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List of works by Melissa A Brown

A guide for functional analysis of BRCA1 variants of uncertain significance

scientific article

A novel synthetic adjuvant enhances dendritic cell function ⬇️

scientific article published on 26 December 2008

Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers

scientific article published on 2 August 2009

Alternatively spliced RNAs encode several isoforms of CD46 (MCP), a regulator of complement activation

scientific article published in January 1991

Analysis of Brca1-deficient mouse mammary glands reveals reciprocal regulation of Brca1 and c-kit

scientific article published on 6 December 2010

Androgen receptor expression predicts breast cancer survival: the role of genetic and epigenetic events ⬇️

scientific article published on April 2, 2012

BRCA1 R1699Q variant displaying ambiguous functional abrogation confers intermediate breast and ovarian cancer risk

scientific article published on August 2012

BRCA1 and BRCA2 5' noncoding region variants identified in breast cancer patients alter promoter activity and protein binding

scientific article published on 24 September 2018

BRCA1 and BRCA2 missense variants of high and low clinical significance influence lymphoblastoid cell line post-irradiation gene expression

scientific article

Caution: Plasmid DNA topology affects luciferase assay reproducibility and outcomes

scientific article published on 01 August 2019

Classifying MLH1 and MSH2 variants using bioinformatic prediction, splicing assays, segregation, and tumor characteristics

scientific article published on May 2009

Clinical Classification ofBRCA1andBRCA2DNA Sequence Variants: The Value of Cytokeratin Profiles and Evolutionary Analysis—A Report From the kConFab Investigators

article

Colocalisation of predicted exonic splicing enhancers in BRCA2 with reported sequence variants

scientific article published on 26 September 2007

Comparison of mRNA splicing assay protocols across multiple laboratories: recommendations for best practice in standardized clinical testing

scientific article

Comprehensive annotation of splice junctions supports pervasive alternative splicing at the BRCA1 locus: a report from the ENIGMA consortium

scientific article published on 25 February 2014

Consequences of germline variation disrupting the constitutional translational initiation codon start sites of MLH1 and BRCA2: Use of potential alternative start sites and implications for predicting variant pathogenicity

scientific article

Constitutional methylation of the BRCA1 promoter is specifically associated with BRCA1 mutation-associated pathology in early-onset breast cancer

scientific article

Deletion mapping and expression in Escherichia coli of the large genomic segment of a birnavirus.

scientific article

Detection of splicing aberrations caused by BRCA1 and BRCA2 sequence variants encoding missense substitutions: implications for prediction of pathogenicity

scientific article

Disruption of BRCA1 function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines

scientific article published on March 2006

Distinct transcription start sites generate two forms of BRCA1 mRNA.

scientific article published on December 1995

Dynamic interactions between the promoter and terminator regions of the mammalian BRCA1 gene

scholarly article

Effect of BRCA2 sequence variants predicted to disrupt exonic splice enhancers on BRCA2 transcripts

scientific article

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation

scientific article

Evolutionary conservation analysis increases the colocalization of predicted exonic splicing enhancers in the BRCA1 gene with missense sequence changes and in-frame deletions, but not polymorphisms

scientific article

Expression and function of the protein tyrosine phosphatase receptor J (PTPRJ) in normal mammary epithelial cells and breast tumors

scientific article

Expression of a truncated Brca1 protein delays lactational mammary development in transgenic mice

article

Fine-scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1.

scientific article

Functional variants at the 11q13 risk locus for breast cancer regulate cyclin D1 expression through long-range enhancers

scientific article published on 27 March 2013

Genetic and Histopathologic Evaluation ofBRCA1andBRCA2DNA Sequence Variants of Unknown Clinical Significance

article

Germline BRCA1 promoter deletions in UK and Australian familial breast cancer patients: Identification of a novel deletion consistent with BRCA1:psiBRCA1 recombination.

scientific article published on April 2002

Identification and characterization of a novel melanoma tumor suppressor gene on human chromosome 6q21.

scientific article

Identification and functional analysis of novel BRCA1 transcripts, including mouse Brca1-Iris and human pseudo-BRCA1

article

Identification of BRCA1 missense substitutions that confer partial functional activity: potential moderate risk variants?

scientific article

Identification of fifteen novel germline variants in the BRCA1 3'UTR reveals a variant in a breast cancer case that introduces a functional miR-103 target site

scientific article

Identification of two evolutionarily conserved and functional regulatory elements in intron 2 of the human BRCA1 gene

article

Leukemia inhibitory factor (LIF) infusion stimulates skeletal muscle regeneration after injury: Injured muscle expresses lif mRNA

scientific article published on 01 May 1994

Localization of plasma membrane and secretory calcium pumps in the mammary gland.

scientific article published on 10 March 2008

Long Noncoding RNAs CUPID1 and CUPID2 Mediate Breast Cancer Risk at 11q13 by Modulating the Response to DNA Damage.

scientific article published on August 2017

Long-range regulators of the lncRNA HOTAIR enhance its prognostic potential in breast cancer

scientific article published on 04 July 2016

Long‐range transcriptional regulation of breast cancer genes ⬇️

scientific article published on October 18, 2012

MMTV-trBrca1 mice display strain-dependent abnormalities in vaginal development

scientific article published in September 2004

Method for the generation and cultivation of functional three-dimensional mammary constructs without exogenous extracellular matrix

scientific article published on 16 February 2005

Methylome sequencing in triple-negative breast cancer reveals distinct methylation clusters with prognostic value.

scientific article published on 02 February 2015

Morphological and molecular analysis of a breast cancer cluster at the ABC Studio in Toowong

scientific article published on 01 August 2012

Multifactorial likelihood assessment of BRCA1 and BRCA2 missense variants confirms that BRCA1:c.122A>G(p.His41Arg) is a pathogenic mutation

scientific article published on 28 January 2014

Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer

scientific article

Non-coding RNAs in Mammary Gland Development and Disease

scientific article

ORAI1-mediated calcium influx in lactation and in breast cancer

scientific article published on 11 January 2011

Posttranscriptional regulation of the breast cancer susceptibility gene BRCA1 by the RNA binding protein HuR.

scientific article published in November 2008

Pre-mRNA splicing aberrations and cancer.

scientific article published on January 2008

Prediction of BRCA1 and BRCA2 mutation status using post-irradiation assays of lymphoblastoid cell lines is compromised by inter-cell-line phenotypic variability

scientific article published on 25 October 2006

Protein arginine methyltransferase 6-dependent gene expression and splicing: association with breast cancer outcomes

scientific article published on 22 July 2012

Publisher Correction: Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

scientific article published on 10 April 2018

Regulation of BRCA1 messenger RNA stability in human epithelial cell lines and during cell cycle progression

scientific article

Roles of heterogeneous nuclear ribonucleoproteins A and B in cell proliferation

scientific article published on July 2005

SNORD-host RNA Zfas1 is a regulator of mammary development and a potential marker for breast cancer

scientific article

Splicing and multifactorial analysis of intronic BRCA1 and BRCA2 sequence variants identifies clinically significant splicing aberrations up to 12 nucleotides from the intron/exon boundary

scientific article

Studies on inherited cancers: outcomes and challenges of 25 years

scientific article

Targeted disruption of Brca1 in restricted compartments of the mouse mammary epithelia.

scientific article

The calcium pump plasma membrane Ca(2+)-ATPase 2 (PMCA2) regulates breast cancer cell proliferation and sensitivity to doxorubicin.

scientific article

The voltage gated Ca(2+)-channel Cav3.2 and therapeutic responses in breast cancer

scientific article published on 31 March 2016

Towards cloning the familial breast-ovarian cancer gene on chromosome 17.

scientific article published on June 1994

Towards controlled terminology for reporting germline cancer susceptibility variants: an ENIGMA report

scientific article published on 08 April 2019

eLCR: electrochemical detection of single DNA base changes via ligase chain reaction.

scientific article published in December 2012

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