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List of works by Chiara Gabbiani

2D-DIGE analysis of ovarian cancer cell responses to cytotoxic gold compounds

scientific article

Activity of Rat Cytosolic Thioredoxin Reductase Is Strongly Decreased bytrans-[Bis(2-amino-5- methylthiazole)tetrachlororuthenate(III)]: First Report of Relevant Thioredoxin Reductase Inhibition for a Ruthenium Compound

scientific article published on 02 November 2007

Aluminum, copper, iron and zinc differentially alter amyloid-Aβ(1-42) aggregation and toxicity

scientific article published on 3 March 2011

Auranofin, Et3PAuCl, and Et3PAuI Are Highly Cytotoxic on Colorectal Cancer Cells: A Chemical and Biological Study.

scientific article

Biophysical characterisation of adducts formed between anticancer metallodrugs and selected proteins: new insights from X-ray diffraction and mass spectrometry studies

scientific article published on 08 January 2008

Butyltin(IV) benzoates: inhibition of thioredoxin reductase, tumor cell growth inhibition, and interactions with proteins

scientific article published on 23 December 2012

Cell and Cell-Free Mechanistic Studies on Two Gold(III) Complexes with Proven Antitumor Properties

Chemistry and biology of three representative gold(III) compounds as prospective anticancer agents

Chemistry and biology of two novel gold(I) carbene complexes as prospective anticancer agents

scientific article published on 18 February 2014

Chemistry, antiproliferative properties, tumor selectivity, and molecular mechanisms of novel gold(III) compounds for cancer treatment: a systematic study

scientific article

Cisplatin and its dibromido analogue: a comparison of chemical and biological profiles

scientific article published on 16 April 2016

Clioquinol decreases amyloid-beta burden and reduces working memory impairment in a transgenic mouse model of Alzheimer's disease

scientific article

Correction to Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex

scholarly article published in ACS Medicinal Chemistry Letters

Cytotoxic Profile and Peculiar Reactivity with Biomolecules of a Novel "Rule-Breaker" Iodidoplatinum(II) Complex

scientific article published on 21 July 2010

DOTAP/DOPE and DC-Chol/DOPE lipoplexes for gene delivery studied by circular dichroism and other biophysical techniques

article

ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme

scientific article

ESI–MS Characterisation of Protein Adducts of Anticancer Ruthenium(II)-Arene PTA (RAPTA) Complexes

scientific article published on 01 May 2007

Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds

scientific article published on 4 October 2008

Exploiting soft and hard X-ray absorption spectroscopy to characterize metallodrug/protein interactions: the binding of [trans-RuCl4(Im)(dimethylsulfoxide)][ImH] (Im = imidazole) to bovine serum albumin

scientific article published on 23 August 2008

Exploring Metallodrug–Protein Interactions by ESI Mass Spectrometry: The Reaction of Anticancer Platinum Drugs with Horse Heart Cytochrome c

scholarly article by Angela Casini et al published 10 April 2006 in ChemMedChem

Exploring metallodrug-protein interactions by mass spectrometry: comparisons between platinum coordination complexes and an organometallic ruthenium compound

scientific article published on 14 March 2009

Exploring the Reactions of β-Amyloid (Aβ) Peptide 1–28 with AlIIIand FeIIIIons

scientific article published on 30 June 2011

Exploring the biochemical mechanisms of cytotoxic gold compounds: a proteomic study

scientific article

First Crystal Structure for a Gold Carbene-Protein Adduct

scientific article

Gold compounds as anticancer agents: chemistry, cellular pharmacology, and preclinical studies

scientific article published on May 2010

Gold compounds as cysteine protease inhibitors: perspectives for pharmaceutical application as antiparasitic agents

scientific article

Gold(III) complexes with 2-substituted pyridines as experimental anticancer agents: solution behavior, reactions with model proteins, antiproliferative properties

scientific article

Gold(III) compounds as anticancer agents: relevance of gold-protein interactions for their mechanism of action

scientific article published on 28 November 2007

Hypericins and thioredoxin reductase: Biochemical and docking studies disclose the molecular basis for effective inhibition by naphthodianthrones

scientific article

Insights into the molecular mechanisms of protein platination from a case study: the reaction of anticancer platinum(II) iminoethers with horse heart cytochrome c.

scientific article published on 9 October 2007

Insights on the mechanism of thioredoxin reductase inhibition by gold N-heterocyclic carbene compounds using the synthetic linear selenocysteine containing C-terminal peptide hTrxR(488-499): an ESI-MS investigation

scientific article

Interaction of a gold(i) dicarbene anticancer drug with human telomeric DNA G-quadruplex: solution and computationally aided X-ray diffraction analysis

Interactions of the organogold(III) compound Aubipyc with the copper chaperone Atox1: a joint mass spectrometry and circular dichroism investigation

scientific article published on 9 October 2015

Mass spectrometry and metallomics: A general protocol to assess stability of metallodrug-protein adducts in bottom-up MS experiments.

scientific article published on 26 January 2017

Mechanisms of cytotoxicity of selected organogold(III) compounds

scientific article published on October 2005

Mechanistic studies on two dinuclear organogold(III) compounds showing appreciable antiproliferative properties and a high redox stability

scientific article

Medicinal gold compounds form tight adducts with the copper chaperone Atox-1: biological and pharmacological implications

scientific article published on 01 December 2012

Metal compounds as inhibitors of β-amyloid aggregation. Perspectives for an innovative metallotherapeutics on Alzheimer's disease

scholarly article by Daniela Valensin et al published October 2012 in Coordination Chemistry Reviews

Metal-based compounds as prospective antileishmanial agents: inhibition of trypanothione reductase by selected gold complexes

scientific article published on 23 August 2013

Metal-based drugs for malaria, trypanosomiasis and leishmaniasis: recent achievements and perspectives

scientific article

Nanoparticles of Mg(OH)2: synthesis and application to paper conservation

scientific article

New Copper(II)/Cyclic Tetrapeptide System That Easily Oxidizes to Copper(III) under Atmospheric Oxygen

scientific article published on 03 November 2007

New platinum-oxicam complexes as anti-cancer drugs. Synthesis, characterization, release studies from smart hydrogels, evaluation of reactivity with selected proteins and cytotoxic activity in vitro

scientific article published on 27 March 2010

New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro: Mechanistic and pharmacological implications

scientific article published on 21 February 2008

Nitrate as a probe of cytochrome c surface: crystallographic identification of crucial "hot spots" for protein-protein recognition

scientific article published on 11 March 2014

Novel platinum(II) compounds with O,S bidentate ligands: synthesis, characterization, antiproliferative properties and biomolecular interactions

scientific article published on February 2014

Organogold(III) compounds as experimental anticancer agents: chemical and biological profiles

scientific article published on 30 July 2016

Outstanding plasmodicidal properties within a small panel of metallic compounds: Hints for the development of new metal-based antimalarials

scientific article published on 17 October 2008

Peculiar features in the crystal structure of the adduct formed between cis-PtI2(NH3)2 and hen egg white lysozyme

scientific article

Peculiar mechanistic and structural features of the carboplatin-cytochrome c system revealed by ESI-MS analysis

scientific article

Photocytotoxic Pt(iv) complexes as prospective anticancer agents

scientific article published on 05 June 2019

Potent in vitro antiproliferative properties for a triplatinum cluster toward triple negative breast cancer cells

scientific article published on 27 June 2016

Proanthocyanidin glycosides from the leaves of Quercus ilex L. (Fagaceae)

Promising in Vitro anti-Alzheimer Properties for a Ruthenium(III) Complex

scientific article

Protein metalation by metal-based drugs: reactions of cytotoxic gold compounds with cytochrome c and lysozyme

scientific article published on 07 November 2012

Proteomic analysis of A2780/S ovarian cancer cell response to the cytotoxic organogold(III) compound Aubipy(c).

scientific article published on 3 April 2014

Proteomic analysis of ovarian cancer cell responses to cytotoxic gold compounds

scientific article published on 10 February 2012

Proteomic analysis of the cytotoxic effects induced by the organogold(III) complex Aubipyc in cisplatin-resistant A2780 ovarian cancer cells: further evidence for the glycolytic pathway implication

scientific article published on June 2015

PtI2(DACH), the iodido analogue of oxaliplatin as a candidate for colorectal cancer treatment: chemical and biological features.

scientific article published on 23 February 2017

Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysis

article

Reactions of metallodrugs with proteins: selective binding of phosphane-based platinum(ii) dichlorides to horse heart cytochrome c probed by ESI MS coupled to enzymatic cleavage

scientific article published on 22 September 2011

Reactivity and biological properties of a series of cytotoxic PtI2(amine)2 complexes, either cis or trans configured

scientific article

Reactivity of an antimetastatic organometallic ruthenium compound with metallothionein-2: relevance to the mechanism of action

scientific article published on 11 August 2009

Recent progress in the application of analytical techniques to anticancer metallodrug proteomics

Ruthenium anticancer drugs and proteins: a study of the interactions of the ruthenium(III) complex imidazolium trans-[tetrachloro(dimethyl sulfoxide)(imidazole)ruthenate(III)] with hen egg white lysozyme and horse heart cytochrome c

scholarly article by Angela Casini et al published 7 August 2007 in Journal of Biological Inorganic Chemistry

Ruthenium arene complexes with triphenylphosphane ligands: cytotoxicity towards pancreatic cancer cells, interaction with model proteins, and effect of ethacrynic acid substitution

article

Selected cytotoxic gold compounds cause significant inhibition of 20S proteasome catalytic activities

scientific article published on 11 August 2014

Selected gold compounds cause pronounced inhibition of Falcipain 2 and effectively block P. falciparum growth in vitro

scientific article published on 10 September 2011

Solution behaviour and biomolecular interactions of two cytotoxic trans-platinum(II) complexes bearing aliphatic amine ligands

scientific article

Solution chemistry and cytotoxic properties of novel organogold(III) compounds

scientific article

Structural and solution chemistry, antiproliferative effects, and DNA and protein binding properties of a series of dinuclear gold(III) compounds with bipyridyl ligands

scientific article published on September 2006

Structural and solution chemistry, protein binding and antiproliferative profiles of gold(I)/(III) complexes bearing the saccharinato ligand

scientific article published on 30 November 2010

Structural characterization, solution studies, and DFT calculations on a series of binuclear gold(III) oxo complexes: relationships to biological properties

scientific article

Structure, solution chemistry, antiproliferative actions and protein binding properties of non-conventional platinum(II) compounds with sulfur and phosphorus donors

scientific article published on 6 January 2011

Structure-function relationships within Keppler-type antitumor ruthenium(III) complexes: the case of 2-aminothiazolium[trans-tetrachlorobis(2-aminothiazole)ruthenate(III)].

scientific article published in July 2005

Synthesis, structural characterization, solution behavior, and in vitro antiproliferative properties of a series of gold complexes with 2-(2'-pyridyl)benzimidazole as ligand: comparisons of gold(III) versus gold(I) and mononuclear versus binuclear d

scientific article

The C2 variant of human serum transferrin retains the iron binding properties of the native protein.

scientific article published in September 2005

The copper(II) binding properties of the cyclic peptide c(HGHK).

scientific article published in December 2004

The copper(II) coordination abilities of three novel cyclic tetrapeptides with -His-Xaa-His- motif

scientific article published on 21 November 2006

The influence of auranofin, a clinically established antiarthritic gold drug, on bone metabolism: analysis of its effects on human multipotent adipose-derived stem cells, taken as a model

scientific article published in August 2008

The mode of action of anticancer gold-based drugs: a structural perspective

scientific article

The molecular mechanisms of antimetastatic ruthenium compounds explored through DIGE proteomics

scientific article

The reaction of artemisinins with hemoglobin: a unified picture

scientific article published on 10 January 2006

The x-ray structure of the adduct between NAMI-A and carbonic anhydrase provides insights into the reactivity of this metallodrug with proteins

scientific article

Thioredoxin reductase, an emerging target for anticancer metallodrugs. Enzyme inhibition by cytotoxic gold(iii) compounds studied with combined mass spectrometry and biochemical assays

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

Trace copper(II) or zinc(II) ions drastically modify the aggregation behavior of amyloid-beta1-42: an AFM study

scientific article

Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B.

scientific article published on 9 October 2009

Unravelling the chemical nature of copper cuprizone

scientific article published on 11 April 2007

X-ray absorption spectroscopy studies of the adducts formed between cytotoxic gold compounds and two major serum proteins

scientific article published on 24 December 2010

[Au2(phen(2Me))2(μ-O)2](PF6)2, a Novel Dinuclear Gold(III) Complex Showing Excellent Antiproliferative Properties

scientific article published on 2 July 2010

cis-Pt I2(NH3)2: a reappraisal

scientific article published on 30 July 2015

fac-{Ru(CO)(3)}(2+) selectively targets the histidine residues of the beta-amyloid peptide 1-28. Implications for new Alzheimer's disease treatments based on ruthenium complexes

scientific article published in June 2010

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