on 01 June 2010

Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia

scientific article

Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development.

scientific article published on 20 December 2011

Aldehyde dehydrogenases in acute myeloid leukemia.

scientific article published on March 2014

Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis

scientific article published on 30 April 2012

Brief report: ectopic expression of NUP98-HOXA10 augments erythroid differentiation of human embryonic stem cells

scientific article published in April 2011

CBL exon 8/9 mutants activate the FLT3 pathway and cluster in core binding factor/11q deletion acute myeloid leukemia/myelodysplastic syndrome subtypes.

scientific article published on 10 March 2009

CD34(+) expansion with Delta-1 and HOXB4 promotes rapid engraftment and transfusion independence in a Macaca nemestrina cord blood transplant model

scientific article published on 16 April 2013

CFU-S in individual erythroid colonies derived in vitro from adult mouse marrow

scientific article published on June 1979

Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes

scientific article

Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene

scientific article

Cellulose as an inert matrix for presenting cytokines to target cells: production and properties of a stem cell factor-cellulose-binding domain fusion protein

scientific article published on April 1999

Characterization of Asxl1, a murine homolog of Additional sex combs, and analysis of the Asx-like gene family

scientific article

Chromosomal distribution of the RTVL-H family of human endogenous retrovirus-like sequences

scientific article published on 01 May 1988

Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells

scientific article published on 16 January 2014

Combination of HOXB4 and Delta-1 ligand improves expansion of cord blood cells ⬇️

scientific article published on October 4, 2010

Complementary and independent function for Hoxb4 and Bmi1 in HSC activity

scientific article published on 06 November 2008

Concise Review: Multidimensional Regulation of the Hematopoietic Stem Cell State ⬇️

scientific article published on January 1, 2012

Constitutive IRF8 expression inhibits AML by activation of repressed immune response signaling

scientific article

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

scientific article

Correlation of murine embryonic stem cell gene expression profiles with functional measures of pluripotency

scientific article published in May 2005

Cytokines acting early in human haematopoiesis

scientific article published on March 1994

Defective development of thymocytes overexpressing the costimulatory molecule, heat-stable antigen

scientific article published on January 1994

Delineating MEIS1 cis-regulatory elements active in hematopoietic cells

scientific article published on 7 October 2013

Delineating domains and functions of NUP98 contributing to the leukemogenic activity of NUP98-HOX fusions

scientific article

Deregulated expression of HOXB4 enhances the primitive growth activity of human hematopoietic cells

scientific article (publication date: August 2002)

Differential effects of HOXB4 and NUP98-HOXA10hd on hematopoietic repopulating cells in a nonhuman primate model.

scientific article published on 6 September 2011

Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny

scientific article published on 01 January 2002

Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells

scientific article

Distinct signaling programs control human hematopoietic stem cell survival and proliferation.

scientific article

Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t(12;13)(p13;q12) acute myeloid leukemia

scientific article

Effects of HOXB4 overexpression on ex vivo expansion and immortalization of hematopoietic cells from different species

scientific article published on 17 May 2007

Enforced adenoviral vector-mediated expression of HOXB4 in human umbilical cord blood CD34+ cells promotes myeloid differentiation but not proliferation

scientific article published in October 2003

Enhanced in vivo selection of bone marrow cells by retroviral-mediated coexpression of mutant O6-methylguanine-DNA-methyltransferase and HOXB4.

scientific article

Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors

scientific article

Ex vivo expansion of normal and chronic myeloid leukemic stem cells without functional alteration using a NUP98HOXA10homeodomain fusion gene ⬇️

scientific article published on July 16, 2012

Exciting times for our field and the Journal ⬇️

scientific article published on January 28, 2011

Expression of an anti-sickling beta-globin in human erythroblasts derived from retrovirally transduced primitive normal and sickle cell disease hematopoietic cells

scientific article

Feasibility of using autologous transplantation to evaluate hematopoietic stem cell-based gene therapy strategies in transgenic mouse models of human disease

scientific article published in September 2002

Functional characterization of multiple domains involved in the subcellular localization of the hematopoietic Pbx interacting protein (HPIP).

scientific article published on October 2002

Functional role of BAALC in leukemogenesis.

scientific article

GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo.

scientific article

Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations.

scientific article

HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation

scientific article published in September 2001

HOXB4-induced expansion of adult hematopoietic stem cells ex vivo

scientific article published in April 2002

Hematopoietic stem cell expansion facilitates multilineage engraftment in a nonhuman primate cord blood transplantation model.

scientific article

Heterogeneity, self-renewal, and differentiation of hematopoietic stem cells

scientific article published on 21 May 2012

High incidence of leukemia in large animals after stem cell gene therapy with a HOXB4-expressing retroviral vector

scientific article

High level in vitro expansion of murine hematopoietic stem cells

scientific article published on 01 January 2008

High-efficiency retroviral transduction of mammalian cells on positively charged surfaces

scientific article

High-level beta-globin expression and preferred intragenic integration after lentiviral transduction of human cord blood stem cells

scientific article published on October 2004

High-throughput analysis of single hematopoietic stem cell proliferation in microfluidic cell culture arrays.

scientific article published on 22 May 2011

Homeostasis and regeneration of the hematopoietic stem cell pool are altered in SHIP-deficient mice

scientific article

Hox genes in hematopoiesis and leukemogenesis.

scientific article

Hox genes: from leukemia to hematopoietic stem cell expansion.

scientific article

Hox homeobox genes as regulators of normal and leukemic hematopoiesis

scientific article published on December 1997

Hox regulation of normal and leukemic hematopoietic stem cells.

scientific article

IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein.

scientific article published on 18 May 2012

Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype

scientific article

Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.

scientific article

Improved engraftment of human acute myeloid leukemia progenitor cells in beta 2-microglobulin-deficient NOD/SCID mice and in NOD/SCID mice transgenic for human growth factors

scientific article published on 01 April 2003

In vitro and in vivo expansion of hematopoietic stem cells.

scientific article published in September 2004

In vitro expansion of hematopoietic stem cells by recombinant TAT-HOXB4 protein

scientific article

In-depth characterization of the microRNA transcriptome in a leukemia progression model

scientific article published on 10 October 2008

Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1

scientific article published on 23 January 2003

Insights into leukemia-initiating cell frequency and self-renewal from a novel canine model of leukemia.

scientific article published on 8 October 2010

Interleukin-3 (IL-3) inhibits erythropoietin-induced differentiation in Ba/F3 cells via the IL-3 receptor alpha subunit

scientific article published on November 1996

Involvement of tyrosine kinase signaling in maintaining murine embryonic stem cell functionality.

scientific article

Isolation and analysis of different subpopulations of normal human breast epithelial cells after their infection with a retroviral vector encoding a cell surface marker

scientific article

Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor

scientific article published on 07 July 2008

Life without huntingtin: normal differentiation into functional neurons

scientific journal article

Linkage of Meis1 leukemogenic activity to multiple downstream effectors including Trib2 and Ccl3.

scientific article

Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3.

scientific article

Loss of expression of the Hoxa-9 homeobox gene impairs the proliferation and repopulating ability of hematopoietic stem cells

scientific article

MN1 overexpression induces acute myeloid leukemia in mice and predicts ATRA resistance in patients with AML.

scientific article

Mapping of CD24 and homologous sequences to multiple chromosomal loci

scientific article (publication date: July 1994)

Meis1 disrupts the genomic imprint of Dlk1 in a NUP98-HOXD13 leukemia model.

scientific article

MicroRNA-146a disrupts hematopoietic differentiation and survival

scientific article published on 07 October 2010

Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal.

scientific article

Molecular interactions involved in HOXB4-induced activation of HSC self-renewal

scientific article published on 29 June 2004

Myelosuppressive conditioning using busulfan enables bone marrow cell accumulation in the spinal cord of a mouse model of amyotrophic lateral sclerosis.

scientific article

NOD/SCID mice engineered to express human IL-3, GM-CSF and Steel factor constitutively mobilize engrafted human progenitors and compromise human stem cell regeneration

scientific article published on 01 February 2004

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.

scientific article published on 21 October 2012

NUP98-HOXA10hd-expanded hematopoietic stem cells efficiently reconstitute bone marrow of mismatched recipients and induce tolerance

scientific article published on 19 November 2010

NUP98-topoisomerase I acute myeloid leukemia-associated fusion gene has potent leukemogenic activities independent of an engineered catalytic site mutation

scientific article published on 20 April 2004

Near-maximal expansions of hematopoietic stem cells in culture using NUP98-HOX fusions

scientific article published on May 2007

No evidence of clonal dominance after transplant of HOXB4-expanded cord blood cells in a nonhuman primate model

scientific article

Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL.

scientific article

Optimization of retroviral-mediated gene transfer to human NOD/SCID mouse repopulating cord blood cells through a systematic analysis of protocol variables.

scientific article

Overexpression of HOXB4 confers a myelo-erythroid differentiation delay in vitro

scientific article published on 01 January 2005

Preselection of retrovirally transduced bone marrow avoids subsequent stem cell gene silencing and age-dependent extinction of expression of human beta-globin in engrafted mice.

scientific article published on May 2000

Priming reloaded?

scientific article published on 01 July 2009

Probing the complexity of miRNA expression across hematopoiesis

scientific article published on 01 January 2011

Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability ⬇️

scientific article published on March 1, 1992

Reduced proliferative capacity of hematopoietic stem cells deficient in Hoxb3 and Hoxb4.

scientific article

Regulation of SLAM-mediated signal transduction by SAP, the X-linked lymphoproliferative gene product

scientific article (publication date: August 2001)

Regulation of cell survival during B lymphopoiesis: increased pre-B cell apoptosis in CD24-transgenic mouse bone marrow

scientific article published on 01 September 2000

Retroviral integration site analysis identifies ICSBP as a collaborating tumor suppressor gene in NUP98-TOP1-induced leukemia.

scientific article published in September 2006

Retroviral marking of acute myelogenous leukemia progenitors that initiate long-term culture and growth in immunodeficient mice

scientific article published in November 1999

Retroviral vectors aimed at the gene therapy of human beta-globin gene disorders

scientific article

Retrovirus-mediated gene transfer to purified hemopoietic stem cells with long-term lympho-myelopoietic repopulating ability.

scientific article

SHIP-deficient mice are severely osteoporotic due to increased numbers of hyper-resorptive osteoclasts

scientific journal article

Selection of transduced CD34+ progenitors and enzymatic correction of cells from Gaucher patients, with bicistronic vectors

scientific article

Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin

scientific article

Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation

scientific article published on 29 December 2010

Sustained in vitro trigger of self-renewal divisions in Hoxb4hiPbx1(10) hematopoietic stem cells.

scientific article

The Flt3 receptor tyrosine kinase collaborates with NUP98-HOX fusions in acute myeloid leukemia

scientific article published on August 2006

The competitive nature of HOXB4-transduced HSC is limited by PBX1: the generation of ultra-competitive stem cells retaining full differentiation potential

scientific article published on 01 April 2003

The role of SHIP in growth factor induced signalling.

scientific article

The src homology 2-containing inositol phosphatase (SHIP) is the gatekeeper of mast cell degranulation ⬇️

scientific article published on September 15, 1998

Transfer of the human telomerase reverse transcriptase (TERT) gene into T lymphocytes results in extension of replicative potential

scientific article

Transplantable cell lines generated with NUP98-Hox fusion genes undergo leukemic progression by Meis1 independent of its binding to DNA

scientific article published on 01 April 2005

Varying levels of aldehyde dehydrogenase activity in adult murine marrow hematopoietic stem cells are associated with engraftment and cell cycle status.

scientific article published on 6 June 2012

Vascular endothelial growth factor receptor-2 induces survival of hematopoietic progenitor cells

scientific article published on 30 March 2003

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