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List of works by Daniel A. Lawrence

A CCR2 macrophage endocytic pathway mediates extravascular fibrin clearance in vivo.

scientific article published on 8 December 2015

A direct, plasmin-independent assay for plasminogen activator

scientific article published on 01 May 1984

A mechanism for assembly of complexes of vitronectin and plasminogen activator inhibitor-1 from sedimentation velocity analysis.

scientific article

A mutant, noninhibitory plasminogen activator inhibitor type 1 decreases matrix accumulation in experimental glomerulonephritis

scientific article published on August 2003

A plasminogen activator inhibitor type 1 mutant retards diabetic nephropathy in db/db mice by protecting podocytes

scientific article

A specific role of integrin Mac-1 in accelerated macrophage efflux to the lymphatics

scientific article published on 7 July 2005

Adjuvant treatment with neuroserpin increases the therapeutic window for tissue-type plasminogen activator administration in a rat model of embolic stroke

scientific article published in August 2002

Amalfi to Washington D. C.--twenty years of plasminogen activator research.

scientific article published in April 2005

Antimetastatic potential of PAI-1-specific RNA aptamers.

scientific article

Beyond fibrinolysis: the role of plasminogen activator inhibitor-1 and vitronectin in vascular wound healing.

scientific article

Characterization and comparative evaluation of a structurally unique PAI-1 inhibitor exhibiting oral in-vivo efficacy

scientific article published in August 2004

Characterization of Tissue Plasminogen Activator Expression and Trafficking in the Adult Murine Brain

scientific article published on 01 July 2018

Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1

scientific article

Characterization of the Annonaceous acetogenin, annonacinone, a natural product inhibitor of plasminogen activator inhibitor-1.

scientific article published on 23 November 2016

Characterization of the binding of different conformational forms of plasminogen activator inhibitor-1 to vitronectin. Implications for the regulation of pericellular proteolysis

scientific article published on 01 March 1997

Conservation of critical functional domains in murine plasminogen activator inhibitor-1.

scientific article published on 12 February 2004

Development of inhibitors of plasminogen activator inhibitor-1.

scientific article

Dual role for plasminogen activator inhibitor type 1 as soluble and as matricellular regulator of epithelial alveolar cell wound healing

scientific journal article

Dual-reporter high-throughput screen for small-molecule in vivo inhibitors of plasminogen activator inhibitor type-1 yields a clinical lead candidate

scientific article published on 03 December 2018

Editorial: The Role of the Plasminogen Activating System in Neurobiology

scientific article published on 4 October 2016

Effect of pharmacologic plasminogen activator inhibitor-1 inhibition on cell motility and tumor angiogenesis

scientific article published on 02 October 2006

Engineering plasminogen activator inhibitor 1 mutants with increased functional stability.

scientific article

Familial dementia caused by polymerization of mutant neuroserpin

scientific article (publication date: 23 September 1999)

Identification of a neurovascular signaling pathway regulating seizures in mice

scientific article

Identification of a novel targeting sequence for regulated secretion in the serine protease inhibitor neuroserpin.

scientific article

Identification of tissue-type plasminogen activator-specific plasminogen activator inhibitor-1 mutants. Evidence that second sites of interaction contribute to target specificity.

scientific article published on April 1995

Imatinib treatment reduces brain injury in a murine model of traumatic brain injury

scientific article

Impaired fibrinolytic system in ApoE gene-deleted mice with hyperlipidemia augments deep vein thrombosis ⬇️

scientific article published on November 25, 2011

Inactivation of plasminogen activator inhibitor by oxidants.

scientific article published in October 1986

Increased stroke size following MCA occlusion in a mouse model of sickle cell disease

scientific article published on March 2014

Inhibition of angiogenesis in vivo by plasminogen activator inhibitor-1

scientific article published on 16 November 2000

Low density lipoprotein receptor-related protein-1 (LRP1) regulates thrombospondin-2 (TSP2) enhancement of Notch3 signaling

scientific article

Mapping of a conformational epitope on plasminogen activator inhibitor-1 by random mutagenesis. Implications for serpin function

scientific article published on 26 February 2003

Matrix-bound PAI-1 supports cell blebbing via RhoA/ROCK1 signaling

scientific article (publication date: 2012)

Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor

scientific article published on 02 February 2007

Mechanisms Underlying Astrocyte Endfeet Swelling in Stroke.

scientific article published on January 2016

Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1

scientific article

Microglial-mediated PDGF-CC activation increases cerebrovascular permeability during ischemic stroke.

scientific article published on 19 July 2017

Molecular regulation of the PAI-1 gene by hypoxia: contributions of Egr-1, HIF-1alpha, and C/EBPalpha.

scientific article published on 28 December 2006

Multifaceted role of plasminogen activator inhibitor-1 in regulating early remodeling of vein bypass grafts

scientific article published on 12 May 2011

Mutants of plasminogen activator inhibitor-1 designed to inhibit neutrophil elastase and cathepsin G are more effective in vivo than their endogenous inhibitors

scientific article

Myeloid Mineralocorticoid Receptor During Experimental Ischemic Stroke: Effects of Model and Sex ⬇️

scientific article published on October 25, 2012

Neuroserpin Differentiates Between Forms of Tissue Type Plasminogen Activator via pH Dependent Deacylation

scientific article

Neuroserpin polymorphisms and stroke risk in a biracial population: the stroke prevention in young women study

scientific article

Neuroserpin, a brain-associated inhibitor of tissue plasminogen activator is localized primarily in neurons. Implications for the regulation of motor learning and neuronal survival

scientific article published in December 1997

Noninhibitory PAI-1 enhances plasmin-mediated matrix degradation both in vitro and in experimental nephritis

scientific article published on 21 June 2006

Novel bis-arylsulfonamides and aryl sulfonimides as inactivators of plasminogen activator inhibitor-1 (PAI-1).

scientific article published on 21 December 2009

PAI-1 and functional blockade of SNAI1 in breast cancer cell migration.

scientific article published on 03 December 2008

PAI-1 augments mucosal damage in colitis

scientific article published on 01 March 2019

PAI-1 promotes the accumulation of exudate macrophages and worsens pulmonary fibrosis following type II alveolar epithelial cell injury.

scientific article

Passenger mutations and aberrant gene expression in congenic tissue plasminogen activator-deficient mouse strains

scientific article published on 15 April 2016

Pharmacological targeting of the PDGF-CC signaling pathway for blood-brain barrier restoration in neurological disorders

scientific article (publication date: 12 August 2016)

Plasminogen Activator Inhibitor-1 Reduces tPA-Dependent Fibrinolysis and Intrahepatic Hemorrhage in Experimental Acetaminophen Overdose

scientific article published on 15 February 2018

Plasminogen activator inhibitor-1 and vitronectin expression level and stoichiometry regulate vascular smooth muscle cell migration through physiological collagen matrices

scientific article published on 12 May 2010

Plasminogen activator inhibitor-1 contains a cryptic high affinity binding site for the low density lipoprotein receptor-related protein

scientific article published on 01 March 1998

Plasminogen activator inhibitor-1 inhibits angiogenic signaling by uncoupling vascular endothelial growth factor receptor-2-αVβ3 integrin cross talk.

scientific article

Plasminogen activator inhibitor-1 mitigates brain injury in a rat model of infection-sensitized neonatal hypoxia-ischemia.

scientific article published on 3 May 2012

Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis

scientific article published on 05 July 2001

Plasminogen activator-1 overexpression decreases experimental postthrombotic vein wall fibrosis by a non-vitronectin-dependent mechanism.

scientific article

Plasminogen promotes sarcoma growth and suppresses the accumulation of tumor-infiltrating macrophages

scientific article published on 01 December 2002

Platelet-Derived Growth Factor C Deficiency in C57BL/6 Mice Leads to Abnormal Cerebral Vascularization, Loss of Neuroependymal Integrity, and Ventricular Abnormalities ⬇️

scientific article published on January 9, 2012

Platelet-derived growth factor (PDGF)-induced tyrosine phosphorylation of the low density lipoprotein receptor-related protein (LRP). Evidence for integrated co-receptor function betwenn LRP and the PDGF.

scientific article

Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration.

scientific article

Proteomic analysis of the Vibrio cholerae type II secretome reveals new proteins, including three related serine proteases

scientific article

Randomized assessment of imatinib in patients with acute ischaemic stroke treated with intravenous thrombolysis

scientific article published on 14 November 2016

Recombinant plasminogen activator inhibitor-1 inhibits intimal hyperplasia

scientific article published on 2 July 2009

Reverse fibrin autography: a method to detect and partially characterize protease inhibitors after sodium dodecyl sulfate--polyacrylamide gel electrophoresis.

scientific article

Rosuvastatin reduced deep vein thrombosis in ApoE gene deleted mice with hyperlipidemia through non-lipid lowering effects.

scientific article published on 29 December 2012

Self-regulation of inflammatory cell trafficking in mice by the leukocyte surface apyrase CD39.

scientific article published on 20 April 2009

Serpin conformational change in ovalbumin. Enhanced reactive center loop insertion through hinge region mutations

scientific article published in May 1997

Serpin mutagenesis

scientific article published on 01 February 2004

Serpin-protease complexes are trapped as stable acyl-enzyme intermediates

scientific article published on 01 October 1995

Slow fusion pore expansion creates a unique reaction chamber for co-packaged cargo

scientific article

Sometimes a cigar is just a cigar

scientific article published on 01 September 2010

Structural differences between active forms of plasminogen activator inhibitor type 1 revealed by conformationally sensitive ligands

scientific article published on 24 April 2008

Structural similarity of the covalent complexes formed between the serpin plasminogen activator inhibitor-1 and the arginine-specific proteinases trypsin, LMW u-PA, HMW u-PA, and t-PA: use of site-specific fluorescent probes of local environment

scientific article published on May 2002

Structure-function relationships of plasminogen activator inhibitor-1 and its potential as a therapeutic agent

scientific article

The acid stabilization of plasminogen activator inhibitor-1 depends on protonation of a single group that affects loop insertion into beta-sheet A.

scientific article published in November 1995

The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion

scientific article

The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor

scientific article

The contributions of integrin affinity and integrin-cytoskeletal engagement in endothelial and smooth muscle cell adhesion to vitronectin

scientific article published on 2 April 2007

The functional dissonance of platelets

scientific article published on 01 August 2012

The serpin PAI-1 inhibits cell migration by blocking integrin alpha V beta 3 binding to vitronectin

scientific article

The tissue-type plasminogen activator-plasminogen activator inhibitor 1 complex promotes neurovascular injury in brain trauma: evidence from mice and humans

scientific article

The vitronectin-binding function of PAI-1 exacerbates lung fibrosis in mice ⬇️

scientific article published on July 6, 2011

Therapeutic administration of plasminogen activator inhibitor-1 prevents hypoxic-ischemic brain injury in newborns.

scientific article published on July 2009

Tissue factor and obesity, a two-way street

scientific article published on 07 November 2011

Tissue-type plasminogen activator and neuroserpin: a well-balanced act in the nervous system?

scientific article published in July 2004

Tissue-type plasminogen activator induces opening of the blood-brain barrier via the LDL receptor-related protein.

scientific article published on November 2003

Tissue-type plasminogen activator requires a co-receptor to enhance NMDA receptor function

scientific article

Tissue-type plasminogen activator-mediated shedding of astrocytic low-density lipoprotein receptor-related protein increases the permeability of the neurovascular unit.

scientific article published on 14 December 2006

Traumatic Brain Injury Leads to Accelerated Atherosclerosis in Apolipoprotein E Deficient Mice.

scientific article

Type 1 plasminogen activator inhibitor binds to fibrin via vitronectin

scientific article published on 01 June 2000

Upregulation of P2Y2R, Active uPA, and PAI-1 Are Essential Components of Hantavirus Cardiopulmonary Syndrome.

scientific article published on 23 May 2018

Visceral adipose tissue inflammation accelerates atherosclerosis in apolipoprotein E-deficient mice.

scientific article

Vitronectin-binding PAI-1 protects against the development of cardiac fibrosis through interaction with fibroblasts

scientific article

tPA Modulation of the Blood-Brain Barrier: A Unifying Explanation for the Pleiotropic Effects of tPA in the CNS.

scientific article published on 27 September 2016

α2 Antiplasmin and microvascular thrombosis in ischemic stroke

scientific article published on 01 December 2014

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