List of works - Luis M. Botana

KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients

article

The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils.

scientific article

First toxicity report of tetrodotoxin and 5,6,11-trideoxyTTX in the trumpet shell Charonia lampas lampas in Europe

scientific article published on 18 June 2008

First Detection of Tetrodotoxin in Greek Shellfish by UPLC-MS/MS Potentially Linked to the Presence of the Dinoflagellate Prorocentrum minimum

scientific article published on 20 May 2015

Modulation of cytosolic calcium levels of human lymphocytes by yessotoxin, a novel marine phycotoxin

scientific article

Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins.

scientific article published on 24 October 2008

Yessotoxin, a novel phycotoxin, activates phosphodiesterase activity. Effect of yessotoxin on cAMP levels in human lymphocytes.

scientific article

New gastropod vectors and tetrodotoxin potential expansion in temperate waters of the Atlantic Ocean.

scientific article

"Fluorescent glycogen" formation with sensibility for in vivo and in vitro detection

scientific article published on November 2007

A fluorescent microplate assay for diarrheic shellfish toxins

scientific article published on 01 June 1997

Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells

scientific article published on 2 December 2003

Paralytic shellfish poisoning detection by surface plasmon resonance-based biosensors in shellfish matrixes

scientific article published on 14 July 2007

Fluorescent microplate cell assay to measure uptake and metabolism of glucose in normal human lung fibroblasts.

scientific article published in June 2002

Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line

scientific article published on February 2002

First toxin profile of ciguateric fish in Madeira Arquipelago (Europe).

scientific article

Sustainable production of biologically active molecules of marine based origin

scientific article published on 03 April 2013

Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins.

scientific article

Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications

scientific article

Detection of gymnodimine-A and 13-desmethyl C spirolide phycotoxins by fluorescence polarization

scientific article published in April 2009

13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro

scientific article published on 30 August 2011

Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice

scientific article published on 27 November 2009

Crambescidin-816 acts as a fungicidal with more potency than crambescidin-800 and -830, inducing cell cycle arrest, increased cell size and apoptosis in Saccharomyces cerevisiae.

scientific article

Maitotoxin-induced calcium entry in human lymphocytes: modulation by yessotoxin, Ca(2+) channel blockers and kinases.

scientific article

Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay

scientific article published in August 2001

Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies.

scientific article published on November 2006

First evidence of spirolides in Spanish shellfish

scientific article published on 08 September 2006

Biphasic Ca2+ responses in human basophils. Evidence that the initial transient elevation associated with the mobilization of intracellular calcium is an insufficient signal for degranulation

scientific article published on 01 February 1993

First Report of Ciguatoxins in Two Starfish Species: Ophidiaster ophidianus and Marthasterias glacialis.

scientific article

Lactone ring of pectenotoxins: a key factor for their activity on cytoskeletal dynamics

scientific article published in January 2007

Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells

scientific article published on 7 April 2007

Apoptotic events induced by the phosphatase inhibitor okadaic acid in normal human lung fibroblasts

scientific article

Mitigation of ROS insults by Streptomyces secondary metabolites in primary cortical neurons

scientific article

Characterization of F-actin depolymerization as a major toxic event induced by pectenotoxin-6 in neuroblastoma cells

scientific article published in June 2002

Differential effects of crambescins and crambescidin 816 in voltage-gated sodium, potassium and calcium channels in neurons.

scientific article

In vitro and in vivo evaluation of paralytic shellfish poisoning toxin potency and the influence of the pH of extraction.

scientific article

Effects of Azaspiracids 2 and 3 on intracellular cAMP, [Ca2+], and pH.

scientific article

Functional compartments in rat mast cells for cAMP and calcium on histamine release

scientific article published on 01 May 2000

Confocal microscopy study of the different patterns of 2-NBDG uptake in rabbit enterocytes in the apical and basal zone

scientific article

Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets.

scientific article

Mechanism of cytotoxic action of crambescidin-816 on human liver-derived tumour cells.

scientific article published on April 2014

Benefit of 13-desmethyl spirolide C treatment in triple transgenic mouse model of Alzheimer disease: beta-amyloid and neuronal markers improvement.

scientific article published in March 2013

The sodium channel of human excitable cells is a target for gambierol.

scientific article published on 20 June 2006

Single laboratory validation of a surface plasmon resonance biosensor screening method for paralytic shellfish poisoning toxins

scientific article

Effect of okadaic acid on glucose regulation.

scientific article

Effect of okadaic acid on immunologic and non-immunologic histamine release in rat mast cells

scientific article published on 01 February 1994

The methyl ester of okadaic acid is more potent than okadaic acid in disrupting the actin cytoskeleton and metabolism of primary cultured hepatocytes

scientific article

Biological methods for marine toxin detection

scientific article published on 12 May 2010

The Cholinergic Antagonist Gymnodimine Improves Aβ and Tau Neuropathology in an in Vitro Model of Alzheimer Disease

article

Azaspiracid-4 inhibits Ca2+ entry by stored operated channels in human T lymphocytes.

scientific article published on 20 April 2005

Development of a F actin-based live-cell fluorimetric microplate assay for diarrhetic shellfish toxins

scientific article published on June 2003

List of works by Luis M. Botana

KIT mutation in mast cells and other bone marrow hematopoietic cell lineages in systemic mast cell disorders: a prospective study of the Spanish Network on Mastocytosis (REMA) in a series of 113 patients

The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils.

First toxicity report of tetrodotoxin and 5,6,11-trideoxyTTX in the trumpet shell Charonia lampas lampas in Europe

First Detection of Tetrodotoxin in Greek Shellfish by UPLC-MS/MS Potentially Linked to the Presence of the Dinoflagellate Prorocentrum minimum

Modulation of cytosolic calcium levels of human lymphocytes by yessotoxin, a novel marine phycotoxin

Marine toxins and the cytoskeleton: okadaic acid and dinophysistoxins.

Yessotoxin, a novel phycotoxin, activates phosphodiesterase activity. Effect of yessotoxin on cAMP levels in human lymphocytes.

New gastropod vectors and tetrodotoxin potential expansion in temperate waters of the Atlantic Ocean.

"Fluorescent glycogen" formation with sensibility for in vivo and in vitro detection

A fluorescent microplate assay for diarrheic shellfish toxins

Cytoskeletal disruption is the key factor that triggers apoptosis in okadaic acid-treated neuroblastoma cells

Paralytic shellfish poisoning detection by surface plasmon resonance-based biosensors in shellfish matrixes

Fluorescent microplate cell assay to measure uptake and metabolism of glucose in normal human lung fibroblasts.

Characterization of distinct apoptotic changes induced by okadaic acid and yessotoxin in the BE(2)-M17 neuroblastoma cell line

First toxin profile of ciguateric fish in Madeira Arquipelago (Europe).

Sustainable production of biologically active molecules of marine based origin

Actin cytoskeleton of rabbit intestinal cells is a target for potent marine phycotoxins.

Design and synthesis of skeletal analogues of gambierol: attenuation of amyloid-β and tau pathology with voltage-gated potassium channel and N-methyl-D-aspartate receptor implications

Detection of gymnodimine-A and 13-desmethyl C spirolide phycotoxins by fluorescence polarization

13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro

Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice

Crambescidin-816 acts as a fungicidal with more potency than crambescidin-800 and -830, inducing cell cycle arrest, increased cell size and apoptosis in Saccharomyces cerevisiae.

Maitotoxin-induced calcium entry in human lymphocytes: modulation by yessotoxin, Ca(2+) channel blockers and kinases.

Study of cytoskeletal changes induced by okadaic acid in BE(2)-M17 cells by means of a quantitative fluorimetric microplate assay

Cell growth inhibition and actin cytoskeleton disorganization induced by azaspiracid-1 structure-activity studies.

First evidence of spirolides in Spanish shellfish

Biphasic Ca2+ responses in human basophils. Evidence that the initial transient elevation associated with the mobilization of intracellular calcium is an insufficient signal for degranulation

First Report of Ciguatoxins in Two Starfish Species: Ophidiaster ophidianus and Marthasterias glacialis.

Lactone ring of pectenotoxins: a key factor for their activity on cytoskeletal dynamics

Irreversible cytoskeletal disarrangement is independent of caspase activation during in vitro azaspiracid toxicity in human neuroblastoma cells

Apoptotic events induced by the phosphatase inhibitor okadaic acid in normal human lung fibroblasts

Mitigation of ROS insults by Streptomyces secondary metabolites in primary cortical neurons

Characterization of F-actin depolymerization as a major toxic event induced by pectenotoxin-6 in neuroblastoma cells

Differential effects of crambescins and crambescidin 816 in voltage-gated sodium, potassium and calcium channels in neurons.

In vitro and in vivo evaluation of paralytic shellfish poisoning toxin potency and the influence of the pH of extraction.

Effects of Azaspiracids 2 and 3 on intracellular cAMP, [Ca2+], and pH.

Functional compartments in rat mast cells for cAMP and calcium on histamine release

Confocal microscopy study of the different patterns of 2-NBDG uptake in rabbit enterocytes in the apical and basal zone

Azaspiracid-1, a potent, nonapoptotic new phycotoxin with several cell targets.

Mechanism of cytotoxic action of crambescidin-816 on human liver-derived tumour cells.

Benefit of 13-desmethyl spirolide C treatment in triple transgenic mouse model of Alzheimer disease: beta-amyloid and neuronal markers improvement.

The sodium channel of human excitable cells is a target for gambierol.

Single laboratory validation of a surface plasmon resonance biosensor screening method for paralytic shellfish poisoning toxins

Effect of okadaic acid on glucose regulation.

Effect of okadaic acid on immunologic and non-immunologic histamine release in rat mast cells

The methyl ester of okadaic acid is more potent than okadaic acid in disrupting the actin cytoskeleton and metabolism of primary cultured hepatocytes

Biological methods for marine toxin detection

The Cholinergic Antagonist Gymnodimine Improves Aβ and Tau Neuropathology in an in Vitro Model of Alzheimer Disease

Azaspiracid-4 inhibits Ca2+ entry by stored operated channels in human T lymphocytes.

Development of a F actin-based live-cell fluorimetric microplate assay for diarrhetic shellfish toxins