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List of works by Manfred Jung

4-Acyl Pyrroles as Dual BET-BRD7/9 Bromodomain Inhibitors Address BETi Insensitive Human Cancer Cell Lines

scientific article published on 04 December 2020

4-Acyl pyrroles: mimicking acetylated lysines in histone code reading

scientific article

4-Biphenylalanine- and 3-Phenyltyrosine-Derived Hydroxamic Acids as Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

scientific article published on 9 August 2016

A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function

scientific article published on 15 October 2019

A Continuous, Fluorogenic Sirtuin 2 Deacylase Assay: Substrate Screening and Inhibitor Evaluation

scientific article published on 20 January 2016

A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.

scientific article published on 2 March 2018

A bioluminogenic HDAC activity assay: validation and screening.

scientific article

A homogeneous nonisotopic histone deacetylase activity assay

scientific article published on 01 February 2003

A non-isotopic assay for histone deacetylase activity

scientific article published on May 1999

A novel arginine methyltransferase inhibitor with cellular activity

scientific article

A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2.

scientific article published on 9 January 2012

A quinone mediator drives oxidations catalysed by alcohol dehydrogenase-containing cell lysates

scientific article published on 21 March 2016

Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1.

scientific article published on 27 February 2011

Adenosine mimetics as inhibitors of NAD+-dependent histone deacetylases, from kinase to sirtuin inhibition

scientific article published on December 2006

Alkoxyurea-Based Histone Deacetylase Inhibitors Increase Cisplatin Potency in Chemoresistant Cancer Cell Lines

scientific article

Amide Analogues of Trichostatin A as Inhibitors of Histone Deacetylase and Inducers of Terminal Cell Differentiation

scientific article published on 01 November 1999

Aminothiazoles as Potent and Selective Sirt2 Inhibitors: A Structure-Activity Relationship Study

scientific article

Arginine methylation of the B cell antigen receptor promotes differentiation.

scientific article

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation

scientific article

Azologization and repurposing of a hetero-stilbene-based kinase inhibitor: towards the design of photoswitchable sirtuin inhibitors

scientific article published on 16 September 2019

BAG3 induction is required to mitigate proteotoxicity via selective autophagy following inhibition of constitutive protein degradation pathways ⬇️

scientific article published on May 6, 2013

Benzodeazaoxaflavins as sirtuin inhibitors with antiproliferative properties in cancer stem cells

scientific article published on 7 September 2012

Binding free energy calculations and biological testing of novel thiobarbiturates as inhibitors of the human NAD+dependent histone deacetylase Sirt2

Bioorganometallic chemistry--synthesis and antitumor activity of cobalt carbonyl complexes

scientific article published on June 1997

Cancer treatment of the future: inhibitors of histone methyltransferases

scientific article

Carbamate prodrug concept for hydroxamate HDAC inhibitors

scientific article

Carbamates as Potential Prodrugs and a New Warhead for HDAC Inhibition

scientific article

Characterization of histone deacetylase 8 (HDAC8) selective inhibition reveals specific active site structural and functional determinants

article

Chemically Induced Degradation of Sirtuin 2 (Sirt2) by a Proteolysis Targeting Chimera (PROTAC) Based on Sirtuin Rearranging Ligands (SirReals).

scientific article

Chromo-pharmacophores: photochromic diarylmaleimide inhibitors for sirtuins

Cofactor Analogues as Active Site Probes in Lysine Acetyltransferases

scientific article published on 06 March 2019

Computer- and structure-based lead design for epigenetic targets

scientific article

Current trends in epigenetic drug discovery

scientific article published on October 2012

Design, Multicomponent Synthesis, and Anticancer Activity of a Focused Histone Deacetylase (HDAC) Inhibitor Library with Peptoid-Based Cap Groups

scientific article

Design, Synthesis, and Biological Evaluation of 2-Aminobenzanilide Derivatives as Potent and Selective HDAC Inhibitors

scientific article published on 24 May 2012

Destabilization of ERBB2 transcripts by targeting 3' untranslated region messenger RNA associated HuR and histone deacetylase-6

scientific article published on July 2008

Determination of drug-serum protein interactions via fluorescence polarization measurements

scientific article published on 7 June 2007

Determination of the antifungal agent posaconazole in human serum by HPLC with parallel column-switching technique.

scientific article

Development of albumin-binding camptothecin prodrugs using a Peptide positional scanning library

scientific article

Diminished sensitivity of chronic lymphocytic leukemia cells to ABT-737 and ABT-263 due to albumin binding in blood

scientific article published on 2 July 2010

Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1)

scientific article published on 24 July 2019

Discovery of inhibitors of Schistosoma mansoni HDAC8 by combining homology modeling, virtual screening, and in vitro validation

scientific article

Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives

scientific article published on January 2015

Effect of inhibitors of histone deacetylase on the induction of cell differentiation in murine and human erythroleukemia cell lines

scientific article published on July 2005

Epigenetic changes modulate schistosome egg formation and are a novel target for reducing transmission of schistosomiasis

scientific article (publication date: May 2014)

Epigenetic drug discovery special issue

scientific article published on 01 June 2011

Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6

scientific article published on 19 December 2019

Farnesyl anthranilate suppresses the growth, in vitro and in vivo, of murine B16 melanomas

scientific article published on 01 September 2000

Farnesyl-O-acetylhydroquinone and geranyl-O-acetylhydroquinone suppress the proliferation of murine B16 melanoma cells, human prostate and colon adenocarcinoma cells, human lung carcinoma cells, and human leukemia cells

scientific article

Fluorescence-based screening assays for the NAD⁺-dependent histone deacetylase smSirt2 from Schistosoma mansoni.

scientific article published on 16 October 2014

From cosubstrate similarity to inhibitor diversity--inhibitors of ADP-ribosyltransferases from kinase inhibitor screening

scientific article

HDAC6 as a target for antileukemic drugs in acute myeloid leukemia ⬇️

scientific article published on March 29, 2012

HDAC8: a multifaceted target for therapeutic interventions

scientific article published on 23 May 2015

Heterogeneous Antibody-Based Activity Assay for Lysine Specific Demethylase 1 (LSD1) on a Histone Peptide Substrate

scientific article published on 31 March 2014

High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding

scientific article

Histone acetyltransferase inhibitors block neuroblastoma cell growth in vivo

scientific article

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy.

scientific article

Histone deacetylase inhibitor, trichostatin A, affects gene expression patterns during morphogenesis of chicken limb buds in vivo

scientific article published on 16 January 2009

Histone deacetylase inhibitors that target tubulin

scientific article published on 05 March 2009

Hydroxamates of para-aminobenzoic acid as selective inhibitors of HDAC8.

scientific article published on 3 September 2014

Hydroxamide derivatives of short-chain fatty acid have erythropoietic activity and induce gamma gene expression in vivo

scientific article

Hydroxamide derivatives of short-chain fatty acids are potent inducers of human fetal globin gene expression

scientific article published in March 2003

Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and In Vitro Testing

scientific article published on 14 February 2018

Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and in Vitro Testing

Identification of Highly Potent Protein Kinase C-Related Kinase 1 Inhibitors by Virtual Screening, Binding Free Energy Rescoring, and in vitro Testing

scientific article

Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.

scientific article published on 17 February 2016

Identification of tri- and tetracyclic pyrimidinediones as sirtuin inhibitors

scientific article published on May 2010

Impairment of prostate cancer cell growth by a selective and reversible lysine-specific demethylase 1 inhibitor

scientific article

In vitro assays for the determination of histone deacetylase activity

scientific article published in August 2005

In vivo application of histone deacetylase inhibitor trichostatin-a impairs murine male meiosis

scientific article published on 28 November 2007

Induction of human gamma globin gene expression by histone deacetylase inhibitors

scientific article

Inhibition of bromodomain-mediated protein–protein interactions as a novel therapeutic strategy

article published in 2012

Inhibition of p300 suppresses growth of breast cancer. Role of p300 subcellular localization

scientific article published on 18 September 2014

Inhibitors of histone deacetylases as potential therapeutic tools for high-risk embryonal tumors of the nervous system of childhood

scientific article published on April 2007

Inhibitors of the NAD(+)-Dependent Protein Desuccinylase and Demalonylase Sirt5

scientific article

Inhibitors to understand molecular mechanisms of NAD(+)-dependent deacetylases (sirtuins).

scientific article

Isoform-selective HDAC1/6/8 inhibitors with an imidazo-ketopiperazine cap containing stereochemical diversity

scientific article published on 5 June 2018

KATching-Up on Small Molecule Modulators of Lysine Acetyltransferases

scientific article

KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells

scientific article published on 06 May 2019

Lestaurtinib inhibits histone phosphorylation and androgen-dependent gene expression in prostate cancer cells

scientific article

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

scientific article published on 02 October 2019

Limited efficacy of specific HDAC6 inhibition in urothelial cancer cells.

scientific article published on 11 March 2014

Metabolite Patterns in Human Myeloid Hematopoiesis Result from Lineage-Dependent Active Metabolic Pathways

scientific article published on 24 August 2020

Mind the methyl: methyllysine binding proteins in epigenetic regulation

scientific article published on 21 January 2014

Molecular basis for the antiparasitic activity of a mercaptoacetamide derivative that inhibits histone deacetylase 8 (HDAC8) from the human pathogen schistosoma mansoni

scientific article

NAD(+) -dependent histone deacetylases (sirtuins) as novel therapeutic targets

scientific article

NIK is required for NF-κB-mediated induction of BAG3 upon inhibition of constitutive protein degradation pathways

scientific article

New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2.

scientific article published in June 2018

New lysine methyltransferase drug targets in cancer

scientific article published on 10 July 2012

No taste for methyl: methylation sensitive proteolysis in drug screening

scientific article published on 01 July 2010

Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity

scientific article published on 5 September 2013

Nonradioactive In Vitro Assays for Histone Deacetylases ⬇️

scientific article published on January 1, 2013

Novel 3-arylideneindolin-2-ones as inhibitors of NAD+ -dependent histone deacetylases (sirtuins).

scientific article published in February 2010

Opening the Selectivity Pocket in the Human Lysine Deacetylase Sirtuin2 - New Opportunities, New Questions

scientific article published on 21 June 2018

Oxidized cytosine metabolites offer a fresh perspective for active DNA demethylation

scientific article published on 23 November 2011

Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs)

scientific article

Phenylpyrrole-based HDAC inhibitors: synthesis, molecular modeling and biological studies

scientific article published on 24 August 2016

Photochromic Indolyl Fulgimides as Chromo-pharmacophores Targeting Sirtuins

scientific article published on 12 June 2018

Photochromic histone deacetylase inhibitors based on dithienylethenes and fulgimides.

scientific article published in June 2017

Posaconazole Therapeutic Drug Monitoring in the Real‐life Setting: A Single‐Center Experience and Review of the Literature ⬇️

scientific article published on July 17, 2013

Preparation data of the bromodomains BRD3(1), BRD3(2), BRD4(1), and BRPF1B and crystallization of BRD4(1)-inhibitor complexes.

scientific article

Pyrido- and benzisothiazolones as inhibitors of histone acetyltransferases (HATs)

Pyridylalanine-containing hydroxamic acids as selective HDAC6 inhibitors

scientific article

R306465 is a novel potent inhibitor of class I histone deacetylases with broad-spectrum antitumoral activity against solid and haematological malignancies

scientific article published on 13 November 2007

Rhodanine carboxylic acids as novel inhibitors of histone acetyltransferases

SIRT1 regulates HIV transcription via Tat deacetylation

scientific article

Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets

scientific article

Schistosome sirtuins as drug targets

scientific article published on January 2015

Screening and Phenotypical Characterization of Schistosoma mansoni Histone Deacetylase 8 (SmHDAC8) Inhibitors as Multistage Antischistosomal Agents

scientific article published on 12 November 2019

Screening assays for epigenetic targets using native histones as substrates

scientific article published on 30 September 2011

Seeding for sirtuins: microseed matrix seeding to obtain crystals of human Sirt3 and Sirt2 suitable for soaking

scientific article

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

scientific article

Small molecule inhibitors of histone acetyltransferases as epigenetic tools and drug candidates

scientific article

Structural and synthetic investigations of tanikolide dimer, a SIRT2 selective inhibitor, and tanikolide seco-acid from the Madagascar marine cyanobacterium Lyngbya majuscula ⬇️

scientific article published on August 2009

Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni

scientific article

Structure-Activity Relationship of Propargylamine-Based HDAC Inhibitors.

scientific article published on 9 November 2017

Structure-Based Design and Biological Characterization of Selective Histone Deacetylase 8 (HDAC8) Inhibitors with Anti-Neuroblastoma Activity

scientific article published on 30 November 2017

Structure-Based Design and Computational Studies of Sirtuin Inhibitors

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

scientific article

Structure-Based Development of an Affinity Probe for Sirtuin 2

scientific article

Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases

scientific article published on 10 October 2019

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2)

scientific article published on 20 September 2019

Structure-activity studies on splitomicin derivatives as sirtuin inhibitors and computational prediction of binding mode

scientific article published on 13 February 2008

Structure-activity studies on suramin analogues as inhibitors of NAD+-dependent histone deacetylases (sirtuins)

scholarly article by Johannes Trapp et al published 8 October 2007 in ChemMedChem

Suberoylanilide hydroxamic acid: a potential epigenetic therapeutic agent for lung fibrosis?

scientific article published in July 2009

Substituted 2-(2-aminopyrimidin-4-yl)pyridine-4-carboxylates as potent inhibitors of JumonjiC domain-containing histone demethylases

scientific article

Subtype selective substrates for histone deacetylases

scientific article published in October 2004

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

scientific article

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors

scientific article published on 01 February 2019

Synthesis and biological activity of splitomicin analogs targeted at human NAD(+)-dependent histone deacetylases (sirtuins)

scientific article published on 22 January 2011

Synthesis and biological evaluation of 8-hydroxy-2,7-naphthyridin-2-ium salts as novel inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)

Synthesis and biological testing of novel pyridoisothiazolones as histone acetyltransferase inhibitors

scientific article published on 2 February 2011

Target-based approach to inhibitors of histone arginine methyltransferases

scientific article published on 14 April 2007

Targeting epigenetic mechanisms: potential of natural products in cancer chemoprevention.

scientific article published on 14 August 2008

Targeting epigenetic modifiers: Inhibitors of histone methyltransferases

article published in 2010

Targeting histone deacetylase 8 as a therapeutic approach to cancer and neurodegenerative diseases

scientific article published on 30 August 2016

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy

scientific article

Tetrazolylhydrazides as Selective Fragment-Like Inhibitors of the JumonjiC-Domain-Containing Histone Demethylase KDM4A.

scientific article

The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases

scientific article published on 19 July 2019

The Discovery of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine SIRT2 Inhibitors.

scientific article

The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors

scientific article published on October 2009

The ergot alkaloid gene cluster: functional analyses and evolutionary aspects

scientific article

The histone deacetylase inhibitor SAHA acts in synergism with fenretinide and doxorubicin to control growth of rhabdoid tumor cells

scientific article

The nephronophthisis gene product NPHP2/Inversin interacts with Aurora A and interferes with HDAC6-mediated cilia disassembly

article

The role of histone demethylases in cancer therapy

scientific article

Therapeutic drug monitoring of posaconazole in hematology patients: experience with a new high-performance liquid chromatography-based method

scientific article

Thiobarbiturates as sirtuin inhibitors: virtual screening, free-energy calculations, and biological testing

scientific article

Tofacitinib and analogs as inhibitors of the histone kinase PRK1 (PKN1).

scientific article

Total synthesis of (18S)- and (18R)-homolargazole by rhodium-catalyzed hydrocarboxylation

scientific article published on 29 January 2014

Two-Step Synthesis of Novel, Bioactive Derivatives of the Ubiquitous Cofactor Nicotinamide Adenine Dinucleotide (NAD)

scientific article published on 29 April 2011

Use of systemic antifungals in daily clinical practice in the haematology and oncology setting: results of a prospective observational analysis

scientific article published on 28 May 2012

Validation of the Slow Off-Kinetics of Sirtuin-Rearranging Ligands (SirReals) by Means of Label-Free Electrically Switchable Nanolever Technology

scientific article published on 06 November 2019

Valproic acid as a histone deacetylase inhibitor. New application for a well-known drug

scientific article published in May 2010

Virtual screening and biological characterization of novel histone arginine methyltransferase PRMT1 inhibitors

scientific article

Virtual screening of PRK1 inhibitors: ensemble docking, rescoring using binding free energy calculation and QSAR model development

scientific article

[Bookmarks in the book of life. Epigenetics]

scientific article published on 01 May 2010

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