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List of works by Luis M. Botana

"Fluorescent glycogen" formation with sensibility for in vivo and in vitro detection

scientific article published on November 2007

(-)-Epigallocatechin-3-gallate interferes with mast cell adhesiveness, migration and its potential to recruit monocytes.

scientific article

13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro

scientific article published on 30 August 2011

13-Desmethyl spirolide-c and 13,19-didesmethyl spirolide-c trans-epithelial permeabilities: human intestinal permeability modelling

scientific article published on 12 June 2011

A Perspective on the Toxicology of Marine Toxins ⬇️

scientific article published on June 12, 2012

A QuEChERS based extraction procedure coupled to UPLC-MS/MS detection for mycotoxins analysis in beer

scientific article published on 27 September 2018

A comparative study of the effect of ciguatoxins on voltage-dependent Na+ and K+ channels in cerebellar neurons

scientific article published on 21 March 2011

A fluorescent microplate assay for diarrheic shellfish toxins

scientific article published on 01 June 1997

A fluorescent microplate assay for microcystin-LR

scientific article published on 01 May 1999

A fluorimetric method based on changes in membrane potential for screening paralytic shellfish toxins in mussels

scientific article published on 01 February 2001

A fluorimetric microplate assay for detection and quantitation of toxins causing paralytic shellfish poisoning

scientific article published on 01 April 2003

A rapid microplate fluorescence method to detect yessotoxins based on their capacity to activate phosphodiesterases

scientific article published in March 2004

A roadmap for hazard monitoring and risk assessment of marine biotoxins on the basis of chemical and biological test systems

scientific article published on January 2013

A single run UPLC-MS/MS method for detection of all EU-regulated marine toxins

scientific article published on 18 July 2018

Absorption and Effect of Azaspiracid-1 Over the Human Intestinal Barrier.

scientific article published on 28 August 2017

Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins.

scientific article

Acute Oral Toxicity of Tetrodotoxin in Mice: Determination of Lethal Dose 50 (LD50) and No Observed Adverse Effect Level (NOAEL).

scientific article published on 24 February 2017

Acute Toxicity Assessment: Macroscopic and Ultrastructural Effects in Mice Treated with Oral Tetrodotoxin

scientific article published on 29 May 2019

Adrenergic activity on rat pleural and peritoneal mast cells. Loss of beta-receptors during the purification procedure

scientific article published on 01 January 1987

Adrenergic agonists do not compete with the antagonist (-)3-[125I]iodocyanopindolol for binding to rat pleural or peritoneal mast cell adrenergic receptor

scientific article published on 01 January 1987

Amiloride-dependent transport is the main mechanism implicated in sodium influx regulation in rat mast cells

scientific article published on 01 September 1993

Apoptotic events induced by the phosphatase inhibitor okadaic acid in normal human lung fibroblasts

scientific article

Assessment of the hydrolysis process for the determination of okadaic acid-group toxin ester: presence of okadaic acid 7-O-acyl-ester derivates in Spanish shellfish

scientific article

Autumnalamide targeted proteins of the immunophilin family

scientific article published on 28 September 2016

Azaspiracid substituent at C1 is relevant to in vitro toxicity

scientific article published on 16 August 2008

Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets.

scientific article

Azaspiracid-4 inhibits Ca2+ entry by stored operated channels in human T lymphocytes.

scientific article published on 20 April 2005

Azaspiracids modulate intracellular pH levels in human lymphocytes.

scientific article

Basis for a new procedure to eliminate diarrheic shellfish toxins from a contaminated matrix

scientific article published in January 2002

Benefit of 13-desmethyl spirolide C treatment in triple transgenic mouse model of Alzheimer disease: beta-amyloid and neuronal markers improvement.

scientific article published in March 2013

Bioengineered protein phosphatase 2A: update on need

scientific article

Biological Activities of Cyclic and Acyclic B-Type Laxaphycins in SH-SY5Y Human Neuroblastoma Cells

scientific article published on 15 July 2020

Biological methods for marine toxin detection

scientific article published on 12 May 2010

Biphasic Ca2+ responses in human basophils. Evidence that the initial transient elevation associated with the mobilization of intracellular calcium is an insufficient signal for degranulation

scientific article published on 01 February 1993

Bromotryptamine and Bromotyramine Derivatives from the Tropical Southwestern Pacific Sponge Narrabeena nigra

scientific article published on 30 May 2019

C-kit mutations and PKC crosstalks: PKC translocates to nucleous only in cells HMC⁵⁶⁰,⁸¹⁶.

scientific article published on September 2011

Calcium oscillations induced by gambierol in cerebellar granule cells.

scientific article

Calcium-pH crosstalks in rat mast cells: modulation by transduction signals show non-essential role for calcium in alkaline-induced exocytosis

scientific article published on 10 December 2004

Calcium-pH crosstalks in the human mast cell line HMC-1: intracellular alkalinization activates calcium extrusion through the plasma membrane Ca2+-ATPase

scientific article published on December 2006

Canning process that diminishes paralytic shellfish poison in naturally contaminated mussels (Mytilus galloprovincialis)

scientific article published on 01 May 1999

Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies.

scientific article published on November 2006

Cell volume decrease as a link between azaspiracid-induced cytotoxicity and c-Jun-N-terminal kinase activation in cultured neurons.

scientific article published on 08 October 2009

Changes in membrane potential: an early signal triggered by neurologically active phycotoxins

scientific article published on June 2006

Changes in rat mast cell responses in sodium-free media. Lack of demonstrable sodium channel activity

scientific article published on 01 May 1991

Characterization and activity determination of the human protein phosphatase 2A catalytic subunit α expressed in insect larvae.

scientific article

Characterization of 9H-(1,3-dichlor-9, 9-dimethylacridin-2-ona-7-yl)-phosphate (DDAO) as substrate of PP-2A in a fluorimetric microplate assay for diarrhetic shellfish toxins (DSP)

scientific article published on 01 December 2000

Characterization of F-actin depolymerization as a major toxic event induced by pectenotoxin-6 in neuroblastoma cells

scientific article published in June 2002

Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line

scientific article published on February 2002

Characterization of the dinophysistoxin-2 acute oral toxicity in mice to define the Toxicity Equivalency Factor.

scientific article

Chronic In Vivo Effects of Repeated Exposure to Low Oral Doses of Tetrodotoxin: Preliminary Evidence of Nephrotoxicity and Cardiotoxicity

scientific article published on 06 February 2019

Chronic ciguatoxin treatment induces synaptic scaling through voltage gated sodium channels in cortical neurons

scientific article published on 19 May 2015

Comparative cytotoxicity of gambierol versus other marine neurotoxins.

scientific article published on 4 May 2011

Comparative study of the stability of saxitoxin and neosaxitoxin in acidic solutions and lyophilized samples.

scientific article

Comparative study of toxicological and cell cycle effects of okadaic acid and dinophysistoxin-2 in primary rat hepatocytes

scientific article published on 17 January 2012

Confocal microscopy study of the different patterns of 2-NBDG uptake in rabbit enterocytes in the apical and basal zone

scientific article

Coupling the Torpedo microplate-receptor binding assay with mass spectrometry to detect cyclic imine neurotoxins

scientific article

Crambescidin-816 acts as a fungicidal with more potency than crambescidin-800 and -830, inducing cell cycle arrest, increased cell size and apoptosis in Saccharomyces cerevisiae.

scientific article

Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction

scientific article

Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells

scientific article published on 2 December 2003

Cytoskeletal toxicity of pectenotoxins in hepatic cells.

scientific article published on 08 September 2008

Cytotoxic effect of azaspiracid-2 and azaspiracid-2-methyl ester in cultured neurons: involvement of the c-Jun N-terminal kinase

scientific article published on 01 October 2008

Cytotoxic effect of palytoxin on mussel.

scientific article published on 3 March 2010

Cytotoxicity of goniodomin A and B in non contractile cells.

scientific article published on 02 April 2016

Decrease of marine toxin content in bivalves by industrial processes.

scientific article published on 5 August 2009

Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications

scientific article

Detection of 13,19-didesmethyl C spirolide by fluorescence polarization using Torpedo electrocyte membranes

scientific article published on 9 April 2010

Detection of Cyclic Imine Toxins in Dietary Supplements of Green Lipped Mussels (Perna canaliculus) and in Shellfish Mytilus chilensis

scientific article published on 24 September 2020

Detection of Paralytic Shellfish Toxins by a Solid-Phase Inhibition Immunoassay Using a Microsphere-Flow Cytometry System

scientific article published on 26 April 2012

Detection of anatoxin-a and three analogs in Anabaena spp. cultures: new fluorescence polarization assay and toxin profile by LC-MS/MS.

scientific article published on 24 January 2014

Detection of gymnodimine-A and 13-desmethyl C spirolide phycotoxins by fluorescence polarization

scientific article published in April 2009

Detection of new emerging type-A trichothecenes by untargeted mass spectrometry.

scientific article published on 6 September 2017

Detection of sodium channel activators by a rapid fluorimetric microplate assay.

scientific article

Determination of DSP toxins: comparative study of HPLC and bioassay to reduce the observation time of the mouse bioassay

scientific article published on 01 January 1996

Determination of phosphodiesterase activity in rat mast cells using the fluorescent cAMP analogue anthraniloyl cAMP

scientific article published on 01 July 1995

Determination of toxicity equivalent factors for paralytic shellfish toxins by electrophysiological measurements in cultured neurons

scientific article

Detoxification agents based on magnetic nanostructured particles as a novel strategy for mycotoxin mitigation in food

scientific article published on 03 May 2019

Development of a F actin-based live-cell fluorimetric microplate assay for diarrhetic shellfish toxins

scientific article published on June 2003

Development of a novel immunobiosensor method for the rapid detection of okadaic acid contamination in shellfish extracts

scientific article published on 24 July 2007

Development of a solid-phase receptor-based assay for the detection of cyclic imines using a microsphere-flow cytometry system.

scientific article published on 7 February 2013

Diarrhetic effect of okadaic acid could be related with its neuronal action: Changes in neuropeptide Y.

scientific article

Difference in, and influence of the purification medium on, sensitivity and maximum response of peritoneal and pleural mast cells stimulated by certain polyamines

scientific article published on 01 July 1985

Different role of cAMP pathway on the human mast cells HMC-1(560) and HMC-1(560,816) activation.

scientific article published on May 2014

Different toxic effects of YTX in tumor K-562 and lymphoblastoid cell lines

scientific article published on 17 June 2015

Differential effects of cAMP-elevating drugs on stimulus-induced cytosolic calcium changes in human basophils

scientific article published on 01 June 1994

Differential effects of ciguatoxin and maitotoxin in primary cultures of cortical neurons

scientific article published on 15 July 2014

Differential effects of crambescins and crambescidin 816 in voltage-gated sodium, potassium and calcium channels in neurons.

scientific article

Dimethylsphingosine increases cytosolic calcium and intracellular pH in human T lymphocytes.

scientific article published on February 2003

Disruption of the actin cytoskeleton induces fluorescent glucose accumulation on the rat hepatocytes Clone 9.

scientific article

Dual effect of dihydropyridines on 45Ca uptake induced by the K+ -channel blocker, 4-aminopyridin on mast cells

scientific article published in November 1988

Effect of calcium on histamine release from pleural and peritoneal mast cells induced by catechol.

scientific article published in December 1986

Effect of gambierol and its tetracyclic and heptacyclic analogues in cultured cerebellar neurons: a structure-activity relationships study

scientific article published on 29 August 2012

Effect of ion composition on the changes in membrane potential induced with several stimuli in rat mast cells

scientific article published on 01 February 1994

Effect of okadaic acid on glucose regulation.

scientific article

Effect of okadaic acid on human basophil secretion

scientific article published on 01 June 1993

Effect of okadaic acid on immunologic and non-immunologic histamine release in rat mast cells

scientific article published on 01 February 1994

Effect of purification, theophylline and sodium fluoride on histamine release produced by antineoplastic drugs on rat mast cells. A distinctive mechanism of action for carboplatin

scientific article published on 01 August 1992

Effect of uncontrolled factors in a validated liquid chromatography-tandem mass spectrometry method question its use as a reference method for marine toxins: major causes for concern

scientific article published on 29 June 2011

Effects of Azaspiracids 2 and 3 on intracellular cAMP, [Ca2+], and pH.

scientific article

Effects of a synthetic analog of polycavernoside A on human neuroblastoma cells.

scientific article published on January 2007

Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study

scientific article

Effects of environmental regimens on the toxin profile of Alexandrium ostenfeldii

scientific article published in February 2010

Effects of the marine phycotoxin palytoxin on neuronal pH in primary cultures of cerebellar granule cells

scientific article published in January 2007

Evaluation of the Impact of Mild Steaming and Heat Treatment on the Concentration of Okadaic Acid, Dinophysistoxin-2 and Dinophysistoxin-3 in Mussels

scientific article

Evaluation of the intestinal permeability and cytotoxic effects of cylindrospermopsin

scientific article

Evaluation of toxicity equivalent factors of paralytic shellfish poisoning toxins in seven human sodium channels types by an automated high throughput electrophysiology system

article

Evaluation of various pH and temperature conditions on the stability of azaspiracids and their importance in preparative isolation and toxicological studies

scientific article

Evidence of Methylobacterium spp. and Hyphomicrobium sp. in azaspiracid toxin contaminated mussel tissues and assessment of the effect of azaspiracid on their growth

scientific article published on 29 September 2011

Evolving to the optoelectronic mouse for phycotoxin analysis in shellfish

scientific article published on 23 September 2014

Experimental basis for the high oral toxicity of dinophysistoxin 1: a comparative study of DSP ⬇️

scientific article

Extraction and cleaning methods to detect yessotoxins in contaminated mussels

scientific article published on 19 January 2007

Feasibility of gymnodimine and 13-desmethyl C spirolide detection by fluorescence polarization using a receptor-based assay in shellfish matrixes

scientific article published on 20 October 2009

Feasibility of using a surface plasmon resonance-based biosensor to detect and quantify yessotoxin

scientific article published on 15 January 2008

First direct fluorescence polarization assay for the detection and quantification of spirolides in mussel samples

scientific article published on 31 May 2011

First evidence of spirolides in Spanish shellfish

scientific article published on 08 September 2006

First report of Fusarium foetens as a mycotoxin producer

scientific article published on 31 January 2019

First toxicity report of tetrodotoxin and 5,6,11-trideoxyTTX in the trumpet shell Charonia lampas lampas in Europe

scientific article published on 18 June 2008

First toxin profile of ciguateric fish in Madeira Arquipelago (Europe).

scientific article

Fluorescent microplate cell assay to measure uptake and metabolism of glucose in normal human lung fibroblasts.

scientific article published in June 2002

Functional compartments in rat mast cells for cAMP and calcium on histamine release

scientific article published on 01 May 2000

Glucose uptake in enterocytes: a test for molecular targets of okadaic acid

scientific article published in January 2003

HCO(3)(-) ions modify the role of PKC isoforms in the modulation of rat mast cell functions

scientific article

HCO3(-) ions increase mast cell sensitivity to thapsigargin-induced Ca(2+) entry.

scientific article

Hapalindoles from the cyanobacterium fischerella: potential sodium channel modulators.

scientific article

High Serum Cyclophilin C levels as a risk factor marker for Coronary Artery Disease

scientific article published on 22 July 2019

High-throughput receptor-based assay for the detection of spirolides by chemiluminescence

scientific article

Human Poisoning from Marine Toxins: Unknowns for Optimal Consumer Protection

scientific article published on 09 August 2018

Human muscarinic acetylcholine receptors are a target of the marine toxin 13-desmethyl C spirolide.

scientific article published on 18 October 2010

Hydralazine-relaxing effect on rat aorta is not mediated through changes in ATPase activity

scientific article published on January 1987

Hypertonicity-induced intracellular pH changes in rat mast cells

scientific article published on 01 September 2000

Impact of the pectenotoxin C-43 oxidation degree on its cytotoxic effect on rat hepatocytes

scientific article

Improvement on sample clean-up for high-performance liquid chromatographic-fluorimetric determination of diarrhetic shellfish toxins using 1-bromoacetylpyrene

scientific article published on 01 January 1998

In Vitro Effects of Chronic Spirolide Treatment on Human Neuronal Stem Cell Differentiation and Cholinergic System Development

scientific article published on 14 March 2018

In Vivo Evaluation of the Chronic Oral Toxicity of the Marine Toxin Palytoxin

scientific article published on 30 July 2020

In vivo arrhythmogenicity of the marine biotoxin azaspiracid-2 in rats.

scientific article published on 11 August 2013

In vivo inhibition of polymyxin B-induced hypotension: evidence of beta-adrenergic inhibitory activity on rat mast cells

scientific article published on 01 January 1986

Induction of actin cytoskeleton rearrangement by methyl okadaate--comparison with okadaic acid.

scientific article published on 19 January 2008

Influence of the anions on the structure and magnetic properties of a series of bis(μ-diphenoxo)-bridged linear trinuclear copper(II) complexes: an experimental and theoretical study

scientific article published on 11 October 2011

Influence of the sample toxic profile on the suitability of a high performance liquid chromatography method for official paralytic shellfish toxins control

scientific article published on 30 November 2006

Influence of the tyrosine kinase inhibitors STI571 (Glivec), lavendustin A and genistein on human mast cell line (HMC-1(560)) activation.

scientific article

Inhibition of Na+/K+ ATPase under hypertonic conditions in rat mast cells.

scientific article

Innovative detection methods for aquatic algal toxins and their presence in the food chain.

scientific article published on 03 July 2013

Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells

scientific article published on 7 April 2007

K-channel blocking drugs induce histamine release and 45Ca uptake in isolated mast cells.

scientific article

KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients

article

Key role of phosphodiesterase 4A (PDE4A) in autophagy triggered by yessotoxin.

scientific article

Kinetic analysis of the interaction between yessotoxin and analogues and immobilized phosphodiesterases using a resonant mirror optical biosensor

scientific article published in July 2005

LC-MS/MS Analysis of the Emerging Toxin Pinnatoxin-G and High Levels of Esterified OA Group Toxins in Galician Commercial Mussels

scientific article published on 05 July 2019

Lack of specific saxitoxin binding to rat mast cells.

scientific article

Lactone ring of pectenotoxins: a key factor for their activity on cytoskeletal dynamics

scientific article

Ligand-binding assays for cyanobacterial neurotoxins targeting cholinergic receptors

scientific article published on 19 March 2010

Lipophilic toxin profile in Galicia (Spain): 2005 toxic episode

scientific article published on 16 February 2007

Maitotoxin-induced calcium entry in human lymphocytes: modulation by yessotoxin, Ca(2+) channel blockers and kinases.

scientific article

Marine toxins and the cytoskeleton

scientific article published on 24 October 2008

Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins.

scientific article published on 24 October 2008

Mast cell exocytosis can be triggered by ammonium chloride with just a cytosolic alkalinization and no calcium increase.

scientific article published on September 2005

Mechanism of cytotoxic action of crambescidin-816 on human liver-derived tumour cells.

scientific article published on April 2014

Microsphere-based immunoassay for the detection of azaspiracids.

scientific article

Milk progesterone radioimmunoassay using radioiodinated tracers: a rapid and reliable assay system

scientific article published on 01 September 1984

Mitigation of ROS insults by Streptomyces secondary metabolites in primary cortical neurons ⬇️

scientific article

Mitogen-activated protein kinases regulate palytoxin-induced calcium influx and cytotoxicity in cultured neurons

scientific article published on 16 July 2007

Mitoxantrone induces nonimmunological histamine release from rat mast cells

scientific article published on 01 March 1996

Modulation of calcium entry and glutamate release in cultured cerebellar granule cells by palytoxin.

scientific article published in June 2006

Modulation of cytosolic calcium levels of human lymphocytes by yessotoxin, a novel marine phycotoxin

scientific article

Modulatory Effect of HCO−3 on Rat Mast Cell Exocytosis: Cross-Talks between Bicarbonate and Calcium

scientific article published on 01 June 1999

Multidetection of paralytic, diarrheic, and amnesic shellfish toxins by an inhibition immunoassay using a microsphere-flow cytometry system

scientific article published on 31 July 2013

New gastropod vectors and tetrodotoxin potential expansion in temperate waters of the Atlantic Ocean.

scientific article

New invertebrate vectors for PST, spirolides and okadaic acid in the North Atlantic.

scientific article published on 5 June 2013

New protocol to obtain spirolides from Alexandrium ostenfeldii cultures with high recovery and purity

scientific article

Non-immunological release of histamine from rat mast cells elicited by antineoplastic agents

scientific article published on 01 January 1992

Nonimmunological release of histamine from rat mast cells elicited by antineoplastic agents: effect of drug combinations

scientific article published on 01 January 1992

Okadaic acid and dinophysis toxin 2 have differential toxicological effects in hepatic cell lines inducing cell cycle arrest, at G0/G1 or G2/M with aberrant mitosis depending on the cell line ⬇️

scientific article published on April 22, 2011

Oral Chronic Toxicity of the Safe Tetrodotoxin Dose Proposed by the European Food Safety Authority and Its Additive Effect with Saxitoxin

scientific article published on 09 May 2020

Oral toxicity of okadaic acid in mice: study of lethality, organ damage, distribution and effects on detoxifying gene expression.

scientific article

Ostreocin-D impact on globular actin of intact cells.

scientific article

Ouabain-induced enhancement of rat mast cells response. Modulation by protein phosphorylation and intracellular pH.

scientific article published in July 2001

PKC and cAMP positively modulate alkaline-induced exocytosis in the human mast cell line HMC-1.

scientific article published on December 2006

PKC potentiates tyrosine kinase inhibitors STI571 and dasatinib cytotoxic effect

scientific article

Palytoxin detection and quantification using the fluorescence polarization technique

scientific article published on 25 February 2012

Palytoxins and cytoskeleton: An overview.

scientific article published on 07 October 2010

Paralytic Shellfish Toxins Occurrence in Non-Traditional Invertebrate Vectors from North Atlantic Waters (Azores, Madeira, and Morocco)

scientific article published on 06 September 2018

Paralytic shellfish poisoning detection by surface plasmon resonance-based biosensors in shellfish matrixes

scientific article published on 14 July 2007

Pharmacokinetic and toxicological data of spirolides after oral and intraperitoneal administration.

scientific article

Potassium currents inhibition by gambierol analogs prevents human T lymphocyte activation

scientific article published on 26 August 2014

Production of functionally active palytoxin-like compounds by Mediterranean Ostreopsis cf. siamensis.

scientific article

Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice

scientific article published on 27 November 2009

Protein kinase C modulates Aurora-kinase inhibition induced by CCT129202 in HMC-1⁵⁶⁰,⁸¹⁶ cell line

scientific article published on January 2013

Protein synthesis inhibition and oxidative stress induced by cylindrospermopsin elicit apoptosis in primary rat hepatocytes

scientific article published on 15 January 2013

Purification of five azaspiracids from mussel samples contaminated with DSP toxins and azaspiracids

scientific article

Pyrazolopyrimidines: synthesis, effect on histamine release from rat peritoneal mast cells and cytotoxic activity

scientific article published in April 2001

Quantification of yessotoxin using the fluorescence polarization technique and study of the adequate extraction procedure

scientific article published in September 2005

Rat pleural and peritoneal mast cells stimulated at different cellular levels: difference in and influence of purification media

scientific article published on 01 January 1993

Reevaluation of the acute toxicity of palytoxin in mice: Determination of lethal dose 50 (LD50) and No-observed-adverse-effect level (NOAEL)

scientific article published on 24 January 2020

Remembering Dr. Rex Munday

scientific article published on 24 August 2017

Resonant mirror biosensor detection method based on yessotoxin-phosphodiesterase interactions.

scientific article published in December 2004

Resveratrol inhibits proliferation of primary rat hepatocytes in G0/G1 by inhibiting DNA synthesis

scientific article published on January 1, 2012

Role of AKAP 149-PKA-PDE4A complex in cell survival and cell differentiation processes

scientific article published on 9 May 2014

Role of HCO−3Ions in Cytosolic pH Regulation in Rat Mast Cells: Evidence for a New Na+-Independent, HCO−3-Dependent Alkalinizing Mechanism

scientific article published on 01 December 1998

Role of the plasma membrane calcium adenosine triphosphatase on domoate-induced intracellular acidification in primary cultures of cerebelar granule cells

scientific article

Role of yessotoxin in calcium and cAMP‐crosstalks in primary and K‐562 human lymphocytes: The effect is mediated by Anchor kinase a mitochondrial proteins ⬇️

scientific article published on December 1, 2012

STI571 (Glivec) affects histamine release and intracellular pH after alkalinisation in HMC-1560, 816.

scientific article

Secretory activity of mast cells in the presence of cholinergic agonists

scientific article published on December 1983

Serotonin involvement in okadaic acid-induced diarrhoea in vivo

scientific article published on 20 June 2021

Simplified immunosuppressive and neuroprotective agents based on gracilin A

scientific article published on 22 March 2019

Single laboratory validation of a surface plasmon resonance biosensor screening method for paralytic shellfish poisoning toxins

scientific article

Solid-Phase Receptor-Based Assay for the Detection of Cyclic Imines by Chemiluminescence, Fluorescence, or Colorimetry

scientific article published on 06 July 2011

Somatostatin structure-activity studies in the stomach

scientific article published on 01 January 1988

Specific and dynamic detection of palytoxins by in vitro microplate assay with human neuroblastoma cells.

scientific article

Spongionella secondary metabolites protect mitochondrial function in cortical neurons against oxidative stress

scientific article published on 27 January 2014

Streptocyclinones A and B ameliorate Alzheimer's disease pathological processes in vitro

scientific article published on 08 September 2018

Structure Elucidation and Biological Evaluation of Maitotoxin-3, a Homologue of Gambierone, from

scientific article published on 01 February 2019

Structure and biological evaluation of new cyclic and acyclic laxaphycin-A type peptides ⬇️

scientific article published on 26 March 2019

Studies of the intracellular Ca2+ levels in human adult skin mast cells activated by the ligand for the human c-kit receptor and anti-IgE

scientific article published on 01 June 1994

Study of Adsorption and Flocculation Properties of Natural Clays to Remove Prorocentrum lima

scientific article

Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay

scientific article published in August 2001

Study of the activation mechanism of adriamycin on rat mast cells

scientific article published on 01 October 1994

Study of the activation mechanism of human GRF(1-29)NH2 on rat mast cell histamine release

scientific article published on 01 February 1995

Study of the interaction between different phosphodiesterases and yessotoxin using a resonant mirror biosensor

scientific article published in June 2006

Study of the neuronal effects of ouabain and palytoxin and their binding to Na,K-ATPases using an optical biosensor

scientific article published on 10 May 2007

Surface Plasmon Resonance Biosensor Screening Method for Paralytic Shellfish Poisoning Toxins: A Pilot Interlaboratory Study

scientific article published on 10 May 2011

Surface plasmon resonance biosensor method for palytoxin detection based on Na+,K+-ATPase affinity.

scientific article published on 27 December 2013

Sustainable production of biologically active molecules of marine based origin

scientific article published on 03 April 2013

Synthesis and antiallergic activity of pyridothienopyrimidines

scientific article published on 01 October 1998

Synthesis and antihistaminic activity of 2-guanadino-3-cyanopyridines and pyrido[2,3-d]-pyrimidines

scientific article published on 01 August 1997

Synthetic ciguatoxin CTX 3C induces a rapid imbalance in neuronal excitability

scientific article published on 19 May 2015

Tetrodotoxins Occurrence in Non-Traditional Vectors of the North Atlantic Waters (Portuguese Maritime Territory, and Morocco Coast)

scientific article published on 29 May 2019

The Cholinergic Antagonist Gymnodimine Improves Aβ and Tau Neuropathology in an in Vitro Model of Alzheimer Disease

article

The Cl−HCO3− exchanger slows the recovery of acute pHi changes in rat mast cells

scientific article published on 01 February 2003

The Marine Guanidine Alkaloid Crambescidin 816 Induces Calcium Influx and Cytotoxicity in Primary Cultures of Cortical Neurons through Glutamate Receptors

scientific article published on 4 April 2017

The antineoplastic drug vinorelbine activates non-immunological histamine release from rat mast cells

scientific article published on 01 April 1997

The c-Jun-N-terminal kinase is involved in the neurotoxic effect of azaspiracid-1.

scientific article published in January 2007

The cytoskeleton, a structure that is susceptible to the toxic mechanism activated by palytoxins in human excitable cells.

scientific article

The effect of rottlerin in calcium regulation in HMC-1(560) cells is mediated by a PKC-delta independent effect

scientific article

The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils.

scientific article

The impact of depuration on mussel hepatopancreas bacteriome composition and predicted metagenome.

scientific article published on 17 January 2018

The kinetic, mechanistic and cytomorphological effects of palytoxin in human intestinal cells (Caco-2) explain its lower-than-parenteral oral toxicity

scientific article

The marine polyether gambierol enhances muscle contraction and blocks a transient K(+) current in skeletal muscle cells

scientific article published on 9 June 2010

The methyl ester of okadaic acid is more potent than okadaic acid in disrupting the actin cytoskeleton and metabolism of primary cultured hepatocytes

scientific article

The sodium channel of human excitable cells is a target for gambierol.

scientific article published on 20 June 2006

Three Rs Approaches in Marine Biotoxin Testing. The Report and Recommendations of a joint ECVAM/DG SANCO Workshop (ECVAM Workshop 54)

scientific article published on 01 May 2006

Transcriptomic Analysis of Ciguatoxin-Induced Changes in Gene Expression in Primary Cultures of Mice Cortical Neurons.

scientific article

Translocation of PKC by yessotoxin in an in vitro model of Alzheimer's disease with improvement of tau and β-amyloid pathology.

scientific article published on 08 April 2013

UPLC-MS-IT-TOF Identification of Circumdatins Produced by Aspergillus ochraceus.

scientific article published on 24 May 2017

Use of biosensors as alternatives to current regulatory methods for marine biotoxins

scientific article

Valinomycin, a degranulating agent in rat mast cells which inhibits calcium-uptake

scientific article published on 01 December 1987

Veratridine elicits histamine release and promotes calcium uptake in mast cells

scientific article published on 01 September 1988

Yessotoxin activates cell death pathways independent of Protein Kinase C in K-562 human leukemic cell line.

scientific article published on 27 May 2015

Yessotoxin, a Promising Therapeutic Tool

scientific article

Yessotoxin, a novel phycotoxin, activates phosphodiesterase activity. Effect of yessotoxin on cAMP levels in human lymphocytes.

scientific article

Zoanthamine Alkaloids from the Zoantharian Zoanthus cf. pulchellus and Their Effects in Neuroinflammation

scientific article published on 20 July 2018

[Effect of colchicine on histamine secretion and calcium uptake in mast cells]

scientific article published on 01 March 1988

[Effect of isoproterenol on the liberation of histamine from rat lung mast cells]

scientific article published on 01 March 1991

[Inhibition of histamine liberation in mast cells from the lung and the intestine of the dog by isoproterenol]

scientific article published on 01 March 1991

[Is the existence of negative interactions between mastocyte populations possible?]

scientific article published on 01 August 1986

[Isolation of mastocytes from rat peritoneal fluid using continuous Ficoll gradients]

scientific article published on 01 December 1983

[Na+ K+ ATPase activity in mast cells from the pleural and peritoneal cavities of the rat]

scientific article published on 01 March 1986

[Response of pleural and peritoneal mastocyte populations in the rat to agents with different mechanisms of action]

scientific article published on 01 December 1986

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