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List of works by Simona Rapposelli

(E)-[2-(4-Methylsulphonylphenyl)-1-cyclopentenyl-1-methyliden](arylmethyloxy)amines. Methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: synthesis and biological properties

scientific article

2-[(3-Methoxyphenylethyl)phenoxy]-based ABCB1 inhibitors: effect of different basic side-chains on their biological properties

scientific article published in December 2008

A Novel H2S-releasing Amino-Bisphosphonate which combines bone anti-catabolic and anabolic functions.

scientific article published on 20 September 2017

A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs

scientific article

A patent update on PDK1 inhibitors (2015-present)

scientific article published on 29 March 2019

A review on the hybrids of hydroxycinnamic acid as multi-target-directed ligands against Alzheimer's disease

scientific article published on 26 December 2017

Anti-ischemic properties of a new spiro-cyclic benzopyran activator of the cardiac mito-KATP channel

scientific article

Antiarrhythmic activity of a new spiro-cyclic benzopyran activator of the cardiac mitochondrial ATP dependent potassium channels

scientific article published on 29 June 2016

Areca catechu-From farm to food and biomedical applications

scientific article published on 11 March 2020

Aryl-substituted methyleneaminoxymethyl (MAOM) analogues of diarylcyclopentenyl cyclooxygenase-2 inhibitors: effects of some structural modifications on their biological properties

scientific article published on July 2002

Arylmethyloxyphenyl derivatives: small molecules displaying P-glycoprotein inhibition

scientific article published on November 2006

Arylthioamides as H2S Donors: l-Cysteine-Activated Releasing Properties and Vascular Effects in Vitro and in Vivo

scientific article

Cardiac ATP-sensitive potassium channels: a potential target for an anti-ischaemic pharmacological strategy.

scientific article published on January 2007

Ceramide analogues in apoptosis: a new strategy for anticancer drug development.

scientific article

Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment

scientific article published on 24 June 2021

Collecting data through high throughput in vitro early toxicity and off-target liability assays to rapidly identify limitations of novel thyromimetics

scientific article published on 31 January 2020

Combined inhibition of AKT/mTOR and MDM2 enhances Glioblastoma Multiforme cell apoptosis and differentiation of cancer stem cells

scientific article published on 21 April 2015

Conformationally restrained ceramide analogues: effects of lipophilic modifications on the antiproliferative activity.

scientific article published in January 2003

Design and synthesis of 2-oxindole based multi-targeted inhibitors of PDK1/Akt signaling pathway for the treatment of glioblastoma multiforme

scientific article published on 22 October 2015

Design and synthesis of H2S-donor hybrids: A new treatment for Alzheimer's disease?

scientific article published on 27 September 2019

Design, Synthesis, and Evaluation of Thyronamine Analogues as Novel Potent Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists

scientific article published on 5 June 2015

Design, synthesis and biological evaluation of novel TRβ selective agonists sustained by ADME-toxicity analysis

scientific article published on 23 December 2019

Design, synthesis and pharmacological evaluation of novel tacrine–caffeic acid hybrids as multi-targeted compounds against Alzheimer’s disease ⬇️

scientific article published on August 16, 2012

Development of classification models for identifying "true" P-glycoprotein (P-gp) inhibitors through inhibition, ATPase activation and monolayer efflux assays

scientific article published on 7 June 2012

Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands

scientific article

Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease

scientific article published on 17 September 2016

Dual Inhibition of PDK1 and Aurora Kinase A: An Effective Strategy to Induce Differentiation and Apoptosis of Human Glioblastoma Multiforme Stem Cells.

scientific article published on 31 October 2016

Dual PDK1/Aurora Kinase A Inhibitors Reduce Pancreatic Cancer Cell Proliferation and Colony Formation

scientific article published on 31 October 2019

Editorial [Hot topic: Effect of Stereochemistry in Medicinal Chemistry and Drug Discovery (Guest Editor: Simona Rapposelli)]

scientific article published on 01 January 2011

Editorial: Multi-Target-Directed Ligands (MTDL) as Challenging Research Tools in Drug Discovery: From Design to Pharmacological Evaluation

scientific article published on 18 February 2019

Enantiopure 3-(arylmethylidene)aminoxy-2-methylpropionic acids: synthesis and antiinflammatory properties

scientific article

Enantioselectivity in Cardioprotection induced by (S)- (−)-2,2-Dimethyl-N-(4′-acetamido-benzyl)-4-spiromorpholone-chromane

scientific article published on 01 March 2009

Endogenous 3-Iodothyronamine (T1AM) and Synthetic Thyronamine-like Analog SG-2 Act as Novel Pleiotropic Neuroprotective Agents Through the Modulation of SIRT6

scientific article published on 26 February 2020

Epibatidine: A Promising Natural Alkaloid in Health

article

Evaluation of the NO-releasing properties of NO-donor linkers

scientific article published in February 2008

Hit-to-Lead Optimization of Mouse Trace Amine Associated Receptor 1 (mTAAR1) Agonists with a Diphenylmethane-Scaffold: Design, Synthesis, and Biological Study.

scientific article published on 12 October 2016

Hydrogen Sulfide: A Worthwhile Tool in the Design of New Multitarget Drugs.

scientific article published on 27 September 2017

Iminothioethers as Hydrogen Sulfide Donors: From the Gasotransmitter Release to the Vascular Effects.

scientific article

Investigating Curcumin/Intestinal Epithelium Interaction in a Millifluidic Bioreactor

scientific article published on 26 August 2020

Lipolytic Effects of 3-Iodothyronamine (T1AM) and a Novel Thyronamine-Like Analog SG-2 through the AMPK Pathway

scientific article published on 20 August 2019

Locking PDK1 in DFG-out conformation through 2-oxo-indole containing molecules: Another tools to fight glioblastoma

scientific article published on 20 April 2016

Memantine prodrug as a new agent for Alzheimer's Disease

scientific article published on 15 March 2019

Mitochondrial potassium channels as pharmacological target for cardioprotective drugs.

scientific article

Monoaryl-substituted salicylaldoximes as ligands for estrogen receptor beta

scientific article published on 13 February 2008

Multi-targeted ChEI-copper chelating molecules as neuroprotective agents

scientific article published on 23 April 2019

NO-Releasing Hybrids of Cardiovascular Drugs

NO-glibenclamide derivatives: prototypes of a new class of nitric oxide-releasing anti-diabetic drugs.

scientific article published on 27 June 2009

NO-releasing hybrids of cardiovascular drugs

scientific article

NO-sartans: a new class of pharmacodynamic hybrids as cardiovascular drugs

scientific article published in November 2004

Nature-based molecules combined with rivastigmine: A symbiotic approach for the synthesis of new agents against Alzheimer's disease

scientific article published on 4 October 2017

New Benzopyran-Based Openers of the Mitochondrial ATP-Sensitive Potassium Channel with Potent Anti-Ischemic Properties

scientific article published on 01 December 2006

New Insights into the Potential Roles of 3-Iodothyronamine (T1AM) and Newly Developed Thyronamine-Like TAAR1 Agonists in Neuroprotection

scientific article published on 12 December 2017

New Multitarget Approaches in the War Against Glioblastoma: A Mini-Perspective

scientific article published on 03 August 2018

New N-arylsulfonyl-N-alkoxyaminoacetohydroxamic acids as selective inhibitors of gelatinase A (MMP-2).

scientific article published on May 2004

New NO-Releasing Pharmacodynamic Hybrids of Losartan and Its Active Metabolite: Design, Synthesis, and Biopharmacological Properties

scientific article published on 01 April 2006

New emerging prospects in the pharmacotherapy of hypertension.

scientific article published on January 2008

Novel adenosine 5′-triphosphate-sensitive potassium channel ligands: a patent overview (2005 – 2010) ⬇️

scientific article published on January 27, 2011

Novel estrogen receptor ligands based on an anthranylaldoxime structure: role of the phenol-type pseudocycle in the binding process

scientific article published in September 2003

Oxidative Stress, Mitochondrial Abnormalities and Proteins Deposition: Multitarget Approaches in Alzheimer's Disease

scientific article

P-gp transporter and its role in neurodegenerative diseases

scientific article published on January 2009

Paving Luteolin Therapeutic Potentialities and Agro-Food-Pharma Applications: Emphasis on In Vivo Pharmacological Effects and Bioavailability Traits

scientific article published in 2021

Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

scientific article published in November 2004

Phosphonomethylphosphorylmethyl(oxy)-analogues of geranylgeranyl diphosphate as stable and selective geranylgeranyl protein transferase inhibitors

Potential role of two novel agonists of thyroid hormone receptor-β on liver regeneration

scientific article published on 29 April 2020

Preclinical validation of 3-phosphoinositide-dependent protein kinase 1 inhibition in pancreatic cancer

scientific article published on 14 May 2019

Predictive models, based on classification algorithms, for compounds potentially active as mitochondrial ATP-sensitive potassium channel openers

scientific article

Proposal of a New Binding Orientation for Non-Peptide AT1 Antagonists: Homology Modeling, Docking and Three-Dimensional Quantitative Structure−Activity Relationship Analysis

article

SAR study on arylmethyloxyphenyl scaffold: looking for a P-gp nanomolar affinity

scientific article published on 21 February 2014

SodiumN-(Methylsulfonyl)-N-(4-nitro-2-phenoxyphenyl)sulfamate: A Water-Soluble Nimesulide Prodrug for Parenteral Use

scientific article published on 27 July 2010

Spirocyclic benzopyran-based derivatives as new anti-ischemic activators of mitochondrial ATP-sensitive potassium channel

scientific article

Stable analogues of geranylgeranyl diphosphate possessing improved geranylgeranyl versus farnesyl protein transferase inhibitory selectivity.

scientific article

Stable propylphosphonic acid analogues of geranylgeranyl diphosphate possessing inhibitory activity on geranylgeranyl protein transferase

scientific article published in November 2004

Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta

scientific article

Sulfonamido-derivatives of unsubstituted carbazoles as BACE1 inhibitors

scientific article

Synthesis and 5-HT2A, 5-HT1A and alpha1-binding affinities of 2-[2-Hydroxy-3-(pyridin-3-yl-methyl)amino]-, 2-[2-hydroxy-3-(2-pyridin-2-yl-ethyl)amino]- and 2-[2-hydroxy-3-(4-N-methyl-piperazin-1-yl)-amino]propoxybenzaldehyde-O-(substituted) benzyl o

scientific article published in March 2007

Synthesis and Affinity Evaluation for AT1 Receptor of Phenylsalicylaldoxime-Derivatives Structurally Related to Sartans

Synthesis and Biological Evaluation of 2′-Oxo-2,3-dihydro-3′H- spiro[chromene-4,5′-[1,3]oxazolidin]-3′yl]acetic Acid Derivatives as Aldose Reductase Inhibitors

scientific article published on 14 February 2011

Synthesis and COX-2 inhibitory properties of N-phenyl- and N-benzyl-substituted amides of 2-(4-methylsulfonylphenyl)cyclopent-1-ene-1-carboxylic acid and of their pyrazole, thiophene and isoxazole analogs

scientific article published in January 2004

Synthesis and Functional Evaluation of Novel Aldose Reductase Inhibitors Bearing a Spirobenzopyran Scaffold

scientific article published on 31 January 2017

Synthesis and In Vivo Imaging of N-(3-[11C]Methoxybenzyl)-2-(3-Methoxyphenyl)ethylaniline as a Potential Targeting Agent for P-glycoprotein.

scientific article published on 27 May 2016

Synthesis and antimicrobial activity of new 7 beta-(benzo[a]dihydrocarbazolyloxyacetyl)-substituted cephalosporins

scientific article published in September 2004

Synthesis and biological activities of vitamin D-like inhibitors of CYP24 hydroxylase ⬇️

scientific article published on November 25, 2011

Synthesis and biological evaluation of (hetero)arylmethyloxy- and arylmethylamine-phenyl derivatives as potent P-glycoprotein modulating agents

scientific article published on 8 February 2008

Synthesis and biological evaluation of 5-membered spiro heterocycle-benzopyran derivatives against myocardial ischemia

scientific article published on 13 January 2011

Synthesis and evaluation of multi-functional NO-donor/insulin-secretagogue derivatives for the treatment of type II diabetes and its cardiovascular complications

scientific article published on 26 December 2014

Synthesis and inhibitory activity towards human leukocyte elastase of new 7alpha-methoxy and 7alpha-chloro (2-acyloxymethyl) cephem derivatives.

scientific article published in February 2001

Synthesis and pharmacological evaluation of multifunctional tacrine derivatives against several disease pathways of AD.

scientific article

Synthesis and prostaglandin synthase inhibitory activity of new aromatic O-alkyloxime ethers substituted with methylsulfonamido or methylsulfonyl groups on their aliphatic portion

scientific article published in September 2003

Synthesis of Anthranylaldoxime Derivatives as Estrogen Receptor Ligands and Computational Prediction of Binding Modes

scientific article published on 01 August 2006

Synthesis of Novel 3,5-Disubstituted-2-oxindole Derivatives As Antitumor Agents against Human Nonsmall Cell Lung Cancer

scientific article

Synthesis of Stable Analogues of Geranylgeranyl Diphosphate Possessing a (Z,E,E)-Geranylgeranyl Side Chain, Docking Analysis, and Biological Assays for Prenyl Protein Transferase Inhibition

scientific article published on 01 February 2006

Synthesis of a resveratrol analogue with high ceramide-mediated proapoptotic activity on human breast cancer cells

scientific article published on November 2005

Synthesis of aniline-type analogues of farnesyl diphosphate and their biological assays for prenyl protein transferase inhibitory activity

scientific article published in December 2003

Synthesis of heteroaromatic analogues of (2-aryl-1-cyclopentenyl-1-alkylidene)-(arylmethyloxy)amine COX-2 inhibitors: effects on the inhibitory activity of the replacement of the cyclopentene central core with pyrazole, thiophene or isoxazole ring

scientific article published on February 2003

Synthesis, antifungal activity, and molecular modeling studies of new inverted oxime ethers of oxiconazole

scientific article published in October 2002

Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-substituted 3,4-diarylsalicylaldoximes on estrogen receptors alpha and beta

scientific article published in April 2003

Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells

scientific article published on 01 November 2012

Variously substituted (phosphonoacetamido)oxy analogues of geranylgeranyl diphosphate (GGdP) as GGdP-transferase (GGTase) inhibitors and antiproliferative agents.

scientific article published on May 2005

alpha-Naphthylaminopropan-2-ol Derivatives as BACE1 Inhibitors

scientific article

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