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List of works by Gianluca Tell

A Potent HIV Protease Inhibitor Identified in an Epimeric Mixture by High-Resolution Protein Crystallography

article

A chicken hnRNP of the A/B family recognizes the single-stranded d(CCCTAA)(n) telomeric repeated motif.

scientific article

A differential proteomic approach to identify proteins associated with thyroid cell transformation.

scientific article published on February 2005

A molecular code dictates sequence-specific DNA recognition by homeodomains.

scientific article

A proteomic approach to identify early molecular targets of oxidative stress in human epithelial lens cells

scientific article

A proteomic approach to the bilirubin-induced toxicity in neuronal cells reveals a protective function of DJ-1 protein

scientific article

A review on protein-protein interaction network of APE1/Ref-1 and its associated biological functions

scientific article published on 19 March 2015

A short review on the implications of base excision repair pathway for neurons: relevance to neurodegenerative diseases

scientific article

A unique combination of transcription factors controls differentiation of thyroid cells

scientific article

APE/Ref-1 is increased in nuclear fractions of human thyroid hyperfunctioning nodules.

scientific article

APE1 polymorphic variants cause persistent genomic stress and affect cancer cell proliferation

scientific article published on 30 March 2016

APE1/Ref-1 in Alzheimer's disease: an immunohistochemical study

scientific article published on 25 September 2009

APE1/Ref-1 interacts with NPM1 within nucleoli and plays a role in the rRNA quality control process.

scientific article

APE1/Ref-1 redox function contributes to inflammatory pain sensitization

scientific article published on 14 May 2018

APE1/Ref-1 regulates PTEN expression mediated by Egr-1

scientific article

Abasic and oxidized ribonucleotides embedded in DNA are processed by human APE1 and not by RNase H2.

scientific article

Acetylation on critical lysine residues of Apurinic/apyrimidinic endonuclease 1 (APE1) in triple negative breast cancers

scientific article published on 16 June 2012

Activation of APE1/Ref-1 is dependent on reactive oxygen species generated after purinergic receptor stimulation by ATP

scientific article

Activation of human T lymphocytes under conditions similar to those that occur during exposure to microgravity: a proteomics study

scientific article published on 01 May 2005

Adhesion to fibronectin promotes the activation of the p125(FAK)/Zap-70complex in human T cells.

scientific article

Aggresome-forming TTRAP mediates pro-apoptotic properties of Parkinson's disease-associated DJ-1 missense mutations.

scientific article

Alterations in the redox state and liver damage: hints from the EASL Basic School of Hepatology.

scientific article published on 27 September 2012

Altered intracellular redox status in Gaucher disease fibroblasts and impairment of adaptive response against oxidative stress

scientific article published on July 2007

An 'environment to nucleus' signaling system operates in B lymphocytes: redox status modulates BSAP/Pax-5 activation through Ref-1 nuclear translocation

scientific article

Analysis of the solution structure of the homeodomain of rat thyroid transcription factor 1 by 1H-NMR spectroscopy and restrained molecular mechanics

scientific article

Architecture of The Human Ape1 Interactome Defines Novel Cancers Signatures

scientific article published on 08 January 2020

Autocrine/paracrine stimulation of purinergic receptors in osteoblasts: contribution of vesicular ATP release

scientific article

BIPHASIC CONTROL OF NF-κB ACTIVATION INDUCED BY THE TRIGGERING OF HLA-DR ANTIGENS EXPRESSED ON B CELLS

scientific article published on 01 May 1997

BRCA1 modulates the expression of hnRNPA2B1 and KHSRP.

scientific article

Base excision repair in Archaea: back to the future in DNA repair

scientific article published on 09 July 2014

Bilirubin-induced cell toxicity involves PTEN activation through an APE1/Ref-1-dependent pathway

scientific article published on 04 May 2007

Bisphosphonates activate nucleotide receptors signaling and induce the expression of Hsp90 in osteoblast-like cell lines

scientific article published on 12 May 2006

Cadmium treatment suppresses DNA polymerase δ catalytic subunit gene expression by acting on the p53 and Sp1 regulatory axis

scientific article published on 19 October 2015

Calreticulin enhances the transcriptional activity of thyroid transcription factor-1 by binding to its homeodomain

scientific article

Cleavage of the APE1 N-Terminal Domain in Acute Myeloid Leukemia Cells Is Associated with Proteasomal Activity

scientific article published on 31 March 2020

Co-operation between the PAI and RED subdomains of Pax-8 in the interaction with the thyroglobulin promoter

scientific article

Combining RNAi and in vivo confocal microscopy analysis of the photoconvertible fluorescent protein Dendra2 to study a DNA repair protein

scientific article published on 01 October 2013

Comparative stability analysis of the thyroid transcription factor 1 and Antennapedia homeodomains: evidence for residue 54 in controlling the structural stability of the recognition helix

scientific article

Control of phosphatase and tensin homolog (PTEN) gene expression in normal and neoplastic thyroid cells

scientific article published on July 2004

Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.

scientific article

Cross-regulation between Egr-1 and APE/Ref-1 during early response to oxidative stress in the human osteoblastic HOBIT cell line: evidence for an autoregulatory loop

scientific article

Cytosine-block telomeric type DNA-binding activity of hnRNP proteins from human cell lines.

scientific article published on January 2003

DNA repair enzyme APE1 from evolutionarily ancient Hydra reveals redox activity exclusively found in mammalian APE1.

scientific article published on 18 September 2017

Definition of the DNA-binding specificity of TTF-1 homeodomain by chromatographic selection of binding sequences

scientific article

DeltaNp73alpha inhibits PTEN expression in thyroid cancer cells

scientific article

Destabilisation, aggregation, toxicity and cytosolic mislocalisation of nucleophosmin regions associated with acute myeloid leukemia.

scientific article published on August 2016

Detection of aromatic catabolic gene expression in heterogeneous organic matter used for reduction of volatile organic compounds (VOC) by biofiltration.

scientific article

Differential proteomic analysis of nuclear extracts from thyroid cell lines

scientific article published on 23 January 2006

Differential proteomic analysis of subfractioned human hepatocellular carcinoma tissues

scientific article published in May 2009

Down-regulation of SM22/transgelin gene expression during H9c2 cells differentiation.

scientific article published on 18 February 2009

Effect of phosphorothioate modifications on the ability of GTn oligodeoxynucleotides to specifically recognize single-stranded DNA-binding proteins and to affect human cancer cellular growth.

scientific article

Effect of salt concentration on TTF-1 HD binding to specific and non-specific DNA sequences

scientific article published on December 1993

Effects of histone acetylation on sodium iodide symporter promoter and expression of thyroid-specific transcription factors

scientific article

Emerging roles of the nucleolus in regulating the DNA damage response: the noncanonical DNA repair enzyme APE1/Ref-1 as a paradigmatical example

scientific article

Endonuclease and redox activities of human apurinic/apyrimidinic endonuclease 1 have distinctive and essential functions in IgA class switch recombination

scientific article published on 31 January 2019

Expression and Prognostic Significance of APE1/Ref-1 and NPM1 Proteins in High-Grade Ovarian Serous Cancer

scientific article published on 01 March 2014

Expression and function of the homeodomain-containing protein Hex in thyroid cells

scientific article

Expression and localization of the homeodomain-containing protein HEX in human thyroid tumors

scientific article (publication date: March 2002)

Expression of Dicer and Drosha in triple-negative breast cancer.

scientific article published on 18 January 2012

Expression, purification and functional characterisation of a Kunitz-type module from chicken type VI collagen.

scientific article

Expression, regulation, and function of paired-box gene 8 in the human placenta and placental cancer cell lines

scientific article

Extracellular ATP stimulates the early growth response protein 1 (Egr-1) via a protein kinase C-dependent pathway in the human osteoblastic HOBIT cell line

scientific article

Extracellular nucleotides activate Runx2 in the osteoblast-like HOBIT cell line: a possible molecular link between mechanical stress and osteoblasts' response

scientific article

Fibronectin binding promotes a PKC-dependent modulation of NF-kappa B in human T cells

scientific article published on 01 February 1998

Functional analysis of a novel RUNX2 missense mutation found in a family with cleidocranial dysplasia

scientific article published on 22 October 2005

Functional interaction among thyroid-specific transcription factors: Pax8 regulates the activity of Hex promoter

scientific article

Functional interference between contacting amino acids of homeodomains.

scientific article published on May 1997

Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology

scientific article published on 01 June 2015

Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology.

scientific article published on 8 July 2013

G-quadruplex DNA recognition by nucleophosmin: new insights from protein dissection.

scientific article

Galectin-3 expression in non-small cell lung carcinoma

Genome-wide analysis and proteomic studies reveal APE1/Ref-1 multifunctional role in mammalian cells.

scientific article published on February 2009

Glyceraldehyde 3-phosphate-induced DNA or protein modifications severely inhibit the protein/DNA interaction

scientific article published on July 1997

H(2)O(2) induces translocation of APE/Ref-1 to mitochondria in the Raji B-cell line

scientific article published on November 2002

H(2)O(2) modulates purinergic-dependent calcium signalling in osteoblast-like cells

scientific article published on 7 September 2007

High mobility group I proteins interfere with the homeodomains binding to DNA.

scientific article published on November 1997

Human AP endonuclease/redox factor APE1/ref-1 modulates mitochondrial function after oxidative stress by regulating the transcriptional activity of NRF1

scientific article published on 11 May 2012

Human AP-endonuclease (Ape1) activity on telomeric G4 structures is modulated by acetylatable lysine residues in the N-terminal sequence

scientific article published on 22 November 2018

Hydrogen-deuterium exchange studies of the rat thyroid transcription factor 1 homeodomain

scientific article published on June 1, 1997

Identification of different isoforms of eEF1A in the nuclear fraction of human T-lymphoblastic cancer cell line specifically binding to aptameric cytotoxic GT oligomers

scientific article

Identification of secondary targets of N-containing bisphosphonates in mammalian cells via parallel competition analysis of the barcoded yeast deletion collection.

scientific article

Impairment of enzymatic antioxidant defenses is associated with bilirubin-induced neuronal cell death in the cerebellum of Ugt1 KO mice

scientific article

In the TTF-1 homeodomain the contribution of several amino acids to DNA recognition depends on the bound sequence

scientific article

Inhibitors of the apurinic/apyrimidinic endonuclease 1 (APE1)/nucleophosmin (NPM1) interaction that display anti-tumor properties

scientific article published on 11 April 2015

Intrusion of a DNA repair protein in the RNome world: is this the beginning of a new era?

scientific article

Isoforms of the Erythropoietin receptor in dopaminergic neurons of the Substantia Nigra

scientific article

Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function

scientific article

Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism

scientific article published on 6 October 2017

Missense mutations of human homeoboxes: A review

scientific article

Mitochondrial translocation of APE1 relies on the MIA pathway

scientific article published on 8 May 2015

Modern strategies to identify new molecular targets for the treatment of liver diseases: The promising role of Proteomics and Redox Proteomics investigations.

scientific article

Molecular analysis of a human PAX6 homeobox mutant

scientific article published on June 2006

Molecular basis and mechanisms of progression of non-alcoholic steatohepatitis.

scientific article published on 22 January 2008

Molecular characterization of Pseudomonas aeruginosa 2NR degrading naphthalene

scientific article published on 01 September 1999

Monoclonal antibodies against pools of mono- and polyacetylated peptides selectively recognize acetylated lysines within the context of the original antigen

scientific article

Monoclonal antibody detection of naphthalene dioxygenase from Pseudomonas aeruginosa 2NR

scientific article published on 01 October 2000

New perspectives in cancer biology from a study of canonical and non-canonical functions of base excision repair proteins with a focus on early steps

scientific article published on 01 February 2020

Nuclear localization of Galectin-3 in transformed thyroid cells: a role in transcriptional regulation

scientific article

Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells

scientific article

Nucleophosmin delocalization in thyroid tumour cells

scientific article published on March 2011

Nucleophosmin is overexpressed in thyroid tumors.

scientific article published on 31 May 2010

Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins.

scientific article

Nucleotide receptors stimulation by extracellular ATP controls Hsp90 expression through APE1/Ref-1 in thyroid cancer cells: a novel tumorigenic pathway

scientific article published in October 2006

Overoxidation of peroxiredoxins as an immediate and sensitive marker of oxidative stress in HepG2 cells and its application to the redox effects induced by ischemia/reperfusion in human liver

scientific article published in March 2005

Oxidized transthyretin in amniotic fluid as an early marker of preeclampsia

scientific article published in January 2007

PTEN and Egr-1 expression in thyroid proliferative lesions

scientific article published on 23 November 2004

Pax-8 protein levels regulate thyroglobulin gene expression

scientific article

Placental aging and oxidation damage in a tissue micro-array model: an immunohistochemistry study.

scientific article published on 22 April 2016

Platinum Salts in Patients with Breast Cancer: A Focus on Predictive Factors

scientific article published on 10 July 2019

Probing the dimeric structure of porcine aminoacylase 1 by mass spectrometric and modeling procedures.

scientific article

Proteomic analysis of human thyroid cell lines reveals reduced nuclear localization of Mn-SOD in poorly differentiated thyroid cancer cells

scientific article

Proteomic analysis of liver tissues subjected to early ischemia/reperfusion injury during human orthotopic liver transplantation

scientific article published in June 2006

Proteomic evaluation of core biopsy specimens from breast lesions

scientific article published on 01 February 2004

RbAp48 is a target of nuclear factor-kappaB activity in thyroid cancer

scientific article published on 23 January 2007

Redox effector factor-1 regulates the activity of thyroid transcription factor 1 by controlling the redox state of the N transcriptional activation domain

scientific article

Redox potential controls the structure and DNA binding activity of the paired domain

scientific article

Redox proteomics and immunohistology to study molecular events during ischemia-reperfusion in human liver

scientific article published on 01 July 2007

Redox state, oxidative stress, and molecular mechanisms of protective and toxic effects of bilirubin on cells.

scientific article published on January 2009

Ref-1 controls pax-8 DNA-binding activity

scientific article published on 01 November 1998

Role of mutual interactions in the chemical and thermal stability of nucleophosmin NPM1 domains.

scientific article

Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin).

scientific article published in June 2013

SIRT1 gene expression upon genotoxic damage is regulated by APE1 through nCaRE-promoter elements.

scientific article published on 19 December 2013

Serum AP-endonuclease 1 (sAPE1) as novel biomarker for hepatocellular carcinoma

article published in 2019

Serum APE1 as a predictive marker for platinum-based chemotherapy of non-small cell lung cancer patients

scientific article

Shotgun proteomics analysis reveals new unsuspected molecular effectors of nitrogen-containing bisphosphonates in osteocytes.

scientific article

Specific inhibition of the redox activity of ape1/ref-1 by e3330 blocks tnf-α-induced activation of IL-8 production in liver cancer cell lines

scientific article

Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism

scientific article

Structural defects of a Pax8 mutant that give rise to congenital hypothyroidism

scientific article published in 1999

Structural studies on Pax-8 Prd domain/DNA complex

scientific article published on 01 April 2007

TRANSCRIPTION FACTORS AND CANCER. THE EXAMPLE OF PAX GENES.

scientific article

TSH controls Ref-1 nuclear translocation in thyroid cells

scientific article

Targeting DNA repair proteins for cancer treatment

scientific article

The PAX6 gene is activated by the basic helix-loop-helix transcription factor NeuroD/BETA2.

scientific article published on December 2003

The Solution Structure of DNA-free Pax-8 Paired Box Domain Accounts for Redox Regulation of Transcriptional Activity in the Pax Protein Family

scientific article

The intracellular localization of APE1/Ref-1: more than a passive phenomenon?

scientific article

The many functions of APE1/Ref-1: not only a DNA repair enzyme

scientific article

The neutrophil gelatinase-associated lipocalin (NGAL), a NF-kappaB-regulated gene, is a survival factor for thyroid neoplastic cells

scholarly article

The prion protein is critical for DNA repair and cell survival after genotoxic stress

scientific article published on 24 December 2014

The redox function of APE1 is involved in the differentiation process of stem cells toward a neuronal cell fate.

scientific article

The regulatory role of APE1 in epithelial-to-mesenchymal transition and in determining EGFR-TKI responsiveness in non-small-cell lung cancer

scientific article published on 14 August 2018

Thyroid tumors: novel insights from proteomic studies.

scientific article published on August 2009

Topology of the thyroid transcription factor 1 homeodomain-DNA complex.

scientific article

Transcriptional Up-Regulation of APE1/Ref-1 in Hepatic Tumor: Role in Hepatocytes Resistance to Oxidative Stress and Apoptosis

scientific article published in December 2015

Transcriptional regulation of human sodium/iodide symporter gene: a role for redox factor-1.

scientific article published on 20 November 2003

Transcriptome and proteome analysis of osteocytes treated with nitrogen-containing bisphosphonates

scientific article published in March 2009

Two novel NPM1 mutations in a therapy-responder AML patient

scientific article published on 01 September 2010

Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment

scientific article published on 13 August 2010

Unexpected phenotype of a typical NPM1 mutant.

scientific article published on 8 September 2009

Unlike the Escherichia coli counterpart, archaeal RNase HII cannot process ribose monophosphate abasic sites and oxidized ribonucleotides embedded in DNA

scientific article published on 12 July 2019

Unveiling the non-repair face of the Base Excision Repair pathway in RNA processing: A missing link between DNA repair and gene expression?

scientific article published on 9 June 2017

[Letter to the Editor] Isolation of mitochondria is necessary for precise quantification of mitochondrial DNA damage in human carcinoma samples

scientific article published in January 2017

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